Potentiation of Amipaque epileptogenic activity by neuroleptics.

Abstract:

:Experiments conducted on rabbits confirmed that chlorpromazine potentiates the weak epileptogenic action of Amipaque (metrizamide). Chlorpromazine withdrawal for a period of 48 h suppresses this potentiating effect in the rabbit. Neuroleptic drugs should therefore be avoided in patients examined with Amipaque. In patients under chronic treatment, neuroleptics ought to be discontinued at least 48 h before examination with Amipaque. With the doses and methods used in the present study, diazepam was not as effective as phenobarbital in preventing epilepsy produced by Amipaque. When premidication is needed or when convulsions occur after Amipaque examinations, combined diazepam and phenobarbital therapy ought to be instituted in order to achieve the best control of epileptic reactions.

journal_name

Neuroradiology

journal_title

Neuroradiology

authors

Gonsette RE,Brucher JM

doi

10.1007/BF00399884

subject

Has Abstract

pub_date

1977-08-25 00:00:00

pages

27-30

issue

1

eissn

0028-3940

issn

1432-1920

journal_volume

14

pub_type

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