Administration of H1 and H2 antagonists for chemoprophylaxis: a double-blind, placebo-controlled study in healthy volunteers.

abstract：:Nintedanib is an intracellular inhibitor of tyrosine kinases used in the treatment of non-small cell lung cancer and idiopathic pulmonary fibrosis (IPF). This phase 1 open-label study investigated the influence of mild and moderate hepatic impairment on the pharmacokinetics (PK), safety, and tolerability of nintedanib...

journal_title：Journal of clinical pharmacology

authors： Marzin K,Kretschmar G,Luedtke D,Kraemer S,Kuelzer R,Schlenker-Herceg R,Schmid U,Schnell D,Dallinger C

更新日期：2018-03-01 00:00:00

abstract：:Cyclosporine (CsA) dosing is based on CsA plasma or blood concentrations measured 12 to 24 hours after drug administration (trough levels). This study evaluated the relationship between the timing of CsA concentrations and subsequent pharmacokinetic parameters to predict an optimal sampling period. Plasma samples were...

journal_title：Journal of clinical pharmacology

authors： Regazzi MB,Rondanelli R,Gastaldi L,Martinelli L,Viganò M

更新日期：1992-11-01 00:00:00

abstract：:The pharmacokinetics (PK) and safety of single-dose buparlisib (30 mg) were assessed in subjects with mild to severe hepatic impairment (n = 6 each) relative to healthy controls (n = 13). Blood samples were collected until 336 hours postdose and evaluated by liquid chromatography tandem mass spectrometry. PK parameter...

journal_title：Journal of clinical pharmacology

authors： Csonka D,Hazell K,Waldron E,Lorenzo S,Duval V,Trandafir L,Kobalava ZD

更新日期：2016-03-01 00:00:00

abstract：:The type II histamine receptor antagonists, cimetidine and ranitidine, widely used in treatment of peptic ulcer disease have been reported to cause bradycardia. To evaluate the cardiovascular effects of H2 antagonists nineteen healthy volunteers were entered into a double-blind crossover comparison of cimetidine 300 m...

journal_title：Journal of clinical pharmacology

authors： Hughes DG,Dowling EA,DeMeersman RE,Garnett WR,Karnes HT

更新日期：1989-05-01 00:00:00

abstract：:ABT-761 is a second-generation 5-lipoxygenase inhibitor in clinical development for the treatment of asthma. The effects of ABT-761 on the pharmacokinetics of an oral contraceptive were assessed in 21 female adult volunteers in a phase I, multiple-dose, open-label study. Subjects received a single dose of oral contrac...

journal_title：Journal of clinical pharmacology

authors： Wong SL,O'Dea RF,Dube LM,Awni WM

更新日期：1998-07-01 00:00:00

abstract：:ABT-335 is the choline salt of fenofibric acid under clinical development as a combination therapy with rosuvastatin for the management of dyslipidemia. ABT-335 and rosuvastatin have different mechanisms of actions and exert complementary pharmacodynamic effects on lipids. The current study assessed the pharmacokineti...

journal_title：Journal of clinical pharmacology

authors： Zhu T,Awni WM,Hosmane B,Kelly MT,Sleep DJ,Stolzenbach JC,Wan K,Chira TO,Pradhan RS

更新日期：2009-01-01 00:00:00

abstract：:A double-blind controlled trial was carried out to compare the effects of chenodeoxycholic acid (CDCA), ursodeoxycholic acid (UDCA), and placebo on cholesterol and triglyceride levels in patients with endogenous hypertriglyceridemias. The dose of both bile acids was four 150-mg capsules day. Total serum cholesterol le...

journal_title：Journal of clinical pharmacology

authors： Carulli N,Ponz de Leon M,Podda M,Zuin M,Strata A,Frigerio G,Digrisolo A

更新日期：1981-10-01 00:00:00

abstract：:The pathophysiology of poliomyelitis and the recognition of the "post-polio syndrome" suggest that susceptibility to muscle relaxants of patients previously affected by this disease, may be altered. We compared the effects of d-tubocurarine (dTc), pancuronium (P), and gallamine (G) on two pediatric surgical patient gr...

journal_title：Journal of clinical pharmacology

authors： Gyermek L

更新日期：1990-02-01 00:00:00

abstract：:Assessment of drug-induced venodilation by the dorsal hand vein compliance method requires stable constriction of the vein. This study was designed to investigate intra- and intersubject reproducibility of the venous preconstriction technique in response to phenylephrine and prostaglandin F2 alpha and to determine the...

journal_title：Journal of clinical pharmacology

authors： Schindler C,Grossmann M,Dobrev D,Francke K,Ravens U,Kirch W

更新日期：2003-03-01 00:00:00

abstract：:Propafenone and its 5-hydroxy metabolite exhibit different electrophysiological properties. Objectives of the CAQ-PAF study were (1) to develop a strategy favoring propafenone instead of 5-hydroxypropafenone in plasma following oral administration of propafenone and (2) to evaluate the potential of low-dose quinidine ...

journal_title：Journal of clinical pharmacology

authors： O'Hara GE,Philippon F,Gilbert M,Champagne J,Michaud V,Charbonneau L,Pruneau G,Hamelin BA,Geelen P,Turgeon J

更新日期：2012-02-01 00:00:00

abstract：:For many years, effective therapy for the management of asthma has been available. Issues of adverse side effects and questionable patient compliance with current therapies have been seen as deterrents for proven beneficial agents such as the anti-inflammatory corticosteroids and the bronchodilating beta 2-agonists. A...

journal_title：Journal of clinical pharmacology

authors： O'Byrne PM

更新日期：1999-03-01 00:00:00

abstract：:The pharmacokinetics and pharmacodynamics of intravenous famotidine were evaluated in 10 infants ranging from 5 to 19 days of age who had a therapeutic indication for the prophylactic treatment of stress ulceration. After a 0.5-mg/kg infusion of famotidine, timed serum (n = 6), urine (24-hour collection), and repeated...

journal_title：Journal of clinical pharmacology

authors： James LP,Marotti T,Stowe CD,Farrar HC,Taylor BJ,Kearns GL

更新日期：1998-12-01 00:00:00

abstract：:Precision medicine in oncology is the result of an increasing awareness of patient-specific clinical features coupled with the development of genomic-based diagnostics and targeted therapeutics. Companion diagnostics designed for specific drug-target pairs were the first to widely utilize clinically applicable tumor b...

journal_title：Journal of clinical pharmacology

authors： Schmidt KT,Chau CH,Price DK,Figg WD

更新日期：2016-12-01 00:00:00

abstract：:The effects of graded doses of anisotropine methylbromide on nocturanl gastric secretion were investigated in a double-blind crossover study in man. Single doses considerably higher than those usually employed for daytime use in adjunctive therapy of peptic ulcer disease significantly reduced acid secretion without si...

journal_title：Journal of clinical pharmacology

authors： Freston JW,Forbes JA

更新日期：1977-01-01 00:00:00

abstract：:X-linked hypophosphatemia (XLH) is an inherited metabolic bone disease with abnormally elevated serum FGF23 resulting in low renal maximum threshold for phosphate reabsorption, low serum phosphate (Pi) and 1,25-dihydroxyvitamin D levels with subsequent development of short stature and skeletal deformities. KRN23 is a ...

journal_title：Journal of clinical pharmacology

authors： Zhang X,Peyret T,Gosselin NH,Marier JF,Imel EA,Carpenter TO

更新日期：2016-04-01 00:00:00

abstract：:The pharmacokinetics and bioavailability of hydrocortisone after rectal administration of a hydrocortisone acetate foam were determined after single and multiple dosing in healthy subjects as well as in patients with inflammatory bowel disease. Endogenous hydrocortisone was suppressed by dexamethasone administration. ...

journal_title：Journal of clinical pharmacology

authors： Tromm A,Möllmann H,Barth J,Hochhaus G,Krieg M,Bigalke C,Möllmann A,Derendorf H

更新日期：2001-05-01 00:00:00

abstract：:This study aimed to investigate a food effect on the bio-availability of modified-release (MR) trimetazidine tablets in 36 healthy volunteers. Trimetazidine, an anti-ischemic drug, protects the myocardial cell from the harmful effects of ischemia. The authors investigated the effect of being under a fasting or fed sta...

journal_title：Journal of clinical pharmacology

authors： Ozbay L,Unal DO,Erol D

更新日期：2012-10-01 00:00:00

abstract：:Traditionally, Phase I tolerance trials have been done with normal volunteers to establish single- and multiple-dose tolerance. We feel that the justification for doing multiple-dose tolerance studies in normals is open to question and that, in fact, more pertinent data can be generated by using the appropriate patien...

journal_title：Journal of clinical pharmacology

authors： Weissman L

更新日期：1981-10-01 00:00:00

abstract：:Disease states such as liver cirrhosis and chronic kidney disease can lead to altered pharmacokinetics (PK) of drugs by influencing drug absorption, blood flow to organs, plasma protein binding, apparent volume of distribution, and drug-metabolizing enzyme and transporter (DMET) abundance. Narrow therapeutic index dru...

journal_title：Journal of clinical pharmacology

authors： Sharma S,Suresh Ahire D,Prasad B

更新日期：2020-10-01 00:00:00

abstract：:The effect of food on the pharmacokinetics of 15 mg oxybutynin XL was evaluated in a single-dose, randomized, crossover, open-label study in healthy volunteers. A validated, stereospecific, high-performance liquid chromatography assay was used to simultaneously determine the plasma concentrations of R- and S-oxybutyni...

journal_title：Journal of clinical pharmacology

authors： Sathyan G,Hu W,Gupta SK

更新日期：2001-02-01 00:00:00

abstract：:To explore the clinical relevance of inhibition of multidrug resistance transporter 1 and organic anion transporting polypeptide transporter, a drug-drug interaction study was conducted using aliskiren and cyclosporine. This was an open-label, single-sequence, parallel-group, single-dose study in healthy subjects. Sub...

journal_title：Journal of clinical pharmacology

authors： Rebello S,Compain S,Feng A,Hariry S,Dieterich HA,Jarugula V

更新日期：2011-11-01 00:00:00

abstract：:The pharmacokinetic profile of solifenacin succinate (YM905; Vesicare), a new once-daily bladder-selective muscarinic receptor antagonist, was examined in 2 controlled trials of healthy young men. A single-dose study evaluated 5-, 10-, 20-, 40-, 60-, 80-, and 100-mg doses. A multidose study evaluated 5-, 10-, 20-, and...

journal_title：Journal of clinical pharmacology

authors： Smulders RA,Krauwinkel WJ,Swart PJ,Huang M

更新日期：2004-09-01 00:00:00

abstract：:The integrated minimal model allows assessment of clinical diagnosis indices, for example, insulin sensitivity (SI ) and glucose effectiveness (SG ), from data of the insulin-modified intravenous glucose tolerance test (IVGTT), which is laborious with an intense sampling schedule, up to 32 samples. The aim of this stu...

journal_title：Journal of clinical pharmacology

authors： Ibrahim MMA,Redestad E,Kjellsson MC

更新日期：2021-01-01 00:00:00

abstract：:Twelve healthy subjects participated in a study to determine the effect of multiple doses of troglitazone on the steady-state pharmacokinetics of digoxin. Subjects received digoxin 0.25 mg orally once daily on days 1 through 20 and 400 mg of troglitazone orally once daily on days 11 through 20. Serial plasma samples a...

journal_title：Journal of clinical pharmacology

authors： Loi CM,Knowlton PW,Stern R,Randinitis EJ,Vassos AB,Koup JR,Sedman AJ

更新日期：1998-02-01 00:00:00

abstract：:A randomized, crossover study was conducted in healthy male volunteers to assess the diurnal variation in the steady-state pharmacokinetics of valproate after multiple 250-mg oral and intravenous infusion doses after an intravenous 750-mg loading dose. Multiple blood samples were collected throughout each 168-hour stu...

journal_title：Journal of clinical pharmacology

authors： Hussein Z,Mukherjee D,Lamm J,Cavanaugh JH,Granneman GR

更新日期：1994-07-01 00:00:00

abstract：:Upadacitinib is a selective Janus kinase 1 inhibitor that was recently approved for treatment of rheumatoid arthritis and is currently being evaluated for treatment of several other autoimmune diseases, including atopic dermatitis (AD). The relationships between upadacitinib plasma exposure and efficacy (assessed as E...

journal_title：Journal of clinical pharmacology

authors： Mohamed MF,Gopalakrishnan S,Teixeira HD,Othman AA

更新日期：2020-11-06 00:00:00

abstract：:Magnesium sulfate is the anticonvulsant of choice for eclampsia prophylaxis and treatment; however, the recommended dosing regimens are costly and cumbersome and can be administered only by skilled health professionals. The objectives of this study were to develop a robust exposure-response model for the relationship ...

journal_title：Journal of clinical pharmacology

authors： Du L,Wenning LA,Carvalho B,Duley L,Brookfield KF,Witjes H,de Greef R,Lumbiganon P,Titapant V,Kongwattanakul K,Long Q,Sangkomkamhang US,Gülmezoglu AM,Oladapo OT

更新日期：2019-11-01 00:00:00

abstract：:As documented in national surveys, for the past several years, marijuana has been the most commonly abused drug in the United States, with approximately 6% of the population 12 years and older having used the drug in the month prior to interview. The use of marijuana is not without significant health hazards. Marijuan...

journal_title：Journal of clinical pharmacology

authors： Khalsa JH,Genser S,Francis H,Martin B

更新日期：2002-11-01 00:00:00

abstract：:Due to the prevalence of both gastrointestinal and cardiovascular diseases, it is likely that patients may be coprescribed gastric parietal cell proton pump inhibitors and beta-adrenergic antagonists. Therefore, the objectives of this phase I study were to assess the potential effects of the coadministration of lansop...

journal_title：Journal of clinical pharmacology

authors： Karol MD,Locke CS,Cavanaugh JH

更新日期：2000-03-01 00:00:00

abstract：:Twenty-three normal volunteers who received morphine sulphate (MS Contin) with naltrexone completed this randomized, analytically blinded, two-way crossover comparison of the bioavailability of one 200-mg oral controlled-release morphine sulfate tablet with two 100-mg MSC tablets. Morphine effects were blocked by thre...

journal_title：Journal of clinical pharmacology

authors： Kaiko RF,Grandy RP,Reder RF,Goldenheim PD,Sackler RS

更新日期：1995-05-01 00:00:00