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Saphenous vein graft failure and clinical outcomes: toward a surrogate end point in patients following coronary artery bypass surgery?

Abstract：

:Saphenous vein graft (SVG) failure is a common finding in patients following coronary artery bypass graft (CABG) surgery. In the literature SVG failure rates have been reported from 25 to over 50% within 10 years. Although common, it remains unclear to what extent SVG failure affects clinical outcome, due to differences in definition, patient selection and follow-up. Particularly the lack of agreement on a universal definition makes comparisons between studies, and therefore generalizability of associations with outcomes, challenging. We suggest using a definition of SVG failure that is based on imaging as well as clinical parameters, that includes reporting SVG failure on both graft and patient level. The use of non-invasive imaging may help improve follow-up rates, and provide a more accurate picture of the real incidence and clinical impact of SVG failure. Given the lack of supportive evidence showing a consistent association between SVG failure and major adverse cardiovascular events, SVG failure should not be considered a valid surrogate endpoint at this time.

journal_name

Am Heart J

journal_title

American heart journal

authors

Harskamp RE,Williams JB,Hill RC,de Winter RJ,Alexander JH,Lopes RD

doi

10.1016/j.ahj.2013.01.019

subject

Has Abstract

pub_date

2013-05-01 00:00:00

pages

639-43

issue

5

eissn

0002-8703

issn

1097-6744

pii

S0002-8703(13)00076-8

journal_volume

165

pub_type

社论

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