In vitro activity of 4'-iodo-4'-deoxydoxorubicin on human colo-rectal cancer as measured by a short-term antimetabolic assay.

Abstract:

:A short-term antimetabolic assay based upon the inhibition of incorporation of nucleic acid precursors was used to compare the cytotoxicity of a new halogenated anthracycline, 4'-iodo-4'-deoxydoxorubicin (IDX), with that of its parent compound doxorubicin (DX) on human colo-rectal carcinoma specimens. IDX showed a marked dose-dependent effect, with frequencies of activity consistently greater than those of DX at all concentrations. The minimal dose required to induce a significant antimetabolic effect for IDX was 1/10 that for DX.

journal_name

Invest New Drugs

authors

Villa R,Zaffaroni N,Giuliani F,Colella G,Sanfilippo O,Silvestrini R

doi

10.1007/BF00177248

subject

Has Abstract

pub_date

1990-05-01 00:00:00

pages

143-4

issue

2

eissn

0167-6997

issn

1573-0646

journal_volume

8

pub_type

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