Common association of HPV 2 with anogenital warts in prepubertal children.

Abstract:

:Anogenital (AG) warts in 31 prepubertal children were HPV typed by nonisotopic in situ hybridization (NISH) using digoxigenin-labeled probes for human papilloma virus (HPV) types 1-5, 6, 11, 16, 18, 31, and 33. Mode of transmission was determined from historical, clinical, and laboratory data independent of HPV typing. HPV 2 was detected most commonly (13/31 warts) followed by HPV 6 (7/31), HPV 11 (5/31), and HPV 16 (1/31). Although not reaching statistical significance, our results suggested that a mucosal HPV type (6, 11, 16) in a child's AG warts implied transmission from mucosal warts and conversely cutaneous HPV 2 transmission from warts at a cutaneous site. HPV typing provided no helpful information regarding actual mode of transmission of AG warts in these children. The high prevalence of HPV 2 in children's AG warts and the low prevalence of sexual abuse (2 of 31 children) found in this study suggest innocent auto- or heteroinoculation from cutaneous warts may be a common means by which children acquire AG warts.

journal_name

Pediatr Dermatol

journal_title

Pediatric dermatology

authors

Handley J,Hanks E,Armstrong K,Bingham A,Dinsmore W,Swann A,Evans MF,McGee JO,O'Leary J

doi

10.1111/j.1525-1470.1997.tb00976.x

subject

Has Abstract

pub_date

1997-09-01 00:00:00

pages

339-43

issue

5

eissn

0736-8046

issn

1525-1470

journal_volume

14

pub_type

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