The probability of in vivo reactivation of herpes simplex virus type 1 increases with the number of latently infected neurons in the ganglia.

Abstract:

:The purpose of this study was to define the relationship between herpes simplex virus (HSV) latency and in vivo ganglionic reactivation. Groups of mice with numbers of latently infected neurons ranging from 1.9 to 24% were generated by varying the input titer of wild-type HSV type 1 strain 17syn+. Reactivation of the virus in mice from each group was induced by hyperthermic stress. The number of animals that exhibited virus reactivation was positively correlated with the number of latently infected neurons in the ganglia over the entire range examined (r = 0.9852, P < 0. 0001 [Pearson correlation]).

journal_name

J Virol

journal_title

Journal of virology

authors

Sawtell NM

doi

10.1128/JVI.72.8.6888-6892.1998

subject

Has Abstract

pub_date

1998-08-01 00:00:00

pages

6888-92

issue

8

eissn

0022-538X

issn

1098-5514

journal_volume

72

pub_type

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