Sunscreen protection against ultraviolet radiation-induced pyrimidine dimers in mouse epidermal DNA.

Abstract:

:Pyrimidine dimers were measured in epidermal DNA of SKH:HR1 mice following exposure to solar-simulated UV radiation (SSUV, 290-400 nm) or to UVA (320-400 nm). Mice were exposed to SSUV or UVA after topical application (2 mg/cm2) of vehicle, a UVB absorber (5% 2-ethylhexyl p-methoxycinnamate [2-EHMC]), or a broad-spectrum UVA absorber (5% Mexoryl SX). The rates of induction of pyrimidine dimers in untreated animals were 5.4 +/- 0.57 x 10(-4) (mean +/- SEM) and 7.6 +/- 0.95 x 10(-6) dimers per 10(8) Da of epidermal DNA per J/m2 of SSUV and UVA, respectively. Topical application of Mexoryl SX reduced the rate of induction of pyrimidine dimers in SSUV-exposed animals to 4.7 +/- 0.44 x 10(-5) dimers per 10(8) Da per J/m2 for a dimer induction protection factor (PF) of 11.5 (5.4 x 10(-4)/4.7 x 10(-5). The rate of dimer induction in Mexoryl SX-treated, UVA-exposed mice was 0.95 +/- 0.2 x 10(-6) dimers per 10(8) Da per J/m2 (PF = 8.0). The 2-EHMC at a concentration of 5% (wt/wt) was significantly less effective than Mexoryl SX in preventing the induction of pyrimidine dimers in animals exposed to either SSUV or UVA. The rates of dimer induction in 2-EHMC-treated mice were 8.2 +/- 1.1 x 10(-5) and 3.8 +/- 0.33 x 10(-6) dimers per Da per J/m2 of SSUV (PF = 6.6) and UVA (PF = 2.0), respectively. Upon normalizing to the efficacy for edema induction, UVA induced approximately one-fourth the number of pyrimidine dimers per equivalent edematous response when compared to SSUV.

journal_name

Photochem Photobiol

authors

Ley RD,Fourtanier A

doi

10.1111/j.1751-1097.1997.tb07961.x

subject

Has Abstract

pub_date

1997-06-01 00:00:00

pages

1007-11

issue

6

eissn

0031-8655

issn

1751-1097

journal_volume

65

pub_type

杂志文章
  • Photochemical Behavior of Some Estrone Aryl and Methyl Sulfonates in Solution: Preparative and Mechanistic Studies.

    abstract::Direct irradiation of estrone aryl and methyl sulfonates in different organic solvents under nitrogen atmosphere was investigated under steady-state conditions. The estrone derivatives reacted efficiently through the photo-Fries rearrangement reaction involving [1;3]-sulfonyl migration providing the ortho-sulfonyl est...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/php.13272

    authors: Quindt MI,Gola GF,Ramirez JA,Bonesi SM

    更新日期:2021-01-01 00:00:00

  • Synthesis, structure and photophysical properties of ferrocenyl or mixed sandwich cobaltocenyl ester linked meso-tetratolylporphyrin dyads.

    abstract::We report here the design and synthesis of porphyrin-metallocene dyads consisting of a metallocene [either ferrocene or mixed sandwich η(5)-[C5H4(COOH)]Co(η(4)-C4Ph4) connected via an ester linkage at meso phenyl position of either free-base or zinc porphyrin. All these dyad systems were characterized by various spect...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/php.12372

    authors: Gokulnath S,Achary BS,Kumar CK,Trivedi R,Sridhar B,Giribabu L

    更新日期:2015-01-01 00:00:00

  • Photoreduction and ketone-sensitized reduction of alkaloids.

    abstract::The photoprocesses of berberine, palmatine, coralyne, sanguinarine, flavopereirine and ellipticine were studied in several solvents. The quantum yields Φ(Δ) of singlet molecular oxygen formation of berberine, palmatine and sanguinarine are moderate in dichloromethane (0.2-0.6) and much smaller in acetonitrile or trifl...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.2010.00880.x

    authors: Görner H,Miskolczy Z,Megyesi M,Biczók L

    更新日期:2011-03-01 00:00:00

  • Safety and Clinical Impact of a Single Red Light Irradiation on Breast Tumor-Bearing Mice.

    abstract::Low-level light therapy has been used in health care as a therapeutic strategy for different diseases. However, its effects on cancer are controversial. This work evaluated the effects of three energies on breast cancer-bearing mice after a single red light-emitting diode (LED) irradiation. 4T1 cells were inoculated i...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/php.13338

    authors: Pereira ST,Silva CR,Nuñez SC,Ribeiro MS

    更新日期:2020-10-03 00:00:00

  • The crystal structure of the L1 intermediate of halorhodopsin at 1.9 angstroms resolution.

    abstract::The mutant T203V of the light driven chloride pump halorhodopsin from Halobacterium salinarum was crystallized and the X-ray structure was solved at 1.6 angstroms resolution. The T203V structure turned out to be nearly identical to the wild type protein with a root mean square deviation of 0.43 angstroms for the carbo...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1562/2006-06-23-RA-947

    authors: Gmelin W,Zeth K,Efremov R,Heberle J,Tittor J,Oesterhelt D

    更新日期:2007-03-01 00:00:00

  • Supramolecular cationic tetraruthenated porphyrin and light-induced decomposition of 2'-deoxyguanosine predominantly via a singlet oxygen-mediated mechanism.

    abstract::The tetraruthenated porphyrin, mu-[meso-5,10,15,20-tetra(pyridyl)porphyrin]tetrakis[bis-(bipyridine) chloride ruthenium(II)] (TRP) is a supramolecular cationic species. The aim of the present investigation was to evaluate the photodynamic properties of TRP and Zn-TRP to damage DNA with emphasis on the mechanistic aspe...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:

    authors: Ravanat JL,Cadet J,Araki K,Toma HE,Medeiros MH,Mascio PD

    更新日期:1998-11-01 00:00:00

  • Axially Decorated SiIV -phthalocyanines Bearing Mannose- or Ammonium-conjugated Siloxanes: Comparative Bacterial Labeling and Photodynamic Inactivation.

    abstract::Herein, we present a comparative study about the photoinactivation of Staphylococcus aureus (Gram-positive model) and Escherichia coli (Gram-negative model) employing a neutral and a dicationic axially functionalized SiIV -phthalocyanine. Depending on the charge of the siloxane moiety (neutral monosaccharide or cation...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/php.12881

    authors: Grüner MC,Niemann S,Faust A,Strassert CA

    更新日期:2018-09-01 00:00:00

  • Multidimensional reaction coordinate for the excited-state H-atom transfer in perylene quinones: importance of the 7-membered ring in hypocrellins A and B.

    abstract::The excited-state intramolecular H-atom transfer reactions of hypocrellins B and A are compared by using time-resolved absorption and fluorescence upconversion techniques. The hypocrellin B photophysics are well described by a simple model involving one ground-state species and excited-state forward and reverse H-atom...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:

    authors: Datta A,Smirnov AV,Wen J,Chumanov G,Petrich JW

    更新日期:2000-02-01 00:00:00

  • Ecotoxicological effects of combined UVB and organic contaminants in coastal waters: A review.

    abstract::Organisms living in coastal waters are exposed to anthropogenic contaminants from terrestrial drainage, ice melting and maritime traffic and to enhanced UVB radiation (UVBR; 280-320 nm) caused by decreased concentrations of ozone in the stratosphere. This article reviews available information about the combined effect...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章,评审

    doi:10.1562/2005-09-18-ra-688.1

    authors: Pelletier E,Sargian P,Payet J,Demers S

    更新日期:2006-07-01 00:00:00

  • Spectroscopic study of the light-harvesting protein C-phycocyanin associated with colorless linker peptides.

    abstract::C-Phycocyanin (PC) trimers associated with linker polypeptides were isolated from the phycobilisome (PBS) rods of Synechococcus sp. PCC 7002. LXY refers to a linker polypeptide (L) having an apparent mass of Y kDa, located at position X in the phycobilisome where X can be R (rod), C (core) or RC (rod-core junction). M...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1562/0031-8655(2001)073<0556:ssotlh>2.0.co;2

    authors: Pizarro SA,Sauer K

    更新日期:2001-05-01 00:00:00

  • Interaction between human alpha1-acid glycoprotein (orosomucoid) and 2-p-toluidinylnaphthalene-6-sulfonate.

    abstract::The interaction between human alpha1-acid glycoprotein (orosomucoid) and the fluorescent probe, 2-p-toluidinylnaphthalene-6-sulfonate (TNS) has been studied. An association constant of 16.7 (+/- 3) x 10(3) M-1 was obtained for the complex at 20 degrees C with a stoichiometry of 1:1. From the effect of temperature on t...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.1995.tb05234.x

    authors: Albani J,Vos R,Willaert K,Engelborghs Y

    更新日期:1995-07-01 00:00:00

  • Absorbance changes by aromatic amino acid side chains in early rhodopsin photointermediates.

    abstract::Absorbance changes were monitored from 250 to 650 nm during the first microsecond after photolysis of detergent suspensions of bovine rhodopsin at 20 degrees C. Global analysis of the resulting data produced difference spectra for bathorhodopsin, BSI and lumirhodopsin which give the change in absorbance of the aromati...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.1997.tb03218.x

    authors: Lewis JW,Jäger S,Kliger DS

    更新日期:1997-12-01 00:00:00

  • Lifetime of fluorescent pyrene butyric acid probe in single living cells for measurement of oxygen fluctuation.

    abstract::We study the fluorescence lifetime of the well-known 1-pyrene butyric acid (PBA) to assess oxygen concentrations in living cells. The behavior of the probe is first studied in water, ethanol, protein solution and liposome suspension. The Stern-Volmer plot of these solutions is linear, and the bimolecular reaction rate...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1562/2004-03-11-RA-109

    authors: Ribou AC,Vigo J,Salmon JM

    更新日期:2004-09-01 00:00:00

  • Somatic-cell mutation induced by UVA and monochromatic UV radiation in repair-proficient and -deficient Drosophila melanogaster.

    abstract::Near-ultraviolet light (UVA: 320-400 nm) constitutes a major part of sunlight UV. It is important to know the effect of UVA on the biological activities of organisms on the earth. We have previously reported that black light induces somatic-cell mutation in Drosophila larvae. To investigate which wavelength of the UVA...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1562/0031-8655(2001)073<0493:SCMIBU>2.0.CO;2

    authors: Negishi T,Nagaoka C,Hayatsu H,Suzuki K,Hara T,Kubota M,Watanabe M,Hieda K

    更新日期:2001-05-01 00:00:00

  • Photosensitized reactions of poly(U) with tris(2,2'-bipyridyl)ruthenium(II) and peroxydisulfate.

    abstract::The reactions of polyuridylic acid [poly(U)] with Ru(bpy)3(3+) [Ru(III)] and SO4.-, following UV and visible light irradiation of Ru(bpy)3(2+) [Ru(II)] in the presence of S2O8(2-), were studied in an argon-saturated aqueous solution using time-resolved absorption and conductivity methods. The kinetics of the Ru(III) c...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.1989.tb04313.x

    authors: Tossi AB,Görner H,Schulte-Frohlinde D

    更新日期:1989-11-01 00:00:00

  • Ultraviolet-C irradiation for prevention of central venous catheter-related infections: an in vitro study.

    abstract::Central venous catheters (CVC) are widely used in the United States and are associated with 250,000 to 500,000 CVC-related infections in hospitals annually. We used a catheter made from ultraviolet-C (UVC) transmissive material to test whether delivery of UVC from the lumen would allow inactivation of microorganisms o...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.2010.00819.x

    authors: Dai T,Tegos GP,St Denis TG,Anderson D,Sinofsky E,Hamblin MR

    更新日期:2011-01-01 00:00:00

  • In vivo near-infrared Raman spectroscopy: demonstration of feasibility during clinical gastrointestinal endoscopy.

    abstract::Raman spectroscopy (RS) has potential for disease classification within the gastrointestinal tract (GI). A near-infrared (NIR) fiber-optic RS system has been developed previously. This study reports the first in vivo Raman spectra of human gastrointestinal tissues measured during routine clinical endoscopy. This was a...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1562/0031-8655(2000)072<0146:IVNIRS>2.0.CO;2

    authors: Shim MG,Song LM,Marcon NE,Wilson BC

    更新日期:2000-07-01 00:00:00

  • Analysis of phosphorescence decay in heterogeneous systems: consequences of finite excitation flash duration.

    abstract::Analysis of phosphorescence lifetimes using the Stern-Volmer equation is a reliable means of determining quencher concentration for a uniform sample. Methods of analysis for heterogeneous systems are based on the assumption that the excitation is produced by a momentary flash. This condition is an idealization because...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:

    authors: Golub AS,Popel AS,Zheng L,Pittman RN

    更新日期:1999-06-01 00:00:00

  • Comparison of methylene blue and methylene violet for photoinactivation of intracellular and extracellular virus in red cell suspensions.

    abstract::Previous studies with methylene blue (MB) in red cell suspensions have demonstrated that extracellular, but not intracellular, virus can be readily photoinactivated. To test if the resistance of intracellular virus to inactivation is related to the permanent positive charge of the phenothiazine, a series of uncharged ...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.1997.tb08588.x

    authors: Skripchenko A,Robinette D,Wagner SJ

    更新日期:1997-03-01 00:00:00

  • In3+-doped TiO2 and TiO2/In2S3 nanocomposite for photocatalytic and stoichiometric degradations.

    abstract::A novel In(3+)-doped TiO(2) and TiO(2)/In(2)S(3) nanocomposites for photocatalytic degradation of environmental pollutants and stoichiometric degradation of warfare agents were prepared by a homogeneous hydrolysis with urea and thioacetamide, respectively. The prepared samples series TiInTAA were annealed at 600°C. Th...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.2011.01052.x

    authors: Stengl V,Opluštil F,Němec T

    更新日期:2012-03-01 00:00:00

  • Retinal conformation and dynamics in activation of rhodopsin illuminated by solid-state H NMR spectroscopy.

    abstract::Solid-state NMR spectroscopy gives a powerful avenue for investigating G protein-coupled receptors and other integral membrane proteins in a native-like environment. This article reviews the use of solid-state (2)H NMR to study the retinal cofactor of rhodopsin in the dark state as well as the meta I and meta II photo...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1751-1097.2008.00510.x

    authors: Brown MF,Martínez-Mayorga K,Nakanishi K,Salgado GF,Struts AV

    更新日期:2009-03-01 00:00:00

  • Photooxidation products of merocyanine 540 formed under preactivation conditions for tumor therapy.

    abstract::In order to gain insight into the preactivation of merocyanine 540 (MC540) 1 for the photodynamic therapy (Gulliya et al., 1990a, Photochem. Photobiol. 52, 831-838) its photo-oxidation was investigated. After irradiation of MC540 1 on a preparative scale three main photodegradation products were isolated with 16-20% y...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.1992.tb02157.x

    authors: Franck B,Schneider U

    更新日期:1992-08-01 00:00:00

  • Cyanine Modification Tuned for Amine Photorelease.

    abstract::Cyanines are emerging as useful agents for photoreleasing biological compounds because of their capability of utilizing near-infrared (NIR) light. Another benefit is their ability to self-sensitize to produce singlet oxygen for the release of aryl amines, a process that has not been as feasible in the past. Here, we h...

    journal_title:Photochemistry and photobiology

    pub_type: 评论,杂志文章

    doi:10.1111/php.13102

    authors: Mathew JP,Greer A

    更新日期:2019-09-01 00:00:00

  • Steric hindrance between chromophore substituents as the driving force of rhodopsin photoisomerization: 10-methyl-13-demethyl retinal containing rhodopsin.

    abstract::A visual chromophore analogue, 10-methyl-13-demethyl (dm) retinal, was synthesized and reconstituted with bleached bovine rhodopsin to form a visual pigment derivative with absorbance maximum at 505 nm. The investigations with this new compound were stimulated from recent results using 13-dm retinal as a chromophore t...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.1997.tb01896.x

    authors: Koch D,Gärtner W

    更新日期:1997-01-01 00:00:00

  • Decreased host-cell reactivation of UV-irradiated adenovirus in human colon tumor cell lines that have normal post-UV survival.

    abstract::An ongoing study in our laboratories is to examine the relationship of DNA repair defects to human cancer. Our underlying hypothesis has been that human tumors may arise that lack interesting DNA repair pathways if these pathways are important in preventing cancer. In this study, we found that the UV-irradiated adenov...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:

    authors: Day RS 3rd,Rasouli-Nia A,Meservy J,Lari SU,Dobler K,Tsunoda S,Miyakoshi J,Takebe H,Murray D

    更新日期:1999-08-01 00:00:00

  • Photophysical properties of tin ethyl etiopurpurin I (SnET2) and tin octaethylbenzochlorin (SnOEBC) in solution and bound to albumin.

    abstract::The photophysical characteristics of two second-generation PDT photosensitizers, tin ethyl etiopurpurin I (SnET2) and tin octaethylbenzochlorin (SnOEBC), have been measured in homogeneous solution and when bound to bovine serum albumin (BSA). The ground state and triplet state absorption spectra have been characterize...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:

    authors: Pogue BW,Redmond RW,Trivedi N,Hasan T

    更新日期:1998-12-01 00:00:00

  • Deciphering UV-induced DNA Damage Responses to Prevent and Treat Skin Cancer.

    abstract::Ultraviolet (UV) radiation is among the most prevalent environmental factors that influence human health and disease. Even 1 h of UV irradiation extensively damages the genome. To cope with resulting deleterious DNA lesions, cells activate a multitude of DNA damage response pathways, including DNA repair. Strikingly, ...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/php.13245

    authors: Lee JW,Ratnakumar K,Hung KF,Rokunohe D,Kawasumi M

    更新日期:2020-05-01 00:00:00

  • Secondary Dark Reactions Following Photodynamic Treatment are More Damaging Than Previously Thought.

    abstract::Photodynamic treatment is often thought to produce reactive oxygen species (ROS) that directly induce killing; the nomenclature and phrases revolve around such notions of light-dependency. Few studies reference the possible existence of oxidation products formed in secondary reactions, which bear cytotoxicity competit...

    journal_title:Photochemistry and photobiology

    pub_type: 评论,杂志文章

    doi:10.1111/php.12984

    authors: Chiemezie C,Greer A

    更新日期:2019-01-01 00:00:00

  • Novel water-soluble photosensitizer based on starch and containing porphyrin.

    abstract::Novel water-soluble polymeric photosensitizers (SPO) based on starch and containing porphyrin chromophores were synthesized and studied. The polymers were soluble in water and in dimethyl sulfoxide. Photophysical studies and solubilization of molecular probes proved the formation of hydrophobic, rigid microdomains in ...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1562/2005-03-07-RA-455

    authors: Nowakowska M,Sterzel M,Zapotoczny S

    更新日期:2005-09-01 00:00:00

  • Suberythemal Sun Exposures at Swedish Schools Depend on Sky Views of the Outdoor Environments - Possible Implications for Pupils' Health.

    abstract::More scheduled outdoor stay is increasingly advocated for school children. This study measured 2(nd) , 5(th) and 8(th) graders' erythemal UV-exposure in September, March and May at four Swedish schools. We related those exposures, as fractions of total available ambient radiation, to the schools outdoor environments d...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/php.12540

    authors: Pagels P,Wester U,Söderström M,Lindelöf B,Boldemann C

    更新日期:2016-01-01 00:00:00