Abstract：
OBJECTIVES:To assess the potential difference in positive biopsy rates between four-sector and six-sector biopsy methods. METHODS:This computer-assisted analysis is based on the records of 156 consecutive patients previously diagnosed with T1c cancer on systematic sextant biopsy of the peripheral zone. For each patient the computer randomly deleted one biopsy result from the left and right prostatic lobes. The deletion process was repeated 1000 times. Based on four randomly chosen biopsy cores, we determined the number of undetected cancers initially diagnosed with sextant biopsy. RESULTS:Based on four-sector biopsy cores of the peripheral zone, between 6 and 30 (3.8% to 19.2% of cases) nonpalpable, isoechoic prostate cancers that were detected with sextant biopsy would have remained undiagnosed. CONCLUSIONS:Our results suggest that the number of biopsy cores used in the early detection of nonpalpable, isoechoic prostate cancer may substantially affect the rate of positive findings.
journal_name
Urologyjournal_title
Urologyauthors
Karakiewicz PI,Aprikian AG,Meshref AW,Bazinet Mdoi
10.1016/S0090-4295(96)00230-0subject
Has Abstractpub_date
1996-11-01 00:00:00pages
747-50issue
5eissn
0090-4295issn
1527-9995pii
S0090-4295(96)00230-0journal_volume
48pub_type
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