HLA antibody screening: comparison of a solid phase enzyme-linked immunoassay with antiglobulin-augmented lymphocytotoxicity.

abstract：BACKGROUND:The subclass of IgG antibodies contributes to their capability to activate complement. It is currently unknown whether the pretransplant IgG subclass composition allows distinguishing harmful from presumably irrelevant donor-specific human leukocyte antigen (HLA) antibodies (HLA-DSA) detected by single-antig...

journal_title：Transplantation

authors： Hönger G,Hopfer H,Arnold ML,Spriewald BM,Schaub S,Amico P

更新日期：2011-07-15 00:00:00

abstract：BACKGROUND:Acute rejection of allografts remains a significant problem in clinical transplantation, and the fundamental mechanism underlying this rejection are as yet only poorly elucidated. Recently, DNA microarrays have come into use for the study of gene expression profiles, and we have taken advantage of this new t...

journal_title：Transplantation

authors： Saiura A,Mataki C,Murakami T,Umetani M,Wada Y,Kohro T,Aburatani H,Harihara Y,Hamakubo T,Yamaguchi T,Hasegawa G,Naito M,Makuuchi M,Kodama T

更新日期：2001-07-27 00:00:00

abstract：BACKGROUND:Immunosuppressive regimens for kidney transplantation which reduce the long-term burden of immunosuppression are attractive, but little data are available to judge the safety and efficacy of the different strategies used. We tested the hypothesis that the simple, cheap, regimen of alemtuzumab induction combi...

journal_title：Transplantation

authors： Chan K,Taube D,Roufosse C,Cook T,Brookes P,Goodall D,Galliford J,Cairns T,Dorling A,Duncan N,Hakim N,Palmer A,Papalois V,Warrens AN,Willicombe M,McLean AG

更新日期：2011-10-15 00:00:00

abstract：BACKGROUND:This study aimed to determine factors associated with body composition changes shortly after liver transplantation (LTx), including the influence of immunosuppressive agents. The combined resting energy expenditure (REE) and handgrip strength provided a valuable assessment in data interpretation of body comp...

journal_title：Transplantation

authors： Brito-Costa A,Pereira-da-Silva L,Papoila AL,Alves M,Mateus É,Nolasco F,Barroso E

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Existing data indicate that non-human leukocyte antigen (HLA) immunogenetic polymorphisms influence the risk of complications after allogeneic hemopoietic stem-cell transplantation. However, prior studies have been limited by small sample size and limited genotyping. METHODS:We examined 22 polymorphisms in ...

journal_title：Transplantation

authors： Mullighan C,Heatley S,Doherty K,Szabo F,Grigg A,Hughes T,Schwarer A,Szer J,Tait B,To B,Bardy P

更新日期：2004-02-27 00:00:00

abstract：BACKGROUND:Arterial hypertension (HT) is common in renal transplant recipients (RTRs). Control of HT is not optimal in this high-risk population despite recommendations for target blood pressure levels under 130/80 mm Hg. METHODS:We performed a cross-sectional analysis of the prevalence of uncontrolled HT, and using a...

journal_title：Transplantation

authors： Vetromile F,Pernin V,Szwarc I,Garrigue V,Delmas S,Mourad G,Fesler P

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:There are limited experimental data on the nature of the humoral response elicited in humans against pig antigens. In this study, we have examined the xenoantibody (XAb) response in eight patients with acute liver failure exposed to pig hepatocytes after treatment with the bioartificial liver (BAL). METHODS...

journal_title：Transplantation

authors： Baquerizo A,Mhoyan A,Kearns-Jonker M,Arnaout WS,Shackleton C,Busuttil RW,Demetriou AA,Cramer DV

更新日期：1999-01-15 00:00:00

abstract：:Injecting semiallogeneic CAF1 spleen into BALB/c newborn mice renders mice tolerant, and the majority of mice show prolonged survival of tolerogen-bearing A/J skin grafts. Moreover, graft survival is associated with enhanced Th2 cytokine responses and graft rejection with Th1 cytokine responses. To further delineate t...

journal_title：Transplantation

authors： Gao Q,Chen N,Field EH

更新日期：1995-12-15 00:00:00

abstract：BACKGROUND:Transplant recipients who develop COVID-19 may be at increased risk for morbidity and mortality. Determining the status of antibodies against SARS-CoV-2 in both candidates and recipients will be important to understand the epidemiology and clinical course of COVID-19 in this population. While there are multi...

journal_title：Transplantation

authors： Bray RA,Lee JH,Brescia P,Kumar D,Nong T,Shih R,Woodle ES,Maltzman JS,Gebel HM

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Subclinical T cell-mediated rejection (subTCMR) is commonly found after liver transplantation and has a good short-term prognosis, even when it is left untreated. Donor-specific antibodies (DSA) are putatively associated with a worse prognosis for recipient and graft after liver transplantation. METHODS:To ...

journal_title：Transplantation

authors： Höfer A,Jonigk D,Hartleben B,Verboom M,Hallensleben M,Hübscher SG,Manns MP,Jaeckel E,Taubert R

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Telomerase activity in grafts may be involved in the alteration of cellular senescence after transplantation or its relevant immunological events. METHODS:At the age of 20 weeks, donor livers harvested from DA (RT1a) were orthotopically transplanted into PVG (RT1c) or LEW (RT1(1)) rats. Rats having undergon...

journal_title：Transplantation

authors： Goto S,Lin YC,Lai CY,Lee CM,Pan TL,Lord R,Chiang KC,Tseng HP,Lin CL,Cheng YF,Yokoyama H,Kitano S,Chen CL

更新日期：2000-03-15 00:00:00

abstract：BACKGROUND:Although antibody mechanisms play a pathogenetic role in liver allograft rejection, no data exist on B lymphocytes, plasma cells, complement, and chemokines in rejected liver tissue. METHODS:Liver biopsy specimens from 25 patients with acute allograft rejection (AR) (rejection activity index, RAI score: 1-9...

journal_title：Transplantation

authors： Krukemeyer MG,Moeller J,Morawietz L,Rudolph B,Neumann U,Theruvath T,Neuhaus P,Krenn V

更新日期：2004-07-15 00:00:00

abstract：:Endothelial damage has been implicated in the pathogenesis of chronic rejection. Conversely, expression of protective genes [including A20, A1, bcl-xl, and hemoxygenase-1 (HO-1)] in the endothelium has been associated with long-term graft survival. Overexpression of protective genes in cultured endothelial cells confe...

journal_title：Transplantation

authors： Evans PC,Taylor ER,Kilshaw PJ

更新日期：2001-02-15 00:00:00

abstract：BACKGROUND:We examined whether oral administration of alloantigen could induce the prolonged survival of cardiac allografts. METHODS:Hearts from CBK (H2k+Kb) transgenic or (C57BL/10xCBA)F1 (H2bxH2k) mice were transplanted into CBA (H2k) recipients pretreated orally with 1 x 10(7) donor splenocytes in the presence or a...

journal_title：Transplantation

authors： Niimi M,Witzke O,Bushell A,Hara M,Morris PJ,Wood KJ

更新日期：2000-11-27 00:00:00

abstract：:Since major histocompatibility (MHC) antigen matching was introduced in the early 1970s as the key factor determining kidney transplant allocation, several studies, mainly arising from organ-sharing organizations in the United States and Europe, have debated this complex issue. The first fundamental concern is the int...

journal_title：Transplantation

authors： Hiesse C,Pessione F,Houssin D

更新日期：2004-02-27 00:00:00

abstract：:There is considerable current interest in the possibility that long-term graft acceptance in clinical solid-organ transplantation might be dependent upon the development of a microchimeric state between the donor and recipient. This possibility has been prompted by the observation that in some transplant patients cell...

journal_title：Transplantation

authors： Bushell A,Pearson TC,Morris PJ,Wood KJ

更新日期：1995-05-27 00:00:00

abstract：BACKGROUND:The mitochondrial respiratory chain is implicated as a major target of kidney damage after ischemia-reperfusion. This study measures changes in integrated mitochondrial function and in the activity of enzymes of the respiratory chain after cold storage and transplantation-reperfusion in vivo. METHODS:Mitoch...

journal_title：Transplantation

authors： Sammut IA,Burton K,Balogun E,Sarathchandra P,Brooks KJ,Bates TE,Green CJ

更新日期：2000-04-15 00:00:00

abstract：BACKGROUND:CTLA4IgG that binds to B7 effectively inhibits the signaling of CD28/B7 pathway and induces antigen-specific T-cell unresponsiveness in vitro and in vivo. We examined whether the development of obliterative bronchiolitis in a murine heterotopic airway transplantation model is T cell dependent and whether CTL...

journal_title：Transplantation

authors： Yamada A,Konishi K,Cruz GL,Takehara M,Morikawa M,Nakagawa I,Murakami M,Abe T,Todo S,Uede T

更新日期：2000-03-15 00:00:00

abstract：BACKGROUND:Early allograft dysfunction (EAD) defined by serum total bilirubin (TB) of 10 mg/dL or greater or prothrombin time-international normalized ratio (PT-INR) of 1.6 or greater on postoperative day 7 (POD 7) or aminotransferase greater than 2000 IU/L within the first week, is associated with early graft loss aft...

journal_title：Transplantation

authors： Okamura Y,Yagi S,Sato T,Hata K,Ogawa E,Yoshizawa A,Kamo N,Yamashiki N,Okajima H,Kaido T,Uemoto S

更新日期：2018-03-01 00:00:00

abstract：:Hepatic artery thrombosis is a dreadful complication of orthotopic liver transplantation. It should be suspected in cases of fulminant liver failure, delayed bile leak, or intermittent sepsis of unknown cause after liver transplantation. Accurate diagnosis is assisted by ultrasound and computerized tomography scans, b...

journal_title：Transplantation

authors： Tzakis AG,Gordon RD,Shaw BW Jr,Iwatsuki S,Starzl TE

更新日期：1985-12-01 00:00:00

abstract：BACKGROUND:Recent insights suggest that endothelial cell (EC) activation plays a major role in renal ischemia-reperfusion (I/R) injury. Interactions between ECs and pericytes via signaling molecules, including angiopoietins, are involved in maintenance of the vascular integrity. Experimental data have shown that enhanc...

journal_title：Transplantation

authors： de Vries DK,Khairoun M,Lindeman JH,Bajema IM,de Heer E,Roest M,van Zonneveld AJ,van Kooten C,Rabelink TJ,Schaapherder AF,Reinders ME

更新日期：2013-08-15 00:00:00

abstract：BACKGROUND:Randomized controlled trials and U.S. Registry data have demonstrated that mycophenolate mofetil (MMF) reduces acute rejection rates and improves graft survival. We undertook the first paired kidney analysis comparing the effects of MMF and azathioprine on graft outcome in the United Kingdom. METHODS:In all...

journal_title：Transplantation

authors： Shah S,Collett D,Johnson R,Thuraisingham RC,Raftery MJ,Rudge CJ,Yaqoob MM

更新日期：2006-12-27 00:00:00

abstract：BACKGROUND:Posttransplantation measurement of soluble CD30 (sCD30) may be useful for identifying kidney graft recipients at risk of impending graft rejection in the early posttransplantation period. METHODS:We measured plasma sCD30 levels and evaluated the levels in relation to the diagnosis of rejection. RESULTS:Rec...

journal_title：Transplantation

authors： Pelzl S,Opelz G,Daniel V,Wiesel M,Süsal C

更新日期：2003-02-15 00:00:00

abstract：:We report two cases of Kaposi's sarcoma (KS) after orthotopic liver transplantation for cirrhosis of the liver related to hepatitis C virus. Both cases were Saudi-born Arabs who were negative for human immunodeficiency virus; one patient was receiving FK506 plus prednisolone, and the other patient was receiving FK506....

journal_title：Transplantation

authors： Rezeig MA,Fashir BM,Hainau B,Al Ashgar HI

更新日期：1997-05-27 00:00:00

abstract：:A major impediment to the wider application of clinical liver transplantation is the paucity of acceptable organs. Most centers refuse organs that come from donors who are hepatitis B core antibody positive because of a fear of transmission of hepatitis B virus (HBV) infection to the recipient. The risk related to the...

journal_title：Transplantation

authors： Van Thiel DH,De Maria N,Colantoni A,Friedlander L

更新日期：1999-08-27 00:00:00

abstract：:The reactions of a number of LEW anti-ACI allospecific rat monoclonal antibodies were examined in a series of breeding studies. Analysis of (LEW X ACI) F2 progeny demonstrated concordance of the monoclonal class I and class II specificities with results of conventional alloantisera typing. In addition, a "gene dosage"...

journal_title：Transplantation

authors： Fuks A,Guttmann RD

更新日期：1983-11-01 00:00:00

abstract：BACKGROUND:Hepatic artery thrombosis (HAT) is a significant cause of morbidity after liver transplantation. The aims of this study are to identify and compare risk factors that might contribute to HAT. METHODS:A total of 424 liver transplants performed at the University of Virginia were reviewed. HAT was defined as co...

journal_title：Transplantation

authors： Oh CK,Pelletier SJ,Sawyer RG,Dacus AR,McCullough CS,Pruett TL,Sanfey HA

更新日期：2001-03-27 00:00:00

abstract：BACKGROUND:Geographic variation in kidney transplantation rates in the United States has been described previously but remains unexplained by age, race, sex, or socioeconomic status differences. Geographic variations in the concentration of poverty appear to impact end-stage renal disease care and potentially access to...

journal_title：Transplantation

authors： Mohan S,Mutell R,Patzer RE,Holt J,Cohen D,McClellan W

更新日期：2014-09-27 00:00:00

abstract：:OKT3 is a murine monoclonal antibody to the CD3 antigen of human T lymphocytes. The production of human antimurine antibodies after treatment with OKT3 has been perceived as a major limitation to its extended use and reuse. Treatment of 142 patients with 168 courses of OKT3 resulted in the development of antimouse ant...

journal_title：Transplantation

authors： First MR,Schroeder TJ,Hurtubise PE,Mansour ME,Penn I,Munda R,Balistreri WF,Alexander JW,Melvin DB,Fidler JP

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Ventricular assist devices (VADs) are increasingly being used in pediatric patients to provide long-term cardiac support. One potential complication of VAD therapy is the development of antibodies directed against human leukocyte antigens (HLA). This phenomenon has not been well described with the Berlin Hea...

journal_title：Transplantation

authors： O'Connor MJ,Harville TO,Rhodes-Clark B,Pye SE,Knecht KR,Imamura M,Frazier EA,Morrow WR

更新日期：2013-06-27 00:00:00