Regulation of the mitochondrial tricarboxylic acid cycle.

Abstract:

:Recent years have seen considerable advances in our understanding of the particular physiological roles of the constituent enzymes of the tricarboxylic acid (TCA) cycle. Despite acquiring a fairly comprehensive overview of the functional importance of these proteins relatively little is known concerning how this important pathway is regulated. In this review we concentrate on the mitochondrial reactions since this organelle is the only one in which a full cycle can, at least theoretically, operate. We summarize what is known about the regulation of the enzymes of the pathway both from historical kinetic studies as well as discussing more recent transcriptional and proteomic studies and our enhanced understanding of subcellular compartmentation within the context of metabolic regulation.

journal_name

Curr Opin Plant Biol

authors

Nunes-Nesi A,Araújo WL,Obata T,Fernie AR

doi

10.1016/j.pbi.2013.01.004

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

335-43

issue

3

eissn

1369-5266

issn

1879-0356

pii

S1369-5266(13)00016-2

journal_volume

16

pub_type

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