Thromboembolic complications in a patient with heparin-induced thrombocytopenia (HIT) showing cross-reactivity to a low molecular weight heparin-treatment with Org 10172 (Lomoparan).

Abstract:

:Heparin-induced thrombocytopenia is an immuno-mediated life-threatening side effect of heparin therapy which poses difficulties in diagnosis and major therapeutic problems. Heparin must be instantly discontinued. We describe the case of a 60-year-old male patient with type II heparin-induced thrombocytopenia, complicated by progressive deep venous thrombosis and pulmonary embolism. He failed to improve when therapy was continued with a low molecular weight heparin (Fragmin) and high doses of intravenous immunoglobulins were administered. The test for heparin-dependent platelet aggregation was positive for unfractionated heparin and low molecular weight heparin, but negative for the heparinoid Org 10172. During subsequent anticoagulant therapy with Org 10172 for seven days the number of platelets increased rapidly and the patient recovered. Nine months later Org 10172 was used again in this patient for thrombosis prophylaxis without any adverse effects. In patients with heparin-induced thrombocytopenia requiring immediately acting anticoagulant therapy, Org 10172 can be considered as an effective alternative drug to unfractionated and low molecular weight heparins.

journal_name

Wien Klin Wochenschr

authors

Muhm M,Claeys L,Huk I,Koppensteiner R,Kyrle PA,Minar E,Stümpflen A,Ehringer H,Polterauer P

subject

Has Abstract

pub_date

1997-02-28 00:00:00

pages

128-31

issue

4

eissn

0043-5325

issn

1613-7671

journal_volume

109

pub_type

杂志文章
  • [Comparative studies of the effectiveness of specific immunotherapy in house dust mite allergy].

    abstract::In a prospective study, 60 patients with allergic rhinoconjunctivitis and/or asthma due to house dust mites were chosen for hyposensitization treatment with Migen (M) or Pharmalgen (P). Immunotherapy stretched over a whole year and every 3 months clinical results were evaluated by the patient's symptom score, by resul...

    journal_title:Wiener klinische Wochenschrift

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Ebner H,Neuchrist C,Havelec L,Kraft D

    更新日期:1989-08-04 00:00:00

  • [Spermatological changes after ligature of the spermatic vein for idiopathic varicocele].

    abstract::Spermatological examinations were performed on 61 patients before and after varicocelectomy. Sperm morphology remained unchanged, but the sperm density increased in 67.2% cases and in 54.1% the sperm motility rose over a period of up to 18 months following the treatment. In 72.1% of the cases an improvement in at leas...

    journal_title:Wiener klinische Wochenschrift

    pub_type: 杂志文章

    doi:

    authors: Maier U,Lunglmayr G

    更新日期:1982-04-30 00:00:00

  • [Total oesophageal resection with interposition of the left hemi-colon in a one-stage procedure (author's transl)].

    abstract::Total oesophageal resection for cancer is a major procedure, involving surgery within the thoracic cage, the abdomen and the cervical mediastinum. Plastic restruction using a segment of colon which is placed retrosternally between the cervical oesophagus and the stomach, is an additional procedure of considerable diff...

    journal_title:Wiener klinische Wochenschrift

    pub_type: 杂志文章

    doi:

    authors: Zängl A

    更新日期:1975-09-19 00:00:00

  • [Bronchial asthmatic disease associated with tobacco dust--an occupational lung disease?].

    abstract::Hypersensitivity to allergens in tobacco leaf as a cause of occupational asthma in workers of the tobacco manufacturing industry has been reported previously. We describe the case of a female employee working in a tobacco plant with asthmatic symptoms occurring at the working place. The symptoms described by the patie...

    journal_title:Wiener klinische Wochenschrift

    pub_type: 杂志文章

    doi:

    authors: Haber H,Raber W,Vetter N

    更新日期:2004-01-01 00:00:00

  • [Effect of bezafibrate in isolated hypercholesterolemia and mixed hyperlipidemia on infarct risk (Stepwise Program for Individual Risk Identification and Therapy): an open multicenter study].

    abstract::The therapeutic effect of bezafibrate (1 x 400 mg/day) on plasma lipids and coronary risk was evaluated in an open, prospective multicenter study in 763 patients with isolated hypercholesterolemia or mixed hyperlipidemia. During the 16 weeks of treatment (712 patients were included in the evaluation) bezafibrate lower...

    journal_title:Wiener klinische Wochenschrift

    pub_type: 临床试验,杂志文章,多中心研究

    doi:

    authors: Sinzinger H,Virgolini I,Kudlacek P

    更新日期:1991-01-01 00:00:00

  • Oversensing of the wearable cardioverter defibrillator during bipolar ventricular stimulation.

    abstract::The wearable cardioverter defibrillator (WCD) is a temporary treatment option for patients with potentially reversible risk of sudden cardiac death. This case demonstrates a pitfall during WCD usage in a pacemaker-dependent patient as well as a possible solution allowing continuation of WCD therapy. Bipolar stimulatio...

    journal_title:Wiener klinische Wochenschrift

    pub_type: 杂志文章

    doi:10.1007/s00508-017-1290-z

    authors: Manninger M,Odeneg T,Fruhwald F,Brussee H,Scherr D

    更新日期:2017-12-01 00:00:00

  • Near infrared spectroscopy: methodological principles and clinical application in preterm infants.

    abstract::Neonatal encephalopathy, plausibly related to hypoxia and ischaemia, remains one of the main problems in perinatal medicine. Efforts are necessary to find new non-invasive methods for assessing brain oxygenation. Near infrared spectroscopy (NIRS) provides information on the concentrations of the oxygenated and deoxyge...

    journal_title:Wiener klinische Wochenschrift

    pub_type: 杂志文章,评审

    doi:

    authors: Bernert G,von Siebenthal K,Kohlhauser C,Casaer P

    更新日期:1995-01-01 00:00:00

  • [Uni- and bilateral lung transplantation: functional results. Vienna Lung Transplant Group].

    abstract::At the end of December 1990 11 patients had survived lung transplantation at the 2nd Department of Surgery, University of Vienna. In these patients 7 single lung (SLTX) and four bilateral lung transplantations (DLTX) were performed. The indication for operation in 6 cases was emphysema, in 2 cases mucoviscidosis, in 2...

    journal_title:Wiener klinische Wochenschrift

    pub_type: 杂志文章

    doi:

    authors: Grimm M,Burghuber OC,Schlick W,Wisser W,Leitha T,Klepetko W

    更新日期:1991-01-01 00:00:00

  • [The prevention of tick-borne encephalitis (author's transl)].

    abstract::Tick-borne encephalitis is one of the most frequently-encountered virus diseases of the central nervous system in Europe. Hence, prophylactic measures for the prevention of tick-borne encephalitis are of particular importance, especially since it is virtually impossible to influence the course of the manifest disease ...

    journal_title:Wiener klinische Wochenschrift

    pub_type: 杂志文章

    doi:

    authors: Reinhardt F

    更新日期:1976-04-16 00:00:00

  • [Chemotherapy of highly malignant thyroid tumors].

    abstract::In a prospective phase II study 15 patients suffering from anaplastic thyroid carcinoma or thyroid sarcoma were treated by surgery and chemotherapy. Chemotherapy varied according to age of the patient and histological subtype of the tumour. The following regimen was used: 100 mg/m2 BSA CDDP, 20 mg/m2 mitoxantrone and ...

    journal_title:Wiener klinische Wochenschrift

    pub_type: 杂志文章

    doi:

    authors: Kober F,Heiss A,Keminger K,Depisch D

    更新日期:1990-04-27 00:00:00

  • ["Small volume resuscitation"--does it open new possibilities in the treatment of hypovolemic shock?].

    abstract::Hypertonic-hyperoncotic solutions are a supplementation to conventional fluid regimens in the management of hypovolemia due to trauma, hemorrhage and shock. In this review the possible modes of action of these solutions are discussed and their efficacy both in experimental and clinical settings is presented. Possible ...

    journal_title:Wiener klinische Wochenschrift

    pub_type: 杂志文章,评审

    doi:

    authors: Kröll W,Pölz W,Schimetta W

    更新日期:1994-01-01 00:00:00

  • [Referral to the pediatric dialysis unit -- the earlier the better?].

    abstract::Whereas recent research has demonstrated clear evidence for beneficial effects of early referral to the nephrologist in chronic renal insufficiency in adults, no such data exist for the pediatric population. In this study, we therefore correlated patient age and residual renal function at first presentation to a speci...

    journal_title:Wiener klinische Wochenschrift

    pub_type: 杂志文章

    doi:10.1007/s00508-005-0458-0

    authors: Böhm M,Arbeiter K,Müller T,Raffelsberger N,Falger J,Balzar E,Aufricht C

    更新日期:2005-10-01 00:00:00

  • [Bárány's discovery and its reception by his contemporaries].

    abstract::Bárány's main achievement is that he unified known, but apparently contradictory facts into one perspective. The concept of a method for examining each ear individually by means of the caloric test fundamentally advanced diagnostics. In 1914 he was honoured with the Nobel Prize, but in his home town of Vienna he was d...

    journal_title:Wiener klinische Wochenschrift

    pub_type: 传,历史文章,杂志文章

    doi:

    authors: Wyklicky H

    更新日期:1986-09-26 00:00:00

  • An outbreak of norovirus gastroenteritis in an Austrian hospital, winter 2006-2007.

    abstract:BACKGROUND:Norovirus is easily spread from person to person by the fecal-oral route and through aerosols or by vehicles such as contaminated food or water. The virus is able to survive in the environment for many days, which enables outbreaks to be prolonged. We describe a norovirus outbreak and its control measures in...

    journal_title:Wiener klinische Wochenschrift

    pub_type: 杂志文章

    doi:10.1007/s00508-008-1135-x

    authors: Fretz R,Schmid D,Jelovcan S,Tschertou R,Krassnitzer E,Schirmer M,Hell M,Allerberger F

    更新日期:2009-01-01 00:00:00

  • Diagnosis of prostate carcinoma on biopsy specimens improved by basal-cell-specific anti-cytokeratin antibody (34 beta E12).

    abstract::The identification of basal cells by the basal-cell-specific anti-cytokeratin antibody 34 beta E12 has been shown to be useful in the diagnosis of prostate carcinoma. To determine the usefulness of 34 beta E12 in prostate biopsies we examined formalin-fixed needle biopsy specimens. In a 17-month period 796 prostate ne...

    journal_title:Wiener klinische Wochenschrift

    pub_type: 杂志文章

    doi:

    authors: Freibauer C

    更新日期:1998-09-18 00:00:00

  • [Interdisciplinary strategies versus doping].

    abstract::Doping is a phenomenon which in the past years through the various incidences in professional cycling has come more and more into the focus of the public interest. Whilst in the young past the problems were to define the term "doping" exactly, today's problem is to prevent adolescents and children of doping. This shal...

    journal_title:Wiener klinische Wochenschrift

    pub_type: 杂志文章,评审

    doi:10.1007/s00508-010-1383-4

    authors: Vitzthum K,Mache S,Quarcoo D,Groneberg DA,Schöffel N

    更新日期:2010-06-01 00:00:00

  • Filgrastim-alone versus pegylated filgrastim-alone for autologous peripheral blood stem cells mobilization in newly diagnosed multiple myeloma patients.

    abstract:BACKGROUND:Autologous hematopoietic stem cell transplantation (aHSCT) is the recommended standard upfront treatment for transplant eligible myeloma patients. Considering possible complications related to chemotherapy-cytokine mobilization, cytokine-alone mobilization is often used. We compared mobilization with filgras...

    journal_title:Wiener klinische Wochenschrift

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00508-017-1205-z

    authors: Skopec B,Skerget M,Zontar D,Zadnik V,Zver S

    更新日期:2017-08-01 00:00:00

  • Recent developments in receptor binding radiopharmaceuticals.

    abstract::The stereoselective and saturable binding between receptor and ligand molecules plays an important role in many biological processes. Therefore ligand-receptor interactions have been increasingly studied in recent years by means of radionuclide labelled ligand molecules of high radiochemical purity and high specific a...

    journal_title:Wiener klinische Wochenschrift

    pub_type: 杂志文章

    doi:

    authors: Angelberger P

    更新日期:1991-01-01 00:00:00

  • [Demarcation of diseases].

    abstract::Feinstein's opinion that diseases overlap does not stand up to professional criticism. Different diseases can certainly present very similarly, but they cannot overlap, in the same way as specialties cannot overlap. The specialties are separated from each other according to their different connections with the disease...

    journal_title:Wiener klinische Wochenschrift

    pub_type: 杂志文章

    doi:

    authors: Braun RN,Braun R,Alkoutani F,Danninger H

    更新日期:1989-03-17 00:00:00

  • [Transformation of a myelodysplastic to a myeloproliferative syndrome (chronic granulocytic leukemia)].

    abstract::A report is presented of the course of a case of the myelodysplastic syndrome which transformed after 16 months into Philadelphia chromosome-negative chronic granulocytic leukaemia. Such a transformation into the myeloproliferative syndrome is considered to be a rare event and some views on the mechanism of this metam...

    journal_title:Wiener klinische Wochenschrift

    pub_type: 杂志文章

    doi:

    authors: Seewann HL

    更新日期:1985-03-29 00:00:00

  • Acupuncture is effective in improving functional communication in post-stroke aphasia : A systematic review and meta-analysis of randomized controlled trials.

    abstract:OBJECTIVE:In this meta-analysis the authors evaluated the effectiveness of acupuncture in improving functional communication and language function in post-stroke aphasia (PSA) patients. METHODS:Data sources: MEDLINE, EMBASE, CENTRAL, AMED, SinoMed, CNKI, VIP, and Wanfang databases, ICTRP, ISRCTN, EUCTR, ClinicalTrials...

    journal_title:Wiener klinische Wochenschrift

    pub_type: 杂志文章,meta分析

    doi:10.1007/s00508-019-1478-5

    authors: Zhang B,Han Y,Huang X,Liu Z,Li S,Chang J,Gao Y

    更新日期:2019-05-01 00:00:00

  • [Geriatric aspects for the management of diabetes mellitus].

    abstract::There is a high prevalence of diabetes mellitus in the elderly population of industrial countries. The present article provides recommendations for the screening, prevention and treatment of elderly diabetic patients according to current scientific evidence. ...

    journal_title:Wiener klinische Wochenschrift

    pub_type: 杂志文章,评审

    doi:10.1007/s00508-016-0955-3

    authors: Huber J,Smeikal M,Lechleitner M,Fasching P

    更新日期:2016-04-01 00:00:00

  • Assessing serum albumin concentration, lymphocyte count and prognostic nutritional index might improve prognostication in patients with myelofibrosis.

    abstract:BACKGROUND:Primary and secondary myelofibrosis (PMF and SMF) are malignant diseases of hematopoietic stem cell characterized by the neoplastic myeloproliferation and a strong inflammatory milieu. The prognostic nutritional index (PNI) integrates information on albumin and absolute lymphocyte count (ALC) and reflects th...

    journal_title:Wiener klinische Wochenschrift

    pub_type: 杂志文章

    doi:10.1007/s00508-018-1318-z

    authors: Lucijanic M,Veletic I,Rahelic D,Pejsa V,Cicic D,Skelin M,Livun A,Tupek KM,Stoos-Veic T,Lucijanic T,Maglicic A,Kusec R

    更新日期:2018-02-01 00:00:00

  • Severe traumatic brain injury in Austria IV: intensive care management.

    abstract:OBJECTIVES:The goal of this paper is to describe the ICU management of severe traumatic brain injury (TBI) in Austria. PATIENTS AND METHODS:Data sets from 415 patients included by 5 Austrian hospitals were available. The analysis focused on complications and outcomes of intensive care, monitoring of intracranial press...

    journal_title:Wiener klinische Wochenschrift

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00508-006-0763-2

    authors: Mauritz W,Janciak I,Wilbacher I,Rusnak M,Australian Severe TBI Study Investigators.

    更新日期:2007-02-01 00:00:00

  • [Fungal infections -- always dangerous for immunosuppressed patients (author's transl)].

    abstract::Four renal transplant recipients, treated with the immunosuppressive combination of azathioprine-prednisolone, developed organ or systemic mycoses caused by Candida albicans and, in one case, additionally by Trichophyton rubrum. Ketoconazole, a new wide-spectrum antimycotic drug, was successfully used in the treatment...

    journal_title:Wiener klinische Wochenschrift

    pub_type: 杂志文章

    doi:

    authors: Zazgornik J,Kopsa H,Schmidt P,Marosi L,Balcke P

    更新日期:1981-07-10 00:00:00

  • Spontaneous recanalization of internal carotid artery occlusion.

    abstract::We present a case of spontaneous recanalization of the internal carotid artery (ICA) that occurred in a 51-year-old male patient. The occlusion of the right ICA was asymptomatic and was detected incidentally during imaging of the opposite carotid artery. The patient underwent neuroradiologic analysis and a tapered, fl...

    journal_title:Wiener klinische Wochenschrift

    pub_type: 杂志文章

    doi:10.1007/s00508-010-1490-2

    authors: Tuskan-Mohar L,Legac M,Bralic M,Budiselic B

    更新日期:2010-11-01 00:00:00

  • [Nocturnal noninvasive ventilation of children and adolescents with neuromuscular diseases: effect on sleep and symptoms].

    abstract:AIM:Sleep disordered breathing (SDB) is an inevitable complication of progressive neuromuscular disorders (NMD). Aim of the study was to prospectively investigate the impact of three months of non-invasive ventilation (NIV) on sleep and SDB-associated symptoms in children and adolescents with advanced NMD. METHODS:Twe...

    journal_title:Wiener klinische Wochenschrift

    pub_type: 杂志文章

    doi:10.1007/BF03040405

    authors: Mellies U,Dohna-Schwake C,Ragette R,Teschler H,Voit T

    更新日期:2003-12-30 00:00:00

  • Decreased cutaneous vitamin D-synthesis in heavily melanized individuals: a rare cause for pathologic fractures of the hip.

    abstract::Painful pathological fractures of the femoral neck and the subtrochanteric region of the femur are reported in two women originating from India. After exclusion of renal or intestinal causes, laboratory data on bone metabolism, scintigraphic and radiographic examinations were characteristic for the presence of seconda...

    journal_title:Wiener klinische Wochenschrift

    pub_type: 杂志文章

    doi:10.1007/BF03040308

    authors: Berger CE,Marteau R,Pabinger C,Kröner A,Ogris E,Engel A

    更新日期:2003-03-31 00:00:00

  • Spinal subdural hematoma following lumbar decompressive surgery: a report of two cases.

    abstract::Spinal subdural hematoma (SSDH) following spine surgery is an extremely rare condition, with only three cases being reported in the literature. Unintended durotomy has been associated with SSDH due to alterations of pressures in the dural compartments. The objective of the present report was to report two rare cases o...

    journal_title:Wiener klinische Wochenschrift

    pub_type: 杂志文章

    doi:10.1007/s00508-014-0632-3

    authors: Lykissas MG,Aichmair A,Herzog RJ,Schroeder JE,Huang RC,Farmer J

    更新日期:2015-01-01 00:00:00

  • [Blood glucose self monitoring].

    abstract::Self monitoring of blood glucose contributes to the integrated management of diabetes mellitus. It, thus, should be available for all patients with diabetes mellitus type-1 and type-2. Self monitoring of blood glucose improves patients safety, quality of life and glucose control. The current article represents the rec...

    journal_title:Wiener klinische Wochenschrift

    pub_type: 杂志文章

    doi:10.1007/s00508-012-0288-9

    authors: Wascher TC

    更新日期:2012-12-01 00:00:00