Serum ascorbic acid and other correlates of gallbladder disease among US adults.

Abstract:

OBJECTIVES:This study examined the correlates of clinical gallbladder disease among US adults and whether serum ascorbic acid levels are associated with a decreased prevalence of gallbladder disease. METHODS:Cross-sectional analyses of data from the Second National Health and Nutrition Examination Survey were conducted. RESULTS:A total of 384 women (8%) and 107 men (3%) reported a history of gallstone disease, and 347 women (7%) and 81 men (2%) reported a history of cholecystectomy. An inverted U-shaped relation was found between serum ascorbic acid level and clinical gallbladder disease among women but not among men. CONCLUSIONS:Ascorbic acid, which affects the catabolism of cholesterol to bile acids and, in turn, the development of gallbladder disease in experimental animals, may reduce the risk of clinical gallbladder disease in humans.

journal_name

Am J Public Health

authors

Simon JA,Hudes ES

doi

10.2105/ajph.88.8.1208

subject

Has Abstract

pub_date

1998-08-01 00:00:00

pages

1208-12

issue

8

eissn

0090-0036

issn

1541-0048

journal_volume

88

pub_type

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