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Recruitment to clinical trials: a meta-ethnographic synthesis of studies of reasons for participation.

Abstract：

OBJECTIVES:Randomized controlled trials are important for evaluating health care interventions, but recruitment can be difficult. Studies of potential participants' perspectives on trial participation are accumulating, but their collective contribution is not obvious. In 2007, we conducted a meta-ethnographic synthesis of people's reasons for accepting or declining participation. This paper reports a second synthesis, conducted separately on the same topic, using studies published subsequently. It discusses both the substantive findings and the methodological implications for updating meta-ethnographies. METHODS:Systematic searches identified relevant papers published between 1996 and 2005 (first synthesis), then 2005 and 2010 (second synthesis). We used a meta-ethnographic interpretive process of translation to examine the relationships between study findings. FINDINGS:The two syntheses were broadly compatible, but the line of argument developed in the second more clearly highlighted how potential participants' health states and health care situations at the time of recruitment could interact with other considerations. In particular, they could influence the nature and significance for trial entry decisions of people's judgements about: their communication and relationship with trial recruiters; the personal implications of trial interventions and processes; and the 'common good' (helping others) and what their non/participation might say about their identity. CONCLUSIONS:Our work highlights the need for trialists to consider potential participants' health and health care situations when designing recruitment approaches. It also provides the first empirical insights on the process of updating meta-ethnographies that we are currently aware of. Approaches to updating meta-ethnographies need further investigation.

journal_name

J Health Serv Res Policy

journal_title

Journal of health services research & policy

authors

McCann S,Campbell M,Entwistle V

doi

10.1177/1355819613483126

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

233-41

issue

eissn

1355-8196

issn

1758-1060

pii

1355819613483126

journal_volume

pub_type

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Recruitment to clinical trials: a meta-ethnographic synthesis of studies of reasons for participation.