Contractile properties of intralobar pulmonary arteries and veins in the fetal lamb model of congenital diaphragmatic hernia.


BACKGROUND/PURPOSE:Pulmonary hypertension plays a significant role in the pathophysiology of congenital diaphragmatic hernia (CDH). Although there has been an intensive research effort directed at mediators that may cause pulmonary vasoconstriction, no single agent has been identified. The authors hypothesize that there may be an alteration in the cGMP-nitric oxide (NO) pathway of vasodilatation contributing to the pulmonary hypertension observed in CDH. The purpose of these studies is to begin to elucidate vasoactive properties of pulmonary vessels with particular attention to the cGMP-NO pathway of vasodilatation in fetal lambs with CDH. METHODS:Fourth-generation pulmonary arteries and pulmonary veins were dissected from both right and left lungs of eight, 139-day gestational fetuses with surgically created CDH. Vessels were studied with standard isolated tissue bath techniques. Experiments examined basal release of NO in endothelium-intact PVs and PAs of both right and left lungs by measuring the contractile force of vessels constricted with norepinephrine (NE) in the presence and absence of the nitric oxide synthase (NOS) inhibitor N(omega)-nitro-L-arginine (L-NA). Concentration-response curves to the vasodilating agents zaprinast and A23187 were also obtained in vessels contracted by NE. RESULTS:Left and right pulmonary artery responses to NE are enhanced over those of historic controls. Pretreatment of left pulmonary arteries with L-NA enhances the vasoconstrictor response to NE, whereas right PAs show no increased response. Relaxation responses to A23187 and zaprinast, in both left and right pulmonary arteries were not different from control lambs. Relaxation responses of both left and right pulmonary veins to A23187 and zaprinast are blunted compared with controls. This blunting is significantly more in left pulmonary veins than right. Further, right but not left pulmonary veins display enhanced vasoconstrictive response to NE after L-NA pretreatment. CONCLUSIONS:The NO-cGMP pathway of vasodilatation is abnormal in the near term, fetal lamb with CDH. These abnormalities were most apparent in pulmonary veins and may reflect abnormal NOS activity or content between left and right lungs of the fetal lamb with CDH. Pulmonary arteries from CDH lambs have basal and stimulated NO release equal to that of historic controls but appear to be hypersensitive to exogenous vasoconstrictors.


J Pediatr Surg


Irish MS,Glick PL,Russell J,Kapur P,Bambini DA,Holm BA,Steinhorn RH




Has Abstract


1998-06-01 00:00:00














  • Gaucher disease: fate of the splenic remnant after partial splenectomy--a case of rapid enlargement.

    abstract::In Gaucher disease, partial splenectomy has been suggested for alleviating the complications of splenomegaly as well as for avoiding the immunologic compromise and potential acceleration of bony and hepatic involvement that may follow total splenic resection. However, the fate of the splenic remnant has been reported ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Fleshner PR,Astion DJ,Ludman MD,Aufses AH Jr,Grabowski GA,Dolgin SE

    更新日期:1989-06-01 00:00:00

  • Malignant vascular tumors of liver in neonates.

    abstract::Malignant vascular tumors of the liver are rare in children, especially in neonates. We report two cases. One was initially diagnosed as infantile hemangioendothelioma. Rapid growth and appearance of pulmonary metastasis while on aggressive medical treatment suggested malignant transformation. The other neonate presen...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Nazir Z,Pervez S

    更新日期:2006-01-01 00:00:00

  • Neonatal kaposiform hemangioendothelioma of the spleen associated with Kasabach-Merritt phenomenon.

    abstract::Kaposiform hemangioendothelioma is a rare locally aggressive vascular tumor that usually manifests during early childhood. Typically the lesion presents with skin, soft tissue and bone involvement and is characterized histologically by ill-defined nodularity and the presence of spindle cells with resemblance to Kaposi...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Shabtaie SA,Wang B,Owyong M,Ruiz-Mesa C,Corrales-Medina FF,Rojas CP,Infante JC,Neville HL,Perez EA,Sola JE,Hogan AR

    更新日期:2016-06-01 00:00:00

  • Laser microdissection allows detection of abnormal gene expression in cystic adenomatoid malformation of the lung.

    abstract:BACKGROUND/PURPOSE:Congenital cystic adenomatoid malformation (CCAM) of the lung may result from a localized aberrant epithelial-mesenchymal interaction during lung development. We used laser microdissection (LMD) to isolate the epithelium and mesenchyme of CCAM, and studied candidate gene expression in these pure cell...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Jancelewicz T,Nobuhara K,Hawgood S

    更新日期:2008-06-01 00:00:00

  • The significance of ductal shunting during extracorporeal membrane oxygenation.

    abstract::The purpose of this study was to evaluate the significance and direction of shunts at the level of the foramen ovale or ductus arteriosus in full-term newborns with neonatal respiratory failure who were placed on extracorporeal membrane oxygenation (ECMO). A decrease in left ventricular dimension was expected when inf...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Burch KD,Covitz W,Lovett EJ Jr,Howell C,Kanto WP Jr

    更新日期:1989-09-01 00:00:00

  • Whole bowel irrigation in pediatric patients.

    abstract::Whole bowel irrigation was used in 24 patients ages 8 to 17 yr, mean 13 yr, in preparation for colonoscopy (18), colon surgery (2), therapeutic irrigation for treatment of drug overdose (2), and constipation (2). An average of 9 liters warm, normal saline with added KCL (5 mEq/liter) was infused through a nasogastric ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Postuma R

    更新日期:1982-08-01 00:00:00

  • Capsulectomy: a cure for the page kidney.

    abstract::Hypertension is a known complication after renal trauma. The cause of posttraumatic hypertension can be renal scarring, infarction, hydonephrosis, infection, vascular injury, and parenchymal compression. The authors report on the case of a 16-year-old boy who experienced hypertension after blunt renal trauma. He had a...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Moriarty KP,Lipkowitz GS,Germain MJ

    更新日期:1997-06-01 00:00:00

  • Idiopathic gastric perforation in neonates and abnormal distribution of intestinal pacemaker cells.

    abstract:BACKGROUND/PURPOSE:The etiology of idiopathic gastric perforation (IGP) in neonates is unclear. Interstitial cells of Cajal (ICC) express tyrosine kinase receptor C-kit, and act as gastrointestinal pacemaker cells. Stem cell factor (SCF) is a C-kit ligand and plays an important role in immune system homeostasis in the ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Ohshiro K,Yamataka A,Kobayashi H,Hirai S,Miyahara K,Sueyoshi N,Suda K,Miyano T

    更新日期:2000-05-01 00:00:00

  • Inflammatory changes secondary to postoperative complications of Hirschsprung's disease as a cause of histopathologic changes typical of intestinal neuronal dysplasia.

    abstract:PURPOSE:The aim of this study was to clarify the pathogenesis of intestinal neuronal dysplasia (IND). METHODS:The bowel habits of 36 postoperative HD patients were assessed retrospectively. Twenty-five had no complaints. Seven had persistent enterocolitis and were the focus of our study. They were divided into group A...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Kobayashi H,Yamataka A,Lane GJ,Miyano T

    更新日期:2004-02-01 00:00:00

  • Granulocytic sarcoma of the scapula: an unusual presentation of acute myeloblastic leukemia.

    abstract::The unusual presentation of acute myeloblastic leukemia as a scapular granulocytic sarcoma in an infant without systemic manifestations is reported for the first time. Granulocytic sarcoma as a presentation of leukemia should be considered in the differential diagnosis of scapular masses during childhood. Surgery is l...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Karnak I,Ciftci AO,Senocak ME,Göğüş S

    更新日期:1997-01-01 00:00:00

  • Comparison of endorectal ileal pullthrough following colectomy with and without ileal reservoir.

    abstract::In an experimental study, 18 dogs underwent total colectomy, mucosal proctectomy, and endorectal ileal pullthrough with ileoanal anastomosis. In 6 dogs, no internal reservoir was constructed (NR). In 6 additional dogs, an S-shaped ileal reservoir (SR) was constructed immediately above the peritoneal reflection. In 6 o...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Kojima Y,Sanada Y,Fonkalsrud EW

    更新日期:1982-10-01 00:00:00

  • The application of solvent-processed human dura in experimental tracheal reconstruction.

    abstract::To evaluate the role of solvent-processed human cadaveric dura in experimental tracheal reconstruction, anesthetized piglets underwent an elliptical excision of a four-ring segment of the trachea. Twelve animals were randomly divided into two equal groups: in group I, the resected trachea was rotated 180 degrees and s...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Lobe TE,Gore DC,Linares H,Tencer A

    更新日期:1991-09-01 00:00:00

  • Juvenile gastrointestinal polyposis or the infantile Cronkhite-Canada syndrome.

    abstract::This is a report of a case of juvenile gastrointestinal polyposis consisting of widespread juvenile polyps encountered from the stomach into the rectum. Only few cases have been reported, and extra intestinal manifestations include clubbing of fingers, macrocephaly, hypotonia, hepatosplenomegaly, anemia, and protein-l...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Scharf GM,Becker JH,Laage NJ

    更新日期:1986-11-01 00:00:00

  • Fibrothorax associated with a ventriculopleural shunt in a hydrocephalic child.

    abstract::Ventriculopleural (VPL) shunts are considered a safe alternative to peritoneal shunts in the management of hydrocephalus. Occasionally, however, they are associated with persistent pleural effusion. We report a child, aged 3 1/2 years, who developed severe fibrothorax following the use of a VPL shunt. The shunt was re...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Yellin A,Findler G,Barzilay Z,Simansky DA,Lieberman Y

    更新日期:1992-12-01 00:00:00

  • Comparative analysis of successful and unsuccessful candidates for the pediatric surgical matching program.

    abstract::Only one third of the applicants for training in pediatric surgery obtain a position through the pediatric surgery matching program. In order to identify factors that contribute to a successful outcome, we conducted a retrospective survey of all participants in the matching process for positions during the years 1983 ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Hirthler MA,Glick PL,Hassett JM Jr,Rossman J,Mendola P,Allen JE,Jewett TC Jr,Cooney DR

    更新日期:1992-02-01 00:00:00

  • Reappraisal of lateral cervical cysts in neonates: pyriform sinus cysts as an anatomy-based nomenclature.

    abstract:BACKGROUND/PURPOSE:Cervical cysts in neonates are recognized as rare branchial remnants. This term includes many different derivatives of the branchial cleft and sinus. METHODS:A retrospective review was performed in seven neonates with lateral cervical cysts seen at a single institution between 1975 and 1996. Two pat...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Mouri N,Muraji T,Nishijima E,Tsugawa C

    更新日期:1998-07-01 00:00:00

  • Pseudoaneurysm after penetrating trauma in children and adolescents.

    abstract:BACKGROUND:Although skin lacerations are common in children and adolescents, the complication of pseudoaneurysm (PA) has rarely been reported. METHODS:The author reports a series of four cases of patients in whom PA developed after lacerations. The diagnosis was made on the basis of the history and clinical findings i...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Zitsman JL

    更新日期:1998-10-01 00:00:00

  • Megacystis-microcolon-intestinal hypoperistalsis syndrome: survival of a male infant.

    abstract::The combination of megacystis with microcolon and severe intestinal hypoperistalsis constitutes a rarely encountered syndrome in neonates. Of 16 previously reported cases, 14 have occurred in females and all but one have been fatal. Various forms of intestinal diversions have been unsuccessful. Aganglionosis has been ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Gillis DA,Grantmyre EB

    更新日期:1985-06-01 00:00:00

  • Paratesticular rhabdomyoma in a young adult: case study and review of the literature.

    abstract::Paratesticular rhabdomyoma is a rare benign tumor, which usually presents as a painless mass in the scrotum or groin. We report the first case of a locally invasive paratesticular rhabdomyoma in a 17-year-old male teenager who presented with chronic scrotal pain. We further review the current literature of this rare t...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章,评审


    authors: Davies B,Noh P,Smaldone MC,Ranganathan S,Docimo SG

    更新日期:2007-04-01 00:00:00

  • Anomalous congenital bands causing intestinal obstruction in children.

    abstract::The records of eight patients treated for intestinal obstruction resulting from bands that have no identifiable embryologic or acquired basis were reviewed retrospectively. All patients presented with symptoms and signs indicative of intestinal obstruction. Patients older than 2 years of age additionally had a history...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Akgür FM,Tanyel FC,Büyükpamukçu N,Hiçsönmez A

    更新日期:1992-04-01 00:00:00

  • Rhabdoid tumor of the liver: Report of 6 pediatric cases treated at a single institute.

    abstract:BACKGROUND:Rhabdoid tumors (RTs) of the liver are rare, aggressive and nonsecreting malignancies occurring mainly during the first year of life. Definition of RT relies on characteristic morphology and on the inactivation of the SMARCB1 tumor suppressor gene. The aim of this study was to analyze clinical data, treatmen...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Cornet M,De Lambert G,Pariente D,Planchon JM,Guettier C,Martelli H,Guérin F,Branchereau S

    更新日期:2018-03-01 00:00:00

  • A case of tracheal agenesis surviving without mechanical ventilation after external esophageal stenting.

    abstract::Tracheal agenesis is a rare and usually lethal congenital malformation of the forgut. Although some infants can be resuscitated with an intra-esophageal intubation temporarily, long-term airway management is difficult because of the collapsing airway. We report a long-term survivor with tracheal agenesis in whom a Gor...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Watanabe T,Okuyama H,Kubota A,Kawahara H,Hasegawa T,Ueno T,Saka R,Morishita Y

    更新日期:2008-10-01 00:00:00

  • Intraoperative measurement of rectourethral fistula: prevention of incomplete excision in male patients with high-/intermediate-type imperforate anus.

    abstract:INTRODUCTION:We report a novel technique to measure the length of the rectourethral fistula (RUF) in male patients with high-/intermediate-type imperforate anus during laparoscopically assisted anorectal pull-through (LAARP) to prevent incomplete excision. METHOD:During LAARP for RUF in 5 male patients (mean age, 4.6 ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Koga H,Kato Y,Shimotakahara A,Miyano G,Lane GJ,Okazaki T,Yamataka A

    更新日期:2010-02-01 00:00:00

  • HIV-positive African children with rectal fistulae.

    abstract:BACKGROUND/PURPOSE:Human immunodeficiency virus (HIV) disease is an increasingly common infection in children in sub-Sahara Africa. Rectal fistulation is one such condition with which these patients present to the paediatric surgeon. This appeared to be an exclusively female condition until 2 male patients were treated...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Wiersma R

    更新日期:2003-01-01 00:00:00

  • Laparoscopic suture rectopexy for full-thickness anorectal prolapse in children: an effective outpatient procedure.

    abstract:BACKGROUND/PURPOSE:Our approach to full-thickness anorectal prolapse has transitioned to laparoscopic suture rectopexy (LSRP). The purpose of this study was to describe the indications, technique, and postoperative outcomes for LSRP. METHODS:Rectopexy was performed using 3 or 4 laparoscopic ports. Redundant rectum was...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Potter DD,Bruny JL,Allshouse MJ,Narkewicz MR,Soden JS,Partrick DA

    更新日期:2010-10-01 00:00:00

  • Early experience with reduced-size liver transplants.

    abstract::Scarcity of small donors results in a high mortality rate for children on liver transplant waiting lists. To alleviate this problem, we have recently started to reduce the size of livers from older donors to use in children. In the last year, a total of 20 liver transplants were performed in 17 patients, including sev...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Superina RA,Strasberg SM,Greig PD,Langer B

    更新日期:1990-11-01 00:00:00

  • Juvenile secretory carcinoma and juvenile papillomatosis: diagnosis and treatment.

    abstract::Carcinoma of the breast in the child is a rare pathologic entity, constitutes less than 1% of all breast lesions in this age group. The case of a girl with a left breast mass first noticed at 4.5 years of age is presented. An eccentric subareolar mass was excised at 6 years of age, sparing her breast bud. This biopsy ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Ferguson TB Jr,McCarty KS Jr,Filston HC

    更新日期:1987-07-01 00:00:00

  • Bevacizumab and interferon reduce venous recanalization following sclerotherapy.

    abstract:PURPOSE:The treatment of venous malformations is difficult because these lesions frequently recur after resection or sclerotherapy. The purpose of this study was to determine whether recanalization of sclerosed venous lumens could be prevented with systemic angiogenic inhibition using bevacizumab or peginterferon alfa-...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Kulungowski AM,Hassanein AH,Foster CC,Greene AK,Fishman SJ

    更新日期:2016-10-01 00:00:00

  • Medial thickening of hepatic artery branches in biliary atresia. A morphometric study.

    abstract:BACKGROUND/PURPOSE:Medial layer hypertrophy of hepatic arterial branches may be associated with biliary atresia (BA) pathogenesis. This study aimed at evaluating medial layer thickness in hepatic arterial branches at portoenterostomy and liver transplantation. METHODS:The authors evaluated 1274 arterial branches both ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: dos Santos JL,da Silveira TR,da Silva VD,Cerski CT,Wagner MB

    更新日期:2005-04-01 00:00:00

  • Infraumbilical entry into the peritoneal cavity through a small incision for the identification and cannulation of an umbilical artery.

    abstract::An infra-umbilical entry into the peritoneal cavity through a small incision, without anesthesia, for the identification and cannulation of an umbilical artery was employed for monitoring and therapy in five prematurely born neonates. The extra-peritoneal approach to umbilical artery identification and cannulation had...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Moore TC,Leake RD

    更新日期:1977-04-01 00:00:00