当前位置： SCI文献检索 > COMPLEMENTARY THERAPIES IN MEDICINE期刊下所有文献 > N-of-1 trials in China.

N-of-1 trials in China.

Abstract：

CONTEXT:The N-of-1 trial design (randomized and blinded single-patient trials) has been popular abroad for 25 years or more. Many papers using the N-of-1 trials have been published in international medical journals. However, little is known about this methodology in China. Our purpose is to describe the current status of N-of-1 trials in China, to explain why they have not been more widely used, and to suggest a roadmap for the development of N-of-1 trials, especially for the study of Traditional Chinese Medicine (TCM). METHODS:An electronic search was conducted using the Chinese Biological Medicine Database (CBM) and China National Knowledge Infrastructure (CNKI) with the keywords "N-of-1 trial, single case OR individual patient AND randomized". We also searched PubMed. The Chinese Science Citation Database (CSCD) as a citation was searched at last. RESULTS:23 studies were retrieved from CBM and 34 from CNKI. There were 13 papers about N-of-1 trials in CBM and 17 in CNKI. Only 3 studies were rigorously designed (i.e., using randomization, control periods and blinding). The other 8 papers were descriptive and review articles, most of which were in TCM. One review was published in SCI-E and one in MEDLINE. Three papers were found in CSCD as citations. Only one of the retrieved studies was funded. CONCLUSIONS:While N-of-1 trials may offer a good tool to individualize clinical care and enrich TCM clinical research, they have not been widely used to date. To spur the development of this method, we would like to suggest three points. First, the Chinese government should endorse and sponsor N-of-1 studies. Second, researchers and physicians should be systematically trained in the method. Third, thorough considerations on trials allow better research and focus on the patients' needs.

journal_name

Complement Ther Med

journal_title

Complementary therapies in medicine

authors

Li J,Tian J,Ma B,Yang K

doi

10.1016/j.ctim.2013.01.003

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

190-4

issue

3

eissn

0965-2299

issn

1873-6963

pii

S0965-2299(13)00020-4

journal_volume

21

pub_type

杂志文章

相关文献

COMPLEMENTARY THERAPIES IN MEDICINE文献大全
  • A systematic review and meta-analysis: The effects of probiotic supplementation on metabolic profile in patients with neurological disorders.

    abstract：BACKGROUND AND OBJECTIVE:The objective of meta-analysis of randomized controlled trials (RCTs) was to evaluate the effects of probiotic supplementation on metabolic status in patients with neurological disorders. METHODS:The following databases were search up to April 2019: Pubmed, Scopus, Google scholar, Web of Scien...

    journal_title：Complementary therapies in medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ctim.2020.102507

    authors： Tamtaji OR,Milajerdi A,Reiner Ž,Asemi Z,Dadgostar E,Heidari-Soureshjani R,Mamsharifi P,Amirani E,Mirzaei H,Hallajzadeh J,Ghaderi A

    更新日期：2020-09-01 00:00:00

  • Efficacy of rhythmical massage in comparison to heart rate variability biofeedback in patients with dysmenorrhea-A randomized, controlled trial.

    abstract：BACKGROUND:20-90% of all women suffer from dysmenorrhea. Standard therapy of primary dysmenorrhea (PD) are NSAIDs and oral contraceptives, effective but not without possible side effects. OBJECTIVE:To examine the efficacy of rhythmical massage (Anthroposophic Medicine) and heart rate variability biofeedback compared t...

    journal_title：Complementary therapies in medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ctim.2018.11.009

    authors： Vagedes J,Fazeli A,Boening A,Helmert E,Berger B,Martin D

    更新日期：2019-02-01 00:00:00

  • Filling the gap between traditional Chinese medicine and modern medicine, are we heading to the right direction?

    abstract：:Traditional Chinese medicine (TCM), the ancient medicine popular in China and surrounding areas, has been recognized as a typical representative of complementary and alternative medicine. Over long period in clinical practice, especially the progress in basic research, data on the effectiveness and beneficial contribu...

    journal_title：Complementary therapies in medicine

    pub_type： 信件

    doi：10.1016/j.ctim.2013.01.001

    authors： Chen X,Pei L,Lu J

    更新日期：2013-06-01 00:00:00

  • Irish set dancing classes for people with Parkinson's disease: The needs of participants and dance teachers.

    abstract：OBJECTIVE:As the number of people diagnosed with Parkinson's disease increases, there is a need to develop initiatives that promote health and wellbeing and support self-management. Additionally, as exercise may slow physical decline, there is a need to develop methods that facilitate greater engagement with community-...

    journal_title：Complementary therapies in medicine

    pub_type： 杂志文章

    doi：10.1016/j.ctim.2016.04.001

    authors： Shanahan J,Bhriain ON,Morris ME,Volpe D,Clifford AM

    更新日期：2016-08-01 00:00:00

  • Perceptions and recommendation behaviors of dermatologists for medical cannabis: A pilot survey.

    abstract：OBJECTIVES:Evidence suggests that cannabinoids may provide therapeutic benefit to patients with dermatologic conditions. The recommendation behaviors of dermatologists with regards to recommending medical cannabis are unknown. We administered a pilot survey to evaluate dermatologists' recommendation behaviors including...

    journal_title：Complementary therapies in medicine

    pub_type： 杂志文章

    doi：10.1016/j.ctim.2020.102552

    authors： Yeroushalmi S,Nelson K,Sparks A,Friedman A

    更新日期：2020-12-01 00:00:00

  • The effect of ginger powder supplementation on insulin resistance and glycemic indices in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial.

    abstract：OBJECTIVE:To identify the effect of some herbal products on insulin resistance. Regarding the scientific evidences existing about ginger, this research was therefore carried out to identify the effect of ginger supplementation on insulin resistance and glycemic indices in diabetes mellitus. METHODS:This is a randomize...

    journal_title：Complementary therapies in medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ctim.2013.12.017

    authors： Mozaffari-Khosravi H,Talaei B,Jalali BA,Najarzadeh A,Mozayan MR

    更新日期：2014-02-01 00:00:00

  • The role of mind-body interventions in pre-dialysis chronic kidney disease and dialysis patients - A systematic review of literature.

    abstract：INTRODUCTION:With the rise in complementary medicine usage, mind-body interventions (MBI), encompassing therapies like yoga and music therapy, have been gaining interest. The use of MBI in non-chronic kidney disease (CKD) patients have demonstrated efficacy for ameliorating pain, stress and anxiety symptoms. As CKD pat...

    journal_title：Complementary therapies in medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ctim.2020.102652

    authors： Chu SWF,Yeam CT,Low LL,Tay WY,Foo WYM,Seng JJB

    更新日期：2020-12-26 00:00:00

  • General practitioners, complementary therapies and evidence-based medicine: the defence of clinical autonomy.

    abstract：:Amidst the substantial change currently gripping primary health care are two developments central to contemporary debate regarding the very nature, territory and identity of general practice - the integration of complementary and alternative medicine (CAM) and the rise of evidence-based medicine (EBM). This paper repo...

    journal_title：Complementary therapies in medicine

    pub_type： 杂志文章

    doi：10.1054/ctim.2000.0396

    authors： Adams J

    更新日期：2000-12-01 00:00:00

  • Randomized-controlled study of treating attention deficit hyperactivity disorder of preschool children with combined electro-acupuncture and behavior therapy.

    abstract：OBJECTIVE:To study the effectiveness of electro-acupuncture with behavior therapy on preschool children with attention deficit hyperactivity disorder (ADHD). METHODS:180 preschool children with ADHD diagnosed by DSM-IV were classified into three subtypes: predominantly inattentive subtype (PI subtype, 60 cases), predo...

    journal_title：Complementary therapies in medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ctim.2010.08.002

    authors： Li S,Yu B,Lin Z,Jiang S,He J,Kang L,Li W,Chen X,Wang X

    更新日期：2010-10-01 00:00:00

  • Measure Yourself Concerns and Wellbeing (MYCaW): an individualised questionnaire for evaluating outcome in cancer support care that includes complementary therapies.

    abstract：BACKGROUND AND AIM:Descriptive and experimental evaluations of cancer support services require an outcome questionnaire that is valid, responsive to change, feasible and interpretable. This paper describes the development of such a tool. DEVELOPMENT OF THE QUESTIONNAIRE:A validated individualised measure MYMOP was ada...

    journal_title：Complementary therapies in medicine

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ctim.2006.03.006

    authors： Paterson C,Thomas K,Manasse A,Cooke H,Peace G

    更新日期：2007-03-01 00:00:00

  • Use of l-3-n-Butylphthalide within 24 h after intravenous thrombolysis for acute cerebral infarction.

    abstract：OBJECTIVE:Observe the clinical efficacy of l-3-n-Butylphthalide (NBP) in acute ischemic stroke (AIS) patients within 24 h after intravenous thrombolysis using recombinant tissue plasminogen activator (hereafter termed "IT"). METHODS:One-hundred and seventy-eight patients with AIS were divided randomly into two groups:...

    journal_title：Complementary therapies in medicine

    pub_type： 杂志文章

    doi：10.1016/j.ctim.2020.102442

    authors： Wang M,Feng Y,Yuan Y,Gui L,Wang J,Gao P,Qin B,Sima D,Wang Q,Pan W

    更新日期：2020-08-01 00:00:00

  • Impact of evidence-based healthcare education for Chinese medicine practitioners: A pre-post evaluation.

    abstract：:WHO Traditional Medicine Strategy 2014-23 recommended evidence-based healthcare (EBHC) education for traditional and complementary medicine (T&CM) professionals, including Chinese medicine practitioners (CMPs). We evaluated the impact of a customized educational workshop on Hong Kong CMPs' knowledge, attitude and prac...

    journal_title：Complementary therapies in medicine

    pub_type： 杂志文章

    doi：10.1016/j.ctim.2019.05.004

    authors： Wong CHL,Wu IXY,Cheung WKW,Ho RST,Leach MJ,Peng W,Zhang Y,Wu JCY,Chung VCH

    更新日期：2019-08-01 00:00:00

  • The effect of inhalation aromatherapy in patients undergoing cardiac surgery: A systematic review and meta-analysis of randomized controlled trials.

    abstract：OBJECTIVE:The goal of this study was to synthesize evidence regarding the efficacy of inhalation aromatherapy in patients undergoing cardiac surgery. METHODS:We conducted an electronic search of four authentic databases. Randomized controlled trials (RCTs), which compared inhalation aromatherapy versus control in pati...

    journal_title：Complementary therapies in medicine

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.ctim.2019.102256

    authors： Abdelhakim AM,Hussein AS,Doheim MF,Sayed AK

    更新日期：2020-01-01 00:00:00

  • The PedCAM Network: past, present, and future.

    abstract：:Established in 2004, the Pediatric Complementary and Alternative Medicine Research & Education (PedCAM) Network (www.pedcam.ca) is a multidisciplinary national and international network focused on pediatric research and education with the vision of safe and effective use of complementary and alternative medicine (CAM)...

    journal_title：Complementary therapies in medicine

    pub_type： 杂志文章

    doi：10.1016/j.ctim.2011.03.002

    authors： Surette S,Vohra S

    更新日期：2013-04-01 00:00:00

  • Herbs as old potential treatments for lymphedema management: A systematic review.

    abstract：INTRODUCTION:Herbs have been reported to be effective in reducing lymphedema burden. This paper aimed to review literature reporting on herbs for lymphedema treatment. METHODS:A systematic review was performed using the PRISMA guideline. Clinical studies on herbal intervention and lymphedema were included. Evidence on...

    journal_title：Complementary therapies in medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ctim.2020.102615

    authors： Sheikhi-Mobarakeh Z,Yarmohammadi H,Mokhatri-Hesari P,Fahimi S,Montazeri A,Heydarirad G

    更新日期：2020-12-01 00:00:00

  • Effectiveness of Spiritist "passe" (Spiritual healing) for anxiety levels, depression, pain, muscle tension, well-being, and physiological parameters in cardiovascular inpatients: A randomized controlled trial.

    abstract：BACKGROUND:Biofield therapies, such as laying on of hands, are used in association with Conventional Medicine as Spiritist "passe", among others. The aim of this study was to evaluate anxiety, depression, pain, muscle tension and well-being, as well as physiological parameters in cardiovascular inpatients submitted to ...

    journal_title：Complementary therapies in medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ctim.2016.11.008

    authors： Carneiro ÉM,Barbosa LP,Marson JM,Terra JA Junior,Martins CJ,Modesto D,Resende LA,Borges MF

    更新日期：2017-02-01 00:00:00

  • Use of medicinal plants in patients with chronic kidney disease from Peru.

    abstract：OBJECTIVE:To describe the use of medicinal plants in patients with chronic kidney disease (CKD) in public healthcare centers in Peru. METHODS:A cross-sectional study was conducted in patients with CKD in healthcare centers of three Peruvian regions: Lima, Arequipa, and Ucayali. A structured questionnaire which include...

    journal_title：Complementary therapies in medicine

    pub_type： 杂志文章

    doi：10.1016/j.ctim.2019.102215

    authors： Herrera-Añazco P,Taype-Rondan A,Ortiz PJ,Málaga G,Del Carpio-Toia AM,Alvarez-Valdivia MG,Juárez-Huanca C,Ciudad-Fernandez L,Bruner-Meléndez R,Samaniego-Mojica W,Perez-Rafael E

    更新日期：2019-12-01 00:00:00

  • "We need them as much as they need us": A systematic review of the qualitative evidence for possible mechanisms of effectiveness of animal-assisted intervention (AAI).

    abstract：OBJECTIVE:Although Animal-Assisted Interventions (AAI) are effective treatments for a variety of psychological problems, the mechanism of treatment effectiveness remains unclear. Qualitative studies of AAI may reveal possible mechanisms. This review aims to synthesize qualitative research and identify factors that migh...

    journal_title：Complementary therapies in medicine

    pub_type： 杂志文章

    doi：10.1016/j.ctim.2018.10.001

    authors： Shen RZZ,Xiong P,Chou UI,Hall BJ

    更新日期：2018-12-01 00:00:00

  • Spa adjuvant therapy improves diabetic lower extremity arterial disease.

    abstract：OBJECTIVE:To investigate the effect of spa adjuvant therapy on diabetic lower extremity arterial disease (LEAD). METHODS:128 patients with type II diabetes were separated into three groups according to the degree of lower extremity vascular stenosis. Patients within each group were then randomly divided to receive no ...

    journal_title：Complementary therapies in medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ctim.2014.05.003

    authors： Qiu Y,Zhu Y,Jia W,Chen S,Meng Q

    更新日期：2014-08-01 00:00:00

  • A survey of the uptake and implementation of research evidence by South Australian acupuncturists in clinical practice: attitudes and associated predictive factors.

    abstract：OBJECTIVE:To examine South Australian acupuncturists' attitudes towards the use of research evidence and concurrently identify predicative factors associated with the uptake and implementation of research evidence. METHODS:Questionnaires were mailed out to the entire South Australian acupuncturist population (n=94). T...

    journal_title：Complementary therapies in medicine

    pub_type： 杂志文章

    doi：10.1016/j.ctim.2007.08.002

    authors： Stomski N,Grimmer-Somers K,Petkov J

    更新日期：2008-08-01 00:00:00

  • Clinical effect of traditional Chinese spinal orthopedic manipulation in treatment of Functional Abdominal Pain Syndrome.

    abstract：OBJECTIVE:To evaluate the clinical effect of Traditional Chinese Spinal Orthopedic Manipulation (TCSOM) in treating Functional Abdominal Pain Syndrome (FAPS) in comparison with Pinaverium Bromide (Dicetel, PBD), and to assess a possible cause for FAPS. METHODS:60 cases of FAPS patients were randomly assigned to the TC...

    journal_title：Complementary therapies in medicine

    pub_type： 杂志文章

    doi：10.1016/j.ctim.2017.03.009

    authors： Xing L,Qu L,Chen H,Gao S

    更新日期：2017-06-01 00:00:00

  • The effect of self-selected complementary therapies on cancer patients' quality of life and symptom distress: A prospective cohort study in an integrative oncology setting.

    abstract：OBJECTIVE:To examine the effectiveness of a multifaceted complementary therapies intervention, delivered in a systematic manner within an Australian public hospital setting, on quality of life and symptom distress outcomes for cancer patients. METHODS:Adults receiving treatment for any form of cancer were eligible to ...

    journal_title：Complementary therapies in medicine

    pub_type： 杂志文章

    doi：10.1016/j.ctim.2018.01.006

    authors： Stomski NJ,Petterson A,Kristjanson L,Lobb EA,Phillips M,Williams A,Morrison P,Joske D

    更新日期：2018-04-01 00:00:00

  • High expectations: The landscape of clinical trials of medical marijuana in oncology.

    abstract：PURPOSE:Given the infancy and evolving complexity of medicinal marijuana, an evolving political landscape, and the growing frequency of its use in cancer care, it is important for oncologists to be actively engaged in developing and successfully implementing clinical trials focusing on medical marijuana. The purpose of...

    journal_title：Complementary therapies in medicine

    pub_type： 杂志文章

    doi：10.1016/j.ctim.2020.102336

    authors： Goyal S,Kubendran S,Kogan M,Rao YJ

    更新日期：2020-03-01 00:00:00

  • The placebo response in clinical trials-the current state of play.

    abstract：:While randomized, placebo-controlled double-blinded trials have become the pharmacological standard over the last 60 years, the gain in knowledge of the mechanisms behind the placebo response in recent years has raised substantial concerns about the appropriateness of some of its underlying assumptions. The following ...

    journal_title：Complementary therapies in medicine

    pub_type： 杂志文章

    doi：10.1016/j.ctim.2012.12.010

    authors： Enck P,Klosterhalfen S

    更新日期：2013-04-01 00:00:00

  • A randomised study of the effects of massage therapy compared to guided relaxation on well-being and stress perception among older adults.

    abstract：OBJECTIVE:The objective was to assess the effects of massage compared to guided relaxation on stress perception and well-being among older adults. DESIGN:A randomised pilot study enrolled adults ages 60 and older to receive 50 min, twice weekly massage therapy or guided relaxation sessions. Questionnaires were adminis...

    journal_title：Complementary therapies in medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ctim.2007.01.004

    authors： Sharpe PA,Williams HG,Granner ML,Hussey JR

    更新日期：2007-09-01 00:00:00

  • Alternative, complementary or concurrent health care? A critical analysis of the use of the concept of complementary therapy.

    abstract：:In this paper I critically address what is becoming the wholesale adoption of the concept of complementary medicine in researchers' analyses of lay participation in alternative therapies. This paper emerged out of a qualitative study of 21 Canadians who use and/or practice alternative therapies. I found that only seve...

    journal_title：Complementary therapies in medicine

    pub_type： 杂志文章

    doi：10.1054/ctim.2000.0423

    authors： Low J

    更新日期：2001-06-01 00:00:00

  • Understanding public perceptions of healing: An arts-based qualitative study.

    abstract：BACKGROUND:Most healing research has focussed on the views of healers, complementary and alternative medical (CAM) practitioners or medical professionals, and little is known about how the general public conceives of healing. Because healing is a complex and often abstract concept, we addressed this gap in the knowledg...

    journal_title：Complementary therapies in medicine

    pub_type： 杂志文章

    doi：10.1016/j.ctim.2019.05.013

    authors： Rahtz E,Warber SL,Dieppe P

    更新日期：2019-08-01 00:00:00

  • Dance for Parkinson's: a new framework for research on its physical, mental, emotional, and social benefits.

    abstract：:Parkinson's is a neurodegenerative disease commonly associated with symptoms such as tremor, rigidity, bradykinesia, freezing during gait, motor control deficits and instability. These physical symptoms can cause a myriad of psychological problems including depression, feelings of loneliness, and low self-esteem. Curr...

    journal_title：Complementary therapies in medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ctim.2014.03.005

    authors： McGill A,Houston S,Lee RY

    更新日期：2014-06-01 00:00:00

  • Efficacy of adjuvant Chinese herbal formula treatment for chronic tinnitus: a retrospective observational study.

    abstract：BACKGROUND:The aim of this study was to evaluate the clinical efficacy of using western anti-tinnitus therapy with or without Chai-Hu-Jia-Long-Gu-Mu-Li-Tang (CHJLGMLT) to treat patients with chronic tinnitus. METHODS:A descriptive case series with chart review was established to compare patients with chronic tinnitus ...

    journal_title：Complementary therapies in medicine

    pub_type： 杂志文章

    doi：10.1016/j.ctim.2015.01.002

    authors： Lin CH,Kuo CE,Yu HC,Lai YK,Huang YC,Tsai MY

    更新日期：2015-04-01 00:00:00

  • Complementary and alternative therapies in dentistry and characteristics of dentists who recommend them.

    abstract：OBJECTIVES:The aims of this study were to analyse whether dentists offer or recommend complementary and alternative medicine (CAM) remedies in their clinical routine, and how effective these are rated by proponents and opponents. A second aim of this study was to give a profile of the dentists endorsing CAM. DESIGN:A ...

    journal_title：Complementary therapies in medicine

    pub_type： 杂志文章

    doi：10.1016/j.ctim.2017.08.008

    authors： Baatsch B,Zimmer S,Rodrigues Recchia D,Büssing A

    更新日期：2017-12-01 00:00:00