Deoxyribonucleic acid flow cytometry and traditional pathologic variables in invasive penile carcinoma: assessment of prognostic significance.


OBJECTIVES:The identification of reliable prognostic factors to guide the selection of patients at high risk of harboring subclinical metastases in penile cancer is important. We evaluated traditional pathologic variables and deoxyribonucleic acid (DNA) flow cytometry to determine the prognostic significance of these variables for the subsequent development of lymph node metastases. METHODS:Clinical data and pathologic specimens were retrospectively reviewed from patients treated surgically at university-affiliated hospitals from 1958 to 1987. Pathologic analysis (grade, depth of invasion, and pathologic stage) and DNA flow cytometry were performed on specimens from 46 patients with invasive penile carcinoma and complete medical records. Pathologic variables were compared with DNA flow cytometry results in patients who never developed lymph node metastasis (32 patients, median follow-up 121 months) and in those who presented with or developed proved lymph node metastases (14 patients, median follow-up 18 months). RESULTS:The distributions of diploid and nondiploid tumors were similar in patients with or without lymph node metastasis. In addition, there was no significant difference in the grade distributions of tumors with respect to lymph node status. Patients with positive nodes more commonly had tumors that invaded greater than 0.5 cm or that exhibited pathologic Stage T2 or greater (deep invasion). All 14 patients who presented with or subsequently developed metastasis had deep primary tumors. Thirteen of 36 patients with clinically negative nodes had superficially invasive tumors (pathologic Stage T1 and depth of invasion 0.5 cm or less), and none developed metastasis (median follow-up 124 months [range 58 to 240]). Tumor grade was significantly related to the likelihood of deep invasion but was not an independent prognostic factor for metastasis. CONCLUSIONS:DNA flow cytometry does not add prognostic information to that obtained by pathologic assessment in patients with invasive penile carcinoma. The presence of pathologic Stage T2 or greater or depth of invasion greater than 0.5 cm defines a group of patients at high risk of inguinal node metastasis. A novel finding was that patients with minimally invasive lesions (0.5 cm or less) and no evidence of corporal invasion (pathologic Stage T1) have little risk of inguinal node metastasis. Close observation of reliable patients meeting these criteria may be a safe alternative to prophylactic lymphadenectomy.






Hall MC,Sanders JS,Vuitch F,Ramirez E,Pettaway CA




Has Abstract


1998-07-01 00:00:00
















  • Chemosensitivity of malignant ovarian-type surface epithelial tumor of testis.

    abstract::Malignant ovarian-type surface epithelial tumors of the testis and paratestis are rare neoplasms. The chemosensitivity of these tumors has not been previously documented. We report a patient with metastatic disease with demonstrated responsiveness to chemotherapy treatments used in advanced ovarian cancer. ...


    pub_type: 杂志文章


    authors: Vaughn DJ,Rizzo TA,Malkowicz SB

    更新日期:2005-09-01 00:00:00

  • Percutaneous ureteral splinting.

    abstract::Percutaneous ureteral splinting using a modified catheter technique is described, and experience in treating 5 patients (4 with postoperative fistulas and 1 with stricture) is reported. The method offers an effective alternative to surgery in achieving ureteral splinting and renal drainage. ...


    pub_type: 杂志文章


    authors: Goldin AR

    更新日期:1977-08-01 00:00:00

  • Influence of patient age on biochemical freedom from disease in patients undergoing conformal proton radiotherapy of organ-confined prostate cancer.

    abstract:OBJECTIVES:To examine a large, single-institution series of patients to test the perception among clinicians that radiotherapy is preferred for "older" patients and surgery should be indicated for "younger" men. Both radiotherapy and surgery are used to control prostate cancer, and both yield similar results in terms o...


    pub_type: 杂志文章


    authors: Rossi CJ Jr,Slater JD,Yonemoto LT,Jabola BR,Bush DA,Levy RP,Grove R,Slater JM

    更新日期:2004-10-01 00:00:00

  • Longitudinal stone diameter on coronal reconstruction of computed tomography as a predictor of ureteral stone expulsion in medical expulsive therapy.

    abstract:OBJECTIVE:To evaluate stone diameter and ureteral dilation using computerized tomography as a predictor of ureteral stone expulsion after medical expulsive therapy. MATERIALS AND METHODS:We retrospectively reviewed the records of 328 patients with symptomatic ureteral stones <10 mm on axial computerized tomography ima...


    pub_type: 杂志文章


    authors: Lee SR,Jeon HG,Park DS,Choi YD

    更新日期:2012-10-01 00:00:00

  • Inadvertent ureteric ligation: diagnosis using multidetector computed tomography.

    abstract::Inadvertent ureteric ligation is an uncommon complication of laparoscopic surgery. We illustrate the appearance and utility of multidetector computed tomography in such a case after laparoscopic anterior resection. ...


    pub_type: 杂志文章


    authors: Quek LH,Pua U

    更新日期:2009-11-01 00:00:00

  • Comparison of polymerase chain reaction and immunologic methods for the detection of nanobacterial infection in type-III prostatitis.

    abstract:OBJECTIVE:To compare the results of polymerase chain reaction (PCR) and immunologic methods for the detection of nanobacteria (NB) in the expressed prostatic secretions (EPSs) of patients with type-III prostatitis. METHODS:In total, 150 patients with type-III prostatitis for whom conventional clinical treatment had fa...


    pub_type: 杂志文章


    authors: Zheng J,Tang J,Yin S,Shen X,Zhou Z

    更新日期:2014-09-01 00:00:00

  • Transitional cell carcinoma of bladder in thirteen-year-old boy.

    abstract::We report a rare case of primary epithelial bladder tumor in a thirteen-year-old boy. Histologically, the tumor was that of a solitary and papillary transitional cell carcinoma, grade 1. This tumor was detectable at cystoscopic examination, and cytologic procedures were without benefit for a diagnosis. ...


    pub_type: 杂志文章


    authors: Yamada Y,Satoh S,Kumazawa J

    更新日期:1992-02-01 00:00:00

  • Femoral neuropathy complicating urologic abdominopelvic procedures.

    abstract::We report on 3 cases of femoral neuropathy following radical surgery for urologic malignancy. The defect was bilateral in 2 patients. Compression from self-retaining retractors was the presumed mechanism of injury in all patients. Spontaneous improvement was observed in each case although the symptoms did not resolve ...


    pub_type: 杂志文章


    authors: Hall MC,Koch MO,Smith JA Jr

    更新日期:1995-01-01 00:00:00

  • Bone Saw for Calcified Peyronie's Disease Plaques.

    abstract:OBJECTIVES:To determine the incidence of calcified Peyronie's disease plaque that cannot be cut with a blade in a 100-case series and to describe the use of a soft tissue-protecting bone saw for plaque incision. METHODS:Chart reviews were done of all surgically treated Peyronie's disease patients at our center between...


    pub_type: 临床试验,杂志文章


    authors: Ostrowski KA,Dugi DD 3rd,Hedges JC,Barry JM

    更新日期:2015-08-01 00:00:00

  • Characterization of patients presenting with male factor infertility in an equal access, no cost medical system.

    abstract:OBJECTIVES:Demographic information on patients presenting for the diagnosis and treatment of male factor infertility has been limited in the past by the paucity of subspecialty trained providers and concentrated sequential patient information. Previously reported studies looking at the characteristics of patients being...


    pub_type: 杂志文章


    authors: Costabile RA,Spevak M

    更新日期:2001-12-01 00:00:00

  • Reconstructive strategy and classification of penoscrotal defects.

    abstract:OBJECTIVE:To classify defects in the penoscrotal region according to their specific anatomic sites. METHODS:From January 2002 to December 2012, 20 male patients underwent reconstruction for penoscrotal defects. The causative factors were Fournier's gangrene in 12 patients, extramammary Paget's disease in 4, skin tumor...


    pub_type: 杂志文章


    authors: Ahn DK,Kim SW,Park SY,Kim YH

    更新日期:2014-11-01 00:00:00

  • Endo-Satinsky Clamp Hybrid In Situ Perfusion in Retroperitoneoscopic Donor Nephrectomy For Right-sided Kidney.

    abstract:OBJECTIVE:To introduce our hybrid technique using an endo-Satinsky clamp and in situ cold perfusion for right-sided retroperitoneoscopic donor nephrectomy (RDN) and to investigate efficacy and safety compared with those standard right-sided RDN. METHODS:This retrospective study included 16 transplant donors who underw...


    pub_type: 杂志文章


    authors: Zhong X,Huang C,Li L,Hu W,Wu R,Xiao Y

    更新日期:2019-08-01 00:00:00

  • Clear cell adenocarcinoma in a female urethral diverticulum.

    abstract::Primary urethral carcinoma is an uncommon diagnosis, and carcinomas arising from within a urethral diverticulum are rare. Because of the limited number of diagnosed cases, optimal treatment guidelines are not available. However, patients require an aggressive treatment approach to provide the best chance for cure. ...


    pub_type: 杂志文章


    authors: Davis R,Peterson AC,Lance R

    更新日期:2003-03-01 00:00:00

  • Biopsy-proved prostate cancer in 100 consecutive men with benign digital rectal examination and elevated serum prostate-specific antigen level. Prevalence and pathologic characteristics.

    abstract::To determine whether a significant percentage of patients with a benign digital rectal examination (DRE) and an elevated serum prostate-specific antigen (PSA) level harbor a prostatic malignancy, 100 consecutive patients underwent transrectal ultrasound (TRUS)-guided biopsy of the prostate. The biopsy results were cor...


    pub_type: 杂志文章


    authors: Guthman DA,Wilson TM,Blute ML,Bergstralh EJ,Zincke H,Oesterling JE

    更新日期:1993-08-01 00:00:00

  • Intra-abdominal pulmonary sequestration: a benign suprarenal mass.

    abstract::A 34-year-old white woman presented with an 8.5-cm left suprarenal mass. Evaluation revealed normal adrenal hormone function. Pathologic examination after surgical removal revealed a rare benign condition, intra-abdominal extralobar pulmonary sequestration (accessory lung). ...


    pub_type: 杂志文章


    authors: Damani MN,Ganem JP,Freeman JA

    更新日期:1999-06-01 00:00:00

  • Polyclonal and monoclonal antibodies to prostate-specific antigen can cross-react with human kallikrein 2 and human kallikrein 1.

    abstract:OBJECTIVES:The human tissue kallikrein family contains three closely related proteases: human kallikrein 1 (hK1), human kallikrein 2 (hK2), and prostate-specific antigen (PSA). The structural homology between these three proteins suggests potential cross-reactivity interference when different immunologic techniques are...


    pub_type: 杂志文章


    authors: Finlay JA,Day JR,Rittenhouse HG

    更新日期:1999-04-01 00:00:00

  • Prescribing Trends in Post-Operative Pain Management After Urologic Surgery: A Quality Care Investigation for Healthcare Providers.

    abstract:OBJECTIVE:To assess prescribing and refilling trends of narcotics in postoperative urology patients at our institution. Although the opioid epidemic remains a public health threat, no series has assessed prescribing patterns across urologic surgery disciplines following discharge. METHODS:All urologic surgeries were r...


    pub_type: 杂志文章


    authors: Ellis JL,Ghiraldi EM,Cohn JA,Nitti M,Friedlander JI,Ginzburg S,Sterious SN,Abbosh P,Ohmann E,Uzzo RG,Simhan J

    更新日期:2021-01-23 00:00:00

  • Successful treatment of propofol-induced priapism with distal glans to corporal cavernosal shunt.

    abstract::We report a case of postoperative pediatric priapism in a boy without a hematologic disorder after a propofol-based general anesthetic. Our case underscores the importance of the early diagnosis and treatment to lessen the risk of complications. Given the wide use of propofol for sedation and anesthesia, clinicians sh...


    pub_type: 杂志文章


    authors: Fuentes EJ,Garcia S,Garrido M,Lorenzo C,Iglesias JM,Sola JE

    更新日期:2009-07-01 00:00:00

  • Localized squamous cell carcinoma of the bladder causing hypercalcemia and inhibition of PTH secretion.

    abstract::We report a case of symptomatic hypercalcemia in a patient with muscle-invasive, resectable squamous cell carcinoma of the bladder. Serum parathyroid hormone was consistent with secretion of parathyroid hormone-related protein. After radical cystoprostatectomy, calcium levels returned to normal. Patients with squamous...


    pub_type: 杂志文章


    authors: Wolchok JD,Herr HW,Kelly WK

    更新日期:1998-03-01 00:00:00

  • Botulinum Toxin Type A Injection After Failure of Augmentation Enterocystoplasty Performed for Neurogenic Detrusor Overactivity: Preliminary Results of a Salvage Strategy. The ENTEROTOX Study.

    abstract:OBJECTIVE:To evaluate the clinical efficacy, urodynamic effect and safety of Botulinum Toxin A (BTXA) injections after failure of augmentation enterocystoplasty (AE) performed for neurogenic detrusor overactivity. PATIENTS AND METHODS:We performed a multicenter retrospective study that included patients who had AE and...


    pub_type: 杂志文章,多中心研究


    authors: Michel F,Ciceron C,Bernuz B,Boissier R,Gaillet S,Even A,Chartier-Kastler E,Denys P,Gamé X,Ruffion A,Normand LL,Perrouin-Verbe B,Saussine C,Manunta A,Forin V,De Seze M,Grise P,Tournebise H,Schurch B,Karsenty G

    更新日期:2019-07-01 00:00:00

  • Endoscopic management of bladder calculi following augmentation cystoplasty.

    abstract:OBJECTIVES:We sought to evaluate the effectiveness and utility of an endoscopic approach to calculi that develop in the bladders of children following augmentation cystoplasty. In addition, we aimed to determine the indications for open vesicolithotomy. METHODS:We reviewed our experience between 1981 and 1993 with 26 ...


    pub_type: 杂志文章


    authors: Palmer LS,Franco I,Reda EF,Kogan SJ,Levitt SB

    更新日期:1994-12-01 00:00:00

  • Differences at Presentation and Treatment of Testicular Cancer in Hispanic Men: Institutional and National Hospital-based Analyses.

    abstract:OBJECTIVE:To describe epidemiologic patterns, stage at presentation, histology, and treatment differences associated with Hispanic men diagnosed with testicular germ cell tumor (TGCT). Hispanics are the fastest growing demographic in the United States and reports suggest that the incidence of TGCT is rising most rapidl...


    pub_type: 杂志文章


    authors: Woldu SL,Aydin AM,Rao AV,Hutchinson RC,Singla N,Clinton TN,Krabbe LM,Passoni NM,Raj GV,Miller DS,Amatruda JF,Sagalowsky AI,Lotan Y,Arriaga Y,Margulis V,Bagrodia A

    更新日期:2018-02-01 00:00:00

  • A prospective, randomized, double-blinded placebo-controlled comparison of extended release oxybutynin versus phenazopyridine for the management of postoperative ureteral stent discomfort.

    abstract:OBJECTIVES:Ureteral stents commonly cause lower urinary tract and flank discomfort. We evaluated the use of extended release oxybutynin versus phenazopyridine versus placebo for the management of ureteral stent discomfort after ureteroscopy. METHODS:Each of 60 patients who received a unilateral stent after ureteroscop...


    pub_type: 杂志文章,随机对照试验


    authors: Norris RD,Sur RL,Springhart WP,Marguet CG,Mathias BJ,Pietrow PK,Albala DM,Preminger GM

    更新日期:2008-05-01 00:00:00

  • Sexual dysfunction in combat veterans with post-traumatic stress disorder.

    abstract:OBJECTIVES:To evaluate the prevalence, clinical correlates, and severity of sexual dysfunction in combat veterans with and without post-traumatic stress disorder (PTSD) using a validated instrument for assessing sexual function. The results of recent studies have suggested that combat veterans with PTSD experience a hi...


    pub_type: 杂志文章


    authors: Cosgrove DJ,Gordon Z,Bernie JE,Hami S,Montoya D,Stein MB,Monga M

    更新日期:2002-11-01 00:00:00

  • Interleukin 6 is associated with cachexia in patients with prostate cancer.

    abstract:OBJECTIVES:To evaluate the relationship between serum interleukin (IL)-6 and cachexia in patients with prostate cancer. METHODS:Serum levels of IL-6, total protein, albumin, total cholesterol, and hemoglobin concentration were determined in 164 blood samples from patients with prostate cancer. The body mass index and ...


    pub_type: 杂志文章


    authors: Kuroda K,Nakashima J,Kanao K,Kikuchi E,Miyajima A,Horiguchi Y,Nakagawa K,Oya M,Ohigashi T,Murai M

    更新日期:2007-01-01 00:00:00

  • When the sling is too proximal: a specific mechanism of persistent stress incontinence after pubovaginal sling placement.

    abstract:OBJECTIVES:To review a series of patients with persistent stress urinary incontinence (SUI) after pubovaginal sling (PVS) placement because of an excessively proximal position of the graft on the bladder neck. METHODS:Four women, who had previously undergone PVS placement for SUI, presented for evaluation of persisten...


    pub_type: 杂志文章,评审


    authors: Poon C,Zimmern P

    更新日期:2004-08-01 00:00:00

  • Halothane-induced nephrotoxicity.

    abstract::Two cases are reported of combined renal and hepatic failure following exposure to halothane anesthesia. Both patients presented with postoperative fever and rapidly deteriorating liver and kidney function. Both required peritoneal dialysis. Both patients died, and in both cases this was the second exposure to halotha...


    pub_type: 杂志文章


    authors: Gelman ML,Lichtenstein NS

    更新日期:1981-04-01 00:00:00

  • Treatment of retrograde ejaculation with brompheniramine.

    abstract::The retrograde ejaculation experienced by a juvenile diabetic man was successfully treated with brompheniramine, a drug having antihistaminic and anticholinergic properties. A possible mechanism of action is suggested. ...


    pub_type: 杂志文章


    authors: Andaloro VA Jr,Dube A

    更新日期:1975-04-01 00:00:00

  • Transurethral Resection Alone Vs Resection Combined With Therapeutic Hydrodistention as Treatment for Ulcerative Interstitial Cystitis: Initial Experience With Propensity Score Matching Studies.

    abstract:OBJECTIVE:To compare the therapeutic efficacy of transurethral resection (TUR) alone with that of TUR combined with therapeutic hydrodistention in patients with ulcerative interstitial cystitis (IC). METHODS:The study subjects were 44 female patients newly diagnosed with IC who underwent TUR to treat ulcerative IC and...


    pub_type: 杂志文章


    authors: Lee SW,Kim WB,Lee KW,Kim JM,Kim YH,Lee B,Kim JH

    更新日期:2017-01-01 00:00:00

  • Relationship between renal parenchymal volume and single kidney glomerular filtration rate before and after unilateral nephrectomy.

    abstract:OBJECTIVES:To measure the renal parenchymal volume (RPV) before and after unilateral nephrectomy and investigate the relationship between the RPV and single kidney glomerular filtration rate (GFR). METHODS:From November 2003 to August 2009, 183 patients who had undergone unilateral nephrectomy were enrolled in the pre...


    pub_type: 杂志文章


    authors: Funahashi Y,Hattori R,Yamamoto T,Kamihira O,Sassa N,Gotoh M

    更新日期:2011-06-01 00:00:00