Vital signs, QT prolongation, and newly diagnosed cardiovascular disease during severe hypoglycemia in type 1 and type 2 diabetic patients.

abstract：OBJECTIVE:To investigate the association between circulating levels of hepatocyte growth factor (HGF), a mesenchymal-derived pleiotrophic factor that is elevated in obesity, and the prevalence of type 2 diabetes. RESEARCH DESIGN AND METHODS:A cross-sectional analysis among 892 postmenopausal women within the Women's H...

journal_title：Diabetes care

authors： Rajpathak SN,Wassertheil-Smoller S,Crandall J,Liu S,Ho GY

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVE:We wanted to determine whether obesity, abdominal fat distribution, and physical inactivity act similarly and independently as risk factors for noninsulin-dependent diabetes mellitus (NIDDM) and impaired glucose tolerance (IGT) in Hindu and Muslim Asian Indians, African-origin Creoles, and Chinese Mauritians....

journal_title：Diabetes care

authors： Dowse GK,Zimmet PZ,Gareeboo H,George K,Alberti MM,Tuomilehto J,Finch CF,Chitson P,Tulsidas H

更新日期：1991-04-01 00:00:00

abstract：OBJECTIVE:To evaluate the relationship between preoperative A1C and clinical outcomes in individuals with diabetes mellitus undergoing noncardiac surgery. RESEARCH DESIGN AND METHODS:Data were obtained from the National Surgical Quality Improvement Program database and the Research Patient Data Registry of the Brigham...

journal_title：Diabetes care

authors： Underwood P,Askari R,Hurwitz S,Chamarthi B,Garg R

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:Diabetic patients have a high prevalence of coronary artery disease (CAD), but timely diagnosis of CAD remains challenging. We assessed the ability of coronary computed tomography angiography (CCTA) to detect CAD in diabetic patients and to predict subsequent cardiac events. RESEARCH DESIGN AND METHODS:We an...

journal_title：Diabetes care

authors： Hadamitzky M,Hein F,Meyer T,Bischoff B,Martinoff S,Schömig A,Hausleiter J

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:Early puberty is associated with increased risk of subsequent cardiovascular disease. Low sex hormone-binding globulin (SHBG) levels are a feature of early puberty and of conditions associated with increased cardiovascular risk. The aim of the present study was to evaluate SHBG as a predictor of glucose metab...

journal_title：Diabetes care

authors： Sørensen K,Aksglaede L,Munch-Andersen T,Aachmann-Andersen NJ,Petersen JH,Hilsted L,Helge JW,Juul A

更新日期：2009-05-01 00:00:00

abstract：:To evaluate the development of autonomic neuropathy, 23 patients with a moderate (group A) and 18 patients with a long (group B) duration of diabetes and without symptoms of autonomic neuropathy were re-investigated 6 yr after the initial studies. Autonomic nerve function was evaluated from heart reactions to deep bre...

journal_title：Diabetes care

authors： Sundkvist G,Lilja B

更新日期：1985-03-01 00:00:00

abstract：OBJECTIVE:Direct medical cost of diabetes in the U.S. has been estimated to be 2.3 times higher relative to individuals without diabetes. This study examines trends in health care expenditures by expenditure category in U.S. adults with diabetes between 2002 and 2011. RESEARCH DESIGN AND METHODS:We analyzed 10 years o...

journal_title：Diabetes care

authors： Ozieh MN,Bishu KG,Dismuke CE,Egede LE

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to determine whether a strategy of aggressive cardiovascular risk management reduced the mortality associated with diabetic foot ulceration. RESEARCH DESIGN AND METHODS:After an initial audit of outcomes demonstrating a high mortality rate in 404 diabetic foot ulcer patients wit...

journal_title：Diabetes care

authors： Young MJ,McCardle JE,Randall LE,Barclay JI

更新日期：2008-11-01 00:00:00

abstract：OBJECTIVE:To investigate the effect of flexible intensive insulin therapy (FIIT) and an automated bolus calculator (ABC) in a Danish type 1 diabetes population treated with multiple daily injections. Furthermore, to test the feasibility of teaching FIIT in a 3-h structured course. RESEARCH DESIGN AND METHODS:The Bolus...

journal_title：Diabetes care

authors： Schmidt S,Meldgaard M,Serifovski N,Storm C,Christensen TM,Gade-Rasmussen B,Nørgaard K

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to evaluate the effects of a combination weight loss program using intermittent low-calorie diets, energy-controlled meal replacement products, and sibutramine on weight loss, diabetes control, and cardiovascular risk factors in overweight or obese subjects with type 2 diabetes. ...

journal_title：Diabetes care

authors： Redmon JB,Raatz SK,Reck KP,Swanson JE,Kwong CA,Fan Q,Thomas W,Bantle JP

更新日期：2003-09-01 00:00:00

abstract：:We describe affinity sensors for monitoring various metabolites in blood plasma by optical means. The principle of detection is similar to that used in radioimmunoassays and is based on the competitive binding of a particular metabolite and a fluorescein-labeled analogue with receptor sites specific for the metabolite...

journal_title：Diabetes care

authors： Schultz JS,Mansouri S,Goldstein IJ

更新日期：1982-05-01 00:00:00

abstract：OBJECTIVE:To evaluate whether use of oral hypoglycemic agents is associated with an altered breast cancer risk in women. RESEARCH DESIGN AND METHODS:Using the U.K.-based General Practice Research Database, we conducted a nested case-control analysis among 22,621 female users of oral antidiabetes drugs with type 2 diab...

journal_title：Diabetes care

authors： Bodmer M,Meier C,Krähenbühl S,Jick SS,Meier CR

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:This study evaluated the feasibility, safety, and efficacy of day-and-night hybrid closed-loop insulin delivery in adolescents with type 1 diabetes under free-living conditions. RESEARCH DESIGN AND METHODS:In an open-label randomized crossover study, 12 suboptimally controlled adolescents on insulin pump the...

journal_title：Diabetes care

authors： Tauschmann M,Allen JM,Wilinska ME,Thabit H,Acerini CL,Dunger DB,Hovorka R

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:We assessed the association between different blood lipid measures and risk of fatal/nonfatal coronary heart disease (CHD). RESEARCH DESIGN AND METHODS:We conducted an observational study of patients with type 2 diabetes from the Swedish National Diabetes Register. Baseline LDL cholesterol, non-HDL cholester...

journal_title：Diabetes care

authors： Eliasson B,Cederholm J,Eeg-Olofsson K,Svensson AM,Zethelius B,Gudbjörnsdottir S,National Diabetes Register.

更新日期：2011-09-01 00:00:00

abstract：OBJECTIVE:Ipragliflozin, a sodium-glucose cotransporter 2 inhibitor, stimulates glycosuria and lowers glycemia in patients with type 2 diabetes (T2DM). The objective of this study was to assess the pharmacodynamics of ipragliflozin in T2DM patients with impaired renal function. RESEARCH DESIGN AND METHODS:Glycosuria w...

journal_title：Diabetes care

authors： Ferrannini E,Veltkamp SA,Smulders RA,Kadokura T

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVE:To explore the possible link between diabetic nephropathy and the enhanced activity of the polyol pathway, known to occur in IDDM subjects. RESEARCH DESIGN AND METHODS:We studied the effects of the aldose reductase inhibitor tolrestat (200 mg/day) on urinary albumin excretion rate and glomerular filtration r...

journal_title：Diabetes care

authors： Passariello N,Sepe J,Marrazzo G,De Cicco A,Peluso A,Pisano MC,Sgambato S,Tesauro P,D'Onofrio F

更新日期：1993-05-01 00:00:00

abstract：OBJECTIVE:The role of adiponectin in the natural history of diabetes is not well characterized. We set out to characterize prediagnosis trajectories of adiponectin in individuals who develop type 2 diabetes. RESEARCH DESIGN AND METHODS:In a case-cohort study (335 incident diabetes case and 2,474 noncase subjects) nest...

journal_title：Diabetes care

authors： Tabák AG,Carstensen M,Witte DR,Brunner EJ,Shipley MJ,Jokela M,Roden M,Kivimäki M,Herder C

更新日期：2012-12-01 00:00:00

abstract：:This study compares the utility of nonenzymatically glycosylated serum proteins (lys-GSP) to glycosylated hemoglobins (HbA1a-c) as control indices of glucose homeostasis in patients with IDDM. The diagnostic value of lys-GSP was also examined in patients with non-insulin-dependent diabetes mellitus, in subjects with i...

journal_title：Diabetes care

authors： Schleicher ED,Gerbitz KD,Dolhofer R,Reindl E,Wieland OH,Edelmann E,Haslbeck M,Kemmler W,Walter H,Mehnert H

更新日期：1984-11-01 00:00:00

abstract：:The plasma glucose and plasma free insulin profiles of six totally insulin-dependent diabetic patients were compared during periods of 4 days in hospital under a conventional insulin therapy (ICIT) comprising 4 daily injections of regular insulin and under continuous subcutaneous insulin infusion (CSII). Two profiles ...

journal_title：Diabetes care

authors： Buysschaert M,Marchand E,Ketelslegers JM,Lambert AE

更新日期：1983-01-01 00:00:00

abstract：OBJECTIVE:Diabetes-related foot ulcers (DFUs) and their sequelae result in large patient and societal burdens. Long-term data determining the efficacy of individual glucose-lowering agents on DFUs are lacking. Using existing data from the Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome R...

journal_title：Diabetes care

authors： Dhatariya K,Bain SC,Buse JB,Simpson R,Tarnow L,Kaltoft MS,Stellfeld M,Tornøe K,Pratley RE,LEADER Publication Committee on behalf of the LEADER Trial Investigators.

更新日期：2018-10-01 00:00:00

abstract：:Once daily injection of existing intermediate/long-acting insulin preparations does not provide a 24-h basal insulinemia in most patients. High variability, pronounced insulin peaks, and (as a result) a high risk of nocturnal hypoglycemia only poorly simulate normal physiology. One principle to prolong insulin action ...

journal_title：Diabetes care

authors： Rosskamp RH,Park G

更新日期：1999-03-01 00:00:00

abstract：OBJECTIVE:To assess the efficacy and safety of initial combination therapy with sitagliptin and metformin in patients with type 2 diabetes and inadequate glycemic control on diet and exercise. RESEARCH DESIGN AND METHODS:In a 24-week, randomized, double-blind, placebo-controlled, parallel-group study, 1,091 patients w...

journal_title：Diabetes care

authors： Goldstein BJ,Feinglos MN,Lunceford JK,Johnson J,Williams-Herman DE,Sitagliptin 036 Study Group.

更新日期：2007-08-01 00:00:00

abstract：:Increasingly more tests are being used to detect and characterize diabetic polyneuropathy, but their value in setting minimal criteria for the diagnosis of neuropathy and for staging severity remains inadequately studied. In 180 diabetics, we compared the percentage of patients with test abnormalities and associations...

journal_title：Diabetes care

authors： Dyck PJ,Bushek W,Spring EM,Karnes JL,Litchy WJ,O'Brien PC,Service FJ

更新日期：1987-07-01 00:00:00

abstract：OBJECTIVE:Whereas single assessments of cardiorespiratory fitness have been shown to predict lower incidence of type 2 diabetes, there are no data on long-term trends in fitness and risk. We investigated the relationship between long-term trends in fitness and the incidence of type 2 diabetes. RESEARCH DESIGN AND METH...

journal_title：Diabetes care

authors： Sawada SS,Lee IM,Naito H,Noguchi J,Tsukamoto K,Muto T,Higaki Y,Tanaka H,Blair SN

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:In vitro evidence shows that immune function is compromised in people with diabetes. Although certain rare infections are more common and infection-related mortality is higher, the risk of acquiring an infectious disease for diabetic patients has never been quantified. RESEARCH DESIGN AND METHODS:A retrospec...

journal_title：Diabetes care

authors： Shah BR,Hux JE

更新日期：2003-02-01 00:00:00

abstract：OBJECTIVE:To determine the proportion of adults with diabetes in the U.S. who have received diabetes patient education and to assess factors that determine whether patients receive this education. RESEARCH DESIGN AND METHODS:A questionnaire on diabetes was administered to a representative sample of 2,405 diabetic indi...

journal_title：Diabetes care

authors： Coonrod BA,Betschart J,Harris MI

更新日期：1994-08-01 00:00:00

abstract：OBJECTIVE:To characterize physiologic subtypes of gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS:Insulin sensitivity and secretion were estimated in 809 women at 24-30 weeks' gestation, using oral glucose tolerance test-based indices. In women with GDM (8.3%), defects in insulin sensitivity or secret...

journal_title：Diabetes care

authors： Powe CE,Allard C,Battista MC,Doyon M,Bouchard L,Ecker JL,Perron P,Florez JC,Thadhani R,Hivert MF

更新日期：2016-06-01 00:00:00

abstract：:In children with insulin-dependent diabetes mellitus (IDDM), deterioration in metabolic control frequently occurs during early adolescence. To prevent this predictable increase in blood glucose levels, we randomly assigned young adolescents with IDDM to an intervention based on problem solving with self-monitoring of ...

journal_title：Diabetes care

authors： Anderson BJ,Wolf FM,Burkhart MT,Cornell RG,Bacon GE

更新日期：1989-03-01 00:00:00

abstract：OBJECTIVE:Dietary recommendations are focused mainly on relative dietary fat and carbohydrate content in relation to diabetes risk. Meanwhile, high-protein diets may contribute to disturbance of glucose metabolism, but evidence from prospective studies is scarce. We examined the association among dietary total, vegetab...

journal_title：Diabetes care

authors： Sluijs I,Beulens JW,van der A DL,Spijkerman AM,Grobbee DE,van der Schouw YT

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:In this prospective, randomized, open trial, we compared the efficacy and safety of aspart insulin given subcutaneously at different time intervals to a standard low-dose intravenous (IV) infusion protocol of regular insulin in patients with uncomplicated diabetic ketoacidosis (DKA). RESEARCH DESIGN AND METH...

journal_title：Diabetes care

authors： Umpierrez GE,Cuervo R,Karabell A,Latif K,Freire AX,Kitabchi AE

更新日期：2004-08-01 00:00:00