Osteopontin: a marker for invasive oral squamous cell carcinoma but not for potentially malignant epithelial dysplasias.

Abstract:

:This study aimed to evaluate and correlate osteopontin (OPN) expression in oral squamous cell carcinoma (OSCC) and potentially malignant disorders including oral leukoplakia and oral submucous fibrosis (OSMF). Expression of OPN was investigated in 140 samples including OSCC, oral leukoplakia, and OSMF with or without dysplasia and normal oral mucosa. By using immunohistochemistry. Both intercellular and intracellular staining of the keratinocytes was considered to be positive, and intensity grading was assessed. Statistical analysis was done using analysis of variance. OPN positivity was detected in 85% cases of OSCC, 55% cases of oral leukoplakia, 35% cases of OSMF, and 60% cases of normal mucosa. These study highlights OPN as a biomarker for malignancy in the form of invasion but not to study progression from dysplasia to malignant transformation.

journal_name

Ann Diagn Pathol

authors

Routray S,Kheur SM,Kheur M

doi

10.1016/j.anndiagpath.2013.03.005

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

421-4

issue

5

eissn

1092-9134

issn

1532-8198

pii

S1092-9134(13)00034-8

journal_volume

17

pub_type

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