Diagnostic value of AgNOR method in thyroid cytopathology: correlation with morphometric measurements.

Abstract:

:A silver staining technique was applied to 51 thyroid smears. The numbers of silver-stained nucleolar organizer regions (AgNORs) were counted, and the mean AgNOR and nuclear area per cell were determined with an image analyzer. The mean AgNOR count per cell was significantly higher in malignant than in benign lesions, but there was a considerable overlap. The mean AgNOR area and the mean SD of the AgNOR area per cell were significantly higher in carcinomas than in benign lesions (P = 10-9 and P = 5 x 10-10, respectively) and there were only two and one benign cases, respectively, of overlap. A strong correlation was observed between the mean AgNOR area and the mean nuclear area (r = 0.88), the former being a better discriminator between benign and malignant lesions. The AgNOR technique may contribute to routine thyroid cytopathology.

journal_name

Diagn Cytopathol

journal_title

Diagnostic cytopathology

authors

Solymosi T,Tóth V,Sápi Z,Bodó M,Gál I,Csanádi L

doi

10.1002/(SICI)1097-0339(199603)14:2<140::AID-DC7>3

subject

Has Abstract

pub_date

1996-03-01 00:00:00

pages

140-4

issue

2

eissn

8755-1039

issn

1097-0339

pii

10.1002/(SICI)1097-0339(199603)14:2<140::AID-DC7>3

journal_volume

14

pub_type

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