Structure-based rationale for the rescue of systemic movement of brome mosaic virus by spontaneous second-site mutations in the coat protein gene.

abstract：:The host cell receptor for Moloney murine leukemia virus was solubilized from murine L-cell membranes and characterized. In initial studies designed to identify a receptor-rich cell line, different mouse cells were screened for binding to Moloney gp70, the viral envelope glycoprotein which determines host cell-binding...

journal_title：Journal of virology

authors： Johnson PA,Rosner MR

更新日期：1986-06-01 00:00:00

abstract：:We have amplified by the polymerase chain reaction, cloned, and sequenced genomic segments of 118 human papillomavirus type 16 (HPV-16) isolates from 76 cervical biopsy, 14 cervical smear, 3 vulval biopsy, 2 penile biopsy, 2 anal biopsy, and 1 vaginal biopsy sample and two cell lines. The specimens were taken from pat...

journal_title：Journal of virology

authors： Chan SY,Ho L,Ong CK,Chow V,Drescher B,Dürst M,ter Meulen J,Villa L,Luande J,Mgaya HN

更新日期：1992-04-01 00:00:00

abstract：:Two poliovirus mutants were isolated that contain an oligonucleotide linker insertion in the 2C-coding region of the viral genome. One, 2C-31, has a strongly temperature-sensitive phenotype and the other, 2C-32, forms small plaques on HeLa cell monolayers at all temperatures. Both mutants have a severe temperature-sen...

journal_title：Journal of virology

authors： Li JP,Baltimore D

更新日期：1988-11-01 00:00:00

abstract：:A Staphylococcus aureus strain was successively cured of three prophages. A lysogenic conversion by a group A phage to production of Panton-Valentine leucocidin and by a group F phage to staphylokinase production could be demonstrated. ...

journal_title：Journal of virology

authors： van der Vijver JC,van Es-Boon M,Michel MF

更新日期：1972-08-01 00:00:00

abstract：:Our study was designed to investigate the nature of an antigen-specific suppressor factor generated by antigen-stimulated herpes simplex virus (HSV)-immune splenocytes. Factor SF-200, a 90,000- to 100,000-dalton fraction obtained after Sephacryl gel filtration, suppressed the generation of HSV-specific cytotoxic T-lym...

journal_title：Journal of virology

authors： Horohov DW,Wyckoff JH 3rd,Moore RN,Rouse BT

更新日期：1986-05-01 00:00:00

abstract：:Two hundred seventeen field isolates of cucumber mosaic cucumovirus (CMV), sampled from 11 natural populations, were typed by RNase protection assay (RPA) using probes from the genomic RNAs of strains in subgroup I and in subgroup II of CMV strains. Most (85%) of the analyzed isolates belonged to subgroup I. For these...

journal_title：Journal of virology

authors： Fraile A,Alonso-Prados JL,Aranda MA,Bernal JJ,Malpica JM,García-Arenal F

更新日期：1997-02-01 00:00:00

abstract：:Posttranslational modification-oligomerization, phosphorylation, and proteolytic cleavage-of the human papillomavirus (HPV) E4 protein occurs as the infected keratinocytes migrate up through the suprabasal wart layers. It has been postulated that these events modify E4 function during the virus life cycle. In HPV type...

journal_title：Journal of virology

authors： Knight GL,Grainger JR,Gallimore PH,Roberts S

更新日期：2004-12-01 00:00:00

abstract：:Previous work demonstrated that a herpes simplex virus type 1 (HSV-1) immediate-early function up-regulates beta interferon but not chloramphenicol acetyltransferase reporter genes driven by the strong simian virus 40 (SV40) or cytomegalovirus promoter-enhancer regions in both transient assays and stable cell lines. T...

journal_title：Journal of virology

authors： Brown CR,Nakamura MS,Mosca JD,Hayward GS,Straus SE,Perera LP

更新日期：1995-11-01 00:00:00

abstract：:Most poxviruses express multiple proteins containing ankyrin (ANK) repeats accounting for a large superfamily of related but unique determinants of poxviral tropism. Recently, select members of this novel family of poxvirus proteins have drawn considerable attention for their potential roles in modulating intracellula...

journal_title：Journal of virology

authors： Werden SJ,Lanchbury J,Shattuck D,Neff C,Dufford M,McFadden G

更新日期：2009-12-01 00:00:00

abstract：:Foot-and-mouth disease (FMD), which is caused by FMD virus (FMDV), remains a major plague among cloven-hoofed animals worldwide, and its outbreak often has disastrous socioeconomic consequences. A live-attenuated FMDV vaccine will greatly facilitate the global control and eradication of FMD, but a safe and effective a...

journal_title：Journal of virology

authors： Yang D,Sun C,Gao R,Wang H,Liu W,Yu K,Zhou G,Zhao B,Yu L

更新日期：2020-07-30 00:00:00

abstract：:The mechanisms involved in the emergence of virulent mammalian viruses were investigated in the adult immunodeficient SCID mouse infected by the attenuated prototype strain of the parvovirus Minute Virus of Mice (MVMp). Cloned MVMp intravenously inoculated in mice consistently evolved during weeks of subclinical infec...

journal_title：Journal of virology

authors： Rubio MP,López-Bueno A,Almendral JM

更新日期：2005-09-01 00:00:00

abstract：:Varicella-zoster virus (VZV) DNA was prepared from nucleocapsids and from enveloped virions of a laboratory strain (Ellen) and directly from the vesicle fluids of patients with zoster infections. VZV Ellen nucleocapsid DNA was cleaved with 11 different restriction endonucleases and electrophoresed in agarose gels. The...

journal_title：Journal of virology

authors： Straus SE,Aulakh HS,Ruyechan WT,Hay J,Casey TA,Vande Woude GF,Owens J,Smith HA

更新日期：1981-11-01 00:00:00

abstract：:During the S phase of the eukaryotic cell cycle and in virus-infected cells, DNA replication takes place at discrete sites in the nucleus, although it is not clear how the proteins involved in the replicative process are directed to these sites. Nuclear factor I is a cellular, sequence-specific DNA-binding protein uti...

journal_title：Journal of virology

authors： Bosher J,Dawson A,Hay RT

更新日期：1992-05-01 00:00:00

abstract：:The mechanisms mediating protective immunity to hepatitis C virus (HCV) infection are incompletely understood because early infection in humans is rarely identified, particularly in those individuals who subsequently demonstrate spontaneous virus eradication. We have established a large national network of patients wi...

journal_title：Journal of virology

authors： Smyk-Pearson S,Tester IA,Klarquist J,Palmer BE,Pawlotsky JM,Golden-Mason L,Rosen HR

更新日期：2008-02-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) productive replication in vitro is most often studied in fibroblasts. In vivo, fibroblasts amplify viral titers, but transmission and pathogenesis require the infection of other cell types, most notably epithelial cells. In vitro, the study of HCMV infection of epithelial cells has been al...

journal_title：Journal of virology

authors： Weng C,Lee D,Gelbmann CB,Van Sciver N,Nawandar DM,Kenney SC,Kalejta RF

更新日期：2018-07-31 00:00:00

abstract：UNLABELLED:Foot-and-mouth disease virus (FMDV) causes a highly contagious, debilitating disease in cloven-hoofed animals with devastating economic consequences. To survive in the host, FMDV has evolved to antagonize the host type I interferon (IFN) response. Previous studies have reported that the leader proteinase (L(...

journal_title：Journal of virology

authors： Du Y,Bi J,Liu J,Liu X,Wu X,Jiang P,Yoo D,Zhang Y,Wu J,Wan R,Zhao X,Guo L,Sun W,Cong X,Chen L,Wang J

更新日期：2014-05-01 00:00:00

abstract：:Viral recombination has been postulated to play two roles in the development of human immunodeficiency virus (HIV) resistance to antiretroviral drugs. First, recombination has the capacity to associate resistance mutations expressed by distinct viruses, thereby contributing to the development of viruses with improved ...

journal_title：Journal of virology

authors： Nora T,Charpentier C,Tenaillon O,Hoede C,Clavel F,Hance AJ

更新日期：2007-07-01 00:00:00

abstract：:The Sydney Blood Bank Cohort (SBBC) consists of eight blood transfusion recipients infected with nef-attenuated human immunodeficiency virus type 1 (HIV-1) acquired from a single donor. Here, we show that viral phenotypes and antibody responses differ considerably between individual cohort members, despite the single ...

journal_title：Journal of virology

authors： Verity EE,Zotos D,Wilson K,Chatfield C,Lawson VA,Dwyer DE,Cunningham A,Learmont J,Dyer W,Sullivan J,Churchill M,Wesselingh SL,Gabuzda D,Gorry PR,McPhee DA

更新日期：2007-09-01 00:00:00

abstract：:Influenza viruses and rhinoviruses are responsible for a large number of acute respiratory viral infections in human populations and are detected as copathogens within hosts. Clinical and epidemiological studies suggest that coinfection by rhinovirus and influenza virus may reduce disease severity and that they may al...

journal_title：Journal of virology

authors： Gonzalez AJ,Ijezie EC,Balemba OB,Miura TA

更新日期：2018-11-12 00:00:00

abstract：:Efficient T-cell responses against recombinant antigens expressed by vaccinia virus vectors require expression of these antigens in the early phase of the virus replication cycle. The kinetics of recombinant gene expression in poxviruses are largely determined by the promoter chosen. We used the highly attenuated modi...

journal_title：Journal of virology

authors： Baur K,Brinkmann K,Schweneker M,Pätzold J,Meisinger-Henschel C,Hermann J,Steigerwald R,Chaplin P,Suter M,Hausmann J

更新日期：2010-09-01 00:00:00

abstract：:Clinical deterioration in human immunodeficiency virus type 1 (HIV-1) disease is associated with an increased viral burden in the peripheral blood and a loss of circulating CD4+ T cells. HIV-1 isolates obtained prior to this stage of disease often have a "slow-low," non-syncytium-inducing (NSI) phenotype, whereas thos...

journal_title：Journal of virology

authors： Kaneshima H,Su L,Bonyhadi ML,Connor RI,Ho DD,McCune JM

更新日期：1994-12-01 00:00:00

abstract：:The nucleotide sequence of the src gene and flanking regions of the Schmidt-Ruppin strain of Rous sarcoma virus (SR-A) was determined. The src region of SR-A was very homologous to that of recovered avian sarcoma virus (rASV1441), with only 17 differences among 1,578 nucleotides. The size of the predicted protein was ...

journal_title：Journal of virology

authors： Takeya T,Hanafusa H

更新日期：1982-10-01 00:00:00

abstract：:Chronic infections with viruses such as hepatitis B virus, hepatitis C virus, and HIV constitute a major global public health problem. Studies of chronic viral infections in humans and mice show that persistent antigenic stimulation induces dysregulation of T cell responses; virus-specific T cells either undergo clona...

journal_title：Journal of virology

authors： Sullivan JA,Kim EH,Plisch EH,Suresh M

更新日期：2012-09-01 00:00:00

abstract：UNLABELLED:CBFβ was recently found to be a key regulator of the ability of human immunodeficiency virus type 1 (HIV-1) Vif to overcome host antiviral APOBEC3 proteins. However, the detailed molecular requirements for the Vif-CBFβ interaction are still not clear. Here, we mapped the minimum Vif domain required for CBFβ ...

journal_title：Journal of virology

authors： Zhou X,Han X,Zhao K,Du J,Evans SL,Wang H,Li P,Zheng W,Rui Y,Kang J,Yu XF

更新日期：2014-03-01 00:00:00

abstract：UNLABELLED:Previously, we reported that a mutant of Tat referred to as Nullbasic inhibits HIV-1 reverse transcription although the mechanism of action is unknown. Here we show that Nullbasic is a reverse transcriptase (RT) binding protein that targets the reverse transcription complex rather than directly inhibiting RT...

journal_title：Journal of virology

authors： Lin MH,Apolloni A,Cutillas V,Sivakumaran H,Martin S,Li D,Wei T,Wang R,Jin H,Spann K,Harrich D

更新日期：2015-05-01 00:00:00

abstract：:Removal of nucleoside triphosphates from extracts prepared from bacteriophage T7-infected Escherichia coli results in a stringent requirement for added ATP to form infective phage particles by in vitro packaging of bacteriophage T7 DNA. Optimal packaging efficiency was achieved at a concentration of about 1.25 mM. Oth...

journal_title：Journal of virology

authors： Masker WE

更新日期：1982-07-01 00:00:00

abstract：UNLABELLED:Cattle have been proposed as the natural reservoir of a novel member of the virus family Orthomyxoviridae, which has been tentatively classified as influenza D virus (IDV). Although isolated from sick animals, it is unclear whether IDV causes any clinical disease in cattle. To address this aspect of Koch's p...

journal_title：Journal of virology

authors： Ferguson L,Olivier AK,Genova S,Epperson WB,Smith DR,Schneider L,Barton K,McCuan K,Webby RJ,Wan XF

更新日期：2016-05-27 00:00:00

abstract：:ICP0 is a nuclear phosphoprotein involved in the activation of herpes simplex virus type 1 (HSV-1) gene expression during lytic infection and reactivation from viral latency. Although available evidence suggests that ICP0 acts at the level of transcription, definitive studies specifically addressing this issue have no...

journal_title：Journal of virology

authors： Jordan R,Schaffer PA

更新日期：1997-09-01 00:00:00

abstract：:Simian virus 40 (SV40) large T antigen (Tag) is a promiscuous transcriptional transactivator; however, its mechanism of transactivation remains unknown. Recent studies have suggested the possible involvement of protein-protein interactions with TBP, the TATA box-binding protein of TFIID, and TEF-1, an enhancer-binding...

journal_title：Journal of virology

authors： Johnston SD,Yu XM,Mertz JE

更新日期：1996-02-01 00:00:00

abstract：:The techniques of deoxyribonucleic acid-ribonucleic acid (DNA-RNA) hybridization and immunological precipitation were used to compare the synthesis of adenovirus-specific macromolecules in African green monkey kidney (AGMK) cells infected with adenovirus, an abortive infection, and coinfected with both adenovirus and ...

journal_title：Journal of virology

authors： Lucas JJ,Ginsberg HS

更新日期：1972-12-01 00:00:00