Abstract：
:The formation of new cementum is an important issue in clinical periodontology, as cementum is required to provide attachment for newly formed periodontal tissues to the root surface. In this study a model of cementogenesis in vitro was used in order to test the effects of root surface demineralization on the migration, attachment and formation of a cementum-like tissue by osteoblastic cells cultured on cementum and to test the specificity of cementum matrix in modulating those effects by comparison of root co-cultures with bone co-cultures. It was demonstrated that root surface demineralization did not significantly alter the orientation, number and attachment of cells to the root co-cultures. The results also demonstrated that cementum and bone matrix appear to behave differently in culture, as seen by their distinct action on the morphological profile of the attached cells and the extracellular matrix deposited by these cells. These results demonstrate that although cementum matrix appears to stimulate the production of cementum-like tissue, this action is not confined to cementum matrix alone, since a similar material was also deposited on dentine and bone surfaces. Thus, these results do not support a specific action of cementum matrix on the modulation of the cementoblast phenotype. The use of co-cultures of neonatal rat calvaria cells with root slices represents a promising model of cementogenesis in vitro; however, studies should be undertaken towards the identification of markers to distinguish between cementoblast and osteoblast phenotypes in order to further validate this model.
journal_name
J Periodontal Resjournal_title
Journal of periodontal researchauthors
Tenorio D,Foyle DM,Hughes FJdoi
10.1111/j.1600-0765.1997.tb00546.xsubject
Has Abstractpub_date
1997-05-01 00:00:00pages
362-74issue
4eissn
0022-3484issn
1600-0765journal_volume
32pub_type
杂志文章abstract：BACKGROUND AND OBJECTIVE:Chronic infections have been reported to be risk factors for coronary heart disease and ischemic stroke. However, the association of coronary heart disease and ischemic stroke with periodontal disease, which is also a chronic inflammatory disease, needs to be evaluated. The present case-control...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/j.1600-0765.2009.01220.x
更新日期：2010-04-01 00:00:00
abstract：:Cystatins are physiological inhibitors of cysteine proteinases which are widely distributed in human tissues and fluids. In the present study we analysed both the cystatin activity and the different cystatin isoforms in gingival crevicular fluid and saliva samples of nine periodontitis patients. All crevicular fluid s...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/j.1600-0765.1997.tb00935.x
更新日期：1997-10-01 00:00:00
abstract：OBJECTIVES AND BACKGROUND:Endothelin-1 (ET-1) is a 21-amino acid peptide with multifunctional regulation. ET-1 expresses in various cells during inflammation. The present study aimed to examine the ET-1 expression in oral epithelial cells after infection with the periodontal pathogen and to investigate the presence of ...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1034/j.1600-0765.2003.00668.x
更新日期：2003-08-01 00:00:00
abstract：:The present study was carried out to examine the ultrastructural localization of laminin and type-IV collagen in the junctional epithelium of rat molar gingiva by means of the indirect immunoperoxidase method. Intense laminin reaction occurred in both the internal and the external basal laminae. Laminin reaction produ...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/j.1600-0765.1990.tb00930.x
更新日期：1990-11-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Little is known about the factors that affect the microbial composition of supragingival biofilms. This study was designed to examine the relationship between total DNA probe counts of supragingival biofilm samples, clinical parameters and supragingival biofilm composition. MATERIAL AND METHOD...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/j.1600-0765.2008.01154.x
更新日期：2009-08-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Periodontal ligament stem cells (PDLSCs) have potential for osteogenic differentiation and show a great foreground in treating bone diseases. Histone three lysine 27 (H3K27) demethylase lysine demethylase 6A (KDM6A) is a critical epigenetic modifier and plays an important role in regulating ost...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/jre.12830
更新日期：2020-12-24 00:00:00
abstract：:The immunoglobulin class distribution of antibody to human collagen type I has been examined in sera and gingival extracts from patients with adult chronic periodontitis. Tissue extracts were made either by simple washing or ultrasonication. With either method, IgG and IgA antibodies to collagen were present in higher...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/j.1600-0765.1992.tb02086.x
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Neutrophil extracellular traps (NETs) are a recently discovered antimicrobial mechanism used by neutrophils that have been proposed as an intervention in the pathogenesis of periodontitis. The objective of our study was to characterize the expression of NETs in gingival tissues with periodontit...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/jre.12621
更新日期：2019-06-01 00:00:00
abstract：OBJECTIVES:Heat shock protein (HSP) can be utilized as a vaccine to cross-protect against multiple pathogenic species. The present study was performed to evaluate Porphyromonas gingivalis heat shock protein 60 (HSP60) as a vaccine candidate to inhibit multiple bacteria-induced alveolar bone loss. MATERIAL AND METHODS:...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/j.1600-0765.2005.00832.x
更新日期：2006-02-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Butyrate is produced by some types of anaerobic periodontal bacteria. Millimolar concentrations of butyrate are found in mature dental plaque from periodontitis patients. Although butyrate reportedly has a variety of effects in many mammalian cells, its effect on gingival epithelial cells is no...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/j.1600-0765.2010.01277.x
更新日期：2010-10-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Diabetes mellitus is believed to increase the risk and severity of periodontitis. However, less evidence is available on the converse effects of periodontitis on diabetes. The objective of the study was to investigate to what degree experimental periodontitis induced by Porphyromonas gingivalis...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/jre.12041
更新日期：2013-10-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to evaluate the effects of non-surgical periodontal therapy on gingival crevicular fluid levels of matrix metalloproteinase-8 (MMP-8), interleukin-6 (IL-6) and prostaglandin E2 (PGE2 ) in patients with rheumatoid arthritis (RA) with periodontal disease. MATERIAL AND METHODS:Twenty-s...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/jre.12337
更新日期：2016-10-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Dental rubber dams (RDs) were used as barrier membranes in guided tissue regeneration for the treatment of periodontal intraosseous defects with acceptable clinical results. The aim of the present study was to investigate the effects of autoclave sterilization on properties of RD as related to ...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1034/j.1600-0765.2003.00693.x
更新日期：2003-10-01 00:00:00
abstract：OBJECTIVES AND BACKGROUND:Povidone-iodine [polyvinylpyrrolidone-iodine complex (PVP-iodine)] might constitute a valuable adjunct to current periodontal therapy because of its broad-spectrum antimicrobial activity, low potential for developing resistance and adverse reactions, wide availability, ease of use, and low fin...
journal_title：Journal of periodontal research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1034/j.1600-0765.2003.02016.x
更新日期：2003-06-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Salvia miltiorrhiza Bunge (Labiatae), or Danshen, is a Chinese medicine used for treatment of cardiac diseases by improving blood circulation and inhibiting inflammatory responses. In this study, we aimed to determine whether an ethanol extract of S. miltiorrhiza can ameliorate tissue damage ca...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/jre.12292
更新日期：2016-02-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Several studies have shown an association between periodontitis and cardiovascular disease (CVD). Atherosclerosis is the major cause of CVD, and a key event in the development of atherosclerosis is accumulation of lipoproteins within the arterial wall. Bacteria are the primary etiologic agents ...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/jre.12527
更新日期：2018-06-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The association between periodontal disease and nutrient intake was examined using linked data from the 2005 National Health and Nutrition Survey, the Comprehensive Survey of Living Conditions and the Survey of Dental Diseases from the same year 'using linked data from the National Health and N...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/jre.12375
更新日期：2017-02-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:T cells and their cytokines are believed to be key factors in periodontal disease and bone resorption. We previously showed that T cells transferred to nude mice were related to inflammatory bone resorption in vivo. However, it has not been clarified whether T cells can induce bone resorption i...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/j.1600-0765.2008.01083.x
更新日期：2008-10-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Several studies have hypothesized that periodontal disease may increase the risk of pre-eclampsia. The correlation between the two diseases would probably be based on hypertension-related cytokine release in the local periodontal environment. The aim of this study was to evaluate the associatio...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/j.1600-0765.2011.01368.x
更新日期：2011-08-01 00:00:00
abstract：:Karyometric and cytophotometric measurements of DNA and RNA have been evaluated in gingival graft epithelium. The study was conducted during the first 20 hours from the time of grafting when the graft epithelium undergoes a process of autolysis. Both basal cell and prickle cell layers were used. The results showed an ...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/j.1600-0765.1975.tb00002.x
更新日期：1975-02-01 00:00:00
abstract：BACKGROUND:The role of water in the etiology of periodontal disease is poorly understood. OBJECTIVES:The objective of this study was to examine the association amongst water softness, risk for periodontitis, and smoking status. METHODS:We examined the association between use of water 'softening and conditioning syste...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/j.1600-0765.2004.00769.x
更新日期：2004-12-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Neutrophils are the primary white blood cells that are recruited to fight the initial phases of microbial infections. While healthy norms have been determined for circulating blood neutrophil counts in order to identify patients with suspected systemic infections, the levels of oral neutrophils...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/jre.12211
更新日期：2015-06-01 00:00:00
abstract：:The effectiveness of an ideal antimicrobial agent depends on its ability to kill microbes with minimal toxicity to host cells. Depending on the treatment regimen, antimicrobial agents come into contact with host cells for various intervals of time. Sanguinarium (SANG), chlorhexidine (CHX) and tetracycline (TET) are 3 ...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/j.1600-0765.1997.tb00542.x
更新日期：1997-04-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Multiple studies support the role of periodontal disease in contributing to the chronic systemic inflammatory burden in a variety of diseases, including ankylosing spondylitis (AS), in the progression which the inflammatory process plays an important role. We assume that patients with AS are mo...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/j.1600-0765.2011.01448.x
更新日期：2012-06-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Biological plausibility of an association between severe periodontitis and cardiovascular disease (CVD) has been proven. Genetic characteristics play an important role in both complex inflammatory diseases. Polymorphisms (single nucleotide polymorphisms [SNPs]) in the long noncoding RNA, antise...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/jre.12555
更新日期：2018-10-01 00:00:00
abstract：:Recent reports suggest that specific serum IgG subclasses are a feature of several forms of periodontitis. GCF antibodies are both serum-derived and locally produced by the abundant plasma cells of the diseased periodontal tissue. Previous work has shown that crevicular fluid (GCF) levels of IgG may be reduced in acti...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/j.1600-0765.1997.tb01401.x
更新日期：1997-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The aim of this study was to investigate reactions of periodontal ligament epithelial cell clusters and major histocompatibility complex class II (OX6)-immunopositive cells to simultaneously induced tooth movement and periodontitis employing Waldo's method. MATERIAL AND METHODS:Elastic gums we...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/j.1600-0765.2011.01376.x
更新日期：2011-10-01 00:00:00
abstract：:This study uses cytokeratins (CK) as markers to investigate the phenotype of the junctional epithelium (JE) in partially erupted human teeth. The gingival samples, which were clinically healthy, were carefully dissected from the teeth. Cryostat sections were cut for histological staining, immunofluorescence microscopy...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/j.1600-0765.1994.tb01212.x
更新日期：1994-05-01 00:00:00
abstract：:Nearly 70-75% of patients with localized juvenile periodontitis (JP) have abnormal polymorphonuclear leukocytic (PMN) chemotaxis. The objective of this study was to determine whether the lower chemotactic response in PMNs from JP patients is associated with a defect in intracellular signal transduction, as measured by...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/j.1600-0765.1989.tb00870.x
更新日期：1989-03-01 00:00:00
abstract：:Bursts of periodontal destruction are modelled as percolation-driven phase shift events. Percolation theory, though widely used to study the flow of liquids through porous nonliving materials (e.g., soils and rocks), can be applied to bacterial or toxicological penetration of living tissue in only an approximate sense...
journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：
更新日期：1993-11-01 00:00:00
