The impact of methylphenidate on seizure frequency and severity in children with attention-deficit-hyperactivity disorder and difficult-to-treat epilepsies.

Abstract:

AIM:Difficult-to-treat epilepsies and attention-deficit-hyperactivity disorder (ADHD) often co-occur. Because of concerns about the use of stimulants in children with this comorbidity, the impact of ADHD treatment on seizure frequency and severity is not known. This pilot study evaluated the safety and efficacy of methylphenidate in this population. METHOD:After a 3 month period in which antiepileptic drugs were adjusted, 22 patients recruited from a specialist outpatient clinic for severe epilepsy (16 males, six females; mean age 11 y 2 mo, SD 3 y 2 mo) received methylphenidate for 3 months in an open label, non-controlled trial; four with generalized or multifocal (symptomatic/cryptogenic) epilepsy, one with generalized (idiopathic) epilepsy, 17 with partial (symptomatic/cryptogenic) epilepsy; five with partial seizures only, 17 with primarily or secondarily generalized seizures). Epilepsy, ADHD symptoms, and side effects were assessed using the Swanson, Nolan, and Pelham Questionnaire, the Child Behavior Checklist, the Hague Seizure Severity Scale, and the Side Effects Rating Scale. RESULTS:Methylphenidate significantly improved ADHD. After 3 months of treatment, 73% of patients no longer had clinically significant symptoms. Methylphenidate also reduced seizure severity (9-point median decrease on the Hague Seizure Severity Scale). Seizure frequency increased in four out of 22 patients, but only one patient withdrew from the study for this reason. Most patients experienced no major side effects. INTERPRETATION:These data are among the first showing that low doses of methylphenidate are safe and effective to treat ADHD symptoms in patients with difficult-to-treat epilepsies. Randomized controlled trials are needed to replicate the findings.

journal_name

Dev Med Child Neurol

authors

Santos K,Palmini A,Radziuk AL,Rotert R,Bastos F,Booij L,Fernandes BS

doi

10.1111/dmcn.12121

subject

Has Abstract

pub_date

2013-07-01 00:00:00

pages

654-60

issue

7

eissn

0012-1622

issn

1469-8749

journal_volume

55

pub_type

临床试验,杂志文章
  • Sitting in patients with spinal muscular atrophy type 1 treated with nusinersen.

    abstract:AIM:To determine factors associated with acquisition of a sitting position in patients with spinal muscular atrophy type 1 (SMA1) treated with nusinersen. METHOD:Using data from the registry of patients with SMA1 treated with nusinersen, we compared the subgroups of sitters and non-sitters after 14 months of therapy a...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/dmcn.14412

    authors: Aragon-Gawinska K,Daron A,Ulinici A,Vanden Brande L,Seferian A,Gidaro T,Scoto M,Deconinck N,Servais L,SMA-Registry Study Group.

    更新日期:2020-03-01 00:00:00

  • A systematic review of risk factors for cerebral palsy in children born at term in developed countries.

    abstract:AIM:The aim of this study was to conduct a systematic review in order to identify the risk factors for cerebral palsy (CP) in children born at term. The secondary aim was to ascertain if the potential for prevention of these risk factors has been adequately explored. METHOD:A MEDLINE search up to 31 July 2011 was comp...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/dmcn.12017

    authors: McIntyre S,Taitz D,Keogh J,Goldsmith S,Badawi N,Blair E

    更新日期:2013-06-01 00:00:00

  • White matter abnormalities and dystonic motor disorder associated with mutations in the SLC16A2 gene.

    abstract:AIM:Mutations in the SLC16A2 gene have been implicated in Allan-Herndon-Dudley syndrome (AHDS), an X-linked learning disability* syndrome associated with thyroid function test (TFT) abnormalities. Delayed myelination is a non-specific finding in individuals with learning disability whose genetic basis is often uncertai...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.2009.03471.x

    authors: Gika AD,Siddiqui A,Hulse AJ,Edward S,Fallon P,McEntagart ME,Jan W,Josifova D,Lerman-Sagie T,Drummond J,Thompson E,Refetoff S,Bönnemann CG,Jungbluth H

    更新日期:2010-05-01 00:00:00

  • EEGs in phenylketonuria. I: Follow-up to adulthood; II: Short-term diet-related changes in EEGs and cognitive function.

    abstract::The authors report the results of two EEG studies on adult patients with phenylketonuria (PKU) who had been treated early. Part I: the authors followed the EEGs of 34 PKU patients from birth to age 21. The frequency of abnormal EEG findings (especially epileptiform activity) steadily increased until age 12, then decre...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.1993.tb11552.x

    authors: Pietz J,Schmidt E,Matthis P,Kobialka B,Kutscha A,de Sonneville L

    更新日期:1993-01-01 00:00:00

  • Sudden-onset squint.

    abstract::Differentiating a sudden-onset concomitant squint from a paralytic squint in an ill child can be difficult, but the distinction is important in view of the neurological implications of the latter. Furthermore, the two types may co-exist, and four such cases are described. The causes of sudden-onset squint are discusse...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.1987.tb02137.x

    authors: Watson AP,Fielder AR

    更新日期:1987-04-01 00:00:00

  • Acquired conduction aphasia in a child.

    abstract::An 11-year old girl is described who acquired conduction aphasia after head trauma. Detailed study of her repetition defect showed that it was because of impaired short-term verbal memory. CT scan showed two hypodense areas in the left hemisphere, which included the supramarginal gyrus and Wernicke's area. This case i...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.1987.tb02514.x

    authors: Martins IP,Ferro JM

    更新日期:1987-08-01 00:00:00

  • Evaluation of care-load for individuals with spastic tetraplegia.

    abstract::A care-load study was performed on a homogeneous group of 51 children, adolescents and young adults with spastic tetraplegia, born in Sweden between 1959 and 1978. All were immobile and severely mentally retarded, none could speak and the majority had epilepsy, scoliosis and contractures. 16 were living with their fam...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.1989.tb04069.x

    authors: Edebol-Tysk K

    更新日期:1989-12-01 00:00:00

  • Autism spectrum disorders: sex differences in autistic behaviour domains and coexisting psychopathology.

    abstract::The purpose of the present study was to examine possible differences between high-functioning males and females with autism spectrum disorder (ASD) regarding the core symptoms of autism and coexisting psychopathology. A total of 23 females and 23 males matched for age, IQ, and ASD diagnoses were recruited(mean age 11y...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.2007.00361.x

    authors: Holtmann M,Bölte S,Poustka F

    更新日期:2007-05-01 00:00:00

  • Consensus research priorities for cerebral palsy: a Delphi survey of consumers, researchers, and clinicians.

    abstract:AIM:Research funds for cerebral palsy are scarce and competition for them is strong. This study aimed to identify questions for future research that were agreed to be a high priority. METHOD:An expert panel of consumers, researchers, and clinicians was assembled (n=127) and surveyed using a Delphi survey comprising th...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.2009.03358.x

    authors: McIntyre S,Novak I,Cusick A

    更新日期:2010-03-01 00:00:00

  • Severe memory impairment in a child with bihippocampal injury after status epilepticus.

    abstract::Epilepsy may contribute to memory deficits in children, but these deficits are generally mild. We describe the neuropsychological profile of a female who had prolonged status epilepticus at 5 years of age, and then developed temporal lobe epilepsy. Brain magnetic resonance imaging 1 month after the onset of status epi...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1017/S0012162206000478

    authors: Jambaqué I,Hertz-Pannier L,Mikaeloff Y,Martins S,Peudenier S,Dulac O,Chiron C

    更新日期:2006-03-01 00:00:00

  • The PEDALS stationary cycling intervention and health-related quality of life in children with cerebral palsy: a randomized controlled trial.

    abstract:AIM:The aim of this study was to assess health-related quality of life (HRQOL) following a stationary cycling intervention in children with cerebral palsy (CP). METHOD:This was a phase I multisite randomized controlled trial with single blinding. HRQOL was evaluated using the Pediatric Quality of Life Inventory SF15 (...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1469-8749.2012.04321.x

    authors: Demuth SK,Knutson LM,Fowler EG

    更新日期:2012-07-01 00:00:00

  • The effects of cisapride on gastro-oesophageal reflux in children with and without neurological disorders.

    abstract::Cisapride was used to treat gastro-oesophageal reflux in seven children with neurodevelopmental disorders and in 15 children who were neurologically normal. 24-hour lower-oesophageal pH monitoring was carried out before and after treatment. The neurologically normal group had a statistically significant decrease after...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.1990.tb08547.x

    authors: Brueton MJ,Clarke GS,Sandhu BK

    更新日期:1990-07-01 00:00:00

  • Obstetric history and the heart-rate response of newborns to sound.

    abstract::Two groups of clinically normal newborns, differing in the number of non-optimal factors in their obstetric history, were compared by measuring heart-rate response to a series of auditory stimuli. There was a significant difference between the groups in the direction of the average heart-rate response. The high risk" ...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.1976.tb03685.x

    authors: Kittner S,Lipsitt LP

    更新日期:1976-08-01 00:00:00

  • Rud syndrome revisited: ichthyosis, mental retardation, epilepsy and hypogonadism.

    abstract::Rud syndrome is a rare disorder of childhood characterized by ichthyosis, mental retardation, epilepsy and hypogonadism. The authors report a family with this autosomal recessive disorder, review the clinical and dermatopathological findings, and contrast Rud syndrome with the other major neuro-ichthyosiform dermatose...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.1985.tb04545.x

    authors: Marxmiller J,Trenkle I,Ashwal S

    更新日期:1985-06-01 00:00:00

  • Multiple sclerosis and acute disseminated encephalomyelitis diagnosed in children after long-term follow-up: comparison of presenting features.

    abstract::The aim of this study was to compare the characteristics of the first demyelinating event between acute disseminated encephalomyelitis (ADEM) and multiple sclerosis (MS). Children with acute demyelinating disease of the central nervous system and an abnormal brain magnetic resonance image (MRI) were studied. Patients ...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.2008.03136.x

    authors: Alper G,Heyman R,Wang L

    更新日期:2009-06-01 00:00:00

  • What types of epilepsy are preceded by febrile seizures? A population-based study of children.

    abstract::In a population of 850,000, the authors studied afebrile seizures that follow febrile seizures. Review of all paediatric EEGs identified 504 children with epilepsy beginning between 1977 and 1985. Follow-up averaged 85 months. 14.9 per cent had preceding febrile seizures: 13 per cent complex partial, 13 per cent parti...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.1994.tb11779.x

    authors: Camfield P,Camfield C,Gordon K,Dooley J

    更新日期:1994-10-01 00:00:00

  • Hemispheric specialization using SPECT and stimulation tasks in children with dysphasia and dystrophia.

    abstract::Developmental dysphasia, a severe childhood learning disorder, is thought to result from problems in hemispheric specialization involving both left and right cerebral hemispheres. Regional cerebral blood flow (rCBF) was measured at rest and during stimulation of both hemispheres independently: dichotic listening for t...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1017/s0012162299001139

    authors: Chiron C,Pinton F,Masure MC,Duvelleroy-Hommet C,Leon F,Billard C

    更新日期:1999-08-01 00:00:00

  • Development of fine motor skills in preterm infants.

    abstract::Fine motor skills are related to functioning in daily life and at school. We reviewed the status of knowledge, in preterm children, on the development of fine motor skills, the relation with gross motor skills, and risk factors for impaired fine motor skills. We searched the past 15 years in PubMed, using ['motor skil...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章,评审

    doi:10.1111/dmcn.12297

    authors: Bos AF,Van Braeckel KN,Hitzert MM,Tanis JC,Roze E

    更新日期:2013-11-01 00:00:00

  • Adolescents with cerebral palsy: stability in measurement of quality of life and health-related quality of life over 1 year.

    abstract::This study assessed stability of measurement of quality of life (QOL) and health-related quality of life (HRQOL) over the course of 1 year among 185 adolescents (mean age 16y, SD 1 y 9 mo) with cerebral palsy (CP). Participants were classified on the Gross Motor Function Classification System as level I (n=55), II (n=...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.2008.03053.x

    authors: Livingston MH,Rosenbaum PL

    更新日期:2008-09-01 00:00:00

  • Relevance of the Pediatric Powered Wheelchair Screening Test for children with cerebral palsy.

    abstract::In a previous study we developed a cognitive assessment battery called the Pediatric Powered Wheelchair Screening Test (PPWST) to help clinicians determine a young child's readiness to drive a powered wheelchair. The current multicenter study sought to determine: (1) whether the PPWST is appropriate for use in a popul...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1017/s0012162204000775

    authors: Furumasu J,Guerette P,Tefft D

    更新日期:2004-07-01 00:00:00

  • Psychometric properties of functional mobility tools in hereditary spastic paraplegia and other childhood neurological conditions.

    abstract:AIM:To evaluate studies on the psychometric properties of measurement tools used to quantify functional mobility in children with hereditary spastic paraplegia (HSP) and other childhood neurological conditions. METHOD:Two independent reviewers identified measures previously used by clinicians to quantify functional mo...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1469-8749.2012.04284.x

    authors: Adair B,Said CM,Rodda J,Morris ME

    更新日期:2012-07-01 00:00:00

  • Longitudinal study of growth and development of young Jamaican children recovering from severe protein-energy malnutrition.

    abstract::The developmental level and nutritional status of a group of 17 children aged between six and 24 months who were admitted to hospital with severe protein-energy malnutrition were studied from admission to hospital until 36 months after returning home. They were compared with a group of 14 adequately nourished children...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.1982.tb13624.x

    authors: Grantham-McGregor SM,Powell C,Stewart M,Schofield WN

    更新日期:1982-06-01 00:00:00

  • Gliomatosis cerebri in a 10-year-old girl masquerading as diffuse encephalomyelitis and spinal cord tumour.

    abstract::Gliomatosis cerebri is the unifying term used when diffuse glial infiltration occurs throughout the cerebral hemispheres. The very few cases reported in children have presented with intractable epilepsy, corticospinal tract deficits, unilateral tremor, headaches, and developmental delay. Antemortem diagnosis is diffic...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1017/s0012162201000214

    authors: Jayawant S,Neale J,Stoodley N,Wallace S

    更新日期:2001-02-01 00:00:00

  • Lesch-Nyhan disease: clinical experience with nineteen patients.

    abstract::The clinical phenotype in Lesch-Nyhan disease has been analyzed in 19 patients studied in hospital. In each case the diagnosis was made on the basis of inactivity of the enzyme hypoxanthine guanine phosphoribosyltransferase in erythrocyte lysates. All had hyperuricemia, and the presence of 'orange sand' in the diaper ...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.1982.tb13621.x

    authors: Christie R,Bay C,Kaufman IA,Bakay B,Borden M,Nyhan WL

    更新日期:1982-06-01 00:00:00

  • Co-dominant inheritance of hyperekplexia and spastic paraparesis.

    abstract::In four generations of a family with autosomal dominant hyperekplexia (startle disease), untreated affected adult members had pes cavus and extensor plantar responses, as well as hyper-reflexia. Electroencephalography during a startle, electromyography, nerve conduction velocities and somatosensory evoked potentials w...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.1996.tb12144.x

    authors: Baxter P,Connolly S,Curtis A,Spencer V,Ravindranath C,Burn J,Gardner-Medwin D

    更新日期:1996-08-01 00:00:00

  • Development of the Daily Activities of Infants Scale: a measure supporting early motor development.

    abstract::We describe the development and preliminary psychometric testing of the Daily Activities of Infants Scale (DAIS), a parent-completed measure of opportunities parents provide infants for development of postural control and movement. First we obtained 1300 photographs of typical activities from 17 families with infants ...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.2008.03007.x

    authors: Bartlett DJ,Fanning JK,Miller L,Conti-Becker A,Doralp S

    更新日期:2008-08-01 00:00:00

  • Obstetric management, tests, and technologies that impact childhood development.

    abstract::Childhood brain development begins before birth, and obstetric management, tests, and technologies designed to diagnose and treat fetal conditions can have an impact on development. Preconception counseling for maternal diabetes and hypertension affect the risk of fetal congenital anomalies and growth restriction. Pat...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章,评审

    doi:10.1111/dmcn.14160

    authors: Novak CM,Graham EM

    更新日期:2019-09-01 00:00:00

  • Lobar holoprosencephaly presenting as spastic diplegia.

    abstract::A child with lobar holoprosencephaly presented with spastic diplegia and mild mental retardation, compounded by attention deficits and hyperactivity. His facial features were normal, and except for borderline microcephaly, there were no other predictors of holoprosencephaly. This patient represents the mild end of the...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.1988.tb14565.x

    authors: Shanks DE,Wilson WG

    更新日期:1988-06-01 00:00:00

  • The development of independent walking in children with cerebral palsy.

    abstract::Electromyographic and kinematic data were collected during treadmill locomotion by normal infants and infants with cerebral palsy. Locomotor patterns of the infants with cerebral palsy were similar to those of normal infants during the stage of supported locomotion, but as they matured, some of the characteristics of ...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.1991.tb14926.x

    authors: Leonard CT,Hirschfeld H,Forssberg H

    更新日期:1991-07-01 00:00:00

  • Postural sway and gait of children with convergent strabismus.

    abstract::Postural sway and gait of 35 children with convergent strabismus were tested and compared with those of a control group. They were found to have a short stride-length and single-limb support time in walking, particularly at slow speeds. The girls had a large postural sway, but not the boys. The results suggest a commo...

    journal_title:Developmental medicine and child neurology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8749.1984.tb04477.x

    authors: Odenrick P,Sandstedt P,Lennerstrand G

    更新日期:1984-08-01 00:00:00