Deoxyribonucleic acid flow cytometry and traditional pathologic variables in invasive penile carcinoma: assessment of prognostic significance.


OBJECTIVES:The identification of reliable prognostic factors to guide the selection of patients at high risk of harboring subclinical metastases in penile cancer is important. We evaluated traditional pathologic variables and deoxyribonucleic acid (DNA) flow cytometry to determine the prognostic significance of these variables for the subsequent development of lymph node metastases. METHODS:Clinical data and pathologic specimens were retrospectively reviewed from patients treated surgically at university-affiliated hospitals from 1958 to 1987. Pathologic analysis (grade, depth of invasion, and pathologic stage) and DNA flow cytometry were performed on specimens from 46 patients with invasive penile carcinoma and complete medical records. Pathologic variables were compared with DNA flow cytometry results in patients who never developed lymph node metastasis (32 patients, median follow-up 121 months) and in those who presented with or developed proved lymph node metastases (14 patients, median follow-up 18 months). RESULTS:The distributions of diploid and nondiploid tumors were similar in patients with or without lymph node metastasis. In addition, there was no significant difference in the grade distributions of tumors with respect to lymph node status. Patients with positive nodes more commonly had tumors that invaded greater than 0.5 cm or that exhibited pathologic Stage T2 or greater (deep invasion). All 14 patients who presented with or subsequently developed metastasis had deep primary tumors. Thirteen of 36 patients with clinically negative nodes had superficially invasive tumors (pathologic Stage T1 and depth of invasion 0.5 cm or less), and none developed metastasis (median follow-up 124 months [range 58 to 240]). Tumor grade was significantly related to the likelihood of deep invasion but was not an independent prognostic factor for metastasis. CONCLUSIONS:DNA flow cytometry does not add prognostic information to that obtained by pathologic assessment in patients with invasive penile carcinoma. The presence of pathologic Stage T2 or greater or depth of invasion greater than 0.5 cm defines a group of patients at high risk of inguinal node metastasis. A novel finding was that patients with minimally invasive lesions (0.5 cm or less) and no evidence of corporal invasion (pathologic Stage T1) have little risk of inguinal node metastasis. Close observation of reliable patients meeting these criteria may be a safe alternative to prophylactic lymphadenectomy.






Hall MC,Sanders JS,Vuitch F,Ramirez E,Pettaway CA




Has Abstract


1998-07-01 00:00:00
















  • Phenacetin-induced renal papillary necrosis: pyonephros, anuria, and bilateral ureteral obstruction.

    abstract::A fifty-five-year-old man was seen with anuria. Retrograde pyelograms demonstrated bilateral ureteral obstruction subsequently shown to have resulted from sloughed renal papillae. A twenty-year history of phenacetin was obtained. Treatment included bilateral ureteral intubation, then ureterotomy on one side. ...


    pub_type: 杂志文章


    authors: Strimer RM,Morin LJ

    更新日期:1975-06-01 00:00:00

  • Magnetic resonance imaging findings after laparoscopic renal cryoablation.

    abstract:OBJECTIVES:To assess the magnetic resonance imaging (MRI) appearance of renal masses after laparoscopic cryoablation. METHODS:Between October 2000 and June 2004, 33 patients underwent laparoscopic cryoablation of 34 renal masses, 24 of whom (25 renal masses, size range 1.5 to 3.7 cm, mean 2.4) were followed up with MR...


    pub_type: 杂志文章,评审


    authors: Bolte SL,Ankem MK,Moon TD,Hedican SP,Lee FT,Sadowski EA,Nakada SY

    更新日期:2006-03-01 00:00:00

  • New ureteral access sheaths: a double standard.

    abstract:OBJECTIVE:To investigate the functional characteristics of the traditional and new single-wire ureteral access sheath (UAS) configurations relating to insertion, positioning, tissue injury, and durability. MATERIALS AND METHODS:Four UAS were tested: Navigator HD (11/13F, Boston Scientific), Re-Trace (10/12F, Coloplast...


    pub_type: 杂志文章


    authors: De S,Sarkissian C,Torricelli FC,Brown R,Monga M

    更新日期:2015-04-01 00:00:00

  • Controversies and Advances With Testosterone Therapy: A 40-Year Perspective.

    abstract::Testosterone therapy (TTh) has become highly controversial. There are important health consequences of testosterone deficiency, and meaningful benefits with treatment. There is level 1 evidence that TTh improves sexual function and desire, body composition, and bone density. Concerns regarding cardiovascular risk were...


    pub_type: 杂志文章,评审


    authors: Morgentaler A

    更新日期:2016-03-01 00:00:00

  • Statins, especially atorvastatin, may favorably influence clinical presentation and biochemical progression-free survival after brachytherapy for clinically localized prostate cancer.

    abstract:OBJECTIVES:To conduct a preliminary investigation on statin use and its impact on clinical presentation and biochemical progression-free survival after brachytherapy. METHODS:A total of 512 consecutive patients were treated with permanent brachytherapy for clinical Stage T1c-T3aNxM0 prostate cancer at least 3 years be...


    pub_type: 杂志文章


    authors: Moyad MA,Merrick GS,Butler WM,Wallner KE,Galbreath RW,Kurko B,Adamovich E

    更新日期:2005-12-01 00:00:00

  • Predictors of short postoperative prostate-specific antigen doubling time for patients diagnosed during PSA era.

    abstract:OBJECTIVES:To determine the preoperative and postoperative predictors of a short prostate-specific antigen (PSA) doubling time (PSADT) after radical prostatectomy for patients diagnosed during the PSA era. METHODS:Between 1989 and 2003, 1785 men underwent radical prostatectomy for 2002 American Joint Committee on Canc...


    pub_type: 杂志文章


    authors: Lin DD,Schultz D,Renshaw AA,Rubin MA,Richie JP,D'Amico AV

    更新日期:2005-03-01 00:00:00

  • On percutaneous drainage of retroperitoneal collections: when is primary surgical drainage preferable?

    abstract::Percutaneous drainage of retroperitoneal collections is a method employed with an ever-increasing frequency. The indication for primary surgical drainage of these collections is rapidly decreasing. Herein we describe what we consider to be the indications for primary surgical drainage of retroperitoneal collections il...


    pub_type: 杂志文章


    authors: Laor E,Schiffman Z,Reid RE,Tolia BM,Freed SZ

    更新日期:1985-08-01 00:00:00

  • Effect of hyperglycemia on expression of aquaporins in the rat vagina.

    abstract:OBJECTIVE:To investigate the effect of hyperglycemia on the expression of the aquaporin (AQP) isoforms in the diabetic rat vagina. METHODS:Female Sprague-Dawley rats (230-240 g, n = 45) were divided into control (n = 10) and experimental (n = 35) groups. Diabetes in the experimental group was induced by intraperitonea...


    pub_type: 杂志文章


    authors: Lee HS,Li Z,Kim SO,Ahn K,Kim NN,Park K

    更新日期:2012-09-01 00:00:00

  • Methylmethacrylate upper ureteral obstruction.

    abstract::A case of upper ureteral obstruction caused by methylmethacrylate cement after fixation of an L2-L3 vertebral fracture is reported. The probable mechanism, radiographic findings, and management of this complication are reviewed. ...


    pub_type: 杂志文章


    authors: Fiore A,Addonizio JC,Katz S,Choudhury M

    更新日期:1986-05-01 00:00:00

  • Urinary Neurotrophin Levels Increase in Women With Stress Urinary Incontinence After a Midurethral Sling Procedure.

    abstract:OBJECTIVE:To investigate the association between urinary neurotrophin levels, maximum flow rate (Qmax) variation, and the appearance of urgency in women with stress urinary incontinence (SUI) after a midurethral sling (MUS) procedure. MATERIALS AND METHODS:Thirty-one women with SUI were treated with a MUS. One year la...


    pub_type: 杂志文章


    authors: Antunes-Lopes T,Coelho A,Pinto R,Barros SC,Cruz CD,Cruz F,Silva CM

    更新日期:2017-01-01 00:00:00

  • Ureteral Extension of Cystic Childhood Renal Tumors: A Case Series and Review of Literature.

    abstract::Ureteral extension of childhood renal tumors is exceedingly rare. Hematuria, hydronephrosis, poorly or nonfunctioning kidney should raise suspicion for ureteral tumor extension. Identifying ureteral extension on preoperative imaging or intraoperatively before ureteral transection is crucial to obtain good oncological ...


    pub_type: 杂志文章


    authors: Abdelhalim A,Hafez AT,Dawaba M

    更新日期:2020-09-01 00:00:00

  • Pattern of calcium metabolism in normo- and hypercalciuric patients with calcium urolithiasis in Saudi Arabia.

    abstract::Urinary calcium excretion was measured in 100 consecutive normocalcemic patients with calcium urolithiasis and 12 Saudi Arabian controls while the patients and the controls were eating their usual diet of unknown calcium content. Only 16 patients were hypercalciuric using the definition of twenty-four-hour urinary cal...


    pub_type: 杂志文章


    authors: Hanash KA,Bissada NK,Woodhouse NJ

    更新日期:1985-07-01 00:00:00

  • Role of preoperative urography in benign prostatic hyperplasia.

    abstract::The excretory urograms of 184 consecutive patients admitted to hospital with a diagnosis of benign prostatic hyperplasia who subsequently underwent prostatectomy were reviewed to determine the usefulness of preoperative urography. Of 184 urograms reviewed, 10 were normal, 136 showed changes consistent with benign pros...


    pub_type: 杂志文章


    authors: Pang SM,Keresteci AG,Rankin JT,Jewett MA

    更新日期:1979-09-01 00:00:00

  • Ambulatory surgery centers and outpatient urologic surgery among Medicare beneficiaries.

    abstract:OBJECTIVE:To determine the effect of an ambulatory surgery center (ASC) opening in a healthcare market on utilization and quality of outpatient urologic surgery. METHODS:This is a retrospective cohort study of Medicare beneficiaries undergoing outpatient urologic surgery from 2001 to 2010. Markets were classified into...


    pub_type: 杂志文章


    authors: Suskind AM,Dunn RL,Zhang Y,Hollingsworth JM,Hollenbeck BK

    更新日期:2014-07-01 00:00:00

  • Granins and prostate cancer.

    abstract:OBJECTIVES:The importance of the expression of granin A (GRN-A, chromogranin-A) has become appreciated in the neuroendocrine differentiation of prostate cancer. We studied the expression of GRN-A in prostate cancer using serum immunoassay and tissue immunohistology procedures for this protein in order to define the cli...


    pub_type: 杂志文章,评审


    authors: Deftos LJ,Abrahamsson PA

    更新日期:1998-05-01 00:00:00

  • Differences at Presentation and Treatment of Testicular Cancer in Hispanic Men: Institutional and National Hospital-based Analyses.

    abstract:OBJECTIVE:To describe epidemiologic patterns, stage at presentation, histology, and treatment differences associated with Hispanic men diagnosed with testicular germ cell tumor (TGCT). Hispanics are the fastest growing demographic in the United States and reports suggest that the incidence of TGCT is rising most rapidl...


    pub_type: 杂志文章


    authors: Woldu SL,Aydin AM,Rao AV,Hutchinson RC,Singla N,Clinton TN,Krabbe LM,Passoni NM,Raj GV,Miller DS,Amatruda JF,Sagalowsky AI,Lotan Y,Arriaga Y,Margulis V,Bagrodia A

    更新日期:2018-02-01 00:00:00

  • The effect of intramuscular testosterone enanthate treatment on stretched penile length in prepubertal boys with hypospadias.

    abstract:OBJECTIVES:To define the responses of stretched penile length (PL) to intramuscular testosterone enanthate (TE) treatment in prepubertal boys with hypospadias. METHODS:We examined 17 Japanese boys with hypospadias at 1.4 +/- 1.3 (mean +/- SD) years of age. Their PLs were 2.79 +/- 0.37 cm and -1.16 +/- 0.88 SD of the m...


    pub_type: 杂志文章


    authors: Ishii T,Hayashi M,Suwanai A,Amano N,Hasegawa T

    更新日期:2010-07-01 00:00:00

  • Origin and types of calcium oxalate monohydrate papillary renal calculi.

    abstract:OBJECTIVES:Subepithelial hydroxyapatite calcification of renal papilla is thought to be involved in the formation of calcium oxalate monohydrate (COM) papillary calculi. To assess the mechanism of formation, we sought to correlate the fine structure of papillary renal calculi with specific pathophysiologic conditions a...


    pub_type: 杂志文章


    authors: Grases F,Costa-Bauzá A,Gomila I,Conte A

    更新日期:2010-12-01 00:00:00

  • Neonatal testicular infarction--possibly due to compression of the umbilical cord?

    abstract::Neonatal testicular infarction is a rare occurrence. We report on a newborn infant with bilateral testicular infarction. At birth, the uncut umbilical cord ran taut between the thighs making a complete loop around the genitals, compressing the testes. At the age of 6 hours, because of increasing agitation and the begi...


    pub_type: 杂志文章


    authors: Eifinger F,Ahrens U,Wille S,Roth B,Engelmann U

    更新日期:2010-06-01 00:00:00

  • Saw palmetto (Serenoa repens) in men with lower urinary tract symptoms: effects on urodynamic parameters and voiding symptoms.

    abstract:OBJECTIVES:To assess the effects of saw palmetto on voiding symptoms and urodynamic parameters in men with lower urinary tract symptoms (LUTS) presumed secondary to benign prostatic hyperplasia (BPH). METHODS:Fifty men with previously untreated LUTS and a minimum International Prostate Symptom Score (IPSS) of 10 or gr...


    pub_type: 临床试验,杂志文章


    authors: Gerber GS,Zagaja GP,Bales GT,Chodak GW,Contreras BA

    更新日期:1998-06-01 00:00:00

  • Bone alterations in patients with idiopathic hypercalciuria and calcium nephrolithiasis.

    abstract:OBJECTIVES:To verify whether alterations in bone density and turnover in patients with calcium nephrolithiasis and hypercalciuria are observable in various subgroups of patients divided according to the pathogenesis of the hypercalciuria. METHODS:Seventy patients with calcium nephrolithiasis and idiopathic hypercalciu...


    pub_type: 杂志文章


    authors: Tasca A,Cacciola A,Ferrarese P,Ioverno E,Visonà E,Bernardi C,Nobile M,Giannini S

    更新日期:2002-06-01 00:00:00

  • Prostato-cutaneous fistula: a rare clinical entity.

    abstract::A 30-year-old man presented with intermittent leak of straw-colored fluid from his left lateral thigh, which on evaluation was diagnosed as prostatocutaneous fistula. Exploration and revision anastomotic urethroplasty was done and the patient remains asymptomatic in follow-up. ...


    pub_type: 杂志文章


    authors: Kumar N,Vasudeva P,Kumar A,Raheja P

    更新日期:2013-08-01 00:00:00

  • Torulopsis glabrata fungal cystitis.

    abstract::The finding of Torulopsis glabrata fungal cystitis has become increasingly evident. The presence of indwelling urinary catheters, diabetes mellitus, and prior antibiotic therapy are significant risk factors in its development. Three cases are presented exemplifying the presentation of this disease. A discussion of its...


    pub_type: 杂志文章


    authors: Siminovitch JM,Herman GP

    更新日期:1984-10-01 00:00:00

  • Cystic pelvic pathology presenting as falsely elevated post-void residual urine measured by portable ultrasound bladder scanning: report of 3 cases and review of the literature.

    abstract::Dedicated portable ultrasound devices generally offer a rapid, noninvasive, largely operator-independent means of assessing post-void residual urine (PVR) volume. In most published series, PVR measured by portable ultrasound correlates well with catheterized urine volume. We report 3 cases in which follow-up of falsel...


    pub_type: 杂志文章,评审


    authors: Cooperberg MR,Chambers SK,Rutherford TJ,Foster HE Jr

    更新日期:2000-04-01 00:00:00

  • Percutaneous ureteral splinting.

    abstract::Percutaneous ureteral splinting using a modified catheter technique is described, and experience in treating 5 patients (4 with postoperative fistulas and 1 with stricture) is reported. The method offers an effective alternative to surgery in achieving ureteral splinting and renal drainage. ...


    pub_type: 杂志文章


    authors: Goldin AR

    更新日期:1977-08-01 00:00:00

  • Microvascular surgery: adjunct to renal transplantation.

    abstract::A new technique for microvascular anastomosis of the polar artery to the renal artery, end to side, is presented. It was performed in 5 cases of renal transplantation with a successful result in all. ...


    pub_type: 杂志文章


    authors: Castro Ferreira M,Menezes de Góes G,Marmo Lucon A,Tedesco-Marchese A,Campos Freire G

    更新日期:1975-12-01 00:00:00

  • Long-term metabolic and nutritional effects of urinary diversion.

    abstract:OBJECTIVES:To evaluate the long-term metabolic and nutritional consequences of interposing intestinal segments in the urinary tract. METHODS:Comprehensive analyses of blood and urine were performed in 20 patients with conduit urinary diversion and in 19 with continent cecal reservoir for urine, all with normal or near...


    pub_type: 杂志文章


    authors: Davidsson T,Lindergård B,Månsson W

    更新日期:1995-12-01 00:00:00

  • Analysis of impact of body mass index on outcomes of laparoscopic renal surgery.

    abstract:OBJECTIVES:As the prevalence of obesity increases in the United States, it has become more important to assess its impact on surgical outcomes. We evaluated the significance of obesity on laparoscopic radical nephrectomy (LRN) and laparoscopic partial nephrectomy (LPN). METHODS:This was a prospective database study ev...


    pub_type: 杂志文章


    authors: Gong EM,Orvieto MA,Lyon MB,Lucioni A,Gerber GS,Shalhav AL

    更新日期:2007-01-01 00:00:00

  • Improving Teamwork: Evaluating Workload of Surgical Team During Robot-assisted Surgery.

    abstract:OBJECTIVE:To investigate the cognitive and physical workload experienced by each operating room team member for different types of urologic procedures. METHODS:Surgeons, anesthesiologists, surgical fellows, bedside assistants, circulating nurses, and scrub nurses completed the National Aeronautics and Space Administra...


    pub_type: 杂志文章


    authors: Cavuoto LA,Hussein AA,Vasan V,Ahmed Y,Durrani A,Khan S,Cole A,Wang D,Kozlowski J,Ahmad B,Guru KA

    更新日期:2017-09-01 00:00:00

  • Modified abdominoplasty for patients with the Prune Belly syndrome.

    abstract:OBJECTIVE:To present the results of a new technique for abdominoplasty in patients with the Prune Belly syndrome (PBS). METHODS:Since 1985, 46 children with PBS underwent surgical treatment that included urinary tract reconstruction (UTR), orchidopexy, and abdominoplasty. In 41 patients, we performed the abdominoplast...


    pub_type: 杂志文章


    authors: Dénes FT,Lopes RI,Oliveira LM,Tavares A,Srougi M

    更新日期:2014-02-01 00:00:00