Abstract:
:Programmed cell death (mainly apoptosis) is involved in all fundamental processes of the immune system. Furthermore, apoptosis is essential for elimination of autoreactive lymphocytes and is, therefore a mechanism to guarantee self-tolerance. There are several genes directly implicated in the regulation of lymphoid apoptosis. However, certain mouse strains expressing the defective mutants of those genes exhibit immunological dysfunctions resembling human autoimmune disease conditions. Thus, further analyses of such animal models could facilitate the better understanding of immunopathological abnormalities developing in humans.
journal_name
Orv Hetiljournal_title
Orvosi hetilapauthors
Müzes G,Igaz Psubject
Has Abstractpub_date
1997-05-25 00:00:00pages
1315-20issue
21eissn
0030-6002issn
1788-6120journal_volume
138pub_type
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