Carbenicillin in the treatment of infections involving anaerobic bacteria.

Abstract:

:Twenty-one patients with serious infections involving anaerobic bacteria were treated with carbenicillin. Multiple anaerobes were involved in 8 cases, and in 10 cases, facultative anaerobes were also isolated. Bacteroides fragilis was isolated in 10 cases. Results were judged excellent in 7 cases, good in 8 cases, and fair in 5 cases. These data suggest that carbenicillin may be an effective antibiotic for the therapy of infections due to anaerobic bacteria, particularly those involving B. fragilis.

authors

Swenson RM,Lorber B

doi

10.1128/aac.9.6.1025

subject

Has Abstract

pub_date

1976-06-01 00:00:00

pages

1025-7

issue

6

eissn

0066-4804

issn

1098-6596

journal_volume

9

pub_type

杂志文章
  • Activity of amphotericin B cholesterol dispersion (Amphocil) in experimental visceral leishmaniasis.

    abstract::Standard therapy of human visceral leishmaniasis with parenteral pentavalent antimonial agents is generally curative but has the disadvantages of a 28-day treatment course, occasional treatment failures, and toxicity. The antifungal and antileishmanial agent amphotericin B has been complexed with lipids to develop a l...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/aac.36.9.1978

    authors: Berman JD,Ksionski G,Chapman WL,Waits VB,Hanson WL

    更新日期:1992-09-01 00:00:00

  • Impact of low-level resistance to fluoroquinolones due to qnrA1 and qnrS1 genes or a gyrA mutation on ciprofloxacin bactericidal activity in a murine model of Escherichia coli urinary tract infection.

    abstract::We investigated the impact of low-level resistance to fluoroquinolones on the bactericidal activity of ciprofloxacin in a murine model of urinary tract infection. The susceptible Escherichia coli strain CFT073 (ciprofloxacin MIC [CIP MIC] of 0.008 microg/ml) was compared to its transconjugants harboring qnrA1 or qnrS1...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.01664-08

    authors: Allou N,Cambau E,Massias L,Chau F,Fantin B

    更新日期:2009-10-01 00:00:00

  • Inhibition of herpes simplex virus DNA synthesis by pokeweed antiviral protein.

    abstract::Pokeweed antiviral protein at a concentration of 3 microM inhibited both the synthesis and release of infectious herpes simplex virus type 1 in cell culture by 90 and 99%, respectively. Addition of pokeweed antiviral protein to Vero cell monolayers before virus infection was 10 to 15% more effective in reducing virus ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/aac.23.3.390

    authors: Teltow GJ,Irvin JD,Aron GM

    更新日期:1983-03-01 00:00:00

  • Activity of methacycline, related tetracyclines, and other antibiotics against various L-forms and their parent bacteria in vitro.

    abstract::The activity of methacycline against microbial L-forms and their parent bacteria was compared with that of oxytetracycline, chlortetracycline, tetracycline, and demethylchlortetracycline, as well as with that of 22 other antibiotics which included examples of major groups of antibiotics. The L-forms and bacteria used ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/aac.2.4.276

    authors: Hubert EG,Kalmanson GM,Montgomerie JZ,Guze LB

    更新日期:1972-10-01 00:00:00

  • Transduction of methicillin resistance in Staphylococcus aureus: recipient effectiveness and beta-lactamase production.

    abstract::The effectiveness of Staphylococcus aureus strain 8325-4 as a recipient for the transduction of methicillin resistance requires the presence of a penicillinase plasmid but was found to be independent of the lysogenic state of the recipient. Effectiveness is conferred by the plasmid in either the autonomous or integrat...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/aac.18.3.424

    authors: Stewart GC,Rosenblum ED

    更新日期:1980-09-01 00:00:00

  • Ceftriaxone levels in blood and tissue during cardiopulmonary bypass surgery.

    abstract::One gram of ceftriaxone was given intravenously to 15 patients approximately 2 h before cardiopulmonary bypass surgery. Ceftriaxone levels in plasma (mean +/- standard deviation) were 60.4 +/- 18.8 micrograms/ml (range, 17.0 to 96.0 micrograms/ml) at the beginning of bypass, 44.2 +/- 16.6 micrograms/ml (range, 9.4 to ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/aac.25.1.37

    authors: Bryan CS,Morgan SL,Jordan AB,Smith CW,Sutton JP,Gangemi JD

    更新日期:1984-01-01 00:00:00

  • Chloramphenicol acetyltransferases specified by fi minus R factors.

    abstract::Chloramphenicol acetyltransferases specified by fi(-) (F fertility-noninhibiting) R factors were compared with those specified by the fi(+) R factors R1, 222, and R6-S. Three classes of enzyme were distinguished: class I was determined by group N fi(-) R factors and was indistinguishable from the enzyme determined by ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/aac.3.1.99

    authors: Foster TJ,Shaw WV

    更新日期:1973-01-01 00:00:00

  • Assessment of serum bactericidal activity after administration of cefoperazone, cefotaxime, ceftizoxime, and moxalactam to healthy subjects.

    abstract::Bactericidal activity in serum produced after administration of 1-g intravenous doses of cefoperazone, cefotaxime, ceftizoxime, and moxalactam was ascertained in six healthy subjects. The assay organisms were a strain of Staphylococcus aureus which was moderately susceptible to the drugs (MBC, 2 to 8 micrograms/ml) an...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/aac.28.1.55

    authors: Barriere SL,Ozasa DC,Mordenti J

    更新日期:1985-07-01 00:00:00

  • In vitro antifungal susceptibilities of Sporothrix schenckii in two growth phases.

    abstract::We have determined the antifungal susceptibilities of 34 clinical isolates of the dimorphic fungus Sporothrix schenckii to 11 drugs using a microdilution method. In general, the type of growth phase (mycelial or yeast) and the temperature of incubation (30 or 35 degrees C) exerted a significant influence on the MICs. ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.49.9.3952-3954.2005

    authors: Trilles L,Fernández-Torres B,Dos Santos Lazéra M,Wanke B,de Oliveira Schubach A,de Almeida Paes R,Inza I,Guarro J

    更新日期:2005-09-01 00:00:00

  • Luliconazole demonstrates potent in vitro activity against dermatophytes recovered from patients with onychomycosis.

    abstract::The in vitro activities of luliconazole, amorolfine, ciclopirox, and terbinafine were determined against 320 dermatophyte isolates from large toenails of onychomycosis patients enrolled into an ongoing phase 2b/3 clinical study. The geometric mean MIC for luliconazole was 0.00022 μg/ml against all isolates, compared t...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.02706-13

    authors: Wiederhold NP,Fothergill AW,McCarthy DI,Tavakkol A

    更新日期:2014-06-01 00:00:00

  • Pharmacokinetic study of an oral cephalosporin, cefdinir, in hemodialysis patients.

    abstract::The pharmacokinetics of cefdinir were investigated in six hemodialysis patients. For the present study, two tests were carried out, one with 4 h of hemodialysis and the other without hemodialysis. Cefdinir was given orally to each patient in a dose of 100 mg, and blood was collected serially for 48 h after dosing in t...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.42.7.1718

    authors: Hishida A,Ohishi K,Nagashima S,Kanamaru M,Obara M,Kitada A

    更新日期:1998-07-01 00:00:00

  • Role of Lock Therapy for Long-Term Catheter-Related Infections by Multidrug-Resistant Bacteria.

    abstract::The management of long-term central venous catheter (LTCVC) infections by multidrug-resistant (MDR) bacteria in cancer patient is a challenge. The objectives of this study were to analyze outcomes in cancer patients with LTCVC-associated infection, identify risks for unfavorable outcomes, and determine the impact of M...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.00569-18

    authors: Freire MP,Pierrotti LC,Zerati AE,Benites L,da Motta-Leal Filho JM,Ibrahim KY,Araujo PH,Abdala E

    更新日期:2018-08-27 00:00:00

  • Pharmacokinetic study of praziquantel administered alone and in combination with cimetidine in a single-day therapeutic regimen.

    abstract::A brief therapeutic regimen of praziquantel, reduced to a single day, has been effective for treatment of neurocysticercosis. To study its pharmacokinetic characteristics, levels of praziquantel in plasma were determined for eight healthy volunteers after the administration of three oral doses of 25 mg/kg of body weig...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1128/AAC.41.6.1256

    authors: Jung H,Medina R,Castro N,Corona T,Sotelo J

    更新日期:1997-06-01 00:00:00

  • Daptomycin-nonsusceptible vancomycin-intermediate staphylococcus aureus vertebral osteomyelitis cases complicated by bacteremia treated with high-dose daptomycin and trimethoprim-sulfamethoxazole.

    abstract::We report two cases of daptomycin (DAP)-nonsusceptible (DNS) vancomycin-intermediate Staphylococcus aureus (VISA) vertebral osteomyelitis cases complicated by bacteremia treated with high-dose daptomycin and trimethoprim-sulfamethoxazole. Both patients responded rapidly and favorably to this combination. The clinical ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.01046-12

    authors: Avery LM,Steed ME,Woodruff AE,Hasan M,Rybak MJ

    更新日期:2012-11-01 00:00:00

  • Decreased permeation of cephalosporins through the outer membrane of Escherichia coli grown in salicylates.

    abstract::Escherichia coli K-12 cells grown in 1 to 5 mM sodium salicylate (SAL) or acetylsalicylate show increased phenotypic resistance to various antibiotics (J. L. Rosner, Proc. Natl. Acad. Sci. USA 82:8771-8774, 1985), including cephalosporins (this study). To determine whether these effects are caused by a decreased uptak...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/aac.33.4.412

    authors: Foulds J,Murray DM,Chai T,Rosner JL

    更新日期:1989-04-01 00:00:00

  • Attributable Cost and Length of Stay Associated with Nosocomial Gram-Negative Bacterial Cultures.

    abstract::Few studies have estimated the excess inpatient costs due to nosocomial cultures of Gram-negative bacteria (GNB), and those that do are often subject to time-dependent bias. Our objective was to generate estimates of the attributable costs of the underlying infections associated with nosocomial cultures by using a uni...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.00462-18

    authors: Nelson RE,Stevens VW,Jones M,Khader K,Schweizer ML,Perencevich EN,Rubin MA,Samore MH

    更新日期:2018-10-24 00:00:00

  • Nonpolymorphic human immunodeficiency virus type 1 protease and reverse transcriptase treatment-selected mutations.

    abstract::The spectrum of human immunodeficiency virus type 1 (HIV-1) protease and reverse transcriptase (RT) mutations selected by antiretroviral (ARV) drugs requires ongoing reassessment as ARV treatment patterns evolve and increasing numbers of protease and RT sequences of different viral subtypes are published. Accordingly,...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.00592-09

    authors: Shahriar R,Rhee SY,Liu TF,Fessel WJ,Scarsella A,Towner W,Holmes SP,Zolopa AR,Shafer RW

    更新日期:2009-11-01 00:00:00

  • Role of Viscoelasticity in Bacterial Killing by Antimicrobials in Differently Grown Pseudomonas aeruginosa Biofilms.

    abstract::Pseudomonas aeruginosa colonizes the sputum of most adult cystic fibrosis patients, forming difficult-to-eradicate biofilms in which bacteria are protected in their self-produced extracellular polymeric substance (EPS) matrices. EPS provide biofilms with viscoelastic properties, causing time-dependent relaxation after...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.01972-18

    authors: Rozenbaum RT,van der Mei HC,Woudstra W,de Jong ED,Busscher HJ,Sharma PK

    更新日期:2019-03-27 00:00:00

  • Cysteine protease inhibitors block Toxoplasma gondii microneme secretion and cell invasion.

    abstract::Toxoplasma gondii enters host cells via an active, self-driven process to fulfill its need for intracellular replication and survival. Successful host cell invasion is governed by sequential release of secretory proteins from three specialized organelles, including the micronemes, which contribute adhesive proteins ne...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.01059-06

    authors: Teo CF,Zhou XW,Bogyo M,Carruthers VB

    更新日期:2007-02-01 00:00:00

  • Characterization of an integron carrying blaIMP-1 and a new aminoglycoside resistance gene, aac(6')-31, and its dissemination among genetically unrelated clinical isolates in a Brazilian hospital.

    abstract::Seven bla(IMP-1)-harboring Acinetobacter sp. isolates and one Pseudomonas putida clinical isolate were recovered from hospitalized patients. All isolates possessed a class 1 integron, named In86, carrying the same cassette array [bla(IMP1), aac(6')-31, and aadA1], which was plasmid located in five of the isolates. Thi...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.00838-06

    authors: Mendes RE,Castanheira M,Toleman MA,Sader HS,Jones RN,Walsh TR

    更新日期:2007-07-01 00:00:00

  • Efficacy of teicoplanin-gentamicin given once a day on the basis of pharmacokinetics in humans for treatment of enterococcal experimental endocarditis.

    abstract::With the aim of investigating home therapy for enterococcal endocarditis, we compared the efficacy of teicoplanin combined with gentamicin given once a day or in three daily doses (t.i.d.) with the standard treatment, ampicillin plus gentamicin administered t.i.d., for treating experimental enterococcal endocarditis. ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.45.5.1387-1393.2001

    authors: López P,Gavaldà J,Martin MT,Almirante B,Gomis X,Azuaje C,Borrell N,Pou L,Falcó V,Pigrau C,Pahissa A

    更新日期:2001-05-01 00:00:00

  • Screening of Neisseria gonorrhoeae for tolerant response to beta-lactam antibiotics.

    abstract::Minimal inhibitory concentrations (MICs) and minimal bactericidal concentrations (MBCs) of penicillin, ampicillin, cefoxitin, and cefuroxime were determined for 103 beta-lactamase-negative Neisseria gonorrhoeae clinical isolates belonging to five different auxotypes. MBC determinations were base on killing 99.9% of th...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/aac.19.4.645

    authors: de Repentigny L,Turgeon PL

    更新日期:1981-04-01 00:00:00

  • Pharmacokinetics of piperaquine transfer into the breast milk of Melanesian mothers.

    abstract::Transfer of piperaquine (PQ) into breast milk was examined in 27 Papua New Guinean women given a 3-day course of dihydroartemisinin-PQ or sulfadoxine-pyrimethamine-PQ during the second/third trimester. Breast milk was sampled on days 1, 2, 3 to 5, 7 to 11, and 14 to 17 postdelivery, a median of 70 days postdose (range...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.00327-15

    authors: Moore BR,Salman S,Benjamin J,Page-Sharp M,Yadi G,Batty KT,Siba PM,Mueller I,Davis TM

    更新日期:2015-07-01 00:00:00

  • Synergistic activities of fortimicin A and beta-lactam antibiotics against Pseudomonas aeruginosa.

    abstract::The inhibitory and bactericidal activities of fortimicin A (FTM-A) alone against Pseudomonas aeruginosa were compared with those of FTM-A in combination with beta-lactam antibiotics. As tested by the checkerboard method, most beta-lactam antibiotics tested had synergistic effects on the inhibitory activity of FTM-A ag...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/aac.20.1.33

    authors: Yamashita K,Kawabe H,Mitsuhashi S

    更新日期:1981-07-01 00:00:00

  • Third type of plasmid conferring gentamicin resistance in Pseudomonas aeruginosa.

    abstract::R1033 is a plasmid of compatibility group P (= P1) transferred from a wild strain of Pseudomonas aeruginosa. It confers resistance to gentamicin by gentamicin acetyl-transferase 1 and to kanamycin and neomycin by neomycin phosphotransferase 1. ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/aac.8.3.227

    authors: Smith DI,Lus RG,Rubio Calvo MC,Datta N,Jacob AE,Hedges RW

    更新日期:1975-09-01 00:00:00

  • Fluorometric measurement of ofloxacin uptake by human polymorphonuclear leukocytes.

    abstract::A fluorometric assay, based on the natural fluorescence of the quinolone nucleus, was used to determine the uptake of ofloxacin by human polymorphonuclear leukocytes. The ratio of cellular concentration to extracellular concentration (C/E) at 20 min and 37 degrees C was 7.2, using an extracellular concentration of 5 m...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/aac.33.5.653

    authors: Pascual A,Garcia I,Perea EJ

    更新日期:1989-05-01 00:00:00

  • In vitro cytotoxicity and mitochondrial toxicity of tenofovir alone and in combination with other antiretrovirals in human renal proximal tubule cells.

    abstract::We assessed the in vitro toxicity of tenofovir (TFV) and compared it with those of zidovudine (AZT), didanosine (ddI), ritonavir (RTV), and lopinavir (LPV) alone and in combination in human renal proximal tubule epithelial cells (RPTECs). The cells were treated with various concentrations and combinations of the teste...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.00437-06

    authors: Vidal F,Domingo JC,Guallar J,Saumoy M,Cordobilla B,Sánchez de la Rosa R,Giralt M,Alvarez ML,López-Dupla M,Torres F,Villarroya F,Cihlar T,Domingo P

    更新日期:2006-11-01 00:00:00

  • Selective antimicrobial modulation of the intestinal tract by norfloxacin in human volunteers and in gnotobiotic mice associated with a human fecal flora.

    abstract::Intestinal endogenous members of the family Enterobacteriaceae were eliminated in 12 human volunteers treated with 400 or 800 mg of oral norfloxacin per day for 5 days. No clones resistant to quinolone derivatives were isolated. Counts of aerotolerant streptococci were affected to various degrees, depending on their s...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/aac.29.6.1047

    authors: Pecquet S,Andremont A,Tancrède C

    更新日期:1986-06-01 00:00:00

  • Forging New Antibiotic Combinations under Iron-Limiting Conditions.

    abstract::Pseudomonas aeruginosa is a multidrug-resistant nosocomial pathogen. We showed previously that thiostrepton (TS), a Gram-positive thiopeptide antibiotic, is imported via pyoverdine receptors and synergizes with iron chelator deferasirox (DSX) to inhibit the growth of P. aeruginosa and Acinetobacter baumannii clinical ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.01909-19

    authors: Chan DCK,Guo I,Burrows LL

    更新日期:2020-02-21 00:00:00

  • Dextromethorphan efficiently increases bactericidal activity, attenuates inflammatory responses, and prevents group a streptococcal sepsis.

    abstract::Group A streptococcus (GAS) is an important human pathogen that causes a wide spectrum of diseases, ranging from mild throat and skin infections to severe invasive diseases such as necrotizing fasciitis and streptococcal toxic shock syndrome. Dextromethorphan (DM), a dextrorotatory morphinan and a widely used antituss...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章

    doi:10.1128/AAC.00950-10

    authors: Li MH,Luo YH,Lin CF,Chang YT,Lu SL,Kuo CF,Hong JS,Lin YS

    更新日期:2011-03-01 00:00:00