Abstract:
:Anogenital (AG) warts in 31 prepubertal children were HPV typed by nonisotopic in situ hybridization (NISH) using digoxigenin-labeled probes for human papilloma virus (HPV) types 1-5, 6, 11, 16, 18, 31, and 33. Mode of transmission was determined from historical, clinical, and laboratory data independent of HPV typing. HPV 2 was detected most commonly (13/31 warts) followed by HPV 6 (7/31), HPV 11 (5/31), and HPV 16 (1/31). Although not reaching statistical significance, our results suggested that a mucosal HPV type (6, 11, 16) in a child's AG warts implied transmission from mucosal warts and conversely cutaneous HPV 2 transmission from warts at a cutaneous site. HPV typing provided no helpful information regarding actual mode of transmission of AG warts in these children. The high prevalence of HPV 2 in children's AG warts and the low prevalence of sexual abuse (2 of 31 children) found in this study suggest innocent auto- or heteroinoculation from cutaneous warts may be a common means by which children acquire AG warts.
journal_name
Pediatr Dermatoljournal_title
Pediatric dermatologyauthors
Handley J,Hanks E,Armstrong K,Bingham A,Dinsmore W,Swann A,Evans MF,McGee JO,O'Leary Jdoi
10.1111/j.1525-1470.1997.tb00976.xsubject
Has Abstractpub_date
1997-09-01 00:00:00pages
339-43issue
5eissn
0736-8046issn
1525-1470journal_volume
14pub_type
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