Abstract:
:Experiments conducted on rabbits confirmed that chlorpromazine potentiates the weak epileptogenic action of Amipaque (metrizamide). Chlorpromazine withdrawal for a period of 48 h suppresses this potentiating effect in the rabbit. Neuroleptic drugs should therefore be avoided in patients examined with Amipaque. In patients under chronic treatment, neuroleptics ought to be discontinued at least 48 h before examination with Amipaque. With the doses and methods used in the present study, diazepam was not as effective as phenobarbital in preventing epilepsy produced by Amipaque. When premidication is needed or when convulsions occur after Amipaque examinations, combined diazepam and phenobarbital therapy ought to be instituted in order to achieve the best control of epileptic reactions.
journal_name
Neuroradiologyjournal_title
Neuroradiologyauthors
Gonsette RE,Brucher JMdoi
10.1007/BF00399884subject
Has Abstractpub_date
1977-08-25 00:00:00pages
27-30issue
1eissn
0028-3940issn
1432-1920journal_volume
14pub_type
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