Abstract:
PURPOSE:To determine the natural history of intracranial calcifications in infants with treated congenital toxoplasmosis. MATERIALS AND METHODS:Between January 1982 and March 1994, cranial computed tomography was performed in 56 infants with treated congenital toxoplasmosis when they were newborns and approximately 1 year old. Locations and sizes of intracranial calcifications were noted. RESULTS:Forty newborns had intracranial calcifications. By 1 year of age, calcifications diminished or resolved in 30 (75%) and remained stable in 10 (25%) of these treated infants. Ten (33%) of the 30 infants whose calcifications diminished versus seven (70%) of the 10 infants with stable calcifications received less intensive antimicrobial treatment than the other treated infants. In contrast, a small number of infants who were untreated or treated 1 month or less had intracranial calcifications that increased or remained stable during their 1st year of life. CONCLUSION:Diminution or resolution of intracranial calcifications was an unexpected and remarkable finding in infants with treated, congenital toxoplasmosis, consonant with their improved neurologic functioning.
journal_name
Radiologyjournal_title
Radiologyauthors
Patel DV,Holfels EM,Vogel NP,Boyer KM,Mets MB,Swisher CN,Roizen NJ,Stein LK,Stein MA,Hopkins J,Withers SE,Mack DG,Luciano RA,Meier P,Remington JS,McLeod RLdoi
10.1148/radiology.199.2.8668790subject
Has Abstractpub_date
1996-05-01 00:00:00pages
433-40issue
2eissn
0033-8419issn
1527-1315journal_volume
199pub_type
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