Abstract:
OBJECTIVE:Given the high prevalence of cervical intraepithelial neoplasia (CIN) grade 2/3 among HIV-infected women, we sought to examine the relationship between CIN 2/3 and HIV-1 genital shedding among women on highly active antiretroviral therapy (HAART). MATERIALS AND METHODS:Paired plasma and cervical wick specimens for HIV-1 RNA measurements were obtained from 44 HIV-infected women with biopsy-confirmed CIN 2/3 (cases) and 44 age-matched HIV-infected women with normal cervical findings on colposcopy (controls). All subjects tested negative for sexually transmitted infections and had been stable on HAART for at least 3 months. HIV-1 viral load was measured in both blood and cervical specimens using commercial real-time polymerase chain reaction assays. RESULTS:Cervical intraepithelial neoplasia 2/3 was not significantly associated with the detection or magnitude of plasma or cervical HIV-1 RNA shedding. HIV was detected in the plasma in 10 cases (23%) and 10 controls (25%) (odds ratio = 1.0; 95% confidence interval = 0.33-3.1). Cervical HIV-1 was detected in 6 cases (13.6%) and 9 controls (20.4%) (odds ratio = 0.61; 95% confidence interval = 0.20-1.90). Mean HIV-1 concentration in cervical secretions among women with CIN 2/3 who shed was 2.93 log10 copies versus 2.72 among controls (p = .65). CONCLUSIONS:Among women on HAART, we found no relationship between CIN 2/3 and HIV-1 genital shedding.
journal_name
J Low Genit Tract Disjournal_title
Journal of lower genital tract diseaseauthors
Huchko MJ,Woo V,Liegler T,Leddy A,Smith-McCune K,Sawaya GF,Bukusi EA,Cohen CRdoi
10.1097/LGT.0b013e3182712286subject
Has Abstractpub_date
2013-07-01 00:00:00pages
354-60issue
3eissn
1089-2591issn
1526-0976journal_volume
17pub_type
杂志文章abstract:OBJECTIVE:This study aimed to compare cervical cytologic and histologic findings between women using depot-medroxyprogesterone acetate (DMPA) and oral contraceptives (OCs) referred for colposcopy and to determine whether there were differences in the occurrence of false-positive cytologic finding between the 2 contrace...
journal_title:Journal of lower genital tract disease
pub_type: 杂志文章
doi:10.1097/LGT.0b013e31820eb140
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to identify the clinicopathologic features and treatment outcome of primary extramammary Paget disease of the vulva (EMPDV). MATERIALS AND METHODS:We performed a retrospective analysis of 14 patients who were treated at our center from April 1994 to November 2010. RESULTS:The mean ...
journal_title:Journal of lower genital tract disease
pub_type: 杂志文章
doi:10.1097/LGT.0000000000000063
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVE:To evaluate the feasibility and efficiency of direct visual inspection after Lugol iodine painting in detecting cervical premalignant and malignant lesions. MATERIALS AND METHODS:This study included 1,012 women recruited from gynecology outpatient clinic screened for premalignant or malignant lesions of the ...
journal_title:Journal of lower genital tract disease
pub_type: 杂志文章
doi:10.1097/LGT.0b013e31815f527c
更新日期:2008-07-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to determine rates of cervical intraepithelial neoplasia (CIN) 2 or greater in high-risk, racially diverse, young women with low-grade cytology. MATERIALS AND METHODS:After institutional review board approval, a cross-sectional study of 21- to 24-year-old women with low-grade cytolog...
journal_title:Journal of lower genital tract disease
pub_type: 杂志文章
doi:10.1097/LGT.0000000000000381
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVE:Cervical cancer is one of the most common malignancies in pregnancy and one percent of women diagnosed with cervical cancer are pregnant or postpartum at the time of the diagnosis. We discuss how pregnancy will affect the management of cancer, and cancer will affect the management of the pregnancy. MATERIAL ...
journal_title:Journal of lower genital tract disease
pub_type: 杂志文章
doi:10.1097/LGT.0b013e31824d6fb8
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVES:Low physician density, undercapacitated laboratory infrastructures, and limited resources are major limitations to the development and implementation of widely accessible cervical cancer prevention programs in sub-Saharan Africa. MATERIALS AND METHODS:We developed a system operated by nonphysician health pr...
journal_title:Journal of lower genital tract disease
pub_type: 杂志文章
doi:10.1097/LGT.0b013e3181cd6d5e
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVE:To determine the validity of the Papanicolaou smear in the diagnosis of bacterial vaginosis, Trichomonas vaginalis, and Candida spp. MATERIALS AND METHODS:We determined the sensitivity, specificity, positive predictive value, and negative predictive value of Pap smears we performed in 824 symptomatic patient...
journal_title:Journal of lower genital tract disease
pub_type: 杂志文章
doi:
更新日期:2001-10-01 00:00:00
abstract:OBJECTIVES:The objective of this multicenter trial was to determine the incidence of human papillomavirus (HPV) in the amniotic fluid of pregnant patients. METHODS:Fifty-three pregnant patients undergoing genetic counseling or amniocentesis for preterm labor were entered into the study. Cervical swabs and amniotic flu...
journal_title:Journal of lower genital tract disease
pub_type: 杂志文章
doi:10.1097/00128360-199807000-00008
更新日期:1998-07-01 00:00:00
abstract:BACKGROUND:: Lack of estrogen after menopause can cause many changes in the lower genital tract of women, including involution of the introitus and collapse of the vestibule into the genital cleft. CASES:: Six cases of hypoestrogenic women are described, with the unusual finding of entrapment of terminal hairs between...
journal_title:Journal of lower genital tract disease
pub_type: 杂志文章
doi:10.1097/LGT.0b013e31821a68a5
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVES:The aims of this study are to analyze a cohort of women with vulvovaginal symptoms and positive cultures for non-albicans Candida (NAC) to determine whether yeast was responsible for their symptoms and to evaluate the mycological effectiveness of various regimens. METHODS:This observational study was perfor...
journal_title:Journal of lower genital tract disease
pub_type: 杂志文章
doi:10.1097/LGT.0000000000000126
更新日期:2016-01-01 00:00:00
abstract::OBJECTIVES.: To determine the prevalence of cervical dysplasia, diagnosed cytologically (squamous intraepithelial lesion [SIL]) or histologically (cervical intraepithelial neoplasia [CIN]), in women with external anogenital warts, and to determine the discriminating risk factors between those with and without cervical...
journal_title:Journal of lower genital tract disease
pub_type: 杂志文章
doi:10.1097/00128360-200301000-00006
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVE:To determine if sites selected for colposcopic biopsy and histologically proven cervical intraepithelial neoplasia are distributed randomly across the cervix. MATERIALS AND METHODS:Data were evaluated from all patients who visited the Walter Reed Army Medical Center Colposcopy Clinic during a 20-month period...
journal_title:Journal of lower genital tract disease
pub_type: 杂志文章
doi:10.1097/00128360-200501000-00008
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVE:In women with negative cervical cytology and positive high-risk human papillomavirus (HR-HPV) test results, we compared the risk of cervical intraepithelial neoplasia 3 (CIN 3) or cancer (CIN 3+) in women with previous abnormal cervical cytology, CIN, or HR-HPV with that in women without this history, and we ...
journal_title:Journal of lower genital tract disease
pub_type: 杂志文章
doi:10.1097/LGT.0b013e318281f182
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVE:This study explores the prevalence and provider- and practice-related correlates of physician recommendation and administration of the quadrivalent human papillomavirus (HPV) vaccine, Gardasil, to 11- to 12-year-old girls and the intention to recommend the HPV vaccine to 11- to 12-year-old boys in Georgia. Th...
journal_title:Journal of lower genital tract disease
pub_type: 杂志文章
doi:10.1097/LGT.0000000000000011
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:To quantify the coverage and monitor the factors associated with opportunistic cervical cytological screening in Spain. MATERIALS AND METHODS:Population-based survey of selected women through the Access Panel technique representative of the general population. A total of 6,852 women (60%) replied to the ques...
journal_title:Journal of lower genital tract disease
pub_type: 杂志文章
doi:10.1097/LGT.0b013e3181599c16
更新日期:2008-04-01 00:00:00
abstract:OBJECTIVES:This study examined dose scheduling, safety, and efficacy of adapalene in the treatment of CIN2 and CIN3. METHODS:Patients were instructed on insertion and removal of an adapalene delivery system. Treatment regimens of 4, 8, and 14 days were utilized. Biopsies were performed on day 90 to assess efficacy. Sa...
journal_title:Journal of lower genital tract disease
pub_type: 杂志文章
doi:10.1046/j.1526-0976.2001.51007.x
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy of metronidazole versus no treatment for the empiric treatment of inflammatory cytologic changes. MATERIALS AND METHODS:Patients with inflammatory changes on Pap smear were serially assigned to receive no treatment or metronidazole by one of three regimens: 2 grams orally as a single...
journal_title:Journal of lower genital tract disease
pub_type: 杂志文章
doi:10.1046/j.1526-0976.2001.005002082.x
更新日期:2001-04-01 00:00:00
abstract:BACKGROUND:The molecular events surrounding the pathogenesis of human cervical cancer remain to be defined to a significant extent. The current study investigates the expression of two putative tumor suppressor genes p16 and Rb in cervical neoplasm. MATERIALS AND METHODS:Tissue was collected from 16 cervical intraepit...
journal_title:Journal of lower genital tract disease
pub_type: 杂志文章
doi:10.1097/00128360-199710000-00008
更新日期:1997-10-01 00:00:00
abstract:OBJECTIVE:The Home Study Course is intended for the practicing colposcopist or practitioner who is seeking to develop or enhance his or her colposcopic skills. The goal of the course is to present colposcopic cases that are unusual or instructive in terms of appearance, presentation, or management, or that demonstrate ...
journal_title:Journal of lower genital tract disease
pub_type: 杂志文章
doi:10.1097/01.lgt.0000171660.77437.f2
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND:Pregnancy-related vulvar fibroadenoma of ectopic breast tissue is rare. Management involves diagnosing the mass as a fibroadenoma by physical examination and delaying excision until the postpartum period. CASE:A 31-year-old multigravid woman at 29 weeks' gestation had a right labial mass that was increasing...
journal_title:Journal of lower genital tract disease
pub_type: 杂志文章
doi:10.1097/00128360-199707000-00035
更新日期:1997-07-01 00:00:00
abstract:OBJECTIVE:We evaluated the performance of the Papanicolaou smear in screening and diagnostic settings. STUDY DESIGN:We analyzed Papanicolaou smear results of 1,850 women recruited into a clinical trial to evaluate an emerging technology for the detection of cervical cancer. Screening and diagnosis groups were based on...
journal_title:Journal of lower genital tract disease
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1097/LGT.0b013e31816b44bc
更新日期:2008-10-01 00:00:00
abstract:OBJECTIVES:Vulvar vestibule is a common term in the medical nomenclature. In our view, this term is inaccurate. MATERIALS AND METHODS:Herein, we provide evidence from embryologic, anatomic, and architectonic textbooks that shows the links between the vestibule and vagina. RESULTS:Our research proves that the term vul...
journal_title:Journal of lower genital tract disease
pub_type: 杂志文章
doi:10.1097/00128360-200401000-00014
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to summarize and review the evidence for the efficacy and safety of adipose-derived stem cells (ADSCs) and platelet-rich plasma (PRP) for the treatment of vulvar lichen sclerosus (LS). MATERIALS AND METHODS:PubMed/MEDLINE, Ovid, Web of Science, and clinicaltrials.gov were searched fr...
journal_title:Journal of lower genital tract disease
pub_type: 杂志文章,评审
doi:10.1097/LGT.0000000000000440
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:This study aimed to conduct a representative survey of human papillomavirus (HPV) prevalence and its genotype distribution in invasive anal cancer specimens in the United States. MATERIALS AND METHODS:Population-based archival anal cancer specimens were identified from Florida, Kentucky, Louisiana, and Michi...
journal_title:Journal of lower genital tract disease
pub_type: 杂志文章
doi:10.1097/LGT.0b013e31827ed372
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVES:The aims of the study were to assess the clinical and histopathological characteristics of a comprehensive cohort of women with vulvovaginal melanoma (VVM) treated at our institution and to study the treatment response of checkpoint inhibitors in this patient cohort. MATERIALS AND METHODS:This is a retrospe...
journal_title:Journal of lower genital tract disease
pub_type: 杂志文章
doi:10.1097/LGT.0000000000000583
更新日期:2020-11-24 00:00:00
abstract:OBJECTIVE:This study aimed to assess the incidence of cervical intraepithelial neoplasia (CIN) by grade (CIN 1, CIN 2, CIN 3) and age in Estonia (a country with less developed cervical cancer screening program and high cervical cancer incidence). MATERIALS AND METHODS:This descriptive study uses data from a health ins...
journal_title:Journal of lower genital tract disease
pub_type: 杂志文章
doi:10.1097/LGT.0b013e3182652213
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVES:The objectives of this study were to quantify personal stories about cervical cancer and to determine the proportion and sentiment (positive vs negative) of messages ("tweets") that discussed cervical cancer prevention strategies on Twitter. METHODS:This study was a cross-sectional Twitter review of English...
journal_title:Journal of lower genital tract disease
pub_type: 杂志文章
doi:10.1097/LGT.0000000000000363
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:Obese women have higher cervical cancer incidence and mortality than their counterparts, possibly related to nonadherence to screening recommendations. We assessed the association of body mass index with adherence to cervical cancer screening recommendations in Hispanic women living in Puerto Rico, a minority...
journal_title:Journal of lower genital tract disease
pub_type: 杂志文章
doi:10.1097/LGT.0000000000000504
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:The Home Study Course is intended for the practicing colposcopist or practitioner who is seeking to develop or enhance his or her colposcopic skills. The goal of the course is to present colposcopic cases that are unusual or instructive in terms of appearance, presentation, or management, or that demonstrate ...
journal_title:Journal of lower genital tract disease
pub_type: 杂志文章
doi:10.1097/00128360-200407000-00013
更新日期:2004-07-01 00:00:00
abstract:PURPOSE:To compare the collection of vaginal exudates with and without the use of a speculum to diagnose vaginal infections. MATERIAL AND METHODS:We examined 45 patients with vaginal discharge. Two vaginal swabs were taken, one with and the other without a speculum. Both were examined by wet mount microscopy to detect...
journal_title:Journal of lower genital tract disease
pub_type: 杂志文章
doi:10.1097/01.lgt.0000179859.29456.ba
更新日期:2005-10-01 00:00:00