Pharmacokinetic evaluation of amphotericin B in lung tissue: lung lymph distribution after intravenous injection and airspace distribution after aerosolization and inhalation of amphotericin B.


:We have studied the pharmacokinetics of amphotericin B (AmB) in lung lymph circulation and bronchial-wash fluid after intravenous infusion and inhalation, respectively. For two experiments with awake sheep, we used lung lymph fistulas and tracheotomy. In experiment 1, AmB concentrations in plasma and lung lymph after intravenous infusion of AmB (1 mg/kg of body weight) over 1.5 h were measured. The mean peak in plasma level was 756.0 +/- 188.8 ng/ml at 3 h after the start of infusion, and the level then decreased gradually to 194.8 +/- 28.9 ng/ml at 24 h. The stable and maximal levels in lung lymph last 5 to 9 h after the start of AmB infusion. The concentrations in lung lymph after 9 h were slightly higher than those in plasma. Thus, the lung lymph-to-plasma ratio of AmB concentrations increased gradually during infusion, and the ratio was more than 1.0 after the end of infusion, suggesting that AmB could be easily moved from plasma to pulmonary interstitium and/or lung lymph circulation. In another experiment, 5 or 30 mg of aerosol AmB was inhaled, and the concentration of AmB in the bronchial-wash fluid was determined by bronchoalveolar lavage. The peak AmB concentration in the fluid was observed at 0.5 h. After that, AmB was slowly eliminated over 24 h. The area under the concentration-time curve for 30 mg of inhaled AmB was higher than that for 5 mg, but maximum concentrations of AmB in serum for 5 and 30 mg were almost similar. These observations identify the pharmacokinetic characteristics of AmB in the lung and may provide a new insight into the strategy for clinical treatment of fungal pneumonia.


Koizumi T,Kubo K,Kaneki T,Hanaoka M,Hayano T,Miyahara T,Okada K,Fujimoto K,Yamamoto H,Kobayashi T,Sekiguchi M




Has Abstract


1998-07-01 00:00:00












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    abstract::Four pre-exposure prophylaxis (PrEP) users with gastro-intestinal disorders (sleeve gastrectomy, terminal ileitis, celiac disease or chronic diarrhea) and receiving oral tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) were included. Despite a self-reported high adherence, trough plasma tenofovir concentrations (...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Calcagno A,Dal Conte I,Cattaneo D,Testi R,Mistrangelo M,Gervasoni C,de Nicolò A,Bonora S,D'Avolio A,Di Perri G

    更新日期:2020-10-26 00:00:00

  • Ceftazidime-Avibactam Is Superior to Other Treatment Regimens against Carbapenem-Resistant Klebsiella pneumoniae Bacteremia.

    abstract::There are no data comparing outcomes of patients treated with ceftazidime-avibactam versus comparators for carbapenem-resistant Enterobacteriaceae infections. At our center, ceftazidime-avibactam treatment of carbapenem-resistant Klebsiella pneumoniae bacteremia was associated with higher rates of clinical success (P ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Shields RK,Nguyen MH,Chen L,Press EG,Potoski BA,Marini RV,Doi Y,Kreiswirth BN,Clancy CJ

    更新日期:2017-07-25 00:00:00

  • Population Pharmacokinetic Model and Limited Sampling Strategies for Personalized Dosing of Levofloxacin in Tuberculosis Patients.

    abstract::Levofloxacin is an antituberculosis drug with substantial interindividual pharmacokinetic variability; therapeutic drug monitoring (TDM) could therefore be helpful to improve treatment results. TDM would be more feasible with limited sampling strategies (LSSs), a method to estimate the area under the concentration cur...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章


    authors: van den Elsen SHJ,Sturkenboom MGG,Van't Boveneind-Vrubleuskaya N,Skrahina A,van der Werf TS,Heysell SK,Mpagama S,Migliori GB,Peloquin CA,Touw DJ,Alffenaar JC

    更新日期:2018-11-26 00:00:00

  • A recombinant retroviral system for rapid in vivo analysis of human immunodeficiency virus type 1 susceptibility to reverse transcriptase inhibitors.

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Shi C,Mellors JW

    更新日期:1997-12-01 00:00:00

  • Emergence of high levels of extended-spectrum-beta-lactamase-producing gram-negative bacilli in the Asia-Pacific region: data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) program, 2007.

    abstract::Of 3,004 gram-negative bacilli collected from intra-abdominal infections in the Asia-Pacific region during 2007, 42.2% and 35.8% of Escherichia coli and Klebsiella spp., respectively, were extended-spectrum beta-lactamase (ESBL) positive. Moreover ESBL rates in India for E. coli, Klebsiella pneumoniae, and Klebsiella ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Hawser SP,Bouchillon SK,Hoban DJ,Badal RE,Hsueh PR,Paterson DL

    更新日期:2009-08-01 00:00:00

  • Delamanid Kills Dormant Mycobacteria In Vitro and in a Guinea Pig Model of Tuberculosis.

    abstract::Tuberculosis (TB) treatment is long and requires multiple drugs, likely due to various phenotypes of TB bacilli with variable drug susceptibilities. Drugs with broad activity are urgently needed. This study aimed to evaluate delamanid's activity against growing or dormant bacilli in vitro as well as in vivo Cultures o...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Chen X,Hashizume H,Tomishige T,Nakamura I,Matsuba M,Fujiwara M,Kitamoto R,Hanaki E,Ohba Y,Matsumoto M

    更新日期:2017-05-24 00:00:00

  • Effect of bleomycin on deoxyribonucleic acid synthesis in toluene-treated Escherichia coli cells.

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Ross SL,Moses RE

    更新日期:1976-02-01 00:00:00

  • Pharmacokinetic-pharmacodynamic modeling of electroencephalogram effect of imipenem in rats with acute renal failure.

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Dupuis A,Limosin A,Paquereau J,Mimoz O,Couet W,Bouquet S

    更新日期:2001-12-01 00:00:00

  • In vitro synergistic activity between bismuth subcitrate and various antimicrobial agents against Campylobacter pyloridis (C. pylori).

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Van Caekenberghe DL,Breyssens J

    更新日期:1987-09-01 00:00:00

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Robbins BL,Rodman J,McDonald C,Srinivas RV,Flynn PM,Fridland A

    更新日期:1994-01-01 00:00:00

  • Successful treatment using gentamicin liposomes of Salmonella dublin infections in mice.

    abstract::Gentamicin entrapped within stable multilamellar liposomes was used to treat mice after they were infected per os with Salmonella dublin. Of 10 mice, 8 survived after a single intravenous (i.v.) injection of 2 mg of gentamicin liposomes per kg compared with 0 of 10 treated with the same amount of free gentamicin. All ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Fierer J,Hatlen L,Lin JP,Estrella D,Mihalko P,Yau-Young A

    更新日期:1990-02-01 00:00:00

  • Antifungal Susceptibility of the Aspergillus viridinutans Complex: Comparison of Two In Vitro Methods.

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Lyskova P,Hubka V,Svobodova L,Barrs V,Dhand NK,Yaguchi T,Matsuzawa T,Horie Y,Kolarik M,Dobias R,Hamal P

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    journal_title:Antimicrobial agents and chemotherapy

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    authors: Meikle V,Mossberg AK,Mitra A,Hakansson AP,Niederweis M

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章,随机对照试验


    authors: Tarning J,Lindegardh N,Lwin KM,Annerberg A,Kiricharoen L,Ashley E,White NJ,Nosten F,Day NP

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  • Persistence of an antibiotic resistance plasmid in intestinal Escherichia coli of chickens in the absence of selective pressure.

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    journal_title:Antimicrobial agents and chemotherapy

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    authors: Chaslus-Dancla E,Gerbaud G,Lagorce M,Lafont JP,Courvalin P

    更新日期:1987-05-01 00:00:00

  • Activities of roxithromycin used alone and in combination with ethambutol, rifampin, amikacin, ofloxacin, and clofazimine against Mycobacterium avium complex.

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Rastogi N,Goh KS,Bryskier A

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  • Persistence of vancomycin resistance in multiple clones of Enterococcus faecium isolated from Danish broilers 15 years after the ban of avoparcin.

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    journal_title:Antimicrobial agents and chemotherapy

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    authors: Bortolaia V,Mander M,Jensen LB,Olsen JE,Guardabassi L

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    journal_title:Antimicrobial agents and chemotherapy

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Neyfakh AA,Borsch CM,Kaatz GW

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Po KHL,Chan EWC,Chen S

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Garrett ER,Heman-Ackah SM

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Pfeifer Y,Schlatterer K,Engelmann E,Schiller RA,Frangenberg HR,Stiewe D,Holfelder M,Witte W,Nordmann P,Poirel L

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Mosquera J,Warn PA,Morrissey J,Moore CB,Gil-Lamaignere C,Denning DW

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  • Penetration of cefotaxime into respiratory secretions.

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Fick RB Jr,Alexander MR,Prince RA,Kasik JE

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Bowman JC,Hicks PS,Kurtz MB,Rosen H,Schmatz DM,Liberator PA,Douglas CM

    更新日期:2002-09-01 00:00:00

  • Interaction of oxyimino beta-lactams with a class C beta-lactamase and a mutant with a spectrum extended to beta-lactams.

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Nukaga M,Tsukamoto K,Yamaguchi H,Sawai T

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Welling PG,Koch PA,Lau CC,Craig WA

    更新日期:1977-03-01 00:00:00

  • Role of a sodium-dependent symporter homologue in the thermosensitivity of beta-lactam antibiotic resistance and cell wall composition in Staphylococcus aureus.

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Sieradzki K,Chung M,Tomasz A

    更新日期:2008-02-01 00:00:00

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Jhun BW,Yang B,Moon SM,Lee H,Park HY,Jeon K,Kwon OJ,Ahn J,Moon IJ,Shin SJ,Daley CL,Koh WJ

    更新日期:2018-06-26 00:00:00

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    abstract::Streptonigrin, a quinone antitumor antibiotic, has been reported to be effective in human trials. A sensitive and precise microbiological assay for the determination of distribution and concentrations of streptonigrin in the body fluids and tissues of treated mice has been developed in an attempt to supplement success...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Pittillo RF,Woolley C

    更新日期:1974-01-01 00:00:00