Abstract:
:The selective constraints influencing mRNA editing in plant organelles are largely unknown. To investigate these, we compared patterns of editing between monocot and dicot mitochondrial mRNA. On average, 24% of sites that are edited form C to U in one species have been substituted during evolution by a genomic T in the other: this is four times the rate of evolution seen at nonedited synonymously variable C residues. A similar, but weaker trend (not statistically significant) is seen at sites edited in chloroplast mRNA. The elevated substitution rate does not appear to be a consequence of a higher mutability of the trinucleotide motif (T-C-purine) associated with editing. nor to be a result of reverse transcription from mature mRNA. Selection to replace the genomic C with a T may account for the accelerated evolution, either due to elimination of inefficient transcripts and protein products or as a consequence of the prior loss of components outside the edit site which are necessary for editing; the latter hypothesis is supported by the frequent loss of editing without genomic mutation at third codon positions. Whatever the cause, the rapid rate of evolution indicates that editing confers little selective advantage at most sites.
journal_name
Mol Biol Evoljournal_title
Molecular biology and evolutionauthors
Shields DC,Wolfe KHdoi
10.1093/oxfordjournals.molbev.a025768subject
Has Abstractpub_date
1997-03-01 00:00:00pages
344-9issue
3eissn
0737-4038issn
1537-1719journal_volume
14pub_type
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journal_title:Molecular biology and evolution
pub_type: 信件
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1093/oxfordjournals.molbev.a004094
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2013-07-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1998-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/oxfordjournals.molbev.a026307
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Molecular biology and evolution
pub_type: 杂志文章
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journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/oxfordjournals.molbev.a040173
更新日期:1994-11-01 00:00:00
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