RNAi in Plasmodium.

Abstract:

:RNA interference (RNAi) has quickly proven to be an immensely useful tool for studying gene function and validation of potential drug targets in almost all organisms that possess the required set of proteins of the interference pathway. In protozoan parasites like Plasmodium, Toxoplasma, Entamoeba, Giardia, Trypanosoma, and Leishmania, this set of enzymes is represented divergently. Hitherto, no RNAi-related genes like Dicer and Argonaute have been identified in Plasmodium and Leishmania species, respectively. However, non-canonical RNAi-related pathways might be present in both parasites, as it has been recently demonstrated in Plasmodium. In this review, we discuss existing challenges and future directions for developing RNAi as a tool for studying gene function and as a possible clinical application against Plasmodium.

journal_name

Curr Pharm Des

authors

Mueller AK,Hammerschmidt-Kamper C,Kaiser A

doi

10.2174/13816128113199990027

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

278-83

issue

2

eissn

1381-6128

issn

1873-4286

pii

CPD-EPUB-20130516-2

journal_volume

20

pub_type

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