Abstract:
OBJECTIVES:We sought to study the safety, feasibility and efficacy of selective suction and pressure-regulated retroinfusion to protect against myocardial ischemia in patients undergoing normal risk and high risk balloon angioplasty. BACKGROUND:In a pig model of acute myocardial ischemia it was previously shown that use of selective suction and pressure-regulated retroinfusion was able to substantially preserve regional myocardial function during ischemia with a higher efficacy than that obtained with unselective synchronized retroperfusion. METHODS:In 42 patients with normal risk (n = 27) or high risk (n = 15) percutaneous transluminal coronary angioplasty (PTCA), alternate balloon inflations of the left anterior descending coronary artery (60 s) were either supported or not supported by selective suction and pressure-regulated retroinfusion of the anterior interventricular vein. In an additional group of 10 patients with normal risk, retroinfusion was directly compared with autoperfusion during 10 min of ischemia. RESULTS:Balloon inflations without retroinfusion resulted in a decrease of regional myocardial function in the ischemic zone to 13% of baseline. In contrast, regional myocardial function was preserved at 76% of baseline (p < 0.05) during balloon inflation supported by retroinfusion. This preservation of regional myocardial function by retroinfusion was maintained during 10 min of ischemia with at least similar efficacy compared with autoperfusion. With retroinfusion, hemodynamic variables were stabilized in normal risk and high risk patients. No complications related to the catheterization of the anterior interventricular vein using a femoral approach (95% success rate) were observed, and clinical follow-up after 3 to 6 months was uneventful with regard to the coronary intervention. CONCLUSIONS:Use of selective suction and pressure-regulated retroinfusion was feasible and safe and had a high efficacy for preserving regional myocardial function and hemodynamic variables during PTCA in normal risk and selected high risk patients.
journal_name
J Am Coll Cardioljournal_title
Journal of the American College of Cardiologyauthors
Boekstegers P,Giehrl W,von Degenfeld G,Steinbeck Gdoi
10.1016/s0735-1097(98)00135-1subject
Has Abstractpub_date
1998-06-01 00:00:00pages
1525-33issue
7eissn
0735-1097issn
1558-3597pii
S0735109798001351journal_volume
31pub_type
临床试验,杂志文章abstract:OBJECTIVES:This study was performed to validate the accuracy of color flow vena contracta (VC) measurements of aortic regurgitation (AR) severity by comparing them to simultaneous intraoperative flow probe measurements of regurgitant fraction (RgF) and regurgitant volume (RgV). BACKGROUND:Color Doppler imaging of the ...
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abstract::Beta-adrenergic blocking agents differ considerably in their effects on myocardial excitable properties. The possibility that intrinsic sympathomimetic activity might contribute to such differences has not been adequately explored. This study examined the influence of intrinsic sympathomimetic activity on the electrop...
journal_title:Journal of the American College of Cardiology
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doi:10.1016/s0735-1097(83)80047-3
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abstract:OBJECTIVES:We investigated the effects of a novel ultrapotent poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitor, PJ34, on cardiac and endothelial dysfunction in a rat model of chronic heart failure (CHF). BACKGROUND:Overactivation of the nuclear enzyme PARP importantly contributes to the development of ce...
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journal_title:Journal of the American College of Cardiology
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doi:10.1016/0735-1097(93)90044-2
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journal_title:Journal of the American College of Cardiology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1995-02-01 00:00:00
abstract::Sudden death in healthy athletes is uncommon but, when it occurs, the primary mechanism is cardiovascular. The major cause of sudden death in the young athlete is hypertrophic cardiomyopathy or related conditions characterized by left ventricular hypertrophy, aortic rupture due to cystic medial necrosis and congenital...
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更新日期:2017-05-16 00:00:00
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journal_title:Journal of the American College of Cardiology
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更新日期:2018-09-18 00:00:00
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doi:10.1016/0735-1097(91)90636-n
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更新日期:2001-06-15 00:00:00
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更新日期:2003-01-15 00:00:00
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更新日期:2005-06-07 00:00:00
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journal_title:Journal of the American College of Cardiology
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更新日期:1994-10-01 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
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更新日期:1987-08-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to determine the role of the endothelium in the vascular actions of protease-activated receptor type 1 (PAR-1) activation in vivo in man. BACKGROUND:Thrombin is central to the pathophysiology of atherothrombosis. Its cellular actions are mediated via PAR-1. Protease-activated r...
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更新日期:2008-05-06 00:00:00
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更新日期:1993-04-01 00:00:00