Scrape cytology of pemphigus vulgaris of the nipple, a mimicker of Paget's disease.

Abstract:

:A case of histologically and immunocytochemically confirmed pemphigus vulgaris of the nipple examined by scrape cytology is reported. The scrape cytology showed isolated and somewhat loosely clustered cells with basophilic cytoplasm and vesicular hyperchromatic nuclei dysplaying prominent nucleoli, suggesting Paget's disease of the nipple. However, histological examination of the resected tissue together with the direct immunofluorescence technique for demonstration of in vivo-bound immunoglobulin to epithelium confirmed the diagnosis of pemphigus vulgaris. The use of an immunoperoxidase stain for IgG on the Papaniolaou-destained smear also gave a positive reaction on the cell membranes and provided a precise cellular diagnosis of the lesions. Cytodiagnostic pitfalls of these rare breast lesions are discussed, as well as the diagnostic value of immunocytochemistry.

journal_name

Diagn Cytopathol

journal_title

Diagnostic cytopathology

authors

Kobayashi TK,Ueda M,Nishino T,Kibe S,Higashida T,Watanabe S

doi

10.1002/(sici)1097-0339(199702)16:2<156::aid-dc13>

subject

Has Abstract

pub_date

1997-02-01 00:00:00

pages

156-9

issue

2

eissn

8755-1039

issn

1097-0339

pii

10.1002/(SICI)1097-0339(199702)16:2<156::AID-DC13>

journal_volume

16

pub_type

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