Is there an association between HIV-1 genital shedding and cervical intraepithelial neoplasia 2/3 among women on antiretroviral therapy?


OBJECTIVE:Given the high prevalence of cervical intraepithelial neoplasia (CIN) grade 2/3 among HIV-infected women, we sought to examine the relationship between CIN 2/3 and HIV-1 genital shedding among women on highly active antiretroviral therapy (HAART). MATERIALS AND METHODS:Paired plasma and cervical wick specimens for HIV-1 RNA measurements were obtained from 44 HIV-infected women with biopsy-confirmed CIN 2/3 (cases) and 44 age-matched HIV-infected women with normal cervical findings on colposcopy (controls). All subjects tested negative for sexually transmitted infections and had been stable on HAART for at least 3 months. HIV-1 viral load was measured in both blood and cervical specimens using commercial real-time polymerase chain reaction assays. RESULTS:Cervical intraepithelial neoplasia 2/3 was not significantly associated with the detection or magnitude of plasma or cervical HIV-1 RNA shedding. HIV was detected in the plasma in 10 cases (23%) and 10 controls (25%) (odds ratio = 1.0; 95% confidence interval = 0.33-3.1). Cervical HIV-1 was detected in 6 cases (13.6%) and 9 controls (20.4%) (odds ratio = 0.61; 95% confidence interval = 0.20-1.90). Mean HIV-1 concentration in cervical secretions among women with CIN 2/3 who shed was 2.93 log10 copies versus 2.72 among controls (p = .65). CONCLUSIONS:Among women on HAART, we found no relationship between CIN 2/3 and HIV-1 genital shedding.


J Low Genit Tract Dis


Huchko MJ,Woo V,Liegler T,Leddy A,Smith-McCune K,Sawaya GF,Bukusi EA,Cohen CR




Has Abstract


2013-07-01 00:00:00












  • Pregnancy-related fibroadenoma of ectopic breast tissue in the vulva.

    abstract:BACKGROUND:Pregnancy-related vulvar fibroadenoma of ectopic breast tissue is rare. Management involves diagnosing the mass as a fibroadenoma by physical examination and delaying excision until the postpartum period. CASE:A 31-year-old multigravid woman at 29 weeks' gestation had a right labial mass that was increasing...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章


    authors: Xanos ET,Kennedy DA,Grosen EA

    更新日期:1997-07-01 00:00:00

  • The absence of human papillomavirus in amniotic fluid.

    abstract:OBJECTIVES:The objective of this multicenter trial was to determine the incidence of human papillomavirus (HPV) in the amniotic fluid of pregnant patients. METHODS:Fifty-three pregnant patients undergoing genetic counseling or amniocentesis for preterm labor were entered into the study. Cervical swabs and amniotic flu...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章


    authors: Maxwell GL,Carlson J,Zakarean M,Veit B,Hoshaw N

    更新日期:1998-07-01 00:00:00

  • Vaginal stenosis after toxic epidermal necrolysis.

    abstract::A 17-year-old adolescent girl developed severe toxic epidermal necrolysis after inhalation of methamphetamine. Recovery was complicated by vaginal synechiae and occlusion necessitating surgery. ...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章


    authors: Rowan DM,Jones RW,Oakley A,de Silva H

    更新日期:2010-10-01 00:00:00

  • Giant condyloma versus verrucous carcinoma: a case report.

    abstract::Giant condyloma acuminatum is a large, slow-growing, exophytic, cauliflower-like tumor of the external genitalia. It is a histologically benign lesion, largely associated with human papillomavirus infection but with a high recurrence rate. The main differential diagnosis includes verrucous carcinoma. Differentiation b...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章


    authors: Bambao C,Nofech-Mozes S,Shier M

    更新日期:2010-07-01 00:00:00

  • Presence of Spontaneous Pain and Comorbid Pain Conditions Identifies Vulvodynia Subgroups.

    abstract:OBJECTIVE:The aims of the study were to define the heterogeneity of vulvodynia by determining data-driven subgroups within the vulvodynia diagnosis using exploratory cluster analysis and to characterize the subgroups identified. MATERIALS AND METHODS:Included were participants in the longitudinal population-based stud...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章


    authors: Reed BD,Plegue MA,Williams DA,Sen A

    更新日期:2016-01-01 00:00:00

  • Fabric-based exocervical and endocervical biopsy in comparison with punch biopsy and sharp curettage.

    abstract:OBJECTIVES:Fabric-based endocervical and exocervical biopsy tools were compared with exocervical punch biopsy and sharp endocervical curettage. We compared the level of pain reported by the patient and the amount of bleeding rated by the physician relative to the type of biopsy used. MATERIALS AND METHODS:This was a 2...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章,随机对照试验


    authors: Winter M,Cestero RM,Burg A,Felix JC,Han C,Raffo AM,Vasilev S

    更新日期:2012-04-01 00:00:00

  • Contribution of Exocervical Biopsy, Endocervical Curettage, and Colposcopic Grading in Diagnosing High-Grade Cervical Intraepithelial Neoplasia.

    abstract:OBJECTIVE:To determine the utility of random biopsy and endocervical curettage (ECC) during colposcopy among women who ultimately underwent cervical excisional biopsy. MATERIALS AND METHODS:In a retrospective observational study, the charts were reviewed of every patient who underwent cervical excisional procedure per...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章


    authors: Diedrich JT,Felix JC,Lonky NM

    更新日期:2016-01-01 00:00:00

  • Massive localized lymphedema of the vulva: report of a case and review of the literature.

    abstract:BACKGROUND:Massive localized lymphedema (MLL) is a recently described entity associated with obesity, most often on the thighs. It rarely occurs on the vulva, and it may pose diagnostic difficulty for both clinician and pathologist in this setting. CASE:An obese 55-year-old woman underwent excision of bilateral polypo...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章,评审


    authors: Heller DS,Fitzhugh VA,Cracchiolo B,Barrett T Jr,Suidan RS

    更新日期:2014-04-01 00:00:00

  • Collagen expression in the pregnant human cervix is decreased with labor.

    abstract:OBJECTIVE:The current study tested the hypothesis that collagen content in the pregnant cervix decreases with labor, using morphologically preserved specimens, avoiding limitations of earlier studies. Collagen abundance remote from pregnancy was also evaluated. MATERIALS AND METHODS:Histologic sections of postpartum c...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章


    authors: Heller DS,Goldsmith LT,Aboujaoude R,Kaplan C,Baergen R,Cole D

    更新日期:2012-01-01 00:00:00

  • Vulvar intraepithelial neoplasia: a synopsis of recent developments.

    abstract::This review highlights recent advances in our understanding of preneoplastic squamous lesions of the vulva, from a pathologist's perspective. Vulvar intraepithelial neoplasia (VIN) is the preferred nomenclature for these lesions. VIN lesions may or may not be symptomatic and have a variable clinical appearance. Three ...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章


    authors: Colgan TJ

    更新日期:1998-01-01 00:00:00

  • Validity of the Papanicolaou Smear in the Diagnosis of Candida spp., Trichomonas vaginalis, and Bacterial Vaginosis.

    abstract:OBJECTIVE:To determine the validity of the Papanicolaou smear in the diagnosis of bacterial vaginosis, Trichomonas vaginalis, and Candida spp. MATERIALS AND METHODS:We determined the sensitivity, specificity, positive predictive value, and negative predictive value of Pap smears we performed in 824 symptomatic patient...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章


    authors: Audisio T,Pigini T,de Riutort SV,Schindler L,Ozan M,Tocalli C,Bertolotto P

    更新日期:2001-10-01 00:00:00

  • Use of electronic medical record-based tools to improve compliance with cervical cancer screening guidelines: effect of an educational intervention on physicians' practice patterns.

    abstract:OBJECTIVE:This study aimed to determine whether electronic medical record (EMR)-based tools influence providers' compliance with guidelines for cervical cancer screening in adolescent (<21 y) patients. MATERIALS AND METHODS:Three EMR-based tools to educate providers on cervical cancer screening guidelines were impleme...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章


    authors: White P,Kenton K

    更新日期:2013-04-01 00:00:00

  • Emphysematous vaginitis.

    abstract:BACKGROUND:Emphysematous vaginitis is a rare condition, characterized by the presence of multiple gas-filled cysts in the vaginal and/or exocervical mucosa. Although its etiology is not completely understood, it is self-limited, with a benign clinical course. Vaginal discharge, sometimes bloody, and pruritus are the mo...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章


    authors: Lima-Silva J,Vieira-Baptista P,Cavaco-Gomes J,Maia T,Beires J

    更新日期:2015-04-01 00:00:00

  • Conservative treatment of microinvasive adenocarcinoma of uterine cervix: long-term follow-up.

    abstract:UNLABELLED:OBIECTIVE: This study aimed to evaluate the safety of conservative treatment in women desiring preservation of fertility with stage IA adenocarcinoma of the cervix. MATERIALS AND METHODS:Clinical report of all women with stage IA adenocarcinoma of the cervix, endocervical subtype, with clear margins on cone...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章


    authors: Sopracordevole F,Canzonieri V,Giorda G,De Piero G,Lucia E,Campagnutta E

    更新日期:2012-10-01 00:00:00

  • Efficacy of treatment of inflammatory cytologic abnormalities detected by papanicolaou smears: a pilot study.

    abstract:OBJECTIVE:To evaluate the efficacy of metronidazole versus no treatment for the empiric treatment of inflammatory cytologic changes. MATERIALS AND METHODS:Patients with inflammatory changes on Pap smear were serially assigned to receive no treatment or metronidazole by one of three regimens: 2 grams orally as a single...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章


    authors: Webb JC,Wharton GG,Hawley-Bowland C,Carlson JW

    更新日期:2001-04-01 00:00:00

  • The vaginal vestibule.

    abstract:OBJECTIVES:Vulvar vestibule is a common term in the medical nomenclature. In our view, this term is inaccurate. MATERIALS AND METHODS:Herein, we provide evidence from embryologic, anatomic, and architectonic textbooks that shows the links between the vestibule and vagina. RESULTS:Our research proves that the term vul...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章


    authors: Friedman M,Siegler E,Löwenstein L

    更新日期:2004-01-01 00:00:00

  • Human Papillomavirus Same Genotype Persistence and Risk: A Systematic Review.

    abstract:OBJECTIVE:The aim of the study was to examine whether high-grade cervical intraepithelial neoplasia (CIN) was more closely associated with human papillomavirus (HPV) same-genotype persistence (SGTP) versus clearance of prior infection with a subsequent infection by a new genotype (genotype switch [GS]), clearance of HP...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章


    authors: Bonde J,Bottari F,Iacobone AD,Cocuzza CE,Sandri MT,Bogliatto F,Khan KS,Ejegod DM,Gary DS,Andrews JC

    更新日期:2021-01-01 00:00:00

  • Risk factors for progression or persistence of squamous intraepithelial lesions diagnosed during pregnancy.

    abstract:OBJECTIVE:This study aimed to assess the risk of progression/persistence of squamous intraepithelial lesions (SILs) during pregnancy according to the age of the woman, the grade of the lesion, the type of human papillomavirus (HPV) infection, and the mode of delivery. MATERIALS AND METHODS:Eighty pregnant women with a...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章


    authors: Cubo-Abert M,Centeno-Mediavilla C,Franco-Zabala P,Merced-Vázquez C,Castellví J,García A,Gil-Moreno A,Xercavins J

    更新日期:2012-01-01 00:00:00

  • Cervical Cancer Screening of Adolescents Should Not Be Encouraged.

    abstract:OBJECTIVE:The study aims to assess the frequency of cytological abnormalities in adolescents and young women, to establish the optimum age to start screening. METHODS:A retrospective study of cervical cytology results were obtained from the data center at the Santa Casa Hospital of São Paulo between January 2006 and D...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章


    authors: Henrique LQ,Campaner AB,dʼAvila FS

    更新日期:2017-01-01 00:00:00

  • ASCCP Colposcopy Standards: Role of Colposcopy, Benefits, Potential Harms, and Terminology for Colposcopic Practice.

    abstract:OBJECTIVES:The American Society for Colposcopy and Cervical Pathology Colposcopy Standards address the role of and approach to colposcopy and biopsy for cervical cancer prevention in the United States. Working Group 1 was tasked with defining the role of colposcopy, describing benefits and potential harms, and developi...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章,评审


    authors: Khan MJ,Werner CL,Darragh TM,Guido RS,Mathews C,Moscicki AB,Mitchell MM,Schiffman M,Wentzensen N,Massad LS,Mayeaux EJ Jr,Waxman AG,Conageski C,Einstein MH,Huh WK

    更新日期:2017-10-01 00:00:00

  • Management of "Atypical Endocervical Cells" Compared to "Atypical Glandular Cells".

    abstract:OBJECTIVE:To assess adherence to management guidelines based on the terminology used to describe atypical glandular cells (AGC) on cytology reports. MATERIALS AND METHODS:We analyzed AGC pathology reports from Hartford Hospital, 2004-2007, and identified cases of AGC with the terminology atypical glandular cells or at...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章


    authors: Sharpless KE,Schnatz PF

    更新日期:2015-07-01 00:00:00

  • Unique collision of hodgkin lymphoma and adenosquamous carcinoma in the uterine cervix: synchronous malignant neoplasms of the cervix.

    abstract::To document the first reported synchronous occurrence of Hodgkin lymphoma and adenosquamous carcinoma involving the female genital tract. Review of cytologic, histologic, and immunohistochemical studies obtained from a 50-year-old, multiparous, postmenopausal, Hispanic female who had a left inguinal mass, bilateral lo...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章


    authors: Lovell MO,Valente PT

    更新日期:2003-10-01 00:00:00

  • Preparing digitized cervigrams for colposcopy research and education: determination of optimal resolution and compression parameters.

    abstract:OBJECTIVE:Visual assessment of digitized cervigrams through the Internet needs to be optimized. The National Cancer Institute and National Library of Medicine are involved in a large effort to improve colposcopic assessment and, in preparation, are conducting methodologic research. MATERIALS AND METHODS:We selected 50...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章


    authors: Jeronimo J,Long R,Neve L,Ferris D,Noller K,Spitzer M,Mitra S,Guo J,Nutter B,Castle P,Herrero R,Rodriguez AC,Schiffman M

    更新日期:2006-01-01 00:00:00

  • Cost-effectiveness of adding human papilloma virus testing to a managed care cervical cancer screening program.

    abstract:OBJECTIVE:The purpose of this study was to demonstrate a methodology for auditing the impact of HCII testing on the direct cost of cervical cancer cytological screening, where the test is collected in all women screened and processed routinely in women age 30 years and older. MATERIALS AND METHODS:After a policy chang...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章


    authors: Lonky NM,Hunter MI,Sadeghi M,Edwards G,Bajamundi K,Monk BJ

    更新日期:2007-10-01 00:00:00

  • Chronic vulvar fissure--a rare manifestation of mycosis fungoides.

    abstract:BACKGROUND:Vulvar fissures are a common cause of vulvar pain and discomfort. The differential diagnosis of the underlying process is broad, and some cases remain undiagnosed. Mycosis fungoides, the dominant component of cutaneous T-cell lymphoma, rarely present as fissures. We report a case of a chronic vulvar fissure ...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章


    authors: Reichman O,Sobel JD,Bentley G

    更新日期:2010-01-01 00:00:00

  • Pseudoepitheliomatous hyperplasia mimicking vulvar cancer in a patient with AIDS.

    abstract:BACKGROUND:Pseudoepitheliomatous hyperplasia (PEH) clinically and histologically mimics squamous cell carcinoma (SCC), specifically in patients with HIV and AIDS. CASE:A 51-year-old G3P2 with AIDS and history of vulvar cancer presented with large bilateral exophytic lesions on the vulva, grossly appearing neoplastic. ...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章


    authors: Frimer M,Chudnoff S,Hebert T,Shahabi S

    更新日期:2011-01-01 00:00:00

  • The Lower Anogenital Squamous Terminology Standardization Project for HPV-Associated Lesions: background and consensus recommendations from the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology.

    abstract::The terminology for human papillomavirus (HPV)-associated squamous lesions of the lower anogenital tract has a long history marked by disparate diagnostic terms derived from multiple specialties. It often does not reflect current knowledge of HPV biology and pathogenesis. A consensus process was convened to recommend ...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章,评审


    authors: Darragh TM,Colgan TJ,Cox JT,Heller DS,Henry MR,Luff RD,McCalmont T,Nayar R,Palefsky JM,Stoler MH,Wilkinson EJ,Zaino RJ,Wilbur DC,Members of LAST Project Work Groups.

    更新日期:2012-07-01 00:00:00

  • Hysteroscopic resection of uterine lipoleiomyoma: case study and literature review.

    abstract:UNLABELLED:▪ ABSTRACT:: A case of a uterine lipoleiomyoma within an endometrial polyp is presented. Lipoleiomyomas represent a rare, benign gynecological entity that can present as post-menopausal bleeding or pelvic mass. Hysteroscopic appearance, MRI images, and histological images of the polyp are included. The Engl...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章


    authors: Holtz DO,Holland G,Ropp BG,Dunton C

    更新日期:2000-10-01 00:00:00

  • Interpretability of excisional biopsies of the cervix: cone biopsy and loop excision.

    abstract:OBJECTIVE:To compare the results of cold knife conization (CKC) and loop electrosurgical excision procedure (LEEP) for cervical intraepithelial neoplasia to determine if excisional method has effects on pathologic interpretation. METHODS:Retrospective review of the perioperative medical records of patients who had a C...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章


    authors: Miroshnichenko GG,Parva M,Holtz DO,Klemens JA,Dunton CJ

    更新日期:2009-01-01 00:00:00

  • Effects of probiotics on the recurrence of bacterial vaginosis: a review.

    abstract:OBJECTIVE:Bacterial vaginosis (BV) is a common cause of genital discomfort in women in reproductive ages, which causes many complications. Bacterial vaginosis is usually treated by metronidazole and clindamycin. However, this protocol does not prevent its recurrence, which is a main complaint of the patients. The numbe...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章,评审


    authors: Homayouni A,Bastani P,Ziyadi S,Mohammad-Alizadeh-Charandabi S,Ghalibaf M,Mortazavian AM,Mehrabany EV

    更新日期:2014-01-01 00:00:00