Immunomodulatory effect of cimetidine in common carp (Cyprinus carpio L.).

Abstract:

:The main indication of cimetidine is being H₂-receptor antagonist, but studies suggest that cimetidine may also act as a non-specific stimulant of cell-mediated immunity and immunomodulator. In order to determine the immunomodulatory effect of dietary intake of cimetidine in the common carp (100 ± 10 g), subjects were fed diets containing 0 (control), 50, 100 and 200 mg cimetidine kg⁻¹ of dry diet for a period of 6 weeks. TLC and NBT assays were significantly (P < 0.05) stimulated in cimetidine-supplemented groups displaying the highest value in 200 mg kg⁻¹ group. A decrease (P < 0.05) in cortisol and ACH50 value was recorded in fish treated with cimetidine. Serum protein, albumin and serum globulin levels were not significantly changed. The findings of the present investigation suggest that the incorporation of cimetidine in the diet of common carp enhances the non-specific immunity.

journal_name

Fish Physiol Biochem

authors

Hosseinifard SM,Ahmadpour A,Mojazi Amiri B,Razeghi Mansour M,Ebrahimpour A

doi

10.1007/s10695-013-9804-8

subject

Has Abstract

pub_date

2013-12-01 00:00:00

pages

1505-11

issue

6

eissn

0920-1742

issn

1573-5168

journal_volume

39

pub_type

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