Abstract:
:The main indication of cimetidine is being H₂-receptor antagonist, but studies suggest that cimetidine may also act as a non-specific stimulant of cell-mediated immunity and immunomodulator. In order to determine the immunomodulatory effect of dietary intake of cimetidine in the common carp (100 ± 10 g), subjects were fed diets containing 0 (control), 50, 100 and 200 mg cimetidine kg⁻¹ of dry diet for a period of 6 weeks. TLC and NBT assays were significantly (P < 0.05) stimulated in cimetidine-supplemented groups displaying the highest value in 200 mg kg⁻¹ group. A decrease (P < 0.05) in cortisol and ACH50 value was recorded in fish treated with cimetidine. Serum protein, albumin and serum globulin levels were not significantly changed. The findings of the present investigation suggest that the incorporation of cimetidine in the diet of common carp enhances the non-specific immunity.
journal_name
Fish Physiol Biochemjournal_title
Fish physiology and biochemistryauthors
Hosseinifard SM,Ahmadpour A,Mojazi Amiri B,Razeghi Mansour M,Ebrahimpour Adoi
10.1007/s10695-013-9804-8subject
Has Abstractpub_date
2013-12-01 00:00:00pages
1505-11issue
6eissn
0920-1742issn
1573-5168journal_volume
39pub_type
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journal_title:Fish physiology and biochemistry
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journal_title:Fish physiology and biochemistry
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