RASSF1A methylation indicates a poor prognosis in hepatoblastoma patients.

Abstract:

PURPOSE:The RAS association domain family protein 1 (RASSF1A) is known to be frequently inactivated by promoter hypermethylation in cancers. This study investigated the association of RASSF1A methylation with clinical outcomes in hepatoblastoma patients and whether it is correlated with the histological phenotype of hepatoblastoma tumors. METHODS:Seventy-four hepatoblastoma tumors were obtained from patients enrolled in the Japanese study group for pediatric liver tumor protocol-2. From nine formalin-fixed, paraffin-embedded specimens, we extracted DNA by dissection under a light microscope. We examined the methylation status of the RASSF1A promoter region by bisulfite pyrosequencing. RESULTS:Twenty-five (33.8 %) hepatoblastoma tumors were classified as having methylated RASSF1A. The RASSF1A methylation was significantly associated with metastatic tumors and a poor prognosis. Despite the complete resection, five pretreatment extent of disease II tumors showed recurrence or distant metastasis postoperatively. Among these cases, four tumors were found to show RASSF1A methylation. When compared to histologically different types of cell, RASSF1A methylation values in samples of the normal liver, fetal type, and embryonal type, were significantly elevated in ascending order. CONCLUSIONS:We confirmed that RASSF1A methylation is a significant prognostic indicator in hepatoblastomas, and it may become a promising molecular marker to stratify patients into appropriate risk groups.

journal_name

Pediatr Surg Int

authors

Honda S,Miyagi H,Suzuki H,Minato M,Haruta M,Kaneko Y,Hatanaka KC,Hiyama E,Kamijo T,Okada T,Taketomi A

doi

10.1007/s00383-013-3371-z

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

1147-52

issue

11

eissn

0179-0358

issn

1437-9813

journal_volume

29

pub_type

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