Abstract：
:Marine natural products (NP) are unanimously acknowledged as the 'blue gold' in the urgent quest for new pharmaceuticals. Although corals are among the marine organisms with the greatest diversity of secondary metabolites, growing evidence suggest that their symbiotic bacteria produce most of these bioactive metabolites. The ex hospite culture of coral symbiotic microbiota is extremely challenging and only limited examples of successful culture exist today. By contrast, in toto aquaculture of corals is a commonly applied technology to produce corals for aquaria. Here, we suggest that coral aquaculture could as well be a viable and economically feasible option to produce the biomass required to execute the first steps of the NP-based drug discovery pipeline.
journal_name
Trends Biotechnoljournal_title
Trends in biotechnologyauthors
Leal MC,Calado R,Sheridan C,Alimonti A,Osinga Rdoi
10.1016/j.tibtech.2013.06.004subject
Has Abstractpub_date
2013-10-01 00:00:00pages
555-61issue
10eissn
0167-7799issn
1879-3096pii
S0167-7799(13)00142-Xjournal_volume
31pub_type
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