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Fibroblasts from women with pelvic organ prolapse show differential mechanoresponses depending on surface substrates.

Abstract：

INTRODUCTION AND HYPOTHESIS:Little is known about dynamic cell-matrix interactions in the context of pathophysiology and treatments for pelvic organ prolapse (POP). This study sought to identify differences between fibroblasts from women with varying degrees of prolapse in reaction to mechanical stimuli and matrix substrates in vitro. METHODS:Fibroblasts from the vaginal wall of three patients with POP Quantification (POP-Q) system stages 0, II, and IV were stretched on artificial polymer substrates either coated or not coated with collagen I. Changes in morphology and anabolic/catabolic compounds that affect matrix remodelling were evaluated at protein- and gene-expression levels. Statistical analysis was performed using one-way analysis of variance (ANOVA), followed by Tukey-Kramer's post hoc test. RESULTS:POP fibroblasts show delayed cell alignment and lower responses to extracellular matrix remodelling factors at both enzymatic- and gene-expression levels compared with healthy fibroblasts. CONCLUSION:POP fibroblasts, when compared with healthy cells, show differential mechanoresponses on two artificial polymer substrates. This should be taken into account when designing or improving implants for treating POP.

journal_name

Int Urogynecol J

journal_title

International urogynecology journal

authors

Ruiz-Zapata AM,Kerkhof MH,Zandieh-Doulabi B,Brölmann HA,Smit TH,Helder MN

doi

10.1007/s00192-013-2069-z

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

1567-75

issue

9

eissn

0937-3462

issn

1433-3023

journal_volume

24

pub_type

杂志文章

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