Ovarian hyperstimulation syndrome: facts and fallacies.

Abstract:

:Severe or critical ovarian hyperstimulation syndrome (OHSS) is a serious complication of ovarian hyperstimulation for assisted reproduction techniques (ART). The syndrome is characterized by cystic enlargement of the ovaries and fluid shifts from the intravascular to the third space. The morbidity in OHSS is mainly determined by the hemodynamic changes caused by increased capillary permeability. The incidence of OHSS depends on definitions, risk factors, ovarian stimulation protocols, luteal support and conception. Currently, research on the pathogenesis of OHSS is focused on increased capillary permeability. Several theories are reviewed. Until the pathogenesis of OHSS becomes clear, treatment is restricted to supportive therapy. The various proposals for management of OHSS are discussed and, based on the available data, directions for the management of various grades of OHSS are summarized. However, prevention and early recognition are still the most important tools to handle OHSS. A flowchart with preventive measures for OHSS is presented derived from the available literature.

journal_name

Obstet Gynecol Surv

authors

Beerendonk CC,van Dop PA,Braat DD,Merkus JM

doi

10.1097/00006254-199807000-00024

subject

Has Abstract

pub_date

1998-07-01 00:00:00

pages

439-49

issue

7

eissn

0029-7828

issn

1533-9866

journal_volume

53

pub_type

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