Abstract:
:Chromosome analysis was performed on samples from 20 Brazilian patients with breast cancer. All the samples were from untreated patients who presented the clinical symptoms for months or years before surgical intervention. Six cases showed axillary lymph node metastases. Clonal chromosome abnormalities were detected in all cases. The numerical alterations most frequently observed involved the loss of chromosomes X, 19, 20, and 22 followed by gain of chromosomes 9 and 8. Among the structural anomalies observed, there was preferential involvement of chromosomes 11, 6, 1, 7, 3, and 12, supporting previous reports that these chromosomes may harbour genes of importance in the development of breast tumors. Two cases with a family history of breast cancer had in common total or partial trisomy 1.
journal_name
Hereditasjournal_title
Hereditasauthors
Cavalli LR,Cavaliéri LM,Ribeiro LA,Cavalli IJ,Silveira R,Rogatto SRdoi
10.1111/j.1601-5223.1997.00261.xsubject
Has Abstractpub_date
1997-01-01 00:00:00pages
261-8issue
3eissn
0018-0661issn
1601-5223journal_volume
126pub_type
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