Abstract:
OBJECTIVES:We sought to assess the prognostic implications of the evolution of restrictive left ventricular filling pattern (RFP) in dilated cardiomyopathy (DCM). BACKGROUND:Previous work has demonstrated that a RFP in DCM is associated with a poor prognosis. Few data are available on the prognostic implications of the evolution of this pattern. METHODS:The evolution of left ventricular filling was studied by Doppler echocardiography in 110 patients with DCM. According to the left ventricular filling pattern at presentation and after 3 months of treatment, the patients were classified into three groups: Group 1A (n = 24) had persistent restrictive filling; Group 1B (n = 29) had reversible restrictive filling; and Group 2 (n = 57) had nonrestrictive filling. RESULTS:During follow-up (41 +/- 20 months), mortality plus heart transplantations was significantly higher in Group 1A than in Groups 1B and 2 (p < 0.0001). On multivariate analysis, the model incorporating E wave deceleration time at 3 months was more powerful at predicting mortality with respect to this variable at baseline (p = 0.0039). Clinical improvement at 1 and 2 years was significantly more frequent in Groups 1B and 2 than in Group 1A (p < 0.0001 at 2 years). CONCLUSIONS:In patients with DCM, the persistence of restrictive filling at 3 months is associated with a high mortality and transplantation rate. The patients with reversible restrictive filling have a high probability of improvement and excellent survival. Doppler echocardiographic reevaluation of these patients after 3 months of therapy gives additional prognostic information with respect to the initial study.
journal_name
J Am Coll Cardioljournal_title
Journal of the American College of Cardiologyauthors
Pinamonti B,Zecchin M,Di Lenarda A,Gregori D,Sinagra G,Camerini Fdoi
10.1016/s0735-1097(96)00539-6subject
Has Abstractpub_date
1997-03-01 00:00:00pages
604-12issue
3eissn
0735-1097issn
1558-3597pii
S0735109796005396journal_volume
29pub_type
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journal_title:Journal of the American College of Cardiology
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更新日期:2007-09-04 00:00:00
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journal_title:Journal of the American College of Cardiology
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doi:10.1016/j.jacc.2007.01.066
更新日期:2007-05-01 00:00:00
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更新日期:2018-09-18 00:00:00
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更新日期:1986-01-01 00:00:00
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更新日期:2019-07-09 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2013-04-09 00:00:00
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更新日期:2004-03-03 00:00:00
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更新日期:2002-02-20 00:00:00
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更新日期:2011-04-05 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/s0735-1097(97)00437-3
更新日期:1998-01-01 00:00:00
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journal_title:Journal of the American College of Cardiology
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doi:10.1016/j.jacc.2014.01.088
更新日期:2014-10-07 00:00:00
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pub_type: 杂志文章
doi:10.1016/0735-1097(94)90026-4
更新日期:1994-09-01 00:00:00