Susceptibility of fetal, virgin, pregnant and lactating rats for the induction of mammary tumors by gamma rays.

abstract：:Previous work showed that treatment of plateau-phase Chinese hamster ovary cells with the radiomimetic double-strand cleaving agent bleomycin induced very small deletions as well as interchromosomal reciprocal translocations, both of which could be ascribed to errors in end joining of DNA double-strand breaks. In an a...

journal_title：Radiation research

authors： Yu Y,Inamdar KV,Turner K,Jackson-Cook CK,Povirk LF

更新日期：2002-09-01 00:00:00

abstract：:We previously described an enhanced sensitivity for cell killing and gamma-H2AX focus induction after both high-dose-rate and continuous low-dose-rate gamma irradiation in 14 primary fibroblast strains derived from hereditary-type retinoblastoma family members (both affected RB1(+/-) probands and unaffected RB1(+/+) p...

journal_title：Radiation research

authors： Wilson PF,Nagasawa H,Fitzek MM,Little JB,Bedford JS

更新日期：2010-01-01 00:00:00

abstract：:Hypoxic BP-8 murine sarcoma cells were exposed to misonidazole and/or radiation and the kinetics and extent of cell death were evaluated with the [125I]iododeoxyuridine-prelabeling assay. Cell death after treatment with lethal doses of misonidazole was rapid and essentially complete within 2 or 3 days after drug expos...

journal_title：Radiation research

authors： Hofer KG,Friedland JL,Dynlacht J,Hofer MG

更新日期：1987-07-01 00:00:00

abstract：:Experimental measurements of the radial restricted linear energy transfer (LETr) for alpha beams of 18.3 MeV/n in tissue-equivalent gas were presented. The radial dose distribution for the alpha beam was deduced from the restricted LET measurements. A differential W value for the alpha particle in the tissue-equivalen...

journal_title：Radiation research

authors： Kanai T,Kawachi K

更新日期：1987-12-01 00:00:00

abstract：:Acute thermotolerance was induced in Chinese hamster ovary cells by heating at 43 degrees C for 45 min followed by incubation at 37 degrees C for up to 85 h. The degree of thermotolerance induced was quantified by a second heat exposure at 43 degrees C. To study the interaction of thermotolerance and thermosensitizati...

journal_title：Radiation research

authors： Jung H

更新日期：1994-09-01 00:00:00

abstract：:The goal of this study was to make a comparison between stereotactic brachytherapy implants and linear accelerator-based radiosurgery of brain tumors with respect to physical dose distributions and radiobiological efficacy. Twenty-four treatment plans made for irradiation of brain tumors with low-dose-rate (125)I brac...

journal_title：Radiation research

authors： Viola A,Major T,Julow J

更新日期：2006-06-01 00:00:00

abstract：:Dose-response relationships observed in laboratory animals can be used to identify possible human risk factors and may also be used in a quantitative manner when human data are not available. This paper presents an analysis of the dose dependency of osteosarcoma incidence in beagle dogs given a single inhalation expos...

journal_title：Radiation research

authors： Shyr LJ,Muggenburg BA

更新日期：1992-10-01 00:00:00

abstract：:Radiation-induced cell death is thought to be caused by nuclear DNA damage that cannot be repaired. However, in this study we found that a delayed increase of mitochondrial reactive oxygen species (ROS) is responsible for some of the radiation-induced cell death in normal human fibroblast cells. We have previously rep...

journal_title：Radiation research

authors： Kobashigawa S,Kashino G,Suzuki K,Yamashita S,Mori H

更新日期：2015-04-01 00:00:00

abstract：:An analysis was conducted of 27,982 deaths among 106,020 persons employed at four Federal nuclear plants in Oak Ridge, Tennessee, between 1943 and 1985. The main objectives were to extend the evaluation of the health effects of employment in the nuclear industry in Oak Ridge to include most workers who were omitted fr...

journal_title：Radiation research

authors： Frome EL,Cragle DL,Watkins JP,Wing S,Shy CM,Tankersley WG,West CM

更新日期：1997-07-01 00:00:00

abstract：:A standardized dichlorofluorescin (DCF) fluorometric assay capable of measuring radiation-induced oxidative stress was used to determine the effectiveness of protons and high-mass, high-atomic number (Z) and high-energy (HZE) particles to produce oxidative stress in vitro. Protons were found to be about equally as eff...

journal_title：Radiation research

authors： Wan XS,Bloch P,Ware JH,Zhou Z,Donahue JJ,Guan J,Stewart J,Kennedy AR

更新日期：2005-04-01 00:00:00

abstract：:Several lines of correlative evidence link transforming growth factor alpha (Tgfa, also known as TGF-alpha) to proliferative activity in jejunal crypt cells. It is therefore tempting to hypothesize that, as a ligand of the epidermal growth factor, it mediates the compensatory proliferative burst in the crypts after ra...

journal_title：Radiation research

authors： Evans SC,Mack DC,Mason KA,Thames HD

更新日期：2001-06-01 00:00:00

abstract：:Metallothionein (MT), the synthesis of which can be induced by metalloelement administration, is a known radical scavenger. This study investigated the possible protective effect of MT against acute radiation injury. Manganese chloride (10 mg of manganese/kg) was administered intraperitoneally to male C3H/He mice 24 h...

journal_title：Radiation research

authors： Murata R,Nishimura Y,Hiraoka M,Abe M,Satoh M

更新日期：1995-09-01 00:00:00

abstract：:Radiation exposure causes DNA breaks leading to structural chromosome aberrations that can be carcinogenic. Lifetime cancer risks are elevated in irradiated children compared to similarly exposed adults. To determine the extent to which age influences the frequency and types of chromosome damage in response to ionizin...

journal_title：Radiation research

authors： Bakhmutsky MV,Joiner MC,Jones TB,Tucker JD

更新日期：2014-06-01 00:00:00

abstract：:The efficiency of boron neutron capture therapy (BNCT) for malignant gliomas depends on the selective and absolute accumulation of (10)B atoms in tumor tissues. Only two boron compounds, BPA and BSH, currently can be used clinically. However, the detailed distributions of these compounds have not been determined. Here...

journal_title：Radiation research

authors： Yokoyama K,Miyatake S,Kajimoto Y,Kawabata S,Doi A,Yoshida T,Okabe M,Kirihata M,Ono K,Kuroiwa T

更新日期：2007-01-01 00:00:00

abstract：:The filter elution technique using nondenaturing conditions is widely used to assay DNA double-strand break (DSB) induction and repair. It has been reported that in the measurement of strand breaks higher rates of elution and of initial rejoining are obtained at pH 9.6 compared to pH 7.2. In the present experiments ne...

journal_title：Radiation research

authors： Flick MB,Warters RL,Yasui LS,Krisch RE

更新日期：1989-09-01 00:00:00

abstract：:The relationship between apoptosis induced by gamma radiation and glutathione in cells of two human cancer cell lines, HeLa from cervix carcinoma and MCF-7 from mammary carcinoma, was examined. MCF-7 cells appeared to be more radioresistant than HeLa cells, and radiation-induced apoptosis, which was monitored by asses...

journal_title：Radiation research

authors： Rosi A,Grande S,Luciani AM,Palma A,Giovannini C,Guidoni L,Sapora O,Viti V

更新日期：2007-03-01 00:00:00

abstract：:The molecular structure of mutants induced in human lymphoblast cells by 500 cGy X rays in the presence of the radioprotector cysteamine (25 mM) has been compared with that induced by an equally mutagenic treatment of 150 cGy X rays alone. Sets of mutants at the hypoxanthine-guanine phosphoribosyl transferase locus we...

journal_title：Radiation research

authors： Liber HL,Benforado K,Little JB

更新日期：1989-05-01 00:00:00

abstract：:In this study, we investigated microvascular perfusion status, changes to fat content and fatty acid composition in the bone marrow of rat femurs after total-body irradiation by quantitative permeability parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and ex vivo high-resolution magic angl...

journal_title：Radiation research

authors： Wang K,Zha Y,Lei H,Xu X

更新日期：2018-02-01 00:00:00

abstract：:The functional and morphological response of the remaining hypertrophied kidney in unilaterally nephrectomized rats to single doses of 0-20 Gy X rays was investigated. Functional and histological end points were assessed serially 4-24 weeks postirradiation. Renal irradiation led to time- and dose-dependent reductions ...

journal_title：Radiation research

authors： Robbins ME,O'Malley Y,Zhao W,Davis CS,Bonsib SM

更新日期：2001-03-01 00:00:00

abstract：:To characterize the differences in the radiosensitivity of individual populations of human hematopoietic stem/progenitor cells (HSPCs), we examined the relationship among cell surface antigens, clonogenic potential and radiation survival. The expressions of CD34, CD38, CD45RA, CD110 and Tie-2, early differentiation pa...

journal_title：Radiation research

authors： Takahashi K,Monzen S,Hayashi N,Kashiwakura I

更新日期：2010-02-01 00:00:00

abstract：:We have examined in mice the effects of mixed ligand treatments with desferrioxamine B (DFOA), Na3Ca-diethylenetriamine pentaacetic acid (DTPA), and DL-penicillamine (PA) on the retention of a mixture of 95Nb and 144Ce. The results show that 95Nb + 144Ce could be mobilized effectively by simultaneous application of sp...

journal_title：Radiation research

authors： Gachályi A,Naményi J,Szegedi I,Varga PL

更新日期：1989-10-01 00:00:00

abstract：:Whether inner-shell ionizations of DNA atoms, called core ionizations, are critical events for cell inactivation by ionizing radiations such as 100 keV electrons and gamma rays has been investigated. The number of core ionizations in DNA atoms per gray of the two types of radiations is calculated from various Monte Ca...

journal_title：Radiation research

authors： Boissière A,Champion C,Touati A,Hervé du Penhoat MA,Sabatier L,Chatterjee A,Chetioui A

更新日期：2007-04-01 00:00:00

abstract：:Normal human fibroblasts in plateau phase ( congruent with 95% G(1) phase) were stained with the vital nuclear dye Hoechst 33342 (blue fluorescence) or the vital cytoplasmic dye Cell Tracker Orange (orange fluorescence) and plated at a ratio of 1:1. Only the blue-fluorescing nuclei were microbeam-irradiated with a def...

journal_title：Radiation research

authors： Ponnaiya B,Jenkins-Baker G,Brenner DJ,Hall EJ,Randers-Pehrson G,Geard CR

更新日期：2004-10-01 00:00:00

abstract：:Induction of interphase death was examined in Chinese hamster ovary cells exposed to accelerated heavy ions (carbon, neon, argon and iron) of various linear energy transfers (LETs) (10-2000 keV/microm). The fraction of cells that underwent interphase death was determined by observing individual cells with time-lapse p...

journal_title：Radiation research

authors： Sasaki H,Yatagai F,Kanai T,Furusawa Y,Hanaoka F,Zhu WG,Mehnati P

更新日期：1997-11-01 00:00:00

abstract：:We studied heat-induced apoptosis and loss of clonogenicity in Rat-1 fibroblasts, thermotolerant Rat-1 (TT Rat-1), Rat-1 transfected with the human hsp-70 gene (M21) and Rat-1 transfected with the human c-myc proto-oncogene (Rat-1:myc). Relative to Rat-1, TT Rat-1 and M21 cells are heat-resistant, but Rat-1:myc cells ...

journal_title：Radiation research

authors： Li WX,Chen CH,Ling CC,Li GC

更新日期：1996-03-01 00:00:00

abstract：:Single crystals of guanine hydrochloride monohydrate, guanine hydrochloride dihydrate and anhydrous guanine dihydrochloride, doped with thioguanine, were irradiated with X and gamma rays. In all three systems the dominant radicals were associated with thioguanine. In the former two systems the stabilized species is th...

journal_title：Radiation research

authors： Herak JN,Sanković K,Krilov D,Hüttermann J

更新日期：1999-03-01 00:00:00

abstract：:Chinese hamster ovary cells were irradiated with 250 kVp X rays and analyzed for the presence of DNA double-strand breaks using either polycarbonate filter elution or pulsed-field agarose gel electrophoresis at neutral pH. Reduction in DNA length detected by filter elution was produced as a nonlinear function of incre...

journal_title：Radiation research

authors： Warters RL,Lyons BW

更新日期：1990-12-01 00:00:00

abstract：:In light-ion radiation therapy, both the dose and the local energy spectrum, which is often characterized with the linear energy transfer (LET), must be considered. In treatment optimization, it is advantageous to use a radiobiological model that analytically accounts for both dose and LET for the ion type of interest...

journal_title：Radiation research

authors： Wedenberg M,Lind BK,Toma-Daşu I,Rehbinder H,Brahme A

更新日期：2010-10-01 00:00:00

abstract：:This is the 14th report in a series of periodic general reports on mortality in the Life Span Study (LSS) cohort of atomic bomb survivors followed by the Radiation Effects Research Foundation to investigate the late health effects of the radiation from the atomic bombs. During the period 1950-2003, 58% of the 86,611 L...

journal_title：Radiation research

authors： Ozasa K,Shimizu Y,Suyama A,Kasagi F,Soda M,Grant EJ,Sakata R,Sugiyama H,Kodama K

更新日期：2012-03-01 00:00:00

abstract：:To investigate whether exposure to atomic bomb radiation altered the prevalence of hepatitis C virus (HCV) infection or accelerated the progress toward chronic hepatitis after HCV infection, the seropositivity of antibody to hepatitis C virus (anti-HCV) was determined for 6,121 participants in the Adult Health Study o...

journal_title：Radiation research

authors： Fujiwara S,Kusumi S,Cologne J,Akahoshi M,Kodama K,Yoshizawa H

更新日期：2000-07-01 00:00:00