The neuropeptide calcitonin gene-related peptide stimulates insulin-like growth factor I production by primary fetal rat osteoblasts.

abstract：:Peripheral quantitative computed tomography (pQCT) captures novel aspects of bone geometry that may contribute to fracture risk and offers the ability to measure both volumetric bone mineral density (vBMD) and a separation of trabecular and cortical compartments of bone, but longitudinal data relating measures obtaine...

journal_title：Bone

authors： Dennison EM,Jameson KA,Edwards MH,Denison HJ,Aihie Sayer A,Cooper C

更新日期：2014-07-01 00:00:00

abstract：:We present a three-dimensional mineralizing model based on a hollow fiber bioreactor (HFBR) inoculated with primary osteoblasts isolated from embryonic chick calvaria. Using non-invasive magnetic resonance microscopy (MRM), the growth and development of the mineralized tissue around the individual fibers were monitore...

journal_title：Bone

authors： Chesnick IE,Avallone FA,Leapman RD,Landis WJ,Eidelman N,Potter K

更新日期：2007-04-01 00:00:00

abstract：:Bone healing is a complex multi-step process, which depends on the position and size of the lesion, and on the mechanical stability of the wounded area. To address more specifically the mechanisms involved in cortical bone healing, we created drill-hole defects in the cortex of mouse femur, a lesion that triggers intr...

journal_title：Bone

authors： Monfoulet L,Malaval L,Aubin JE,Rittling SR,Gadeau AP,Fricain JC,Chassande O

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Patients with primary hyperparathyroidism (PHPT) generally show reduced bone mineral density (BMD) at cortical sites with relatively preserved trabecular bone. However, the increased fracture risk at all skeletal sites suggests that areal BMD probably is not effective in capturing all the determinants of bon...

journal_title：Bone

authors： Romagnoli E,Cipriani C,Nofroni I,Castro C,Angelozzi M,Scarpiello A,Pepe J,Diacinti D,Piemonte S,Carnevale V,Minisola S

更新日期：2013-03-01 00:00:00

abstract：:Mutations in the SCN8A gene encoding the neuronal voltage-gated sodium channel Nav1.6 are known to be associated with epileptic encephalopathy type 13. We identified a novel de novo SCN8A mutation (p.Phe360Ala, c.1078_1079delTTinsGC, Exon 9) in a 6-year-old girl with epileptic encephalopathy accompanied by severe juve...

journal_title：Bone

authors： Rolvien T,Butscheidt S,Jeschke A,Neu A,Denecke J,Kubisch C,Meisler MH,Pueschel K,Barvencik F,Yorgan T,Oheim R,Schinke T,Amling M

更新日期：2017-10-01 00:00:00

abstract：:Osteocytes are suggested to play a central role in bone remodeling. Evaluation of iliac crest biopsies is a standard procedure for evaluating bone conditions in the clinical setting. Despite the widespread use of such biopsies, little is known about the population of osteocytes in the iliac crest from normal individua...

journal_title：Bone

authors： Bach-Gansmo FL,Brüel A,Jensen MV,Ebbesen EN,Birkedal H,Thomsen JS

更新日期：2016-10-01 00:00:00

abstract：:Bone remodeling is required for healthy calcium homeostasis and for repair of damage occurring with stress and age. Osteoclasts resorb bone and osteoblasts form bone. These processes normally occur in a tightly regulated sequence of events, where the amount of formed bone equals the amount of resorbed bone, thereby re...

journal_title：Bone

authors： Henriksen K,Neutzsky-Wulff AV,Bonewald LF,Karsdal MA

更新日期：2009-06-01 00:00:00

abstract：:Interleukin-1 (IL-1) has been shown to promote osteoclast (OC) differentiation, in addition to acting as a survival factor for mature osteoclasts. In this study, we investigate the expression of IL-1 during human osteoclast formation, taking advantage of a recently reported in vitro culture system that generates human...

journal_title：Bone

authors： Haynes DR,Atkins GJ,Loric M,Crotti TN,Geary SM,Findlay DM

更新日期：1999-09-01 00:00:00

abstract：:MLO-A5 cells are a fully differentiated osteoblastic cell line with the ability to rapidly synthesise mineralised extracellular matrix (ECM). We used MLO-A5 cells to develop a system for studying the mechanical modulation of bone matrix formation in 3D using a cyclic compressive loading stimulus. Polyurethane (PU) ope...

journal_title：Bone

authors： Sittichockechaiwut A,Scutt AM,Ryan AJ,Bonewald LF,Reilly GC

更新日期：2009-05-01 00:00:00

abstract：INTRODUCTION:Mechanical stresses on the bone are an important aspect of physical activity that promotes bone preservation and increases in bone mass. Exercise intensities leading to bone preservation and accrual have not been adequately defined for humans in general, and postmenopausal women in particular. MATERIALS A...

journal_title：Bone

authors： Borer KT,Fogleman K,Gross M,La New JM,Dengel D

更新日期：2007-10-01 00:00:00

abstract：:Osteocytes form over 90% of the bone cells and are postulated to be mechanosensors responsible for regulating the function of osteoclasts and osteoblasts in bone modeling and remodeling. Physical activity results in mechanical loading on the bones. Osteocytes are thought to be the main mechanosensory cells in bone. Up...

journal_title：Bone

authors： Ganesh T,Laughrey LE,Niroobakhsh M,Lara-Castillo N

更新日期：2020-08-01 00:00:00

abstract：PURPOSE:Low trauma rib fracture (hereinafter, rib fracture) is common in the elderly, but its risk factors and mortality consequence are rarely studied. We sought to define the epidemiology of rib fracture and the association between rib fracture and postfracture mortality. METHODS:The study was part of the Dubbo Oste...

journal_title：Bone

authors： Mai HT,Tran TS,Ho-Le TP,Pham TT,Center JR,Eisman JA,Nguyen TV

更新日期：2018-11-01 00:00:00

abstract：:Bone homeostasis is regulated by a balance of bone formation and bone resorption; dysregulation of bone homeostasis may cause bone-related diseases (e.g., osteoporosis, osteopetrosis, bone fracture). Members of the nuclear factor of activated T cells (NFAT) family of transcription factors play crucial roles in the reg...

journal_title：Bone

authors： Kim HM,He L,Lee S,Park C,Kim DH,Han HJ,Han J,Hwang J,Cha-Molstad H,Lee KH,Ko SK,Jang JH,Ryoo IJ,Blenis J,Lee HG,Ahn JS,Kwon YT,Soung NK,Kim BY

更新日期：2020-02-01 00:00:00

abstract：:The incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) are well known for their insulinotropic effects and they are thought to affect bone homeostasis as mediators in the so-called entero-osseous axis. We examined the contributions of endogenous GIP and GLP-1, resp...

journal_title：Bone

authors： Helsted MM,Gasbjerg LS,Lanng AR,Bergmann NC,Stensen S,Hartmann B,Christensen MB,Holst JJ,Vilsbøll T,Rosenkilde MM,Knop FK

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Radiation treatment results in a severe diminution of osseous vascularity. Intermittent parathyroid hormone (PTH) has been shown to have an anabolic effect on osteogenesis, though its impact on angiogenesis remains unknown. In this murine model of distraction osteogenesis, we hypothesize that radiation treat...

journal_title：Bone

authors： Kang SY,Deshpande SS,Donneys A,Rodriguez JJ,Nelson NS,Felice PA,Chepeha DB,Buchman SR

更新日期：2013-09-01 00:00:00

abstract：:Skeletal unloading in an animal hindlimb suspension model and microgravity experienced by astronauts or as a result of prolonged bed rest causes site-specific losses in bone mineral density of 1%-2% per month. This is accompanied by reductions in circulating levels of 1,25-(OH)(2)D(3), the active metabolite of vitamin...

journal_title：Bone

authors： Narayanan R,Smith CL,Weigel NL

更新日期：2002-09-01 00:00:00

abstract：:The genetic influences on bone mass likely change throughout the life span, but most genetic studies of bone mass regulation have focused on adults. There is, however, a growing awareness of the importance of genes influencing the acquisition of bone mass during childhood on lifelong bone health. The present investiga...

journal_title：Bone

authors： Duren DL,Sherwood RJ,Choh AC,Czerwinski SA,Chumlea WC,Lee M,Sun SS,Demerath EW,Siervogel RM,Towne B

更新日期：2007-02-01 00:00:00

abstract：:Trabecular bone score (TBS) is a recently-developed analytical tool that performs novel grey-level texture measurements on lumbar spine dual X-ray absorptiometry (DXA) images, and thereby captures information relating to trabecular microarchitecture. In order for TBS to usefully add to bone mineral density (BMD) and c...

journal_title：Bone

authors： Harvey NC,Glüer CC,Binkley N,McCloskey EV,Brandi ML,Cooper C,Kendler D,Lamy O,Laslop A,Camargos BM,Reginster JY,Rizzoli R,Kanis JA

更新日期：2015-09-01 00:00:00

abstract：PURPOSE:To compare the power of FRAX® without bone mineral density (BMD) and simpler screening tools (OST, ORAI, OSIRIS, SCORE and age alone) in predicting fractures. METHODS:This study was a prospective, population-based study performed in Denmark comprising 3614 women aged 40-90 years, who returned a questionnaire c...

journal_title：Bone

authors： Rubin KH,Abrahamsen B,Friis-Holmberg T,Hjelmborg JV,Bech M,Hermann AP,Barkmann R,Glüer CC,Brixen K

更新日期：2013-09-01 00:00:00

abstract：:Bone geometry plays a prominent role in bone strength. Cross-sectional studies have shown that advancing age is associated with increasing diameter of long bones, related to both periostal apposition and endosteal resorption. However, there are few data provided by prospective studies, especially concerning the change...

journal_title：Bone

authors： Briot K,Kolta S,Fechtenbaum J,Said-Nahal R,Benhamou CL,Roux C

更新日期：2010-08-01 00:00:00

abstract：:Bisphosphonates (BPs) are the first-line therapy for osteoporosis. In recent years, atypical femoral fractures (AFF) have been described in patients on BPs therapy. However, the relationship between BPs and AFF remains to be clarified. We evaluated clinical and hormonal characteristics of AFF patients, in order to det...

journal_title：Bone

authors： Franceschetti P,Bondanelli M,Caruso G,Ambrosio MR,Lorusso V,Zatelli MC,Massari L,Degli Uberti EC

更新日期：2013-10-01 00:00:00

abstract：:It is well known that physical inactivity leads to loss of muscle mass, but it also causes bone loss. Mechanistically, osteoclastogenesis and bone resorption have recently been shown to be regulated by vibration. However, the underlying mechanism behind the inhibition of osteoclast formation is yet unknown. Therefore,...

journal_title：Bone

authors： Kulkarni RN,Voglewede PA,Liu D

更新日期：2013-12-01 00:00:00

abstract：:Regeneration of bone defects caused by trauma, infection, tumours or inherent genetic disorders is a clinical challenge that usually necessitates bone grafting materials. Autologous bone or autograft is still considered the clinical "gold standard" and the most effective method for bone regeneration. However, limited ...

journal_title：Bone

authors： García-Gareta E,Coathup MJ,Blunn GW

更新日期：2015-12-01 00:00:00

abstract：:Disuse osteopenia and bone loss have been extensively reported in long duration space mission and long term bed rest. The pathology of the bone loss is similar to osteoporosis but highly confined to weight bearing bones. The current anabolic and/or anti-resorptive drugs have systemic effects and are costly over extend...

journal_title：Bone

authors： Uddin SM,Qin YX

更新日期：2015-06-01 00:00:00

abstract：:Strontium ranelate (S12911) has previously been shown to stimulate bone formation and inhibit bone resorption in rats. To determine whether strontium ranelate affects normal bone remodeling, we studied the effect of strontium ranelate on alveolar bone in monkeys. Strontium ranelate, at dosages of 100, 275, and 750 mg/...

journal_title：Bone

authors： Buehler J,Chappuis P,Saffar JL,Tsouderos Y,Vignery A

更新日期：2001-08-01 00:00:00

abstract：:A macro-micro-nano-multi-level study was conducted to explore age-related structural and mechanical properties of bone, as well as the effects of aging on bone properties. A total of 70 male Wistar rats were used, ranging in the ages of 1, 3, 5, 7, 9, 11, 14, 15, 16, and 17 months (n = 7/age group). After micro-comput...

journal_title：Bone

authors： Zhang R,Gong H,Zhu D,Ma R,Fang J,Fan Y

更新日期：2015-07-01 00:00:00

abstract：:In an attempt to elucidate the biochemical defect in pseudoachondroplasia, proteoglycan metabolism was investigated in cartilage from a patient with the dominant form of this condition. Iliac-crest cartilage was radioactively labeled with 35S-sulfate and the newly synthesized proteoglycans examined for their hydrodyna...

journal_title：Bone

authors： Beck M,Lingnau K,Spranger J

更新日期：1988-01-01 00:00:00

abstract：:The purpose was to investigate whether the reduction in bone mechanical strength induced by immobilization could be prevented by a bisphosphonate compound, clodronate. The torsional breaking strength of the tibia was measured using a specially constructed torsion machine. Maximum torque capacity, maximum angle of defo...

journal_title：Bone

authors： Lepola V,Jalovaara P,Väänänen K

更新日期：1994-05-01 00:00:00

abstract：:Intracortical remodeling in the adult skeleton removes and replaces areas of compact bone that have sustained microdamage. Although studies have been performed in animal species in which there is an existing baseline of remodeling activity, laboratory rodents have been considered to have limited suitability as models ...

journal_title：Bone

authors： Bentolila V,Boyce TM,Fyhrie DP,Drumb R,Skerry TM,Schaffler MB

更新日期：1998-09-01 00:00:00

abstract：:Recent in vitro and animal studies suggest that cholesterol and its metabolites inhibit the functional activity of osteoblasts and thereby induce reduced bone mineralization. However, scant information is available on the clinical implication of these findings with special regard to postmenopausal bone loss. Therefore...

journal_title：Bone

authors： Tankó LB,Bagger YZ,Nielsen SB,Christiansen C

更新日期：2003-01-01 00:00:00