A novel DNA and protein combination COVID-19 vaccine formulation provides full protection against SARS-CoV-2 in rhesus macaques.

abstract：:The New Delhi metallo-β-lactamase (NDM-1) is one of the most important resistance traits in Enterobacteriaceae. We characterized nine bla NDM-1 producing Enterobacteriaceae recovered from seven patients who have recently travelled or been treated in India (n=1) or mainland China (n=6) during December 2010-May 2012. Al...

journal_title：Emerging microbes & infections

authors： Ho PL,Li Z,Lo WU,Cheung YY,Lin CH,Sham PC,Cheng VC,Ng TK,Que TL,Chow KH

更新日期：2012-11-01 00:00:00

abstract：:Indispensable for shortening treatment of drug-susceptible tuberculosis (TB), pyrazinamide (PZA, Z) is also essential in the treatment of multidrug-resistant (MDR)-TB. While resistance to PZA in MDR-TB is associated with poor treatment outcome, bacillary susceptibility to PZA along with the use of fluoroquinolone (FQ)...

journal_title：Emerging microbes & infections

authors： Zhang Y,Chiu Chang K,Leung CC,Wai Yew W,Gicquel B,Fallows D,Kaplan G,Chaisson RE,Zhang W

更新日期：2012-07-01 00:00:00

abstract：:Shigella flexneri is a leading cause of bacterial dysentery in developing countries. Among the 15 known serotypes, four (1b, 3a, 3b and 4b) contain a group 6 epitope due to an acetyl group connected to the O-2 position of rhamnose III on the tetrasaccharide structure of the lipopolysaccharide. O-acetyltransferase enco...

journal_title：Emerging microbes & infections

authors： Sun Q,Lan R,Wang Y,Wang J,Xia S,Wang Y,Zhang J,Yu D,Li Z,Jing H,Xu J

更新日期：2012-09-01 00:00:00

abstract：:Malaria remains a severe health problem in Sub-Saharan Africa, with approximately one million deaths and 365 million cases each year. In terms of malaria control, insecticide-treated bednets are an effective tool, and many organizations have distributed free or highly subsidized bednets in malaria endemic areas. Never...

journal_title：Emerging microbes & infections

authors： Hoshi T,Martin Banda P,Foster Pemba D,Sunahara T,Minakawa N

更新日期：2013-10-01 00:00:00

abstract：:The H5N1 influenza A virus that is currently circulating in Asia, Africa and Europe has resulted in persistent outbreaks in poultry with sporadic transmission to humans. Thus far, it is believed that H5N1 does not possess sufficient ability for human-to-human transmission and subsequent pandemic infection. Both recept...

journal_title：Emerging microbes & infections

authors： Zhao H,Zhou J,Jiang S,Zheng BJ

更新日期：2013-12-01 00:00:00

abstract：:Though Elizabethkingia meningosepticum typically causes meningitis in neonates, its occurrence in adult is rare, with sixteen cases described worldwide. We report a case of E. meningosepticum meningitis in an immunocompetent adult. Bacterial identification was made a day earlier than conventional method by using matri...

journal_title：Emerging microbes & infections

authors： Hayek SS,Abd TT,Cribbs SK,Anderson AM,Melendez A,Kobayashi M,Polito C,Wayne Wang YF

更新日期：2013-04-01 00:00:00

abstract：:Men who have sex with men (MSM) have accounted for an alarmingly increasing proportion of nationally reported human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) cases recently. While the latest HIV epidemic among this population was not well understood, the underlying reasons for the rapid inc...

journal_title：Emerging microbes & infections

authors： Xu J,Han X,Reilly KH,Shang H

更新日期：2013-07-01 00:00:00

abstract：:Hepatitis B virus (HBV) infection remains a global health problem with over 350 million chronically infected, causing an increased risk of cirrhosis and hepatocellular carcinoma. Current antiviral chemotherapy for HBV infection include five nucleos(t)ide analog reverse transcriptase inhibitors (NRTIs) that all target ...

journal_title：Emerging microbes & infections

authors： Jones SA,Hu J

更新日期：2013-09-01 00:00:00

abstract：:Laribacter hongkongensis is a gram-negative emerging bacterium associated with invasive bacteremic infections in patients with liver disease and fish-borne community-acquired gastroenteritis and traveler's diarrhea. Although the complete genome of L. hongkongensis has been sequenced, no animal model is available for f...

journal_title：Emerging microbes & infections

authors： Xie J,He JB,Shi JW,Xiao Q,Li L,Woo PC

更新日期：2014-10-01 00:00:00

abstract：:Highly pathogenic H5N1 and low pathogenic H9N2 influenza viruses are endemic to poultry markets in Bangladesh and have cocirculated since 2008. H9N2 influenza viruses circulated constantly in the poultry markets, whereas highly pathogenic H5N1 viruses occurred sporadically, with peaks of activity in cooler months. Thi...

journal_title：Emerging microbes & infections

authors： Marinova-Petkova A,Feeroz MM,Rabiul Alam SM,Kamrul Hasan M,Akhtar S,Jones-Engel L,Walker D,McClenaghan L,Rubrum A,Franks J,Seiler P,Jeevan T,McKenzie P,Krauss S,Webby RJ,Webster RG

更新日期：2014-02-01 00:00:00

abstract：:A major challenge of infectious disease elimination is the need to interrupt pathogen transmission across all vulnerable populations. Ethnic minorities are among the key vulnerable groups deserving special attention in disease elimination initiatives, especially because their lifestyle might be intrinsically linked to...

journal_title：Emerging microbes & infections

authors： Hurtado LA,Cáceres L,Chaves LF,Calzada JE

更新日期：2014-04-01 00:00:00

abstract：:Hand, foot and mouth disease (HFMD) is an important public health problem that has emerged over the past several years. HFMD predominantly infects children under seven years old and occasionally causes severe disease in adults. Among the enteroviruses, enterovirus 71 (EV71) and coxsackievirus 16 (CA16) are the major c...

journal_title：Emerging microbes & infections

authors： Wang X,Xing M,Zhang C,Yang Y,Chi Y,Tang X,Zhang H,Xiong S,Yu L,Zhou D

更新日期：2014-05-01 00:00:00

abstract：:Type-III interferons (IFN-λ, IFNL) are the most recently described family of IFNs. This family of innate cytokines are increasingly being ascribed pivotal roles in host-pathogen interactions. Herein, we will review the accumulating evidence detailing the immune biology of IFNL during viral infection, and the implicati...

journal_title：Emerging microbes & infections

authors： Egli A,Santer DM,O'Shea D,Tyrrell DL,Houghton M

更新日期：2014-07-01 00:00:00

abstract：:The Chinese National Institutes for Food and Drug Control (NIFDC) is the national laboratory responsible for the quality control of pharmaceutical products. In recent years, to ensure the quality of biological products and improve the research and development (R&D) of new biological drugs and vaccines, NIFDC conducted...

journal_title：Emerging microbes & infections

authors： Liang Z,Mao Q,Wang Y,Li C,Gao K,Wang J

更新日期：2014-09-01 00:00:00

abstract：:Slave trading of Africans to the Americas, during the 16th to the 19th century was responsible for the first recorded emergence in the New World of two arthropod-borne viruses (arboviruses), yellow fever virus and dengue virus. Many other arboviruses have since emerged from their sylvatic reservoirs and dispersed glob...

journal_title：Emerging microbes & infections

authors： Liang G,Gao X,Gould EA

更新日期：2015-03-01 00:00:00

abstract：:Limited research has been conducted on healthcare-associated infective endocarditis (HAIE), although it is of increasing importance. The aim of this study is to compare the epidemiology, clinical characteristics, and prognosis of community-acquired IE (CA-IE) with HAIE and non-nosocomial healthcare-associated IE (NNHC...

journal_title：Emerging microbes & infections

authors： Yang F,Zhang B,Yu J,Shao L,Zhou P,Zhu L,Chen S,Zhang W,Weng X,Zhang J,Huang Y

更新日期：2015-07-01 00:00:00

abstract：:Since its emergence in 2012, more than 900 laboratory-confirmed cases of Middle East respiratory syndrome (MERS) have been reported with a fatality rate of more than 30%. However, no antigen detection assay for commercial use is available for diagnosis. In this study, the full-length nucleocapsid protein (NP) gene of ...

journal_title：Emerging microbes & infections

authors： Chen Y,Chan KH,Kang Y,Chen H,Luk HK,Poon RW,Chan JF,Yuen KY,Xia N,Lau SK,Woo PC

更新日期：2015-04-01 00:00:00

abstract：:Typhoid fever remains a severe public health problem in developing countries. The emergence of resistant typhoid, particularly multidrug-resistant typhoid infections, highlights the necessity of monitoring the resistance characteristics of this invasive pathogen. In this study, we report a typhoid fever outbreak cause...

journal_title：Emerging microbes & infections

authors： Yan M,Li X,Liao Q,Li F,Zhang J,Kan B

更新日期：2016-06-22 00:00:00

abstract：:Adhesion is an important virulence trait of Vibrio alginolyticus. Bacterial adhesion is influenced by environmental conditions; however, the molecular mechanism underlying this effect remains unknown. The expression levels of flrA, flrB and flrC were significantly downregulated in adhesion-deficient V. alginolyticus s...

journal_title：Emerging microbes & infections

authors： Luo G,Huang L,Su Y,Qin Y,Xu X,Zhao L,Yan Q

更新日期：2016-08-03 00:00:00

abstract：:The aim of the present study was to investigate the role of nitric oxide (NO) in the antifungal activity of Shikonin (SK) against Candida albicans (C. albicans) and to clarify the underlying mechanism. The results showed that the NO donors S-nitrosoglutathione (GSNO) and L-arginine could enhance the antifungal activit...

journal_title：Emerging microbes & infections

authors： Liao Z,Yan Y,Dong H,Zhu Z,Jiang Y,Cao Y

更新日期：2016-08-17 00:00:00

abstract：:Live animal markets (LAMs) are an essential source of food and trade in Latin American countries; however, they can also serve as 'hotbeds' for the emergence and potential spillover of avian influenza viruses (AIV). Despite extensive knowledge of AIV in Asian LAMs, little is known about the prevalence South American L...

journal_title：Emerging microbes & infections

authors： Jiménez-Bluhm P,Karlsson EA,Ciuoderis KA,Cortez V,Marvin SA,Hamilton-West C,Schultz-Cherry S,Osorio JE

更新日期：2016-12-07 00:00:00

abstract：:Amdoparvovirus is a newly defined parvoviral genus that contains four species (Carnivore amdoparvovirus 1-4), including the well-known Aleutian mink disease virus (AMDV). Amdoparvoviruses cause an immune-associated and often lethal wasting syndrome in Mustelidae and Caninae hosts. In this study, we molecularly investi...

journal_title：Emerging microbes & infections

authors： Canuti M,Doyle HE,P Britton A,Lang AS

更新日期：2017-05-10 00:00:00

abstract：:Humoral responses are essential for the protective efficacy of most Ebola virus (EBOV) candidate vaccines; however, the in vivo development of protective anti-EBOV B-cell responses is poorly defined. Here, by using the virus-like particle (VLP) as a model antigen, we demonstrate that humoral responses are generated th...

journal_title：Emerging microbes & infections

authors： Cooper CL,Martins KA,Stronsky SM,Langan DP,Steffens J,Van Tongeren S,Bavari S

更新日期：2017-06-07 00:00:00

abstract：:Protein- or peptide-based viral inactivators are being developed as novel antiviral drugs with improved efficacy, pharmacokinetics and toxicity profiles because they actively inactivate cell-free human immunodeficiency virus type 1 (HIV-1) virions before attachment to host cells. By contrast, most clinically used anti...

journal_title：Emerging microbes & infections

authors： Qi Q,Wang Q,Chen W,Du L,Dimitrov DS,Lu L,Jiang S

更新日期：2017-06-21 00:00:00

abstract：:Coxsackievirus A16 (CVA16) is one of the major pathogens responsible for hand, foot and mouth disease, which affects more than two million children in the Asian-Pacific region annually. Previous studies have shown that scavenger receptor B2 is a functional receptor for CVA16 that facilitates the uncoating process. How...

journal_title：Emerging microbes & infections

authors： Zhang X,Shi J,Ye X,Ku Z,Zhang C,Liu Q,Huang Z

更新日期：2017-07-26 00:00:00

abstract：:Zika virus (ZIKV) is a flavivirus that has recently been associated with an increased incidence of neonatal microcephaly and other neurological disorders. The virus is primarily transmitted by mosquito bite, although other routes of infection have been implicated in some cases. The Aedes aegypti mosquito is considered...

journal_title：Emerging microbes & infections

authors： Guedes DR,Paiva MH,Donato MM,Barbosa PP,Krokovsky L,Rocha SWDS,Saraiva K,Crespo MM,Rezende TM,Wallau GL,Barbosa RM,Oliveira CM,Melo-Santos MA,Pena L,Cordeiro MT,Franca RFO,Oliveira AL,Peixoto CA,Leal WS,Ayres CF

更新日期：2017-08-09 00:00:00

abstract：:Classical human astroviruses (HAstV) are the third most common cause of non-bacterial acute gastroenteritis. Due to the lack of routine molecular assays, novel HAstV are underdiagnosed and the magnitude of their contribution to clinical disease remains unknown. To better understand their prevalence and the susceptible...

journal_title：Emerging microbes & infections

authors： Cordey S,Vu DL,Zanella MC,Turin L,Mamin A,Kaiser L

更新日期：2017-09-20 00:00:00

abstract：:The hepatitis C virus (HCV) exhibits global genotypic diversity. HCV genotyping plays an important role in epidemiological studies and clinical management. Herein, we report the results of HCV genotype and subtype detection in a large number of clinical samples, as performed by an independent laboratory in China. In t...

journal_title：Emerging microbes & infections

authors： Chen Y,Yu C,Yin X,Guo X,Wu S,Hou J

更新日期：2017-11-01 00:00:00

abstract：:There has been limited research on the therapeutic efficacy of molecular diagnosis of spinal tuberculosis. We attempted to determine whether the utilization of molecular diagnosis to detect multidrug-resistant spinal tuberculosis can improve clinical outcomes. A multicenter retrospective study was conducted from Febru...

journal_title：Emerging microbes & infections

authors： Wu W,Lyu J,Cheng P,Cheng Y,Zhang Z,Li L,Zheng Y,Xu J

更新日期：2017-11-08 00:00:00

abstract：:The incidence of hemorrhagic fever with renal syndrome (HFRS) in Qingdao, China was three times higher than that of the average national level. Here we characterized the epidemiology, ecological determinants and pathogen evolution of HFRS in Qingdao during 2007-2015. In this longitudinal study, a total of 1846 HFRS pa...

journal_title：Emerging microbes & infections

authors： Jiang F,Wang L,Wang S,Zhu L,Dong L,Zhang Z,Hao B,Yang F,Liu W,Deng Y,Zhang Y,Ma Y,Pan B,Han Y,Ren H,Cao G

更新日期：2017-11-29 00:00:00