Abstract:
:Nitric oxide (NO) under basal conditions is an important regulator of vascular tone. Under ischemic conditions, however, NO can combine with superoxide anion to produce the damaging hydroxyl free radical. The current project observes the effect of inhibiting NO production (L-Nitro-amino-methyl-arginine, L-NAME) on flaps rendered ischemic by secondary (2 degrees) venous obstruction. Eighty rats had 3 x 6 cm skin flaps based on the epigastric vessels. Primary (1 degree) ischemia was produced by arteriovenous occlusion for 2 hours; (2 degrees) venous ischemia was induced by clamping the vein, alone for either 3 or 5 hours. Thirty minutes prior to 2 degrees ischemia, rats received either L-NAME (30 mg/kg) or saline buffer. Flap survival was assessed 7 days later and Chi-square analysis was used. At 3 hours of ischemia, treatment improved survival from 55% to 85% (P < 0.05). Treatment also improved survival at 5 hours of ischemia from 5% to 35% (P < 0.04). Although under resting conditions, NO is a potent vasodilator, during 2 degrees venous obstruction it may contribute to flap necrosis.
journal_name
Microsurgeryjournal_title
Microsurgeryauthors
Knox LK,Angel MF,Gamper T,Amiss LR,Morgan RFdoi
10.1002/(SICI)1098-2752(1996)17:8<425::AID-MICR1>3subject
Has Abstractpub_date
1996-01-01 00:00:00pages
425-7issue
8eissn
0738-1085issn
1098-2752pii
10.1002/(SICI)1098-2752(1996)17:8<425::AID-MICR1>3journal_volume
17pub_type
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