The fate is not always written in the genes: epigenomics in epidemiologic studies.

abstract：:The L5178Y mouse lymphoma cell mutagenesis assay is used to detect the mutagenic activity of chemicals in a mammalian cell system. To evaluate this assay we compared the results of assays performed independently on 63 chemicals by laboratories at SRI International and Litton Bionetics, Inc. The two laboratories used s...

journal_title：Environmental and molecular mutagenesis

authors： Caspary WJ,Daston DS,Myhr BC,Mitchell AD,Rudd CJ,Lee PS

更新日期：1988-01-01 00:00:00

abstract：:Lead is a widely existing environmental pollutant with potential carcinogenicity. To investigate the association of blood lead level (B-Pb) with potential chromosomal damage and cancer, we analyzed micronucleus (MN) frequency of peripheral blood lymphocytes (PBLs) and the methylation status of six human tumor suppress...

journal_title：Environmental and molecular mutagenesis

authors： Yu LB,Tu YT,Huang JW,Zhang YN,Zheng GQ,Xu XW,Wang JW,Xiao JQ,Christiani DC,Xia ZL

更新日期：2018-07-01 00:00:00

abstract：:AQ-13 ([N1-(7-chloro-quinolin-4yl)-3-(N3,N3-diethylamino)propylamine] dihydrochloride trihydrate) is an aminoquinoline antimalarial drug that is effective against chloroquine-resistant strains of Plasmodium falciparum. It is structurally similar to the widely used chloroquine diphosphate (CQ). We evaluated these drugs...

journal_title：Environmental and molecular mutagenesis

authors： Riccio ES,Lee PS,Winegar RA,Krogstad DJ,De D,Mirsalis JC

更新日期：2001-01-01 00:00:00

abstract：:Several genotoxicity endpoints have been evaluated to define nonlinear dose-responses for SN 1 and SN 2 alkylating genotoxicants. Dose-response studies acknowledging the process of multistage tumorigenesis are important; however, data pertaining nonlinearity are not yet available. In this communication, the role of DN...

journal_title：Environmental and molecular mutagenesis

authors： Becker K,Thomas AD,Kaina B

更新日期：2014-03-01 00:00:00

abstract：:A transplacental carcinogenicity study was conducted by exposing pregnant Swiss (CD-1) mice to 0, 50, 100, 200, or 300 mg 3'-azido-3'-deoxythymidine (AZT)/kg body weight (BW) daily for the duration of gestation (18-19 days) [National Toxicology Program,2006]. The incidence of alveolar/bronchiolar adenomas and carcinom...

journal_title：Environmental and molecular mutagenesis

authors： Koujitani T,Ton TV,Lahousse SA,Hong HH,Wakamatsu N,Sills RC

更新日期：2008-12-01 00:00:00

abstract：:Third instar larvae of Drosophila melanogaster transdihybrid for mwh and flr were exposed to varying concentrations of cisplatin by feeding on dry media wetted with aqueous solutions of the test compound. Larval feeding continued until pupation, and surviving transdihybrid adults were collected seven days following co...

journal_title：Environmental and molecular mutagenesis

authors： Katz AJ

更新日期：1987-01-01 00:00:00

abstract：:Contamination of ground water by industrial waste poses potential health hazards for man and his environment. The improper disposal of toxic wastes could allow genotoxic chemicals to percolate into ground waters, and these contaminated ground waters may produce toxicity, including mutation and eventually cancer, in ex...

journal_title：Environmental and molecular mutagenesis

authors： Chandra S,Chauhan LK,Murthy RC,Gupta SK

更新日期：2006-06-01 00:00:00

abstract：:The aim of this study was to investigate genotoxic effects of lamivudine (an analogue of cytidine) using in vitro sister chromatid exchange (SCE), chromosome aberration (CA), and micronucleus (MN) tests in human peripheral lymphocytes. The cells were treated with 75, 100, 125, and 150 microg/ml concentrations of lamiv...

journal_title：Environmental and molecular mutagenesis

authors： Bayram S,Topaktaş M

更新日期：2008-05-01 00:00:00

abstract：:N-Hydroxymethylacrylamide (NHMA), a mouse carcinogen inactive in the Salmonella assay and mouse micronucleus (MN) assay, was tested for reproductive effects in a mouse continuous breeding study. In that study, increased embryonic deaths were observed after 13 weeks exposure of parental animals to NHMA via drinking wat...

journal_title：Environmental and molecular mutagenesis

authors： Witt KL,Hughes LA,Burka LT,McFee AF,Mathews JM,Black SL,Bishop JB

更新日期：2003-01-01 00:00:00

abstract：:The mutagenic activity of airborne particulate matter collected in Pisa, a small nonindustrial town located in Italy, has been monitored over 1 year using the Ames Salmonella Test. Airborne particulate was collected on fibreglass filters using a Hi-Vol sampler and extracted by sonication and Soxhlet acetone extraction...

journal_title：Environmental and molecular mutagenesis

authors： Barale R,Zucconi D,Giorgelli F,Carducci AL,Tonelli M,Loprieno N

更新日期：1989-01-01 00:00:00

abstract：:Loss of heterozygosity (LOH) is a critical event in the development of human cancers. LOH is thought to result from either a large deletion or recombination between homologous alleles during repair of DNA double-strand breaks (DSBs). These types of genetic alterations produce mutations in the TK gene mutation assay, w...

journal_title：Environmental and molecular mutagenesis

authors： Honma M

更新日期：2005-03-01 00:00:00

abstract：:The modulation of 1,3-butadiene (BD)-induced DNA adducts by occupational exposure, glutathione S-transferase (GST) genotypes, single-strand breaks, and cytogenetic end points was studied in 15 workers and 11 controls. The exposed group consisted of 8 smokers and 7 nonsmokers, whereas the control group consisted of 7 n...

journal_title：Environmental and molecular mutagenesis

authors： Zhao C,Vodicka P,Sram RJ,Hemminki K

更新日期：2001-01-01 00:00:00

abstract：:Benzene is an important industrial chemical and widespread environmental pollutant known to induce leukemia and other blood disorders. To be carcinogenic, benzene must be metabolized to produce toxic metabolites. To investigate whether single nucleotide polymorphisms (SNPs) in the metabolic enzyme genes are associated...

journal_title：Environmental and molecular mutagenesis

authors： Xing C,Chen Q,Li G,Zhang L,Zheng M,Zou Z,Hou L,Wang QF,Liu X,Guo X

更新日期：2013-07-01 00:00:00

abstract：:A mutagenesis moonshot addressing the influence of the environment on our genetic wellbeing was launched just 2 months before astronauts landed on the moon. Its impetus included the discovery that X-rays (Muller HJ. [1927]: Science 64:84-87) and chemicals (Auerbach and Robson. [1946]: Nature 157:302) were germ-cell mu...

journal_title：Environmental and molecular mutagenesis

authors： DeMarini DM

更新日期：2020-01-01 00:00:00

abstract：:The objective of our study was to develop a micronucleus (MN) assay for detecting genotoxic damage after inhalation exposure in mouse alveolar Type II and Clara cells, potential target cells for lung carcinogens. Ten male C57BL/6J mice were exposed to ethylene oxide (630 mg/m(3)) for 4 hr via inhalation; 10 unexposed ...

journal_title：Environmental and molecular mutagenesis

authors： Lindberg HK,Falck GC,Catalán J,Santonen T,Norppa H

更新日期：2010-03-01 00:00:00

abstract：:It is estimated that 15% of all cancers are etiologically linked to viral infection. Specific cancers including adult T-cell leukemia, hepatocellular carcinoma, and uterine cervical cancer are associated with infection by human T-cell leukemia virus type I, hepatitis B virus, and high-risk human papilloma virus, respe...

journal_title：Environmental and molecular mutagenesis

authors： Gatza ML,Chandhasin C,Ducu RI,Marriott SJ

更新日期：2005-03-01 00:00:00

abstract：:BDF1 mice were exposed in inhalation chambers to benzene (900 ppm, 300 ppm) and/or toluene (500 ppm, 250 ppm) 6 hr per day, 5 days per week, for up to 8 weeks. Benzene alone induced a slight anemia after 4 and 8 weeks and a reduction of BFU-E and CFU-E numbers in the marrow. The coexposure to toluene reduced the degre...

journal_title：Environmental and molecular mutagenesis

authors： Plappert U,Barthel E,Seidel HJ

更新日期：1994-01-01 00:00:00

abstract：:DNA damage and its subsequent repair occur heterogeneously throughout the genome, which reflects the nature of the damaging agents, gross chromosomal structure, the specific nucleotide sequence, and transcriptional status. We selected to investigate the repair of DNA damage in an artificial, transgenic situation. Here...

journal_title：Environmental and molecular mutagenesis

authors： Yang H,Kotturi GP,de Boer JG,Glickman BW

更新日期：1999-01-01 00:00:00

abstract：:Sickle cell anemia (SCA) is a hereditary hematological disease that is characterized by a point mutation in the beta globin S gene and has no specific treatment; hydroxyurea (HU) is the only therapeutic agent used in clinical practice. In the present study, we evaluated the deoxyribonucleic acid (DNA) damage index (DI...

journal_title：Environmental and molecular mutagenesis

authors： Maia Filho PA,Pereira JF,Almeida Filho TP,Cavalcanti BC,Sousa JC,Lemes RPG

更新日期：2019-04-01 00:00:00

abstract：:Chromosome aberrations can occur by secondary mechanism(s) associated with cytotoxicity, induced by chemicals that do not attack DNA. Aberrations are formed from DNA double-strand breaks, and DSBs are known to be induced by nonmutagenic (Ames test negative) noncarcinogens at toxic levels [Storer et al. (1996): Mutat R...

journal_title：Environmental and molecular mutagenesis

authors： Hilliard CA,Armstrong MJ,Bradt CI,Hill RB,Greenwood SK,Galloway SM

更新日期：1998-01-01 00:00:00

abstract：:The in vivo Pig-a mutation assay has been adapted for measuring mutation in rats, mice, monkeys, and humans. To date, the assay has been used mainly to assess the mutagenicity of chemicals that are known to be powerful point mutagens. The assay has not been used to measure the biological effects associated with ionizi...

journal_title：Environmental and molecular mutagenesis

authors： Ohtani S,Unno A,Ushiyama A,Kimoto T,Miura D,Kunugita N

更新日期：2012-10-01 00:00:00

abstract：:The genotoxicity of humic acid and its possible interaction with the herbicides alachlor and maleic hydrazide have been evaluated in cultured human lymphocytes from two donors. Humic acid and the two herbicides have been tested (alone and combined) for sister-chromatid exchange (SCE) induction. In addition, the effect...

journal_title：Environmental and molecular mutagenesis

authors： Ribas G,Carbonell E,Creus A,Xamena N,Marcos R

更新日期：1997-01-01 00:00:00

abstract：:An automated approach for scoring in vitro micronuclei (MN) has been described in which flow cytometric analysis is combined with compound exposure, processing, and sampling in a single 96-well plate (Bryce SM et al. [2010]: Mutat Res 703:191-199). The current report describes protocol optimization and an interlaborat...

journal_title：Environmental and molecular mutagenesis

authors： Bryce SM,Avlasevich SL,Bemis JC,Tate M,Walmsley RM,Saad F,Van Dijck K,De Boeck M,Van Goethem F,Lukamowicz-Rajska M,Elhajouji A,Dertinger SD

更新日期：2013-04-01 00:00:00

abstract：:Environmental tobacco smoke (ETS) is a major source of indoor air pollution. Extractable-respirable particulate (ERP) from the ETS-contaminated indoor air (ERP-ETS) was collected from six passenger train cars and one control room. The mutagenicity of ERP-ETS was tested in the Ames/Salmonella test in the presence of ma...

journal_title：Environmental and molecular mutagenesis

authors： Zhou R,Yu G,Zhou Y,Zeng X

更新日期：1999-01-01 00:00:00

abstract：:The induction and nature of mutations in the lacI transgene were evaluated in multiple tissues after exposure of adult male B6C3F1 lacI transgenic mice to cyclophosphamide (CP). Mice were given a single i.p. injection of 25 mg CP/kg, 100 mg CP/kg, or vehicle (PBS) and then necropsied 6 weeks after treatment to allow D...

journal_title：Environmental and molecular mutagenesis

authors： Gorelick NJ,Andrews JL,deBoer JG,Young R,Gibson DP,Walker VE

更新日期：1999-01-01 00:00:00

abstract：:The nuclease P1 modification of the 32P-postlabeling technique was used to study the biological activity of 7H-dibenzo[c,g]carbazole (DBC) and some of its derivatives, including N-methyldibenzo[c,g]carbazole (N-MeDBC), 5,9-dimethyldibenzo[c,g]carbazole (5,9-diMeDBC), 5,9,N-trimethyldibenzo[c,g]carbazole (5,9,N-triMeDB...

journal_title：Environmental and molecular mutagenesis

authors： Gábelová A,Périn-Roussel O,Jounaidi Y,Périn F

更新日期：1997-01-01 00:00:00

abstract：:The term "the DNA damage response" (DDR) encompasses a sophisticated array of cellular initiatives set in motion as cells are exposed to DNA-damaging events. It has been known for over half a century that all organisms have the ability to restore genomic integrity through DNA repair. More recent discoveries of signal ...

journal_title：Environmental and molecular mutagenesis

authors： Ljungman M

更新日期：2010-10-01 00:00:00

abstract：:Investigations have been carried out which have measured the influence of the repair polymerases on the yield of different types of chromosomal aberrations. The studies were mainly concerned with the effect of inhibiting the polymerases on the yield of aberrations. The polymerases fill in single strand regions, and th...

journal_title：Environmental and molecular mutagenesis

authors： Moore RC,Bender MA

更新日期：1993-01-01 00:00:00

abstract：:We evaluated the mutagens in fumes produced by heating three different cooking oils used in Taiwan to temperatures of 100 degrees C, 200 degrees C, and 300 degrees C, and constructed models to study the efficacy of fume extractors used commonly by Taiwanese women. Particulates of volatile emissions from lard (at 200 d...

journal_title：Environmental and molecular mutagenesis

authors： Chiang TA,Wu PF,Ko YC

更新日期：1998-01-01 00:00:00

abstract：:DNA damage induced by solar ultraviolet (UV) radiation plays an important role in the induction of skin cancer. Although UVA constitutes the majority of solar UV radiation, it is less damaging to DNA than UVB. The DNA damage produced by UVA radiation, however, can be augmented in the presence of a photosensitizer. We ...

journal_title：Environmental and molecular mutagenesis

authors： Toyooka T,Ibuki Y,Takabayashi F,Goto R

更新日期：2006-01-01 00:00:00