Effects of fluoride on in vitro enamel demineralization analyzed by ¹⁹F MAS-NMR.

Abstract:

:The mechanistic action of fluoride on inhibition of enamel demineralization was investigated using (19)F magic angle spinning nuclear magnetic resonance (MAS-NMR). The aim of this study was to monitor the fluoride-mineral phase formed on the enamel as a function of the concentration of fluoride ions [F(-)] in the demineralizing medium. The secondary aim was to investigate fluorapatite formation on enamel in the mechanism of fluoride anti-caries efficacy. Enamel blocks were immersed into demineralization solutions of 0.1 M acetic acid (pH 4) with increasing concentrations of fluoride up to 2,262 ppm. At and below 45 ppm [F(-)] in the solution, (19)F MAS-NMR showed fluoride-substituted apatite formation, and above 45 ppm, calcium fluoride (CaF2) formed in increasing proportions. Further increases in [F(-)] caused no further reduction in demineralization, but increased the proportion of CaF2 formed. Additionally, the combined effect of strontium and fluoride on enamel demineralization was also investigated using (19)F MAS-NMR. The presence of 43 ppm [Sr(2+)] in addition to 45 ppm [F(-)] increases the fraction of fluoride-substituted apatite, but delays formation of CaF2 when compared to the demineralization of enamel in fluoride-only solution.

journal_name

Caries Res

journal_title

Caries research

authors

Mohammed NR,Kent NW,Lynch RJ,Karpukhina N,Hill R,Anderson P

doi

10.1159/000350171

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

421-8

issue

5

eissn

0008-6568

issn

1421-976X

pii

000350171

journal_volume

47

pub_type

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