The effect of a low carotenoid diet on malondialdehyde-thiobarbituric acid (MDA-TBA) concentrations in women: a placebo-controlled double-blind study.

Abstract:

OBJECTIVE:The purpose of the study was to evaluate the effect of a low carotenoid diet (83 micrograms Beta-carotene) on malondialdehyde-thiobarbituric acid (MDA-TBA) concentrations of nine pre-menopausal women. METHODS:Subjects lived on the metabolic research unit of the Western Human Nutrition Research Center (WHNRC), where diet, exercise and other activities were controlled. Five subjects (Group C, control group) consumed a low carotenoid diet and received an additional 0.5 mg/day of Beta-carotene while four subjects (Group P, placebo group) received only the low carotenoid diet during days 1 to 60 (period 1). All subjects received 0.5 mg/day of Beta-carotene during days 60 to 100 (period 2), plus three capsules/day mixed carotenoid supplement (Neo-Life Company) during study days 100 to 120. Changes in MDA-TBA concentrations were analyzed during the study periods and between the groups. RESULTS:At the start of the study (day 1), no significant difference in the MDA-TBA concentration was observed between the control (Group C) and the placebo (Group P) subjects. During period 1 (days 2 to 60), when Group P subjects consumed the low carotenoid diet without supplementation, the MDA-TBA values for Group P rose markedly and were significantly (p < 0.05) higher than the MDA-TBA values for Group C subjects who were receiving carotenoid supplementation. During period 2 (days 60 to 100) when both groups received carotenoid supplementation, the MDA-TBA values of Group P subjects were significantly (p < 0.05) reduced to the point where they were similar to the MDA-TBA values for Group C subjects. CONCLUSIONS:These findings provide evidence to support the beneficial effects of carotenoids in preventing lipid peroxidation in the cells. Further studies are needed to identify the exact mechanism by which carotenoids prevent lipid peroxidation and the amount needed for normal activity.

journal_name

J Am Coll Nutr

authors

Dixon ZR,Shie FS,Warden BA,Burri BJ,Neidlinger TR

doi

10.1080/07315724.1998.10720455

subject

Has Abstract

pub_date

1998-02-01 00:00:00

pages

54-8

issue

1

eissn

0731-5724

issn

1541-1087

journal_volume

17

pub_type

临床试验,杂志文章,随机对照试验
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    pub_type: 临床试验,杂志文章,随机对照试验

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    pub_type: 杂志文章

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    更新日期:2006-04-01 00:00:00

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    journal_title:Journal of the American College of Nutrition

    pub_type: 临床试验,杂志文章,随机对照试验

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    pub_type: 杂志文章,随机对照试验

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  • Whole blood ionized magnesium in the healthy neonate.

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  • Relation of serum zinc and copper to lipids and lipoproteins: the Yi People Study.

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  • The glycemic and insulinemic index of plain sweet biscuits: relationships to in vitro starch digestibility.

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    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.2005.10719489

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    更新日期:2005-12-01 00:00:00

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    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章,评审

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    journal_title:Journal of the American College of Nutrition

    pub_type: 临床试验,杂志文章

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    更新日期:2008-12-01 00:00:00

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    pub_type: 临床试验,杂志文章,随机对照试验

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