Neural stem cell survival factors.


:Neural stem and progenitor cells (NSCs and NPs) give rise to the central nervous system (CNS) during embryonic development. NSCs and NPs differentiate into three main cell-types of the CNS; astrocytes, oligodendrocytes, and neurons. NSCs are present in the adult CNS and are important in maintenance and repair. Adult NSCs hold great promise for endogenous or self-repair of the CNS. Intriguingly, NSCs have been implicated as the cells that give rise to brain tumors. Thus, the balance between survival, growth and differentiation is a critical aspect of NSC biology, during development, in the adult, and in disease processes. In this review, we survey what is known about survival factors that control both embryonic and adult NSCs. We discuss the neurosphere culture system as this is widely used to measure NSC activity and behavior in vitro and emphasize the importance of clonality. We define here NSC survival factors in their broadest sense to include any factor that influences survival and proliferation of NSCs and NPs. NSC survival factors identified to date include growth factors, morphogens, proteoglycans, cytokines, hormones, and neurotransmitters. Understanding NSC and NP interaction in response to these survival factors will provide insight to CNS development, disease and repair.


Arch Biochem Biophys


Ramasamy S,Narayanan G,Sankaran S,Yu YH,Ahmed S




Has Abstract


2013-06-01 00:00:00














  • Investigation of the mechanism of nicotine demethylation in Nicotiana through 2H and 15N heavy isotope effects: implication of cytochrome P450 oxidase and hydroxyl ion transfer.

    abstract::Heavy-atom isotope effects for the N-demethylation of nicotine have been determined in vivo in static-phase biosynthetically incompetent plant cell cultures of Nicotiana species. A (2)H kinetic isotope effect of 0.587 and a (15)N kinetic isotope effect of 1.0028 were obtained. An identical (15)N kinetic isotope effect...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章


    authors: Molinié R,Kwiecień RA,Paneth P,Hatton W,Lebreton J,Robins RJ

    更新日期:2007-02-15 00:00:00

  • Applications of NMR to structure determination of RNAs large and small.

    abstract::Nuclear magnetic resonance (NMR) spectroscopy is a powerful tool to investigate the structure and dynamics of RNA, because many biologically important RNAs have conformationally flexible structures, which makes them difficult to crystallize. Functional, independently folded RNA domains, range in size between simple st...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章,评审


    authors: Barnwal RP,Yang F,Varani G

    更新日期:2017-08-15 00:00:00

  • Benzoic acid inhibition of the alpha, beta, and gamma isozymes of Agaricus bisporus tyrosinase.

    abstract::Inhibition of the catecholase and cresolase reactions of the alpha, beta, and gamma isozymes of Agaricus bisporus tyrosinase by benzoic acid was investigated at 25.0 and 8.0 degrees C at pH 5.60 in air-saturated solutions. Benzoic acid is a simple competitive inhibitor of the cresolase reaction of all three isozymes. ...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章


    authors: Menon S,Fleck RW,Yong G,Strothkamp KG

    更新日期:1990-07-01 00:00:00

  • Association of a heat-stable inhibitor protein with cyclic-3',5'-AMP-dependent protein kinase from the nematode Ascaris suum: purification and characterization of the inhibitor.

    abstract::An inhibitor protein of the catalytic subunit of the cyclic 3',5'-AMP-dependent protein kinase from the nematode Ascaris suum was isolated and characterized. The molecular weight of the inhibitor was estimated as 28,000 by electrophoresis under denaturing conditions and as 30,000 by gel permeation chromatography on Su...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章


    authors: Hoffmann R,Jung S,Hofer HW

    更新日期:1992-09-01 00:00:00

  • Mechanistic studies of sodium pump.

    abstract::Sodium pump was the first ion pump discovered. A member of the family of active transporters that catalyze adenosine 5'-triphosphate hydrolysis by forming a phosphorylated enzyme intermediate, sodium pump couples the energy released to unequal countertransport of sodium and potassium ions. The ion gradient generated b...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章,评审


    authors: Faller LD

    更新日期:2008-08-01 00:00:00

  • Transcriptional regulation of rat liver glutathione S-transferase genes by phenobarbital and 3-methylcholanthrene.

    abstract::The relative rates of transcription of the rat liver glutathione S-transferase Ya-Yc and Yb genes were determined in purified liver nuclei isolated at different times after phenobarbital or 3-methylcholanthrene administration. The transcriptional rates of the Ya-Yc and Yb genes were elevated approximately fivefold 8 a...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章


    authors: Ding VD,Pickett CB

    更新日期:1985-08-01 00:00:00

  • Characterization of cyanogenic beta-glucosidase (linamarase) from cassava (Manihot esculenta Crantz).

    abstract::Linamarase (EC was purified from cassava petiole, stem, and root cortex by ammonium sulfate precipitation, column chromatography on Sepharose 6B, and chromatofocusing. The last step resolved the enzyme from each source into three forms with pI values of 4.3, 3.3, and 2.9. Each form was found to be oligomeric...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章


    authors: Eksittikul T,Chulavatnatol M

    更新日期:1988-10-01 00:00:00

  • Mechanism of simultaneous iodination and coupling catalyzed by thyroid peroxidase.

    abstract::Thyroid peroxidase (TPO) simultaneously catalyzes two very different types of reaction in the thyroid gland- iodination and coupling. The present study addresses the mechanism of this simultaneous dual activity. Compound I, the two-electron oxidation product of TPO, exists in two different forms--an oxoferryl porphyri...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章


    authors: Taurog A,Dorris ML,Doerge DR

    更新日期:1996-06-01 00:00:00

  • Metabolism of alpha-D-[1,2-13C]glucose pentaacetate and alpha-D-glucose penta[2-13C]acetate in rat hepatocytes.

    abstract::Hepatocytes from fed rats were incubated for 120 min in the presence of alpha-D-[1,2-13C]glucose pentaacetate (1.7 mM), both D-[1,2-13C]glucose (1.7 mM) and acetate (8.5 mM), alpha-D-glucose penta[2-13C]acetate (1.7 mM), or D-[1,2-13C]glucose (8.3 mM). The amounts of 13C-enriched L-lactate and D-glucose and those of a...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章


    authors: Malaisse WJ,Ladrière L,Kadiata MM,Verbruggen I,Willem R

    更新日期:2000-09-01 00:00:00

  • Detection of a functional xenobiotic response element in a widely employed FoxO-responsive reporter construct.

    abstract::FHRE-Luc is a promoter reporter construct that is widely used to assess the activity of FoxO (forkhead box, class O) transcription factors. We here demonstrate that this promoter construct responds to exposure of HepG2 human hepatoma cells to known agonists of the aryl hydrocarbon receptor (AhR), 3-methylcholanthrene,...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章


    authors: Eckers A,Sauerbier E,Anwar-Mohamed A,Hamann I,Esser C,Schroeder P,El-Kadi AO,Klotz LO

    更新日期:2011-12-15 00:00:00

  • Superoxide from glucose oxidase or from nitroblue tetrazolium?

    abstract::Glucose oxidase reduces nitroblue tetrazolium, or ferricytochrome c, faster anaerobically than aerobically. This result is inconsistent with the conclusion that GO2 can reduce O2 to O2- which is then responsible for the reduction of NBT and of cytochrome c. Nevertheless, the aerobic reductions are partially inhibitabl...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章


    authors: Liochev SI,Fridovich I

    更新日期:1995-04-20 00:00:00

  • Protein denaturation during freezing and thawing in phosphate buffer systems: monomeric and tetrameric beta-galactosidase.

    abstract::During freezing in sodium and potassium phosphate (NaP and KP) buffer solutions, changes in pH may impact the stability of proteins. Since the degradation pathways for the model proteins, monomeric and tetrameric beta-galactosidase (beta-gal), chosen for this study are governed by conformational changes (i.e., physica...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章


    authors: Pikal-Cleland KA,Rodríguez-Hornedo N,Amidon GL,Carpenter JF

    更新日期:2000-12-15 00:00:00

  • The synthesis of mannose 1-phosphate in brain.

    abstract::The interconversion of mannose-6-P and mannose-1-P in brain has been shown to be catalyzed by a distinct enzyme. The enzyme has been separated from most of the phosphoglucomutase activity of the brain. The residual phosphoglucomutase activity (less than 1%) may be associated with phosphomannomutase itself. Mannose-1,6...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章


    authors: Guha SK,Rose ZB

    更新日期:1985-11-15 00:00:00

  • Tannins elevate the level of poly(ADP-ribose) in HeLa cell extracts.

    abstract::Phenolic phytochemicals such as tannins, which are natural constituents of green tea, red wine, and other plant products, are considered to have cancer-preventive properties. An important endogenous mediator of tumorigenesis is the nuclear enzyme poly(ADP-ribose) polymerase 1 (PARP-1). PARP-1 synthesizes polymers of A...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章


    authors: Keil C,Petermann E,Oei SL

    更新日期:2004-05-01 00:00:00

  • 3,5,3'-triiodothyronine induces mitochondrial permeability transition mediated by reactive oxygen species and membrane protein thiol oxidation.

    abstract::Ca(2+)-loaded rat liver mitochondria treated with 3,5,3'-triiodothyronine (T3) undergo nonspecific inner membrane permeabilization, as evidenced by mitochondrial swelling, a decrease in membrane potential (delta psi), and an increase in the rate of oxygen uptake. T3 analogues thyroxine (T4), 3',5'-diiodothyronine (T2)...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章


    authors: Castilho RF,Kowaltowski AJ,Vercesi AE

    更新日期:1998-06-01 00:00:00

  • Formation of spin trap adducts during the decomposition of peroxynitrite.

    abstract::Peroxynitrite-mediated one-electron oxidations may be an important event in its cytotoxic mechanisms, and yet, free radical formation in the presence of peroxynitrite is difficult to study by EPR-spin trapping because adducts from most spin traps are destroyed by the oxidant. This led to some controversy with regard t...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章


    authors: Gatti RM,Alvarez B,Vasquez-Vivar J,Radi R,Augusto O

    更新日期:1998-01-01 00:00:00

  • Effects of fluorescein isothiocyanate on insulin actions in rat adipocytes.

    abstract::The effects of fluorescein isothiocyanate II (FITC) on the actions of insulin in rat adipocytes were studied. When adipocytes were incubated with FITC at pH 7.4 (2 mM agent, 8 min), the cells were completely deprived of their specific insulin-binding activity and rendered unresponsive to the hormone. The effect of FIT...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章


    authors: Goto Y,Sumida Y,Flanagan JE,Robinson FW,Simpson IA,Cushman SW,Kono T

    更新日期:1992-03-01 00:00:00

  • A model for hydropathy-based peptide interactions.

    abstract::Two peptides are specified when the noncoding DNA strand is read in the 5' to 3', or the 3' to 5' direction, and both peptides form strong complexes with the natural peptide, as found by J. E. Blalock and K. L. Bost with ACTH [1986) Biochem. J. 234, 679-683). We report here that strong hydropathic complementarity (pai...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章


    authors: Markus G,Tritsch GL,Parthasarathy R

    更新日期:1989-08-01 00:00:00

  • Two phosphorylated forms of myosin in thrombin-stimulated platelets.

    abstract::Three forms of 20-kDa myosin light chain (MLC), unphosphorylated, monophosphorylated, and diphosphorylated MLC (designated 20K, 20K-P, and 20K-PP) were demonstrated in thrombin-stimulated human platelets by two different gel electrophoretic methods: in the presence of glycerol urea or in two dimensions (isoelectric an...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章


    authors: Naka M,Saitoh M,Hidaka H

    更新日期:1988-03-01 00:00:00

  • Role of mitochondrial cardiolipin peroxidation in apoptotic photokilling of 5-aminolevulinate-treated tumor cells.

    abstract::In 5-aminolevulinic acid (ALA)-based photodynamic therapy (PDT), ALA taken up by tumor cells is metabolized to protoporphyrin IX (PpIX), which sensitizes photodamage leading to apoptotic or necrotic cell death. Since lipophilic PpIX originates in mitochondria, we postulated that photoperoxidation of highly unsaturated...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章


    authors: Kriska T,Korytowski W,Girotti AW

    更新日期:2005-01-15 00:00:00

  • A novel acetyl-CoA carboxylase inhibitor reduces de novo fatty acid synthesis in HepG2 cells and rat primary hepatocytes.

    abstract::To identify the novel inhibitor of de novo lipogenesis in hepatocytes, we screened for inhibitory activity of triglyceride (TG) synthesis using [14C]acetate in the human hepatoma cell line, HepG2. Using this assay system we discovered the novel compound, benzofuranyl alpha-pyrone (TEI-B00422). TEI-B00422 also inhibite...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章


    authors: Sugimoto Y,Naniwa Y,Nakamura T,Kato H,Yamamoto M,Tanabe H,Inoue K,Imaizumi A

    更新日期:2007-12-01 00:00:00

  • Kinetic mechanism of activation of muscle glycogen phosphorylase b by adenosine 5'-monophosphate.

    abstract::The kinetic analysis of the enzymatic reaction catalyzed by glycogen phosphorylase b from the rabbit skeletal muscle has been carried out in the direction of glycogen synthesis under the conditions of the saturation of the enzyme by glycogen. The applicability of 12 different variants of the Monod-Wyman-Changeux model...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章


    authors: Klinov SV,Kurganov BI

    更新日期:1994-07-01 00:00:00

  • A monoclonal antibody to avidin dissociates quaternary structure and curtails biotin binding to avidin and streptavidin.

    abstract::An anti-avidin mAb, viz., H12G4, is shown to release bound biotin in a dose-dependent manner from holoavidin and holostreptavidin and inhibit the binding of ligand to the two apoproteins. The release of biotin by this mAb is accompanied by quenching of ligand-induced enhanced fluorescence of the FITC-avidin conjugate....

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章


    authors: Subramanian N,Subramanian S,Karande AA,Adiga PR

    更新日期:1997-08-15 00:00:00

  • The role of peroxisomal fatty acyl-CoA beta-oxidation in bile acid biosynthesis.

    abstract::The physiological role of the peroxisomal fatty acyl-CoA beta-oxidizing system (FAOS) is not yet established. We speculated that there might be a relationship between peroxisomal degradation of long-chain fatty acids in the liver and the biosynthesis of bile acids. This was investigated using [1-14C]butyric acid and [...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章


    authors: Hayashi H,Miwa A

    更新日期:1989-11-01 00:00:00

  • Vitamin K-dependent carboxylase: effect of detergent concentrations, vitamin K status, and added protein precursors on activity.

    abstract::Activity of the rat liver microsomal vitamin K-dependent carboxylase has been studied at various concentrations of detergent. The activity which could be solubilized by 0.25% Triton X-100 was low but could be greatly increased if vitamin K-deficient rats were given vitamin K a few minutes before they were killed. At h...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章


    authors: Shah DV,Swanson JC,Suttie JW

    更新日期:1983-04-01 00:00:00

  • The 85-kDa, arachidonic acid-specific phospholipase A2 is expressed as an activated phosphoprotein in Sf9 cells.

    abstract::A human, 85-kDa arachidonoyl-specific, cytosolic phospholipase A2 was expressed using the baculovirus-insect cell expression system. Expression resulted in the production of an active protein which consisted of approximately 3% of the total protein in the host Spodoptera frugiperda (Sf9) cells at 67 h after infection....

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章


    authors: de Carvalho MS,McCormack FX,Leslie CC

    更新日期:1993-11-01 00:00:00

  • Regulation of NADP-malate dehydrogenase in C4 plants: relationship among enzyme activity, NADPH to NADP ratios, and thioredoxin redox states in intact maize mesophyll chloroplasts.

    abstract::NADP-malate dehydrogenase activity, the ratio of NADPH to NADP, and thioredoxin redox state in Zea mays chloroplasts were determined after various treatments. Following transfer from dark to light, NADP-malate dehydrogenase was activated more than 20-fold within 10 min while the proportion of pyridine nucleotide as NA...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章


    authors: Rebeille F,Hatch MD

    更新日期:1986-08-15 00:00:00

  • The pH dependence of the kinetic parameters of ketol acid reductoisomerase indicates a proton shuttle mechanism for alkyl migration.

    abstract::The enzyme ketol acid reductoisomerase catalyzes the second common reaction in the biosynthesis of the branched chain amino acids. The reaction is complex as an alkyl migration and a ketone reduction apparently occur as separate steps during the conversion of acetolactate to 2,3-dihydroxy-3-methylbutyrate. This paper ...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章


    authors: Mrachko GT,Chunduru SK,Calvo KC

    更新日期:1992-05-01 00:00:00

  • Characterization of the subunits of beta-conglycinin.

    abstract::Four subunits of beta-conglycinin were purified from soybean cultivar CX 635-1-1-1, and were designated alpha, alpha', beta, and beta' in accordance with nomenclature proposed by Thanh and Shibasaki [(1977) Biochim. Biophys. Acta 490, 370-384]. Of these subunits, beta' has not previously been reported or characterized...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章


    authors: Coates JB,Medeiros JS,Thanh VH,Nielsen NC

    更新日期:1985-11-15 00:00:00

  • Induction of rabbit hepatic microsomal cytochrome P-450 by imidazole: enhanced metabolic activity and altered substrate specificity.

    abstract::Pretreatment of rabbits with imidazole resulted in a twofold increase in hepatic microsomal cytochrome P-450 content, with the apparent induction of two or more distinct forms of the cytochrome [K. K. Hajek and R. F. Novak (1982) Biochem. Biophys. Res. Commun. 108, 664-672]. The metabolic properties of imidazole-induc...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章


    authors: Kaul KL,Novak RF

    更新日期:1984-12-01 00:00:00