Use of doxycycline for leptospirosis after high-risk exposure in São Paulo, Brazil.

Abstract:

:A clinical trial pilot study, double-blinded, randomized, and controlled with a placebo to assess the effectiveness of oral doxycycline (200 mg, single dose) in preventing leptospirosis after high exposure to potentially contaminated water was performed in São Paulo, SP, Brazil. Confirmed cases were defined as those with leptospira IgM antibody and symptoms; asymptomatic cases were those presenting with IgM antibodies but no symptoms; and suspected cases were individuals with symptoms but no IgM antibody. Forty subjects were given doxycycline and 42 were given placebo. In the drug-treated group there were 2 confirmed cases, 11 asymptomatic cases, and 6 suspected cases. In the placebo group there were 5 confirmed, 6 symptomatic, and 5 suspected cases. Even though we found a protective association of doxycycline for confirmed leptospirosis cases (RR = 2.3) and seroconversion only (RR = 2.0), the association was not statistically significant because of the small number of individuals enrolled in this pilot study. We observed that the 22% of the volunteers already had IgM antibodies to leptospirosis at the first sampling. Finally, the attack rate to confirmed, asymptomatic, and suspected cases of Leptospirosis was 8.5%, 22%, and 13%, respectively, in this population.

authors

Gonsalez CR,Casseb J,Monteiro FG,Paula-Neto JB,Fernandez RB,Silva MV,Camargo ED,Mairinque JM,Tavares LC

doi

10.1590/s0036-46651998000100012

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

59-61

issue

1

eissn

0036-4665

issn

1678-9946

journal_volume

40

pub_type

临床试验,杂志文章,随机对照试验
  • Etiology and severity of community acquired pneumonia in children from Uruguay: a 4-year study.

    abstract::The 4-year study (1987-1990) covered the major clinical-epidemiological characteristics of pneumonia in children as diagnosed at the emergency service of the Children's Hospital, as well as etiologies, and factors involved in the most severe cases. Etiology was determined in 47.7% of the 541 pneumonia cases, involving...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46651994000300010

    authors: Hortal M,Suarez A,Deleon C,Estevan M,Mogdasy MC,Russi JC,Contera M,Meny M

    更新日期:1994-05-01 00:00:00

  • [Ultramicro-ELISA for the detection of IgM antibodies anti M. leprae].

    abstract::The availability of an ultramicroanalytic system (SUMA) and species-specific antigen of M. leprae obtained by chemical synthesis, have made possible the standardization and validation of an ultramicroELISA assay for detecting specific human IgM antibodies to this mycobacterium. The specificity of this test to demonstr...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:

    authors: Laferte J,Abreu EG,Robaina R,Verez V

    更新日期:1991-11-01 00:00:00

  • Cryo-microtome sections of coproculture larvae of Strongyloides stercoralis and Strongyloides ratti as antigen sources for the immunodiagnosis of human strongyloidiasis.

    abstract::Cryo-microtome sections of larvae of Strongyloides stercoralis and S. ratti respectively obtained from human and rat feces cultures, were used as antigens. Fluoresceinate conjugates against human IgG were employed at the ideal titer of 10 for S. stercoralis and 100 for S. ratti. The sensitivity of the indirect immunof...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46651997000600001

    authors: Costa-Cruz JM,Bullamah CB,Gonçalves-Pires Mdo R,Campos DM,Vieira MA

    更新日期:1997-11-01 00:00:00

  • [Geographic distribution of Lutzomyia verrucarum (Townsend, 1913) (Diptera, Psychodidae, Phlebotominae), vector of human bartonellosis in Peru].

    abstract::Lutzomyia verrucarum (Townsend, 1913) (Diptera: Psychodidae); the natural vector of Bartonella bacilliformis, agent of human bartonellosis (peruvian verruga or Carrion's disease), is a native species of Peru; its geographic distribution occurrs between latitudes 5 degrees and 13 degrees 25' South: in the Occidental an...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46651993000600002

    authors: Caceres AG

    更新日期:1993-11-01 00:00:00

  • Candida esophagitis: species distribution and risk factors for infection.

    abstract::Although Candida albicans is the main cause of fungal esophagitis, other species such as C. tropicalis, C. krusei and C. stellatoidea have also been implicated. Several studies have identified risk factors for C. albicans esophagitis. However, data for non-C. albicans species is still sparse. The aim of this study was...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46652008000500002

    authors: Kliemann DA,Pasqualotto AC,Falavigna M,Giaretta T,Severo LC

    更新日期:2008-09-01 00:00:00

  • [Clinico-mycological study of onychomycosis in elderly patients].

    abstract::Physical examination of nails was carried out in 210 elderly patients and nail scrapings were obtained from onychomycosis suggested lesions in order to determine their causative agents, incidence and clinical characteristics. Diagnostic was confirmed by the isolation of the agents from 74 patients, mainly from toe-nai...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46651993000300001

    authors: Rodríguez-Soto ME,Fernández-Andreu CM,Moya Duque S,Rodríguez Díaz RM,Martínez-Machín G

    更新日期:1993-05-01 00:00:00

  • [A case of human brain infection caused by racemose cysticercus of parenchymal localization in Valdivia, Chile].

    abstract::A clinical case of cerebral infection by parenchymal racemose cysticercus, diagnosed by means of morphological characteristics in a patient of Valdivia city is described. The rare frequency of parenchymal location of racemose cysticercus as well as its differential diagnosis with other larval stages of cestodes that d...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46651991000300011

    authors: Ortega E,Torres P

    更新日期:1991-05-01 00:00:00

  • Coral snake antivenom produced in chickens (Gallus domesticus).

    abstract::The production of anti-snake venom from large mammal's blood has been found to be low-yielding and arduous, consequently, antivenom immunoglobulins for treatment are achieved regularly as polyvalent serum. We have standardized an undemanding technique for making purified immunoglobulin IgY antivenom consisting of poly...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/S0036-46652014000100009

    authors: Aguilar I,Sánchez EE,Girón ME,Estrella A,Guerrero B,Rodriguez-Acosta FA

    更新日期:2014-01-01 00:00:00

  • Headache in chagasic women.

    abstract::The aim of this study was to compare the frequency of headache between Chagasic and Non-chagasic women. The cross-sectional study comprised 647 female > or = 40 years old, Chagasic (n = 362) and Controls (n = 285) at a Brazilian University Hospital. Chagasic were classified as Cardiac (n = 179), Megas (n = 58) or Inde...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46651999000200010

    authors: dos Santos VM,da Cunha SF,Teixeira Vde P,Monteiro JP,dos Santos JA,dos Santos TA,dos Santos LA,da Cunha DF

    更新日期:1999-03-01 00:00:00

  • Angiostrongylus costaricensis: first record of its occurrence in the State of Espirito Santo, Brazil, and a review of its geographic distribution.

    abstract::Abdominal angiostrongyliasis is a parasitic disease caused by Angiostrongylus costaricensis, a metastrongylid nematode with wide geographic distribution, occurring from the United States to Argentina. In Brazil, the disease has been reported from the States of Rio Grande do Sul, Santa Catarina, Paraná, São Paulo, Fede...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46651995000400016

    authors: Pena GP,Andrade Filho J,de Assis SC

    更新日期:1995-07-01 00:00:00

  • Presence of rotavirus and free-living amoebae in the water supplies of Karachi, Pakistan.

    abstract::Rotavirus and pathogenic free-living amoebae are causative agents of important health problems, especially for developing countries like Pakistan where the population has limited access to clean water supplies. Here, we evaluated the prevalence of rotavirus and free-living amoebae (Acanthamoeba spp., Balamuthia mandri...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/S1678-9946201759032

    authors: Yousuf FA,Siddiqui R,Khan NA

    更新日期:2017-06-01 00:00:00

  • Unusual case of lagochilascariasis with breast involvement: the first case report in pregnancy.

    abstract::Lagochilascariasis is a neglected neotropical helminthiasis, responsible for human infections through the ingestion of raw or undercooked meat from wild animals infected by larvae encysted in their tissues. It is characterized by a chronic evolution with periods of remission and recurrences, affecting mainly the head ...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type:

    doi:10.1590/S1678-9946202062086

    authors: Assy JGPL,Esper HR,Quiroga MMM,Brandão ADS,Said RDC,Pinheiro OC,Ribeiro APDS,Santo MCCDE,França FOS

    更新日期:2020-11-09 00:00:00

  • Chagas'disease: IgA, IgM and IgG antibodies to T. cruzi amastigote, trypomastigote and epimastigote antigens in acute and in different chronic forms of the disease.

    abstract::In an attempt to find a better T. cruzi antigen and possible immunological markers for the diagnosis of different clinical forms of Chagas'disease, amastigote and trypomastigote antigens obtained from immunosuppressed mice infected with T. cruzi (Y strain) were assessed in comparison with conventional epimastigote ant...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46651990000300005

    authors: Primavera KS,Umezawa ES,Peres BA,Camargo ME,Hoshino-Shimizu S

    更新日期:1990-05-01 00:00:00

  • Relevant prevalence of Mycoplasma hominis and Ureaplasma urealyticum serogroups in HIV-1 infected men without urethritis symptoms.

    abstract::M. hominis and U. urealyticum are the better-known mycoplasma species pathogenic to the human genitourinary tract, causing mainly urethritis, bacterial vaginosis and pregnancy complications. In HIV-infected patients, the prevalence and role of these species is still not well known. The aim of this work was to determin...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46652000000400002

    authors: Cordova CM,Cunha RA

    更新日期:2000-07-01 00:00:00

  • Vertical transmission of dengue virus in Aedes aegypti collected in Puerto Iguazú, Misiones, Argentina.

    abstract::A finding of vertical transmission of the DEN 3 virus in male specimens of Aedes aegypti, collected in the 2009 fall-winter period, in Puerto Iguazú city, Misiones, Argentina, using the RT-PCR technique in a 15-specimen pool is reported. This result is analyzed within the context of the epidemiological situation of Ar...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/S0036-46652014000200013

    authors: Espinosa M,Giamperetti S,Abril M,Seijo A

    更新日期:2014-03-01 00:00:00

  • FACTORS RELATED TO ORAL CANDIDIASIS IN ELDERLY USERS AND NON-USERS OF REMOVABLE DENTAL PROSTHESES.

    abstract::This study examined the association between oral candidiasis in elderly users and nonusers of prosthesis and its predisposing factors. To this end, we performed a cross-sectional study where saliva samples from 48 patients were collected they used prosthesis and 43 patients (control group) who did not use. Among the 9...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/S1678-9946201658017

    authors: Bianchi CM,Bianchi HA,Tadano T,Paula CR,Hoffmann-Santos HD,Leite DP Jr,Hahn RC

    更新日期:2016-01-01 00:00:00

  • Herpes simplex virus type 2 infection in pregnancy: asymptomatic viral excretion at delivery and seroepidemiologic survey of two socioeconomically distinct populations in São Paulo, Brazil.

    abstract::The objective of the present study was to estimate the prevalence of herpes simplex virus type 2 (HSV 2) antibodies in child bearing women of 2 Brazilian populations with different socioeconomic status and to determine the risk of neonatal HSV exposure by means of maternal cultures at the onset of labor. The study was...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章,多中心研究

    doi:10.1590/s0036-46651993000300011

    authors: Weinberg A,Canto CL,Pannuti CS,Kwang WN,Garcia SA,Zugaib M

    更新日期:1993-05-01 00:00:00

  • A simple PCR-based procedure for plague diagnosis.

    abstract::Supernatant of boiled spleen saline-suspensions of Yersinia pestis experimentally infected animals were used as template for PCR amplification without DNA extraction. PCR sensitivity was enhanced by a second round of amplification (Nested). No amplification was observed from non-infected animals. ...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46651996000500009

    authors: Leal NC,Abath FG,Alves LC,de Almeida AM

    更新日期:1996-09-01 00:00:00

  • Fusobacterium necrophorum causing infective endocarditis and liver and splenic abscesses.

    abstract::A 25-year-old male without prior co-morbidities was admitted to hospital with Fusobacterium necrophorum bacteremia, where he was found to have liver and splenic abscesses. Further evaluation with echocardiography revealed a bicuspid aortic valve with severe insufficiency and a 1.68 x 0.86 cm vegetation. The patient re...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章,评审

    doi:10.1590/s0036-46652011000300009

    authors: Handler MZ,Miriovsky B,Gendelman HE,Sandkovsky U

    更新日期:2011-05-01 00:00:00

  • [Human gastroenteritis associated with Vibrio parahaemolyticus in Recife, Brazil].

    abstract::A study was carried out on the occurrence of Vibrio parahaemolyticus in 1,100 diarrheal feces, routinely sent to a private clinical laboratory for microbiologic diagnosis, in Recife. V. parahaemolyticus was isolated from 14 (1.3%) fecal samples. However, if we considered only the specimens from adult patients, the iso...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46651991000100012

    authors: Magalhães V,Lima RA,Tateno S,Magalhães M

    更新日期:1991-01-01 00:00:00

  • Effects of eucalyptol on house fly (Diptera: Muscidae) and blow fly (Diptera: Calliphoridae).

    abstract::The effects of eucalyptol were evaluated against the house fly, Musca domestica L., and blow fly, Chrysomya megacephala (F.). The bioassay of adults, using topical application, indicated that M. domestica males were more susceptible than females, with the LD50 being 118 and 177 microg/fly, respectively. A higher LD50 ...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46652004000200008

    authors: Sukontason KL,Boonchu N,Sukontason K,Choochote W

    更新日期:2004-03-01 00:00:00

  • Hantavirus pulmonary syndrome in the Province of Rio Negro, Argentina, 1993-1996.

    abstract::Early in 1995 the first case of Hantavirus Pulmonary Syndrome was serologically confirmed in El Bolsón (Province of Río Negro, Argentina), corresponding to the third outbreak reported in Argentina. A total of 26 cases of HPS related to the Andean region of Rio Negro Province, were reported from 1993 to 1996, 17 in El ...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46651997000400002

    authors: Cantoni G,Lazaro M,Resa A,Arellano O,Amestoy AM,De Bunder S,Herrero E,Perez A,Larrieu E

    更新日期:1997-07-01 00:00:00

  • [In vitro susceptibility of Cryptococcus strains to 5 antifungal drugs].

    abstract::A comparative study of the "in vitro" susceptibility of 24 Cryptococcus strains to 5 antifungal drugs (amphotericin B, 5 fluorocytosine, miconazole, itraconazole and ketoconazole), was carried out. These strains were grouped according to species, varieties and isolation's origins. The minimum inhibitory concentration ...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46651989000500009

    authors: Bava AJ,Negroni R

    更新日期:1989-09-01 00:00:00

  • Fonsecaea pedrosoi cerebral phaeohyphomycosis ("chromoblastomycosis"): first human culture-proven case reported in Brazil.

    abstract::Cerebral phaeohyphomycosis ("chromoblastomycosis") is a rare intracranial lesion. We report the first human culture-proven case of brain abscesses due to Fonsecaea pedrosoi in Brazil. The patient, a 28 year-old immunocompetent white male, had ocular manifestations and a hypertensive intracranial syndrome. Magnetic res...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46652003000400008

    authors: Nóbrega JP,Rosemberg S,Adami AM,Heins-Vaccari EM,Lacaz Cda S,de Brito T

    更新日期:2003-07-01 00:00:00

  • Nosocomial infection in long-term care facilities. A survey in a Brazilian psychiatric hospital.

    abstract::Nosocomial infection among male patients in a public psychiatric hospital was studied and the definitions for use in long-term care facilities were employed for diagnosis. The overall nosocomial infection rate was 6.7 per 1,000 day inpatients; 55.6% of these infections were identified in the respiratory tract, 50% of ...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46651999000600006

    authors: Almeida RC,Pedroso RP

    更新日期:1999-11-01 00:00:00

  • Geoprocessing and spatial analysis for identifying leptospirosis risk areas: a systematic review.

    abstract::Leptospirosis is a reemerging zoonosis caused by bacteria of the genus Leptospira sp. with global importance in the medical and veterinary fields, being responsible for about 59 thousand deaths each year in the world. The use of Geographic Information Systems (GIS) in the health sector is propitious and has been adopt...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/S1678-9946202062035

    authors: Souza IPO,Uberti MS,Tassinari WS

    更新日期:2020-06-05 00:00:00

  • Soil contamination of a public park by human and canine mastadenovirus, as well as hookworms and Toxocara spp eggs.

    abstract::Public parks are leisure environments widely used by both, adults and children, often accompained by their pets. Soil contamination of these environments by enteric viruses and intestinal parasites occurs through these animals feces. The aim of this work was to detect Carnivore protoparvovirus 1 (CPV-1) and different ...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/S1678-9946201961060

    authors: Eisen AKA,Demoliner M,Oliveira KG,Troian EA,Mallmann L,Filippi M,Almeida PR,Spilki FR

    更新日期:2019-11-25 00:00:00

  • [Hydatidosis immunodiagnosis: determination of Taenia crassiceps cysticerws antigens in hydatid and vesicular fluid].

    abstract::The specificity and sensitivity of the enzyme immunoassay (EIA), presently used in South America areas where hydatidosis caused by Echinococcus granulosus is endemic, was compared to two alternative EIA. One of these uses an hydatid antigen of different preparation and the other vesicular fluid of Taenia crassiceps ci...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46651993000200007

    authors: Coltorti E,Cammarieŕi G

    更新日期:1993-03-01 00:00:00

  • Canine visceral leishmaniasis due to Leishmania (L.) infantum chagasi in Amazonian Brazil: comparison of the parasite density from the skin, lymph node and visceral tissues between symptomatic and asymptomatic, seropositive dogs.

    abstract::Canine visceral leishmaniasis (CVL) is recognizable by characteristic signs of disease and is highly lethal. The infection, however, may be quite inapparent in some seropositive dogs, and this has raised the polemic question as to whether or not such animals can be a source of infection for Lutzomyia longipalpis, the ...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46652010000500007

    authors: Lima LV,Carneiro LA,Campos MB,Chagas EJ,Laurenti MD,Corbett CE,Lainson R,Silveira FT

    更新日期:2010-09-01 00:00:00

  • Human ocular sparganosis in southern Brazil.

    abstract::We report the first case of human ocular sparganosis in the state of Santa Catarina, southern Brazil. A young female patient presented with three periocular moveable inflammatory masses in her right eye, during two years. By surgical excisional biopsy, a helminth larval stage was removed and identified as sparganum. C...

    journal_title:Revista do Instituto de Medicina Tropical de Sao Paulo

    pub_type: 杂志文章

    doi:10.1590/s0036-46652011000100009

    authors: Mentz MB,Procianoy F,Maestri MK,Rott MB

    更新日期:2011-01-01 00:00:00