Alveolar echinococcosis: Em2plus-ELISA and Em18-western blots for follow-up after treatment with albendazole.

Abstract:

:Eleven cases of alveolar echinococcosis (Echinococcus multilocularis infection) with non-resectable lesions but treated with albendazole for 17 to 69 months were followed-up clinically and serologically for 4.5-11.5 years. Based on the clinical outcome and computerized tomography (CT) scanning, they were divided into 4 groups of 2 cured cases, 5 stabilized cases, 3 cases with recurrences, and one treatment failure. Forty-seven sequentially collected sera from the 11 cases were analysed by sequential enzyme-linked immunosorbent assay (ELISA) using Em2plus antigen (Em2plus-ELISA) and Western blotting to detect antibody response against Em18 (Em18-Western blots). The antibody levels in one of the cured and 2 of the stabilized cases fell below the cut-off level in the Em2plus-ELISA 4.5-6 years after effective treatment, whereas all other cases, including 2 of those with recurrences, showed large reductions initially but increased again during the follow-up period. Em18-Western blots of the 2 cured cases and 2 of the stabilized cases became negative. IgG subclasses with responses against Em18 which fell to zero included IgG1 (2), IgG3 (one) and IgG4 (one). All other cases showed no decrease in antibody response against Em18. There were, in general, reasonably reliable correlations between the success or failure of chemotherapy and antibody responses by Em2plus-ELISA and Em18-Western blots. These results suggest that both Em2plus-ELISA and Em18-Western blot are potentially useful in evaluating and predicting the efficacy of chemotherapy.

authors

Ma L,Ito A,Liu YH,Wang XG,Yao YQ,Yu DG,Chen YT

doi

10.1016/s0035-9203(97)90291-1

subject

Has Abstract

pub_date

1997-07-01 00:00:00

pages

476-8

issue

4

eissn

0035-9203

issn

1878-3503

journal_volume

91

pub_type

杂志文章
  • The susceptibility of Culicoides variipennis Coq. (Diptera: Ceratopogonidae) to laboratory infection with Rift Valley fever virus.

    abstract::The vector potential of Culicoides variipennis for Rift Valley fever virus (RVFV) was investigated. Insects from a colony maintained at the Animal Virus Research Institute, Pirbright, were fed through a membrane on a mixture of mouse blood and RVFV (virus concentration of blood meal 7 X 95 log10 MLD50ml). Engorged ins...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(82)90216-4

    authors: Jennings M,Platt GS,Bowen ET

    更新日期:1982-01-01 00:00:00

  • Antibody detection tests for Onchocerca volvulus: comparison of the sensitivity of a cocktail of recombinant antigens used in the indirect enzyme-linked immunosorbent assay with a rapid-format antibody card test.

    abstract::There is a need for a specific, sensitive, and practical diagnostic test to monitor onchocerciasis elimination campaigns. In April 2001, an enzyme-linked immunosorbent assay (ELISA) using 3 recombinant antigens and a rapid-format antibody card test (immunochromatographic test; ICT) using an individual antigen were com...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/s0035-9203(03)80018-4

    authors: Rodríguez-Pérez MA,Domínguez-Vázquez A,Méndez-Galván J,Sifuentes-Rincón AM,Larralde-Corona P,Barrera-Saldaña HA,Bradley JE

    更新日期:2003-09-01 00:00:00

  • Strengthening health care systems to improve infant health in rural Nepal.

    abstract::The functioning of the government primary health care system as it affects infant health in the Baglung District of Nepal, is discussed. the Baglung District is a remote rural area of 232,000 population in the western Himalayan foothills, entirely based on subsistence farming, and without drivable roads. The governm...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(89)90691-3

    authors: Costello AM

    更新日期:1989-01-01 00:00:00

  • Urban beri-beri in The Gambia, west Africa.

    abstract::Thirty-eight patients with beri-beri (13 dry, 14 wet and 11 mixed type) were seen at the Royal Victoria Hospital, Banjul, The Gambia, in 1990-1991, with a peak in September-October (25 cases) during the latter half of the rainy season. They were all non-confined residents of urban areas. Overt risk factors were pregna...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(93)90449-z

    authors: Rolfe M,Walker RW,Samba KN,Cham K

    更新日期:1993-01-01 00:00:00

  • An epidemiological study of urban and rural children in Pakistan: examining the relationship between delayed psychomotor development, low birth weight and postnatal growth failure.

    abstract:BACKGROUND:Low birth weight is known to be associated with postnatal growth failure. It is not yet established that both conditions are determinants of psychomotor development. The study investigated whether or not low birth weight leads to delayed psychomotor development of a child, and whether it can be mitigated by ...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1093/trstmh/tru162

    authors: Avan BI,Raza SA,Kirkwood BR

    更新日期:2015-03-01 00:00:00

  • Entomological impact and social participation in dengue control: a cluster randomized trial in Fortaleza, Brazil.

    abstract:BACKGROUND:This study intended to implement a novel intervention strategy, in Brazil, using an ecohealth approach and analyse its effectiveness and costs in reducing Aedes aegypti vector density as well as its acceptance, feasibility and sustainability. The intervention was conducted from 2012 to 2013 in the municipali...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/trstmh/tru187

    authors: Caprara A,Lima JW,Peixoto AC,Motta CM,Nobre JM,Sommerfeld J,Kroeger A

    更新日期:2015-02-01 00:00:00

  • Treatment outcome of patients with smear-negative and smear-positive pulmonary tuberculosis in the National Tuberculosis Control Programme, Malawi.

    abstract::National tuberculosis control programmes (NTPs) in sub-Saharan Africa do not routinely record or report treatment outcome data on smear-negative pulmonary tuberculosis (PTB) patients. Twelve-month treatment outcome on patients with smear-negative PTB registered in all district and mission hospitals in Malawi during th...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/s0035-9203(99)90153-0

    authors: Harries AD,Nyirenda TE,Banerjee A,Boeree MJ,Salaniponi FM

    更新日期:1999-07-01 00:00:00

  • Wide-scale installation of insecticide-treated curtains confers high levels of protection against malaria transmission in a hyperendemic area of Burkina Faso.

    abstract::In a region of Sudanese savannah in Burkina Faso, insecticide-treated curtains were installed in 8 out of 16 zones, each covering an area of about 50 km2. Longitudinal entomological monitoring using CDC light traps was performed in 4 villages (2 intervention, 2 control) over a period of 3 years (including 1 year prior...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0035-9203(99)90343-7

    authors: Cuzin-Ouattara N,Van den Broek AH,Habluetzel A,Diabaté A,Sanogo-Ilboudo E,Diallo DA,Cousens SN,Esposito F

    更新日期:1999-09-01 00:00:00

  • Serum concentrations of chloroquine in a patient with a late recrudescence of Kenyan Plasmodium falciparum malaria.

    abstract::A Swedish tourist who had visited Kenya fell ill with Plasmodium falciparum malaria 11 days after returning home, in spite of taking pyrimethamine (50 mg weekly) as malaria prophylaxis. Chloroquine treatment (25 mg base/kg body-weight) giving serum concentrations of 0.30 mumol/l cleared the patent parasitaemia and the...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(81)90093-6

    authors: Faehlmann M,Rombo L,Hedman P

    更新日期:1981-01-01 00:00:00

  • Identification of Cryptosporidium subtype isolates from HIV-seropositive patients in Equatorial Guinea.

    abstract:BACKGROUND:Cryptosporidium spp. are enteric parasites that infect humans and animals. In immunocompromised patients infection can be fatal. This study was conducted to identify sub-populations of Cryptosporidium hominis and C. parvum isolates from HIV-seropositive patients in Equatorial Guinea. METHODS:In a previous s...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章,多中心研究

    doi:10.1093/trstmh/tru108

    authors: Blanco MA,Montoya A,Iborra A,Fuentes I

    更新日期:2014-09-01 00:00:00

  • Anaemia caused by asymptomatic Plasmodium falciparum infection in semi-immune African schoolchildren.

    abstract::A cohort of 250 Ghanaian schoolchildren aged 5-15 years was followed clinically and parasitologically for 4 months in 1997/98 in order to study the effect of asymptomatic Plasmodium falciparum infections on haematological indices and bone-marrow responses. Of the 250 children 65 met the predefined study criteria. Thus...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/s0035-9203(99)90073-1

    authors: Kurtzhals JA,Addae MM,Akanmori BD,Dunyo S,Koram KA,Appawu MA,Nkrumah FK,Hviid L

    更新日期:1999-11-01 00:00:00

  • A cohort study of Plasmodium falciparum diversity during the dry season in Ndiop, a Senegalese village with seasonal, mesoendemic malaria.

    abstract::Prolonged carriage of Plasmodium falciparum in humans during the dry season is critical for parasite survival, as the infected subjects constitute a major reservoir in the absence of transmission. Yet, very little is known about the host/parasite interactions contributing to parasite persistence. In order to study the...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/s0035-9203(99)90122-0

    authors: Zwetyenga J,Rogier C,Spiegel A,Fontenille D,Trape JF,Mercereau-Puijalon O

    更新日期:1999-07-01 00:00:00

  • Antimicrobial susceptibility test of Helicobacter pylori isolated from Jos, Nigeria.

    abstract::Fifty-five strains of Helicobacter pylori isolated from November 1997 until October 1998 from 33 female and 22 male adults attending for endoscopy at the Evangel Hospital, Jos, Nigeria were assayed for antibiotic susceptibility to amoxycillin, clarithromycin, metronidazole and tetracycline by the E-test strip method. ...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/s0035-9203(99)90089-5

    authors: Ani AE,Malu AO,Onah JA,Queiroz DM,Kirschner G,Rocha GA

    更新日期:1999-11-01 00:00:00

  • A comparison of skin-test responses using antigen from Leishmania donovani and a lizard trypanosome.

    abstract::261 individuals were skin tested with leishmanin from Leishmania donovani and with an antigen from a lizard trypanosome isolated in an area endemic for kala-azar in Ethiopia. 83 of the 261 responded positively, with indurations of 5 mm or greater, to one antigen but negatively to the other, and 42 reacted positively t...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(80)90247-3

    authors: Fuller GK,Lemma A,Haile T

    更新日期:1980-01-01 00:00:00

  • Enzyme typing of Plasmodium falciparum from African and some other Old World countries.

    abstract::Freeze-dried and freshly cultured isolates of Plasmodium falciparum from different countries have been examined for variation in six enzymes, GPI, PGD, LDH, GDH, ADA and PEPE, using starch gel electrophoresis. Variant forms of each enzyme occur. For most enzymes, similar forms occur in isolates from different parts of...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(81)90331-x

    authors: Sanderson A,Walliker D,Molez JF

    更新日期:1981-01-01 00:00:00

  • Tuberculosis control activities in the private and public health sectors of Kenya from 2013 to 2017: how do they compare?

    abstract:BACKGROUND:Large numbers of tuberculosis (TB) patients seek care from private for-profit providers. This study aimed to assess and compare TB control activities in the private for-profit and public sectors in Kenya between 2013 and 2017. METHODS:We conducted a retrospective cross-sectional study using routinely collec...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1093/trstmh/trz062

    authors: Mailu EW,Owiti P,Ade S,Harries AD,Manzi M,Omesa E,Kiende P,Macharia S,Mbithi I,Kamene M

    更新日期:2019-12-01 00:00:00

  • Chemotherapy of Entamoeba histolytica: studies in vitro with bacitracin and its zinc salt.

    abstract::Twenty-one Entamoeba histolytica isolates from a range of geographical locations and representing 3 different zymodemes were tested under xenic anaerobic conditions for their sensitivities to bacitracin and bactracin zinc. Isolates were over 13 times more sensitive to bacitracin zinc than to bacitracin. Our results in...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(94)90519-3

    authors: Andrews BJ,Bjorvatn B

    更新日期:1994-01-01 00:00:00

  • Anti-leishmanial effect of allopurinol ribonucleoside and the related compounds, allopurinol, thiopurinol, thiopurinol ribonucleoside, and of formycin B, sinefungin and the lepidine WR6026.

    abstract::Allopurinol and allopurinol ribonucleoside tested in vitro and in vivo for activity against Leishmania donovani. Activity in vitro was low against the amastigote form of this parasite with ED50 values of the order of 54 and 96 microM and 86 and 213 microM respectively for the two compounds. In vivo inhibition of up to...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(85)90255-x

    authors: Neal RA,Croft SL,Nelson DJ

    更新日期:1985-01-01 00:00:00

  • Seroepidemiology of the poliovirus in Monrovia (Liberia).

    abstract::Neutralizing antibodies against poliovirus have been studied in 265 persons in Monrovia (Liberia). 34% of the individuals studied possessed antibodies against the three polioviruses, 23% against two, 26% against one; the remaining 17% showed none. The three poliovirus antibodies were evenly distributed amongst the pop...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(77)90075-x

    authors: Rodriguez-Burgos A,Bada JL,Fernandez-Calvo JL,Artola VM

    更新日期:1977-01-01 00:00:00

  • The potential for the establishment of new arbovirus transmission cycles in Europe.

    abstract::Mosquito-borne viruses are an increasing health threat to humans, and potentially other vertebrates, in areas where they have not previously existed or from which they had been eradicated. Chikungunya virus emergence exemplifies how multiple factors can act synergistically resulting in rapid, large-scale redistributio...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1093/trstmh/trv061

    authors: Higgs S,Vanlandingham DL

    更新日期:2015-09-01 00:00:00

  • The efficacy of antivenom in the treatment of bites by the Papuan taipan (Oxyuranus scutellatus canni).

    abstract::A prospective series of 156 patients systemically envenomed following the bite of a Papuan taipan (Oxyuranus scutellatus canni) were studied. All patients were treated with appropriate antivenom and clinical course and outcome were compared. The proportion of patients requiring intubation was significantly smaller, an...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(95)90562-6

    authors: Trevett AJ,Lalloo DG,Nwokolo NC,Naraqi S,Kevau IH,Theakston RD,Warrell DA

    更新日期:1995-05-01 00:00:00

  • Epidemiology of a natural focus of Leishmania braziliensis in the Pacific lowlands of Colombia. III. Natural infections in wild mammals.

    abstract::A natural infection of Leishmania braziliensis panamensis in the edentate, Choloepus hoffmanni is recorded from the Pacific Coast of Columbia. ...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(88)90136-8

    authors: Loyola EG,Alzate A,Sánchez A,González A

    更新日期:1988-01-01 00:00:00

  • Predictable ecology and geography of avian influenza (H5N1) transmission in Nigeria and West Africa.

    abstract::The emerging virus strain termed highly pathogenic H5N1 avian influenza (HP-H5N1) has spread widely in the past decade and is now the focus of considerable concern in several sectors. We tested the hypothesis that spatial distributions of veterinary and human HP-H5N1 cases are related to coarse-scale environmental fea...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/j.trstmh.2008.01.016

    authors: Williams RA,Fasina FO,Peterson AT

    更新日期:2008-05-01 00:00:00

  • Onchocerciasis in Ecuador, IV. Comparative studies of the disease relating to the Chachi and black populations in the province of Esmeraldas.

    abstract::The frequency, intensity and clinical features of onchocerciasis in the two ethnic groups (Blacks and Chachilla--an indigenous tribe) in the endemic foci of the disease in Esmeraldas province (Ecuador) were evaluated. The incidence of infection and intensity of the disease seen in both groups were directly related to ...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(84)90183-4

    authors: Molea J,Guderian RH,Proaño R,Carrillo R,Swanson WL

    更新日期:1984-01-01 00:00:00

  • Leishmania donovani parasitaemia in Kenyan visceral leishmaniasis.

    abstract::Twenty Kenyan patients with visceral leishmaniasis were evaluated for the presence of Leishmania donovani in their peripheral blood. Smears, cultures and hamster inoculations detected parasitaemia in 11, 10 and six patients, respectively, and at least one method detected parasitaemia in 15 patients (75%). The likeliho...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(85)90339-6

    authors: Chulay JD,Adoyo MA,Githure JI

    更新日期:1985-01-01 00:00:00

  • Canine and rodent leishmanial isolates from Egypt.

    abstract::Two leishmanial stocks isolated in Egypt, one from a dog and the other from Rattus norvegicus, were typed according to their excreted factor (EF) serotype and the electrophoretic mobility of their glucose phosphate isomerase. The canine isolate was indistinguishable from L. donovani (= L. infantum ) strains. The rat i...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(84)90295-5

    authors: Azab ME,Rifaat MA,Schnur LF,Makhlouf SA,El-Sherif E,Salem AM

    更新日期:1984-01-01 00:00:00

  • Adverse reactions following diethylcarbamazine (DEC) intake in 'endemic normals', microfilaraemics and elephantiasis patients.

    abstract::This paper reports on adverse reactions following a 12-day course of 6 mg/kg diethylcarbamazine (DEC) therapy in brugian filariasis patients in Indonesia. Microfilaria-positive individuals (n = 26), 'endemic normals' (n = 12) and elephantiasis patients (n = 17) were included in the study. Fever, headache and body ache...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/s0035-9203(99)90194-3

    authors: Haarbrink M,Terhell AJ,Abadi GK,Mitsui Y,Yazdanbakhsh M

    更新日期:1999-01-01 00:00:00

  • C-reactive protein and haptoglobin in the evaluation of a community-based malaria control programme.

    abstract::When cross-sectional surveys are used to evaluate malaria intervention programmes in the community, the prevalence of morbidity is difficult to assess because of the fluctuating nature of malarial fever. We have therefore investigated the impact of bed net usage on 2 surrogate markers of malarial morbidity: (i) elevat...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/s0035-9203(96)90461-7

    authors: McGuire W,D'Alessandro U,Olaleye BO,Thomson MC,Langerock P,Greenwood BM,Kwiatkowski D

    更新日期:1996-01-01 00:00:00

  • High-performance liquid chromatographic method for the separation and quantitative estimation of anti-parasitic melaminophenyl arsenical compounds.

    abstract::A sensitive high-performance liquid chromatographic method has been developed for the separation and quantitative estimation of melaminophenyl arsenical drugs used in the treatment of human and veterinary trypanosomiases. Five clinically relevant compounds (melarsoprol, melarsonyl potassium, cymelarsan, melarsen oxide...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(94)90117-1

    authors: Berger BJ,Fairlamb AH

    更新日期:1994-05-01 00:00:00

  • Cross reactivity between Trypanosoma cruzi and Leishmania antigens in the lymphocyte blastogenesis assay.

    abstract::The in vitro blastogenesis response of lymphocytes from 19 patients, with either visceral or mucocutaneous leishmaniasis or Chagas disease, to antigens of the Leishmania-Trypanosoma complex was studied. Cells from all patients responded to both homologous and heterologous antigens and the magnitude of the responses di...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(87)90291-4

    authors: Carvalho EM,Reed SG,Johnson WD Jr

    更新日期:1987-01-01 00:00:00