Abstract:
:Direct current and differential pulse polarography DPP were used for the determination of three penicillins, namely, ampicillin, benzylpenicillin and carbenicillin, in pure form and in their dosage forms. The method is based upon treatment of penicillins with nitrous acid followed by polarographic measurement of the produced derivatives polarographically. The nitroso derivatives formed exhibited reduction waves over the whole pH range in Britton-Robinson buffers. The waves were characterized as being diffusion-controlled and free from adsorption phenomena. The current-concentration plots were rectilinear over the concentration range 8-200 and 2-160 micrograms ml-1 for DCt and DPP, respectively, for all the studied compounds. The proposed method was further applied to determine penicillins in pharmaceutical preparations, and the results obtained were in good agreement with those given by the companies.
journal_name
J Pharm Biomed Analjournal_title
Journal of pharmaceutical and biomedical analysisauthors
Belal F,Rizk MS,Eid Mdoi
10.1016/s0731-7085(97)00197-0subject
Has Abstractpub_date
1998-06-01 00:00:00pages
275-82issue
2eissn
0731-7085issn
1873-264Xpii
S0731-7085(97)00197-0journal_volume
17pub_type
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journal_title:Journal of pharmaceutical and biomedical analysis
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journal_title:Journal of pharmaceutical and biomedical analysis
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journal_title:Journal of pharmaceutical and biomedical analysis
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journal_title:Journal of pharmaceutical and biomedical analysis
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journal_title:Journal of pharmaceutical and biomedical analysis
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journal_title:Journal of pharmaceutical and biomedical analysis
pub_type: 杂志文章,评审
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