Abstract：
:Cisplatin has been the cornerstone of germ cell testicular tumors therapy since its introduction more tan 30 years ago, and a basic part of the schemes given to multiple ovarian, lung, head and neck, and bladder tumors among others. Some tumors present primary resistance to this drug, others will develop it despite good initial response. In the case of testicular germ cell tumors most of them are very sensitive to this drug but up to 20% of patients with metastatic disease will present resistance, most of them secondary after a very good initial response. Cisplatin acts by binding to DNA to activate genetic damage recognition mechanisms and apoptosis through the mitochondrial pathway. Resistance mechanisms to cisplatin have been classified in those that happen (1) before its binding to DNA and (2) once it binds to DNA. Most advances in their discovery have used other neoplasias as models, mainly ovarian and lung tumors. In this review we will describe the biological mechanisms behind resistance to cisplatin from the global perspective but trying to focus in testicular germ cell tumors.
journal_name
Arch Esp Uroljournal_title
Archivos espanoles de urologiaauthors
Germà-Lluch JR,Piulats JMsubject
Has Abstractpub_date
2013-06-01 00:00:00pages
524-35issue
5eissn
0004-0614issn
1576-8260journal_volume
66pub_type
杂志文章,评审abstract：OBJECTIVE:The need and timing of perioperative heparin prophylaxis is matter of debate. The aim of our work is to review the incidence of venous thromboembolism (VTE) after radical retro pubic prostatectomy (RRP) in patients undergoing preoperative blood donation, compressive stockings, haemodilution, surgical preventi...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：10.4321/s0004-06142009000200017
更新日期：2009-03-01 00:00:00
abstract：OBJECTIVES:Experimental data show the relationship between the area of injured urothelium and recurrence rates in superficial bladder cancer. Tumor cell adherence is increased by the exposure to the extracellular matrix (ECM). Transurethral resection uncovers the ECM and might lead to recurrent tumors. The question if ...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：OBJECTIVE:To report a case of tubulocystic renal carcinoma diagnosed in an adult, after a work up study for hematuria. METHODS/RESULTS:59-year-old male, CT scan was performed during a study for self-limited hematuria showing a 4.2 cm solid mass with areas suspicious of pseudocystic malignancy. Due to its debut with he...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：2012-11-01 00:00:00
abstract：OBJECTIVE:Recently, intraoperative floppy-iris syndrome (IFIS) has been related to tamsulosin treatment. This review evaluates the epidemiological evidence of the association of tamsulosin with IFIS and the necessity of a prior ophthalmolo-gic examination in this group of patients. METHOD:Systematic review of the lite...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章,评审
doi：10.4321/s0004-06142008000800008
更新日期：2008-10-01 00:00:00
abstract：OBJECTIVE:Renal cell carcinoma is constantly associated with calcification, but ossification is extremely scarce. METHOD: We retrospectively analyzed two cases with clear cell renal cell carcinoma with osseous metaplasia. RESULTS: We criticized the oldest case of woman whose a 32x31mm irregular renal mass with calcific...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章,评审
doi：
更新日期：2020-09-01 00:00:00
abstract：:The author studied all of the 1361 male patients that had been hospitalized from December 1986 to September 1990 for chronic urinary retention to determine the incidence of urothelial tumor of the bladder. Sixty-nine (5.07%) were found to have primary urothelial carcinoma of the bladder. However, in another study grou...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：1992-07-01 00:00:00
abstract：:We report on a patient diagnosed as having ganglioneuroblastoma, an uncommon disease entity. The results of clinical examination and complementary tests, including a descending urogram and ultrasound evaluation are presented. The surgical procedure employed is described and the result of pathological analysis of the s...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：1989-09-01 00:00:00
abstract：:Prostate Cancer (PCa) remains an exception among solid cancers since organ-sparing procedures are not considered as a standard option. Despite most men harbour low to intermediate risk disease at diagnosis, the vast majority are advised towards radical treatment. We performed a literature review to highlight and discu...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章,评审
doi：
更新日期：2016-07-01 00:00:00
abstract：OBJECTIVE:To report a case of laparoscopic radical cystectomy and pelvic lymphadenectomy with vaginal extraction of the surgical specimen in an elderly patient with muscle invasive bladder tumor. METHOD:A 78 year old patient with history of hematuria was diagnosed of muscle invasive bladder cancer. Laparoscopic radica...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：10.4321/s0004-06142009000400007
更新日期：2009-05-01 00:00:00
abstract：:In a context where there is evidence that not every patient with low risk prostate cancer needs to be treated from the start, active treatments are expensive and public health care systems need to save money, studies on cost-effectiveness are a priority. To elaborate this article, we reviewed the publications on cost ...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：2014-06-01 00:00:00
abstract：:Urinary unidiversion permits the possibility of enhancing the quality of life and probably the survivorship of previously diverted patients. A modification of this technique is described which utilizes Brickne's loop and a segment of the sigmoid to create a low pressure bladder, thus sparing more intestine. The good r...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：1990-06-01 00:00:00
abstract：OBJECTIVES:After the death of Professor Francisco Romero Aguirre (Zaragoza 6/7/1918-6/28/2006) we want to make known his great teaching vocation, so that we covered his link with University from the start of his studies to his professorship as first professor in urology in the Spanish University (1961), and his work at...
journal_title：Archivos espanoles de urologia
pub_type： 传,历史文章,杂志文章
doi：
更新日期：2007-10-01 00:00:00
abstract：OBJECTIVE:To compare the morbidity of conventional inguinal lymphadenectomy for epidermoid carcinoma of the penis using ligation versus ultrasonic sealing of the lymph nodes with Ligasure. METHODS:29 cases of carcinoma of the penis are analyzed; 8 underwent superficial and deep inguinal lymphadenectomy using the conve...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：2002-06-01 00:00:00
abstract：:Patient reported outcome measures (PROMs) are essential to fully understand the impact of diseases and the effectiveness of treatment from a patient's perspective. Generic and disease-specific tools have been used to assess the impact of nephrolithiasis on patients' quality of life (QoL), as well as the impact of vari...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：2021-01-01 00:00:00
abstract：:The penis physiological states of flaccidity or erection, result from the contraction or relaxation, respectively, of smooth muscle cells in the corpora cavernosa (CSMCs). They result from the interaction of various inter and intracellular molecular signaling pathways. During the more usual state of flaccidity seems t...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：2010-10-01 00:00:00
abstract：OBJECTIVES:To describe two cases of malakoplakia of the bladder with an unusual form of presentation and review the cases previously reported in the literature. METHODS/RESULTS:Two patients, a 61-year-old female and a 71-year-old male, are described. Both patients had a history of recurrent infection caused by colifor...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章,评审
doi：
更新日期：1998-03-01 00:00:00
abstract：OBJECTIVES:To assess the bladder compliance in a series of cystoceles referred for urodynamic study. METHODS:Retrospective study of a series of patients with cystocele undergoing medical history, videurodynamic study, pelvic MRI and lower urinary tract, urological ultrasound and cystoscopy. We Excluded cases with neur...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：10.4321/s0004-06142010000500005
更新日期：2010-06-01 00:00:00
abstract：OBJECTIVE:To describe the laparoscopic approach for uretero-ileal anastomosis strictures and to analyse our long term series. METHODS:A retrospective review was performed evaluating our series of patients with benign ureteroileal anastomosis strictures treated laparoscopically from 2011 to 2017. Demographics and perio...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：2017-05-01 00:00:00
abstract：OBJECTIVES:There are few studies on crystalluria in the developing countries. The aim of the present study was carrying out a first study in Morocco on the frequency and the chemical nature of the crystalluria according to the sex and the age of human individuals living in the Tadla Azilal moroccan area. METHOD:200 sa...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：10.4321/s0004-06142006000600018
更新日期：2006-07-01 00:00:00
abstract：OBJECTIVE:To report one case of transitional cell carcinoma with areas of small cell carcinoma presenting in its evolution an adrenal metastasis with the neuroendocrine component only. We perform a bibliography review for the cases of small cell carcinoma of the bladder, its epidemiology, prognosis and treatment. METH...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章,评审
doi：10.4321/s0004-06142007000300016
更新日期：2007-04-01 00:00:00
abstract：OBJECTIVE:Cystic tumors of the adrenal gland are uncommon, but are being increasingly more frequently diagnosed during routine radiological evaluation as "incidentalomas". We discuss the differential diagnosis, therapeutic approach and the existing controversies concerning the management of this tumor type. METHODS:Tw...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：1998-10-01 00:00:00
abstract：OBJECTIVES:We intend to analyze the prognostic value of positive surgical margins depending on their number and location in pT2 patients. METHODS:We analyze 448 (34.3%) patients with positive surgical margins from a series of 1,310 T1-T2 patients treated with radical prostatectomy between 1989-2012. Of them 164 are pT...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：2014-04-01 00:00:00
abstract：:A case of acute urinary retention secondary to a giant bladder diverticulum in a 23-year-old patient is described. Its etiopathogenesis is briefly discussed, highlighting its congenital origin which, in our view, must be based on the histological examination of the specimen. ...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：1990-03-01 00:00:00
abstract：OBJECTIVES:The objective of quality management is the identification of improvement areas to achieve total client and other involved agents satisfaction. In this paper we describe the start up of a Quality Improvement Plan (QIP) in a Urology Department. METHODS:We assessed the current maturity and performance of the U...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：2015-01-01 00:00:00
abstract：:A simple endourological management of benign renal cyst is described. Percutaneous circular electrosection of the peripheric cyst wall is performed, thereafter the cyst wall is extracted en bloc and an aspirative drainage is placed for 2 days. Five patients with symptomatic renal cyst were treated with this method. No...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：1993-12-01 00:00:00
abstract：OBJECTIVES:To assess the complications of polypropylene mesh in the treatment of female pelvic floor disorders. METHODS:Retrospective study of patients with pelvic floor pathology (SUI, cystocele, rectocele, enterocele) undergoing pelvic floor intervention with surgical meshes from March 2002 to October 2009. We evalu...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：2011-09-01 00:00:00
abstract：:We present a case of vesical extrophy complicated by an adenocarcinoma in a 35-year old patient. It is this type of neoformation which most frequently affects the extrophic bladder and which, contrary to what has happened in most of the cases published, quickly presented bone and skin metastases. ...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：1981-05-01 00:00:00
abstract：:Various surgical procedures have been described for correction of stress urinary incontinence (SUI) which have afforded different results. Modifications to these procedures have been made in an attempt to reduce morbidity and the operating time without detriment to the efficacy of the procedures. Herein we describe tw...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章,评审
doi：
更新日期：1991-01-01 00:00:00
abstract：OBJECTIVES:Intravenous urography (IVU) has been classically considered as an essential examination in the great majority of urologic diseases due to the great amount of information that supplies both functional and morphological, mainly for ureteral abnormalities where other exams do not reach enough definition. Nevert...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：2003-12-01 00:00:00
abstract：OBJECTIVES:Studying the psychosocial sphere of patients who undergo any treatment allows to have more information about its repercussion and can help the choice of an appropriate and personalized treatment. Due to the absence of specific instruments at present, the objective is to design and validate a health questionn...
journal_title：Archivos espanoles de urologia
pub_type： 杂志文章
doi：
更新日期：2019-01-01 00:00:00
